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1. 发明授权

US07485455B2 Nucleic acid encoding sodium channel subunit 有权
标题翻译：核酸编码钠通道亚单位
公开(公告)号：US07485455B2
公开(公告)日：2009-02-03
申请号：US10632342
申请日：2003-08-01
申请人： Jonathan C. Makielski , Bin Ye , Michael J. Ackerman
发明人： Jonathan C. Makielski , Bin Ye , Michael J. Ackerman
IPC分类号： C12N15/12 , C12N5/10 , C12N15/63
CPC分类号： C12Q1/6883 , C07K14/705 , C12Q2600/156
摘要： The present invention discloses four groups of SCN5A variants that represent the most common SCN5A variants in humans. A specific mutation in one of the variants has been shown to display a different phenotype in relation to a human heart disease than other variants and known human sodium channel α subunits with corresponding mutations. The present invention provides new tools to study mutations and to design or identify new diagnostic and treatment strategies or agents for sodium channel related diseases or conditions.
摘要翻译：本发明公开了四组代表人类中最常见的SCN5A变体的SCN5A变体。与其他变体和具有相应突变的已知人钠通道α亚基相比，其中一个变体中的特异性突变显示出与人类心脏病相关的不同表型。本发明提供用于研究突变并设计或鉴定用于钠通道相关疾病或病症的新诊断和治疗策略或药剂的新工具。

2. 发明申请

US20080293087A1 SULFONYLUREA RECEPTOR SHORT FORMS FROM MITOCHONDRIA AND USES THEREOF 审中-公开
标题翻译：来自麻醉药的SUFFYYURURA受体短型及其用途
公开(公告)号：US20080293087A1
公开(公告)日：2008-11-27
申请号：US11931916
申请日：2007-10-31
申请人： Jonathan C. Makielski , Nian-Qing Shi , Bin Ye
发明人： Jonathan C. Makielski , Nian-Qing Shi , Bin Ye
IPC分类号： C12Q1/02 , C07H21/00 , C07K14/00 , C12N15/63 , C12N5/00
CPC分类号： C07K14/705
摘要： The present invention relates to isolated sulfonylurea receptor polynucleotides and polypeptides, as well as vectors and cells lines containing the polynucleotides and polypeptides. The present invention also relates to methods of using cell lines containing the polynucleotides and polypeptides to identify agents that are useful in ischemic preconditioning.
摘要翻译：本发明涉及分离的磺酰脲受体多核苷酸和多肽，以及含有多核苷酸和多肽的载体和细胞系。本发明还涉及使用含有多核苷酸和多肽的细胞系来鉴定可用于缺血预处理的试剂的方法。

3. 发明授权

US07737145B2 Diamine derivatives as inhibitors of leukotriene A4 hydrolase 有权
标题翻译：二胺衍生物作为白三烯A4水解酶的抑制剂
公开(公告)号：US07737145B2
公开(公告)日：2010-06-15
申请号：US11644244
申请日：2006-12-22
申请人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
发明人： Damian Arnaiz , Greg Brown , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica J. Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Ping Wei , Bin Ye
IPC分类号： A01N43/60 , A61K31/495 , C07D241/36 , C07D271/00 , C07D487/00 , C07D491/00 , C07D495/00 , C07D497/00 , C07D498/00 , C07D513/00
CPC分类号： C07D487/08 , C07B2200/07 , C07C217/58 , C07C229/08 , C07C229/38 , C07C233/78 , C07C255/57 , C07C271/20 , C07C2601/14 , C07D207/04 , C07D207/09 , C07D207/16 , C07D211/26 , C07D211/34 , C07D211/58 , C07D243/08 , C07D263/14 , C07D263/32 , C07D277/22 , C07D277/68 , C07D295/04 , C07D295/096 , C07D295/16 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/02 , C07D451/04
摘要： This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed.
摘要翻译：本发明涉及式（I）化合物：其中r，q，R，R2，R3，R4，R5a，R5b，R5c，R6a，R6b，R6c，R7，R8和R9在本文中描述为单立体异构体或作为立体异构体或其药学上可接受的盐，溶剂合物，包合物，多晶型物，铵离子，N-氧化物或前药的混合物; 其是白三烯A4水解酶抑制剂，因此可用于治疗炎症性疾病。还公开了包含本发明化合物的药物组合物和制备本发明化合物的方法。

4. 发明申请

US20080176833A1 DIHYDROPYRIDINE DERIVATIVES AS USEFUL AS PROTEIN KINASE INHIBITORS 有权
标题翻译：作为蛋白激酶抑制剂有用的二氢吡啶衍生物
公开(公告)号：US20080176833A1
公开(公告)日：2008-07-24
申请号：US11955777
申请日：2007-12-13
申请人： Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
发明人： Marc Adler , Stefan Baeurle , Judi Bryant , Ming Chen , Yuo-Ling Chou , Paul Hrvatin , Seock-Kyu Khim , Monica Kochanny , Wheeseong Lee , Michael Mamounas , Janet Meurer Ogden , Gary Bruce Phillips , Victor Selchau , Christopher West , Bin Ye , Shendong Yuan , Martin Krueger
IPC分类号： A61K31/55 , C07D213/02 , A61K31/4427 , C07D455/02 , A61K31/4375 , C07D295/00 , A61K31/5377 , A61P35/00 , C07D239/24 , A61K31/506 , C07D221/00 , A61K31/496 , C07D223/02
CPC分类号： C07D401/04 , C07D211/90 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/10 , C07D409/14 , C07D413/14 , C07D471/04
摘要： This invention provides novel dihydropyridine derivatives of the formula I having protein tyrosine kinase inhibitory activity, to process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-Met-mediated conditions.
摘要翻译：本发明提供具有蛋白酪氨酸激酶抑制活性的新颖的具有蛋白酪氨酸激酶抑制活性的二氢吡啶衍生物，其制备方法及其用于治疗c-Met介导的疾病或c-Met介导的病症的用途。

5. 发明申请

US20070155727A1 Amide inhibitors of leukotriene A4 hydrolase 审中-公开
标题翻译：白三烯A4水解酶的酰胺抑制剂
公开(公告)号：US20070155727A1
公开(公告)日：2007-07-05
申请号：US11644822
申请日：2006-12-22
申请人： Ming Chen , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Wei , Bin Ye , Hong Ye
发明人： Ming Chen , Emmanuel Claret , Arwed Cleve , David Davey , William Guilford , Seock-Kyu Khim , Thomas Kirkland , Monica Kochanny , Amy Liang , David Light , John Parkinson , David Vogel , Guo Wei , Bin Ye , Hong Ye
IPC分类号： A61K31/551 , A61K31/407 , C07D487/02 , C07D243/08
CPC分类号： C07D207/04 , C07C237/04 , C07C237/06 , C07C237/30 , C07C255/58 , C07C275/40 , C07C275/42 , C07C275/62 , C07C311/05 , C07C311/08 , C07C311/09 , C07C311/37 , C07C2601/08 , C07C2601/14 , C07D211/06 , C07D243/08 , C07D295/04 , C07D295/16 , C07D487/02 , C07D487/08
摘要： This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4a, R4b, R4c, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, R9 and R10 are described herein, or pharmaceutically acceptable salts, solvates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and which are therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of using and preparing the compounds of the invention are also disclosed.
摘要翻译：本发明涉及式（I）化合物：其中r，q，R，R 2，R 3，R 4a，R 4， R 4b，R 4c，R 5a，R 5b，R 5c，R 5，R 5， R 6b，R 6b，R 6，R 7，R 8，R 8，R 8，本文描述了本发明的其它药学上可接受的盐，溶剂合物，多晶型物，铵离子，N-氧化物或前体药物; 其是白三烯A 4水解酶抑制剂，因此其可用于治疗炎症性疾病。还公开了包含本发明化合物的药物组合物和使用和制备本发明化合物的方法。

6. 发明授权

US06864368B2 N-heterocyclic derivatives as NOS inhibitors 失效
公开(公告)号：US06864368B2
公开(公告)日：2005-03-08
申请号：US10122006
申请日：2002-04-12
申请人： Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
发明人： Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
IPC分类号： C07D403/14 , A61K31/506 , A61K31/5377 , A61K31/547 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D213/00 , C07D233/00 , C07D239/00 , C07D241/02 , C07D265/00 , C07D279/00 , C07D317/44 , C07D319/00 , C07D333/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

7. 发明授权

US06864263B2 N-heterocyclic derivatives as NOS inhibitors 失效
公开(公告)号：US06864263B2
公开(公告)日：2005-03-08
申请号：US10121659
申请日：2002-04-12
申请人： Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
发明人： Damian O. Arnaiz , John J. Baldwin , David D. Davey , James J. Devlin , Roland Ellwood Dolle, III , Shawn David Erickson , Kirk McMillan , Michael M. Morrissey , Michael H. J. Ohlmeyer , Gonghua Pan , Vidyadhar Madhav Paradkar , John Parkinson , Gary B. Phillips , Bin Ye , Zuchun Zhao
IPC分类号： C07D403/14 , A61K31/506 , A61K31/5377 , A61K31/547 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/08 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07D213/00 , C07D233/00 , C07D239/00 , C07D241/02 , C07D265/00 , C07D279/00 , C07D317/44 , C07D319/00 , C07D333/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.

8. 发明授权

US6140351A Ortho-anthranilamide derivatives as anti-coagulants 失效
标题翻译：邻氨基苯甲酰胺衍生物作为抗凝剂
公开(公告)号：US6140351A
公开(公告)日：2000-10-31
申请号：US187459
申请日：1998-11-05
申请人： Damian O. Arnaiz , Yuo-Ling Chou , Brian D. Griedel , Rushad E. Karanjawala , Monica J. Kochanny , Wheeseong Lee , Amy Mei Liang , Michael M. Morrissey , Gary B. Phillips , Karna Lyn Sacchi , Steven T. Sakata , Kenneth J. Shaw , R. Michael Snider , Shung C. Wu , Bin Ye , Zuchun Zhao
发明人： Damian O. Arnaiz , Yuo-Ling Chou , Brian D. Griedel , Rushad E. Karanjawala , Monica J. Kochanny , Wheeseong Lee , Amy Mei Liang , Michael M. Morrissey , Gary B. Phillips , Karna Lyn Sacchi , Steven T. Sakata , Kenneth J. Shaw , R. Michael Snider , Shung C. Wu , Bin Ye , Zuchun Zhao
IPC分类号： C07D333/38 , C07D333/70 , C07D401/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/06 , C07D473/34 , A61K31/44 , C07D409/00 , C07D411/00
CPC分类号： C07D401/04 , C07D333/38 , C07D333/70 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D473/06 , C07D473/34
摘要： This invention is directed to compounds of formula (III): ##STR1## wherein B, C, D, E, R.sup.1, R.sup.2 and R.sup.3 are disclosed herein. These compounds are disclosed as being useful as anti-coagulants.
摘要翻译：本发明涉及式（III）化合物：其中B，C，D，E，R 1，R 2和R 3在本文中公开。这些化合物被公开用作抗凝剂。

9. 发明申请

US20150364122A1 Music Note Indicating Method And System For Electronic Piano, Mobile Terminal And Electronic Piano 审中-公开
标题翻译：音乐笔记电子钢琴，手机终端和电子钢琴指示方法及系统
公开(公告)号：US20150364122A1
公开(公告)日：2015-12-17
申请号：US14729305
申请日：2015-06-03
申请人： Bin Ye
发明人： Bin Ye
IPC分类号： G10H1/00 , G10C5/00
CPC分类号： G10H1/0016 , G10G1/02 , G10H2220/061 , G10H2220/441 , G10H2240/251
摘要： Provided is a music note indicating method for an electronic piano, a mobile terminal, an electronic piano and a music note indicating system. The electronic piano includes a keyboard with a plurality of keys, a controlling device and a plurality of LED indicating lamps. The plurality of LED indicating lamps are located in a plane parallel to the keyboard. The method includes: obtaining a music score information of a predetermined music score by a mobile terminal; analyzing the music score information to generate a music note sequence comprising at least one first music note data by the mobile terminal; generating a control signal according to the at least one first music note data and sending the control signal to the controlling device by the mobile terminal; and controlling the plurality of LED indicating lamps to indicate the music note sequence according to the control signal by the controlling device.
摘要翻译：提供了一种用于电子钢琴，移动终端，电子钢琴和音乐笔记指示系统的音乐笔记指示方法。电子钢琴包括具有多个键的键盘，控制装置和多个LED指示灯。多个LED指示灯位于与键盘平行的平面中。该方法包括：通过移动终端获得预定乐谱的乐谱信息; 分析音乐乐谱信息以生成由移动终端包括至少一个第一音乐数据的音乐音符序列; 根据所述至少一个第一音乐音符数据生成控制信号，并由所述移动终端向控制设备发送控制信号; 以及根据控制装置的控制信号，控制多个LED指示灯来指示音乐音符序列。

10. 发明申请

US20110045508A1 Urinary CA125 Peptides as Biomarkers of Ovarian Cancer 有权
标题翻译：尿CA125肽作为卵巢癌生物标志物
公开(公告)号：US20110045508A1
公开(公告)日：2011-02-24
申请号：US12865508
申请日：2009-01-30
申请人： Bin Ye , Daniel Cramer
发明人： Bin Ye , Daniel Cramer
IPC分类号： G01N33/68 , C12P21/00
CPC分类号： G01N33/57449 , C07K14/4748
摘要： The present invention is directed to diagnostic methods based upon the detection of peptides derived from the degradation of CA125. In particular, it is concerned with assays of urine samples collected from women for the purpose of determining whether they are at increased risk for having ovarian cancer, have decreased their risk as the result of clinical or non-clinical procedures, to monitor the efficacy of a treatment method, or to determine whether cancer has recurred or advanced.
摘要翻译：本发明涉及基于检测衍生自CA125降解的肽的诊断方法。特别地，它涉及从妇女收集的尿液样品的测定，以确定它们是否具有增加的患有卵巢癌的风险，降低其作为临床或非临床程序的结果的风险，以监测其功效治疗方法，或确定癌症是否复发或进展。

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