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1. 发明申请

US20080027051A1 Novel Heteroaryl Substituted Benzoxazoles 失效
标题翻译：新型杂芳基取代苯并恶唑
公开(公告)号：US20080027051A1
公开(公告)日：2008-01-31
申请号：US11763151
申请日：2007-06-14
申请人： Jonas Malmstrom , David Pyring , Can Slivo , Daniel Sohn , Britt-Marie Swahn , David Wensbo
发明人： Jonas Malmstrom , David Pyring , Can Slivo , Daniel Sohn , Britt-Marie Swahn , David Wensbo
IPC分类号： A61K31/443 , A61K31/506 , A61K31/5377 , A61P25/28 , A61P3/00 , C07D239/28 , C07D413/04 , C07D413/14
CPC分类号： C07D413/04
摘要： The present invention relates to novel heteroaryl substituted benzoxazole derivatives and therapeutic uses for such compounds, having the structural formula (Ia) below: and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted benzoxazole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measureing clinical efficacy of Alzheimer's disease therapeutic agents.
摘要翻译：本发明涉及新颖的杂芳基取代的苯并恶唑衍生物和具有以下结构式（Ia）的化合物及其药学上可接受的盐，组合物和使用方法的治疗用途。此外，本发明涉及适用于在活体患者中成像淀粉样蛋白沉积物的新型杂芳基取代的苯并恶唑衍生物，其组合物，使用方法和制备此类化合物的方法。更具体地说，本发明涉及在体内淀粉样蛋白沉积物在体内成像以使阿尔茨海默病的抗原异常诊断以及阿尔茨海默病治疗剂的临床疗效的测定方法。

2. 发明授权

US07670591B2 Heteroaryl substituted benzoxazoles 失效
标题翻译：杂芳基取代的苯并恶唑
公开(公告)号：US07670591B2
公开(公告)日：2010-03-02
申请号：US11763151
申请日：2007-06-14
申请人： Jonas Malmstrom , David Pyring , Can Slivo , Daniel Sohn , Britt-Marie Swahn , David Wensbo
发明人： Jonas Malmstrom , David Pyring , Can Slivo , Daniel Sohn , Britt-Marie Swahn , David Wensbo
IPC分类号： A61K51/04 , A61K31/443 , C07D413/04
CPC分类号： C07D413/04
摘要： The present invention relates to novel heteroaryl substituted benzoxazole derivatives and therapeutic uses for such compounds, having the structural formula (Ia) below: and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted benzoxazole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents.
摘要翻译：本发明涉及新颖的杂芳基取代的苯并恶唑衍生物和具有以下结构式（Ia）的化合物及其药学上可接受的盐，组合物和使用方法的治疗用途。此外，本发明涉及适用于在活体患者中成像淀粉样蛋白沉积物的新型杂芳基取代的苯并恶唑衍生物，其组合物，使用方法和制备此类化合物的方法。更具体地说，本发明涉及一种在体内淀粉样蛋白沉积物在体内成像以使阿尔茨海默病的止血诊断成为可能并测量阿尔茨海默病治疗剂的临床疗效的方法。

3. 发明授权

US08163928B2 Heteroaryl substituted benzothiazoles 失效
标题翻译：杂芳基取代的苯并噻唑
公开(公告)号：US08163928B2
公开(公告)日：2012-04-24
申请号：US12162255
申请日：2007-01-25
申请人： Ylva Gravenfors , Catrin Jonasson , Jonas Malmstrom , Gunnar Nordvall , David Pyring , Can Slivo , Daniel Sohn , Peter Strom , David Wensbo
发明人： Ylva Gravenfors , Catrin Jonasson , Jonas Malmstrom , Gunnar Nordvall , David Pyring , Can Slivo , Daniel Sohn , Peter Strom , David Wensbo
IPC分类号： A61K51/00 , A61K51/04
CPC分类号： C07D417/04 , C07B59/002 , C07D513/04
摘要： The present invention relates to novel heteroaryl substituted benzothiazole derivatives, precursors thereof, and therapeutic uses for such compounds, having the structural formula (I) below: [Chemical formula should be inserted here. Please see paper copy] and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted benzothiazole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents.
摘要翻译：本发明涉及新颖的杂芳基取代的苯并噻唑衍生物，其前体，以及具有以下结构式（I）的化合物的治疗用途：[化学式应在此插入。请参阅纸本]及其药学上可接受的盐，组合物和使用方法。此外，本发明涉及适用于在活体患者中成像淀粉样蛋白沉积物的新型杂芳基取代的苯并噻唑衍生物，其组合物，使用方法和制备此类化合物的方法。更具体地说，本发明涉及一种在体内淀粉样蛋白沉积物在体内成像以使阿尔茨海默病的止血诊断成为可能并测量阿尔茨海默病治疗剂的临床疗效的方法。

4. 发明授权

US08957215B2 Heteroaryl substituted benzothiazoles 有权
标题翻译：杂芳基取代的苯并噻唑
公开(公告)号：US08957215B2
公开(公告)日：2015-02-17
申请号：US13453579
申请日：2012-04-23
申请人： Ylva Gravenfors , Catrin Jonasson , Jonas Malmstrom , Gunnar Nordvall , David Pyring , Can Slivo , Daniel Sohn , Peter Strom , David Wensbo
发明人： Ylva Gravenfors , Catrin Jonasson , Jonas Malmstrom , Gunnar Nordvall , David Pyring , Can Slivo , Daniel Sohn , Peter Strom , David Wensbo
IPC分类号： C07D417/04 , C07D417/14 , C07B59/00 , C07D513/04
CPC分类号： C07D417/04 , C07B59/002 , C07D513/04
摘要： The present invention relates to novel heteroaryl substituted benzothiazole derivatives, precursors thereof, and therapeutic uses for such compounds, having the structural formula (I) below: and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted benzothiazole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents.
摘要翻译：本发明涉及新颖的杂芳基取代的苯并噻唑衍生物，其前体，以及具有以下结构式（I）的化合物及其药学上可接受的盐，组合物和使用方法的治疗用途。此外，本发明涉及适用于在活体患者中成像淀粉样蛋白沉积物的新型杂芳基取代的苯并噻唑衍生物，其组合物，使用方法和制备此类化合物的方法。更具体地说，本发明涉及一种在体内淀粉样蛋白沉积物在体内成像以使阿尔茨海默病的止血诊断成为可能并测量阿尔茨海默病治疗剂的临床疗效的方法。

5. 发明申请

US20090028787A1 Novel Heteroaryl Substituted Benzothiazoles 失效
标题翻译：新型杂芳基取代苯并噻唑
公开(公告)号：US20090028787A1
公开(公告)日：2009-01-29
申请号：US12162255
申请日：2007-01-25
申请人： Ylva Gravenfors , Catrin Jonasson , Jonas Malmstrom , Gunnar Nordvall , David Pyring , Can Slivo , Daniel Sohn , Peter Strom , David Wensbo
发明人： Ylva Gravenfors , Catrin Jonasson , Jonas Malmstrom , Gunnar Nordvall , David Pyring , Can Slivo , Daniel Sohn , Peter Strom , David Wensbo
IPC分类号： A61K31/496 , C07D417/14 , C07D417/04 , A61K31/5377 , A61P25/28 , A61K49/00 , A61K31/4439 , C07D413/14
CPC分类号： C07D417/04 , C07B59/002 , C07D513/04
摘要： The present invention relates to novel heteroaryl substituted benzothiazole derivatives, precursors thereof, and therapeutic uses for such compounds, having the structural formula (I) below: [Chemical formula should be inserted here. Please see paper copy] and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted benzothiazole derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents.
摘要翻译：本发明涉及新颖的杂芳基取代的苯并噻唑衍生物，其前体，以及具有以下结构式（I）的化合物的治疗用途：[化学式应在此插入。请参阅纸本]及其药学上可接受的盐，组合物和使用方法。此外，本发明涉及适用于在活体患者中成像淀粉样蛋白沉积物的新型杂芳基取代的苯并噻唑衍生物，其组合物，使用方法和制备此类化合物的方法。更具体地说，本发明涉及一种在体内淀粉样蛋白沉积物在体内成像以使阿尔茨海默病的止血诊断成为可能并测量阿尔茨海默病治疗剂的临床疗效的方法。

6. 发明申请

US20100092385A1 Novel Heteroaryl Substituted Imidazo [1,2-A] Pyridine Derivatives 审中-公开
标题翻译：新型杂芳基取代的咪唑并[1,2-A]吡啶衍生物
公开(公告)号：US20100092385A1
公开(公告)日：2010-04-15
申请号：US12524019
申请日：2008-01-21
申请人： Michaela Vallin , Jonas Malmstrom , David Pyring , Can Slivo , David Wensbo
发明人： Michaela Vallin , Jonas Malmstrom , David Pyring , Can Slivo , David Wensbo
IPC分类号： A61K51/04 , A61K31/5377 , A61K31/496 , A61K31/437 , C07D413/14 , C07D401/14 , C07D471/04 , A61P25/28 , A61K49/00 , A61K49/10
CPC分类号： C07D471/04 , A61K49/10 , A61K51/041 , A61K51/0453 , A61K51/0455 , A61K51/0459 , A61K51/0463
摘要： The present invention relates to novel heteroaryl substituted imidazopyridine derivatives, precursors thereof, and therapeutic uses of such compounds, having the structural formula (Ia) and to their pharmaceutically acceptable salt, compositions and methods of use. Furthermore, the invention relates to novel heteroaryl substituted imidazopyridine derivatives that are suitable for imaging amyloid deposits in living patients, their compositions, methods of use and processes to make such compounds. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease as well as measuring clinical efficacy of Alzheimer's disease therapeutic agents.
摘要翻译：本发明涉及新颖的杂芳基取代的咪唑并吡啶衍生物，其前体和具有结构式（Ia）的这类化合物及其药学上可接受的盐，组合物和使用方法的治疗用途。此外，本发明涉及适用于在活体患者中成像淀粉样蛋白沉积物的新型杂芳基取代的咪唑并吡啶衍生物，其组合物，使用方法和制备此类化合物的方法。更具体地说，本发明涉及一种在体内淀粉样蛋白沉积物在体内成像以使阿尔茨海默病的止血诊断成为可能并测量阿尔茨海默病治疗剂的临床疗效的方法。

7. 发明申请

US20050113370A1 Therapeutic substituted indazole derivatives 审中-公开
标题翻译：治疗性取代的吲唑衍生物
公开(公告)号：US20050113370A1
公开(公告)日：2005-05-26
申请号：US10504411
申请日：2003-02-11
申请人： Jonas Malmstrom , Britt-Marie Swahn
发明人： Jonas Malmstrom , Britt-Marie Swahn
IPC分类号： A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P1/02 , A61P7/10 , A61P9/00 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P29/00 , A61P29/02 , A61P31/18 , A61P35/00 , A61P43/00 , C07D231/56 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/12 , C07D413/02 , C07D417/02
CPC分类号： C07D231/56 , C07D401/10 , C07D401/12 , C07D403/12 , C07D405/04
摘要： The invention provides a compound of Formula I Formula I wherein R1 is aryl or heteroaryl each of which is optionally substituted with one or more of the following R3, —OR3, —OCOR3, —COOR3, —COR3, —CONR3R4, —NHCOR3, —NR3R4, —NHSO2R3, —S2R3, —SO2NR3R4, —SR3, CN, halogeno or NO2; R2 is NO2, NH2, —NR5R6 or —NR6R7; as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译：本发明提供式I式I的化合物，其中R 1为芳基或杂芳基，其各自任选被以下R 3， SO 3，-OCOR 3，-COOR 3，-COR 3，-CONR 3 O， R 4，-NHCOR 3，-NR 3 R 4，-NHSO 2， 3个，3个，3个，3个，3个，3个，3个，3个，3个，3个 R 4，-SR 3，CN，卤素或NO 2; 或者R 2是NO 2 2，NH 2，-NR 5 S 6，或 -NR 6 R 7; 作为其盐的游离碱或其药学上可接受的盐，溶剂化物或溶剂合物，其制备方法，含有所述化合物的药物制剂以及所述化合物在治疗中的用途。

8. 发明授权

US06937844B2 Methods and arrangements for short range wireless communication 有权
标题翻译：短距离无线通信的方法和安排
公开(公告)号：US06937844B2
公开(公告)日：2005-08-30
申请号：US10156826
申请日：2002-05-30
申请人： Jonas Malmstrom , Johan Wennerberg , Marcus Jonsson
发明人： Jonas Malmstrom , Johan Wennerberg , Marcus Jonsson
IPC分类号： H04L12/28 , H04L12/56 , H04B5/00
CPC分类号： G06F13/4226 , G06F13/4045
摘要： The present invention relates to a arrangement and method for providing wireless communication between GPIB devices and a host computer. An GPIB adapter (100) according to the present invention provides wireless communication between a GPIB device (200) and a computer (120), the adapter comprises a command handle (140)r adapted for communication with a wireless communication module (130). The adapter further comprises a GPIB control unit (150) and the command handler is adapted for executing GPIB function calls directed to a GPIB device through the GPIB control unit (150). The command handler comprises a GPIB driver (344) which is adapted for communication with the GPIB control unit (150). The arrangement makes it possible for the adapter to provide complete GPIB functionality.
摘要翻译：本发明涉及在GPIB设备和主机之间提供无线通信的配置和方法。根据本发明的GPIB适配器（100）提供GPIB设备（200）和计算机（120）之间的无线通信，适配器包括适于与无线通信模块（130）通信的命令句柄（140）r。适配器还包括GPIB控制单元（150），并且命令处理器适于通过GPIB控制单元（150）执行指向GPIB设备的GPIB功能调用。命令处理器包括适于与GPIB控制单元（150）通信的GPIB驱动器（344）。该布置使得适配器可以提供完整的GPIB功能。

9. 发明申请

US20110098292A1 New Compounds Useful for Treating CNS Disorders 审中-公开
标题翻译：用于治疗CNS疾病的新化合物
公开(公告)号：US20110098292A1
公开(公告)日：2011-04-28
申请号：US11571184
申请日：2005-06-29
申请人： Jonas Malmstrom , Jenny Viklund
发明人： Jonas Malmstrom , Jenny Viklund
IPC分类号： A61K31/428 , C07D417/14 , A61K31/4439 , A61K31/5377 , C07D417/04 , A61P25/30 , A61P9/10 , A61P25/28 , A61P25/16 , A61P25/00
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention provides new compounds of formula (I) as well as a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.
摘要翻译：本发明提供新的式（I）化合物及其制备方法和其中使用的新中间体，含有所述治疗活性化合物的药物制剂和所述活性化合物在治疗中的用途。

10. 发明申请

US20080251120A1 Thin Film Solar Cell and Manufacturing Method 审中-公开
标题翻译：薄膜太阳能电池及制造方法
公开(公告)号：US20080251120A1
公开(公告)日：2008-10-16
申请号：US10592061
申请日：2005-03-03
申请人： Jonas Malmstrom , Lars Stolt
发明人： Jonas Malmstrom , Lars Stolt
IPC分类号： H01L31/0248 , H01L31/0272 , H01L31/18
CPC分类号： H01L31/0322 , H01L31/022425 , H01L31/056 , Y02E10/52 , Y02E10/541 , Y02P70/521
摘要： The present invention relates to a thin film solar cell and a method of manufacturing such cells. In particular the invention relates to the use of a composite back contact (314) in Cu(In,Ga)Se2 (CIGS) based thin film solar cells with thin absorber layers. The composite back contact (314) is provided between the substrate (105) and the absorber (115) and comprises: a back reflector layer (311) that enhance the reflectance at the absorber/composite back contact interface; and at least a contact layer that contact layer (310, 313) that ensures suitable electrical properties of the back contact with respect to the absorber; and/or a conductance layer (312) that ensures low sheet resistance for the in-plane current flow.
摘要翻译：本发明涉及一种薄膜太阳能电池及其制造方法。特别地，本发明涉及在具有薄吸收层的Cu（In，Ga）Se 2（CIGS）基薄膜太阳能电池中使用复合背接触件（314）。所述复合背接触件（314）设置在所述基底（105）和所述吸收体（115）之间，并包括：增强所述吸收体/复合背接触界面处的反射率的后反射层（311）以及至少接触层，其接触层（310,313）确保所述背接触件相对于所述吸收体的适合的电特性; 和/或电导层（312），其确保面内电流的低的薄层电阻。

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