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1. 发明授权

US08846623B2 Cancer-targeting peptides and uses thereof in cancer treatment and diagnosis 有权
标题翻译：癌症靶向肽及其在癌症治疗和诊断中的用途
公开(公告)号：US08846623B2
公开(公告)日：2014-09-30
申请号：US13816613
申请日：2011-10-25
申请人： John Yu , Alice L. Yu , H. C. Wu , Sheng-Hung Wang , I-Ju Chen
发明人： John Yu , Alice L. Yu , H. C. Wu , Sheng-Hung Wang , I-Ju Chen
IPC分类号： A61K38/00 , A61K31/496 , A61K47/48 , A61K45/06 , A61K38/10 , A61K49/00 , C07K5/117 , A61K31/337 , C07K7/08 , A61K31/475 , A61K51/12 , A61K31/704 , A61K9/127
CPC分类号： G06F19/16 , A61K9/127 , A61K9/1271 , A61K31/337 , A61K31/475 , A61K31/496 , A61K31/704 , A61K38/10 , A61K45/06 , A61K47/48815 , A61K47/6911 , A61K49/0043 , A61K49/0056 , A61K51/1234 , C07K5/1024 , C07K7/08 , G01N2333/47 , G01N2500/04 , A61K2300/00
摘要： Cancer-targeting peptides having a PX1LX2 motif, in which X1 is His or an amino acid residue with a hydrophobic side chain and X2 is Pro, Phe, or Trp. Also disclosed herein are conjugates containing the cancer-targeting peptides and uses thereof in cancer treatment and diagnosis.
摘要翻译：具有PX1LX2基序的癌靶向肽，其中X1是His或具有疏水侧链的氨基酸残基，X2是Pro，Phe或Trp。本文还公开了含有癌靶向肽的缀合物及其在癌症治疗和诊断中的用途。

2. 发明申请

US20130142867A1 CANCER-TARGETING PEPTIDES AND USES THEREOF IN CANCER TREATMENT AND DIAGNOSIS 有权
标题翻译：癌症治疗及其在癌症治疗和诊断中的应用
公开(公告)号：US20130142867A1
公开(公告)日：2013-06-06
申请号：US13816613
申请日：2011-10-25
申请人： John Yu , Alice L. Yu , H.C. Wu , I-Ju Chen , Sheng-Hung Wang
发明人： John Yu , Alice L. Yu , H.C. Wu , I-Ju Chen , Sheng-Hung Wang
IPC分类号： C07K7/08 , A61K31/704 , A61K9/127 , A61K38/10 , A61K45/06
CPC分类号： G06F19/16 , A61K9/127 , A61K9/1271 , A61K31/337 , A61K31/475 , A61K31/496 , A61K31/704 , A61K38/10 , A61K45/06 , A61K47/48815 , A61K47/6911 , A61K49/0043 , A61K49/0056 , A61K51/1234 , C07K5/1024 , C07K7/08 , G01N2333/47 , G01N2500/04 , A61K2300/00
摘要： Cancer-targeting peptides having a PX1LX2 motif, in which X1 is His or an amino acid residue with a hydrophobic side chain and X2 is Pro, Phe, or Trp. Also disclosed herein are conjugates containing the cancer-targeting peptides and uses thereof in cancer treatment and diagnosis.
摘要翻译：具有PX1LX2基序的癌靶向肽，其中X1是His或具有疏水侧链的氨基酸残基，X2是Pro，Phe或Trp。本文还公开了含有癌靶向肽的缀合物及其在癌症治疗和诊断中的用途。

3. 发明授权

US5032507A Potentiation of erythropoiesis 失效
标题翻译：红细胞生成的增强
公开(公告)号：US5032507A
公开(公告)日：1991-07-16
申请号：US120470
申请日：1987-11-13
申请人： John Yu , Alice L. Yu , Joan Vaughan , Jean E. F. Rivier , Wylie W. Vale, Jr.
发明人： John Yu , Alice L. Yu , Joan Vaughan , Jean E. F. Rivier , Wylie W. Vale, Jr.
IPC分类号： A61K38/00 , A61K38/04 , A61K38/22 , A61P7/00 , C07K14/435 , C07K14/575
CPC分类号： A61K38/22 , Y10S435/81
摘要： A method for modulating the rate of erythropoiesis in human hematopoietic progenitor cells. FRP is found to be an efficacious potentiator of, and inhibin a suppressor of, erythropoietin-induced differentiation. FRP and inhibin are shown to be functional antagonists of each other, and thus represent an effective means for modulating erythropoiesis in a number of disease states which are directly caused by or associated with an abnormal rate of erythropoiesis.
摘要翻译：调节人类造血祖细胞中红细胞生成速率的方法。发现FRP是促红细胞生成素诱导分化的有效增效剂，抑制抑制素。 FRP和抑制素显示为彼此的功能性拮抗剂，因此代表了直接由异常红细胞生成速率引起或与之相关的许多疾病状态调节红细胞生成的有效手段。

4. 发明授权

US09028836B2 Globo H and related anti-cancer vaccines with novel glycolipid adjuvants 有权
标题翻译： Globo H和具有新型糖脂佐剂的相关抗癌疫苗
公开(公告)号：US09028836B2
公开(公告)日：2015-05-12
申请号：US13568510
申请日：2012-08-07
申请人： Chi-Huey Wong , Chung-Yi Wu , Alice L. Yu , John Yu
发明人： Chi-Huey Wong , Chung-Yi Wu , Alice L. Yu , John Yu
IPC分类号： A61K39/385 , A61K39/00 , C12N15/113
CPC分类号： A61K39/0011 , A61K2039/55511 , A61K2039/6037 , A61K2039/6081 , A61K2039/627 , C12N15/1137 , C12N2310/14
摘要： An immunogenic composition containing a glycan conjugate including a carrier protein, and a glycan including Globo H, an immunogenic fragment thereof, or stage-specific embryonic antigen-4 (SSEA-4), wherein the glycan is conjugated with the carrier protein through a linker.
摘要翻译：含有载体蛋白的聚糖缀合物和包含Globo H，其免疫原性片段或阶段特异性胚胎抗原-4（SSEA-4）的聚糖的免疫原性组合物，其中所述聚糖通过接头与载体蛋白缀合。

5. 发明授权

US08268969B2 Globo H and related anti-cancer vaccines with novel glycolipid adjuvants 有权
标题翻译： Globo H和具有新型糖脂佐剂的相关抗癌疫苗
公开(公告)号：US08268969B2
公开(公告)日：2012-09-18
申请号：US12537129
申请日：2009-08-06
申请人： Chi-Huey Wong , Chung-Yi Wu , Alice L. Yu , John Yu
发明人： Chi-Huey Wong , Chung-Yi Wu , Alice L. Yu , John Yu
IPC分类号： C07K16/00 , A01N43/04 , C07H17/00
CPC分类号： A61K39/0011 , A61K2039/55511 , A61K2039/6037 , A61K2039/6081 , A61K2039/627 , C12N15/1137 , C12N2310/14
摘要： Immunogenic compositions, cancer vaccines and methods for treating cancer are provided. Compositions comprising: (a) a glycan such as Globo H or an immunogenic fragment thereof, wherein the glycan is conjugated with a carrier protein by a linker such as para-nitrophenyl; and (b) an adjuvant comprising glycolipid capable of binding CD1d on a dendritic cell, such as an α-galactosyl-ceramide derivative, wherein the immunogenic composition induces an immune response that induces a higher relative level of IgG isotype antibodies as compared to IgM isotype antibodies, are provided. Immunogenic compositions comprising the carrier protein diphtheria toxin cross-reacting material 197 (DT-CRM197) and the adjuvant C34 are provided. Antibodies generated by immunogenic compositions disclosed herein further neutralize at least one of the antigens Globo H, stage-specific embryonic antigen-3 (SSEA-3) and stage-specific embryonic antigen-4 (SSEA-4). Therapeutics against breast cancer stem cells comprising immunogenic compositions comprising Globo H, SSEA-3 or SSEA-4 conjugated with DT-CRM197.
摘要翻译：提供免疫原性组合物，癌症疫苗和治疗癌症的方法。组合物，其包含：（a）聚糖如Globo H或其免疫原性片段，其中所述聚糖通过诸如对硝基苯基之类的接头与载体蛋白缀合; 和（b）包含能够结合树突状细胞上的CD1d的糖脂如α-半乳糖基 - 神经酰胺衍生物的佐剂，其中所述免疫原性组合物诱导与IgM同种型相比诱导更高相对水平的IgG同种型抗体的免疫应答抗体。提供了包含载体蛋白质白喉毒素交叉反应材料197（DT-CRM197）和佐剂C34的免疫原性组合物。由本文公开的免疫原性组合物产生的抗体进一步中和至少一种抗原Globo H，阶段特异性胚胎抗原-3（SSEA-3）和阶段特异性胚胎抗原-4（SSEA-4）。包括含有与DT-CRM197缀合的Globo H，SSEA-3或SSEA-4的免疫原性组合物的乳腺癌干细胞的治疗剂。

6. 发明申请

US20090317411A1 COMPOSITIONS FOR INDUCING IMMUNE RESPONSES SPECIFIC TO GLOBO H AND SSEA3 AND USES THEREOF IN CANCER TREATMENT 审中-公开
标题翻译：诱导GLOBO H和SSEA3特异性免疫应答的组合物及其在癌症治疗中的应用
公开(公告)号：US20090317411A1
公开(公告)日：2009-12-24
申请号：US12485546
申请日：2009-06-16
申请人： Chi-Huey Wong , Alice L. Yu , John. Yu
发明人： Chi-Huey Wong , Alice L. Yu , John. Yu
IPC分类号： A61K39/00 , A61K31/7105 , A61P35/00
CPC分类号： A61K39/0011 , A61K2039/55511 , A61K2039/6037 , A61K2039/6081 , A61K2039/627 , C12N15/1137 , C12N2310/14
摘要： An immune composition containing Globo H or its fragment (e.g., SSEA3) and an adjuvant, e.g., α-GalCer, for eliciting immune responses against Globo H or its fragment and uses thereof in cancer treatment. Also disclosed is a method of treating cancer by inhibiting the activity of one of FUT1 and FUT2, both of which involve in Globo H biosynthesis.
摘要翻译：包含Globo H或其片段（例如SSEA3）和佐剂（例如α-GalCer）的免疫组合物，用于引发针对Globo H或其片段的免疫应答及其在癌症治疗中的用途。还公开了通过抑制FUT1和FUT2之一的活性来治疗癌症的方法，两者都涉及Globo H生物合成。

7. 发明申请

US20120328646A1 Globo H and Related Anti-Cancer Vaccines with Novel Glycolipid Adjuvants 有权
标题翻译： Globo H和相关抗癌疫苗与新型糖脂佐剂
公开(公告)号：US20120328646A1
公开(公告)日：2012-12-27
申请号：US13568510
申请日：2012-08-07
申请人： Chi-Huey Wong , Chung-Yi Wu , Alice L. Yu , John Yu
发明人： Chi-Huey Wong , Chung-Yi Wu , Alice L. Yu , John Yu
IPC分类号： A61K39/385 , A61P35/00 , C07K14/33 , C07K14/00 , C07K14/34
CPC分类号： A61K39/0011 , A61K2039/55511 , A61K2039/6037 , A61K2039/6081 , A61K2039/627 , C12N15/1137 , C12N2310/14
摘要： An immunogenic composition containing a glycan conjugate including a carrier protein, and a glycan including Globo H, an immunogenic fragment thereof, or stage-specific embryonic antigen-4 (SSEA-4), wherein the glycan is conjugated with the carrier protein through a linker.
摘要翻译：含有载体蛋白的聚糖缀合物和包含Globo H，其免疫原性片段或阶段特异性胚胎抗原-4（SSEA-4）的聚糖的免疫原性组合物，其中所述聚糖通过接头与载体蛋白质缀合。

8. 发明授权

US08486914B2 Hirsutella sinensis mycelia compositions and methods for treating sepsis and related inflammatory responses 失效
标题翻译： Hirsutella sinensis菌丝体组合物和治疗败血症和相关炎症反应的方法
公开(公告)号：US08486914B2
公开(公告)日：2013-07-16
申请号：US12750655
申请日：2010-03-30
申请人： Chi-Huey Wong , Alice L. Yu , Wen-Bin Yang , Eugene Fan , Hsien-Yeh Hsu , Peishan Lee , Tseng-Rong Tu , Chin-Chung Hung
发明人： Chi-Huey Wong , Alice L. Yu , Wen-Bin Yang , Eugene Fan , Hsien-Yeh Hsu , Peishan Lee , Tseng-Rong Tu , Chin-Chung Hung
IPC分类号： A61K31/715
CPC分类号： A61K31/715
摘要： Compositions comprising Hirsutella sinensis mycelia extracts and chromatographically separated polysaccharide-enriched fractions thereof are provided. Methods for extracting Hirsutella sinensis mycelia are provided. Compositions for methods for their use in amelioration, prevention and treatment of sepsis, acute endotoxemia and inflammatory responses are disclosed.
摘要翻译：提供了包含中华绒螯蟹菌丝体提取物和色谱分离的多糖富集部分的组合物。提供了中华绒螯蟹提取物的方法。公开了其用于改善，预防和治疗败血症，急性内毒素血症和炎性反应的方法的组合物。

9. 发明申请

US20110028428A1 HIRSUTELLA SINENSIS MYCELIA COMPOSITIONS AND METHODS FOR TREATING SEPSIS AND RELATED INFLAMMATORY RESPONSES 失效
标题翻译： HIRSUTELLA SINENSIS MYCELIA组合物和治疗食欲和相关的炎症反应的方法
公开(公告)号：US20110028428A1
公开(公告)日：2011-02-03
申请号：US12750655
申请日：2010-03-30
申请人： Chi-Huey Wong , Alice L. Yu , Wen-Bin Yang , Eugene Fan , Hsien-Yeh Hsu , Peishan Lee , Tseng-Rong Tu , Chin-Chung Hung
发明人： Chi-Huey Wong , Alice L. Yu , Wen-Bin Yang , Eugene Fan , Hsien-Yeh Hsu , Peishan Lee , Tseng-Rong Tu , Chin-Chung Hung
IPC分类号： A61K31/715 , A61P29/00 , A61P27/02 , A61P1/04 , A61P19/02
CPC分类号： A61K31/715
摘要： Compositions comprising Hirsutella sinensis mycelia extracts and chromatographically separated polysaccharide-enriched fractions thereof are provided. Methods for extracting Hirsutella sinensis mycelia are provided. Compositions for methods for their use in amelioration, prevention and treatment of sepsis, acute endotoxemia and inflammatory responses are disclosed.
摘要翻译：提供了包含中华绒螯蟹菌丝体提取物和色谱分离的多糖富集部分的组合物。提供了中华绒螯蟹提取物的方法。公开了其用于改善，预防和治疗败血症，急性内毒素血症和炎性反应的方法的组合物。

10. 发明授权

US08158367B2 Cancer diagnosis based on levels of antibodies against Globo H and its fragments 有权
标题翻译：基于针对Globo H及其片段的抗体水平的癌症诊断
公开(公告)号：US08158367B2
公开(公告)日：2012-04-17
申请号：US12485516
申请日：2009-06-16
申请人： Chi-Huey Wong , Chung-Yi Wu , Cheng-Chi Wang , Alice L. Yu
发明人： Chi-Huey Wong , Chung-Yi Wu , Cheng-Chi Wang , Alice L. Yu
IPC分类号： G01N33/53
CPC分类号： G01N33/57488 , G01N33/57415
摘要： A cancer diagnostic method using a glycan array that contains Gb5 and Globo H, Bb2, Bb3, and/or Bb4.
摘要翻译：使用含有Gb5和Globo H，Bb2，Bb3和/或Bb4的聚糖阵列的癌症诊断方法。

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