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1. 发明申请

US20060073539A1 Apparatus and methods for using biological material to discriminate an agent 审中-公开
标题翻译：使用生物材料鉴别药剂的装置和方法
公开(公告)号：US20060073539A1
公开(公告)日：2006-04-06
申请号：US10212918
申请日：2002-08-06
申请人： John Wikswo , Franz Baudenbacher , R. Balcarcel , Theodore Bapty , David Cliffel , Sven Eklund , Owen McGuinness , Todd Monroe , Ales Prokop , Mark Stremler , Andreas Werdich , Yang Yuansheng
发明人： John Wikswo , Franz Baudenbacher , R. Balcarcel , Theodore Bapty , David Cliffel , Sven Eklund , Owen McGuinness , Todd Monroe , Ales Prokop , Mark Stremler , Andreas Werdich , Yang Yuansheng
IPC分类号： C12Q1/02
CPC分类号： G01N33/5005 , C12M41/32 , G01N33/5023 , G01N33/5038 , G01N33/5041 , G01N2015/1006 , Y10T436/115831
摘要： An apparatus and methods for using biological material to discriminate an agent. In one embodiment of the present invention, the method includes the steps of providing at least one cell, exposing at least one cell to an agent, measuring the response of the cell to the agent in terms of a physical quantity related to at least one of the cellular physiological activities of the cell, and identifying the agent from the measured response. The method further includes the step of quantifying the agent from the measured response.
摘要翻译：用于使用生物材料来鉴别试剂的装置和方法。在本发明的一个实施方案中，该方法包括以下步骤：提供至少一个细胞，将至少一个细胞暴露于药剂，根据与下列中的至少一个相关的物理量测量细胞对药剂的反应：细胞的细胞生理活性，以及根据测定的反应鉴定药剂。该方法还包括从所测量的响应量化试剂的步骤。

2. 发明授权

US07704745B2 Apparatus and methods for monitoring the status of a metabolically active cell 有权
标题翻译：用于监测代谢活性细胞状态的装置和方法
公开(公告)号：US07704745B2
公开(公告)日：2010-04-27
申请号：US10213049
申请日：2002-08-06
申请人： Franz Baudenbacher , John P. Wikswo , R. Robert Balcarcel , David Cliffel , Sven Eklund , Jonathan Mark Gilligan , Owen McGuinness , Todd Monroe , Ales Prokop , Mark Andrew Stremler , Andreas Augustinus Werdich
发明人： Franz Baudenbacher , John P. Wikswo , R. Robert Balcarcel , David Cliffel , Sven Eklund , Jonathan Mark Gilligan , Owen McGuinness , Todd Monroe , Ales Prokop , Mark Andrew Stremler , Andreas Augustinus Werdich
IPC分类号： G01N33/00
CPC分类号： G01N33/5005 , C12M41/32 , G01N33/5023 , G01N33/5038 , G01N33/5041 , G01N2015/1006 , Y10T436/115831
摘要： An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the status of the cell from the measured intracellular or extracellular signaling of the cell.
摘要翻译：用于监测消耗氧气的电池的状态的装置和方法。在本发明的一个实施方案中，该方法包括以下步骤：将细胞限制在感测体积中，动态地测量细胞内的细胞内或细胞外信号传导，以及根据测量的细胞内或细胞外信号传导确定细胞的状态。

3. 发明申请

US20120156763A1 Apparatus and Methods for Using Biological Material to Discriminate an Agent 审中-公开
标题翻译：使用生物材料鉴别药剂的装置和方法
公开(公告)号：US20120156763A1
公开(公告)日：2012-06-21
申请号：US13218287
申请日：2011-08-25
申请人： John P. Wikswo , Franz J. Baudenbacher , R. Robert Balcarcel , Theodore A. Bapty , David Cliffel , Sven Eklund , Owen McGuinness , Todd Monroe , Ales Prokop , Mark Andrew Stremler , Andreas Augustinus Werdich , Yang Yuansheng
发明人： John P. Wikswo , Franz J. Baudenbacher , R. Robert Balcarcel , Theodore A. Bapty , David Cliffel , Sven Eklund , Owen McGuinness , Todd Monroe , Ales Prokop , Mark Andrew Stremler , Andreas Augustinus Werdich , Yang Yuansheng
IPC分类号： C12M1/34
CPC分类号： G01N33/5005 , C12M41/32 , G01N33/5023 , G01N33/5038 , G01N33/5041 , G01N2015/1006 , Y10T436/115831
摘要： An apparatus and methods for using biological material to discriminate an agent. In one embodiment of the present invention, the method includes the steps of providing at least one cell, exposing at least one cell to an agent, measuring the response of the cell to the agent in terms of a physical quantity related to at least one of the cellular physiological activities of the cell, and identifying the agent from the measured response. The method further includes the step of quantifying the agent from the measured response.
摘要翻译：用于使用生物材料来鉴别试剂的装置和方法。在本发明的一个实施方案中，该方法包括以下步骤：提供至少一个细胞，将至少一个细胞暴露于药剂，根据与下列中的至少一个相关的物理量测量细胞对药剂的反应：细胞的细胞生理活性，以及根据测定的反应鉴定药剂。该方法还包括从所测量的响应量化试剂的步骤。

4. 发明申请

US20090305319A1 Apparatus and methods for monitoring the status of a metabolically active cell 有权
标题翻译：用于监测代谢活性细胞状态的装置和方法
公开(公告)号：US20090305319A1
公开(公告)日：2009-12-10
申请号：US10213049
申请日：2002-08-06
申请人： Franz J. Baudenbacher , John P. Wikswo , R. Robert Balcarcel , David Cliffel , Sven Eklund , Jonathan Mark Gilligan , Owen McGuinness , Todd Monroe , Ales Prokop , Mark Andrew Stremler , Andreas Augustinus Werdich
发明人： Franz J. Baudenbacher , John P. Wikswo , R. Robert Balcarcel , David Cliffel , Sven Eklund , Jonathan Mark Gilligan , Owen McGuinness , Todd Monroe , Ales Prokop , Mark Andrew Stremler , Andreas Augustinus Werdich
IPC分类号： C12Q1/02 , C12M3/00
CPC分类号： G01N33/5005 , C12M41/32 , G01N33/5023 , G01N33/5038 , G01N33/5041 , G01N2015/1006 , Y10T436/115831
摘要： An apparatus and methods for monitoring the status of a cell that consumes oxygen. In one embodiment of the present invention, the method includes the steps of confining the cell in a sensing volume, measuring dynamically intracellular or extracellular signaling of the cell, and determining the status of the cell from the measured intracellular or extracellular signaling of the cell.
摘要翻译：用于监测消耗氧气的电池的状态的装置和方法。在本发明的一个实施方案中，该方法包括以下步骤：将细胞限制在感测体积中，动态地测量细胞内的细胞内或细胞外信号传导，以及根据测定的细胞内或细胞外信号传导确定细胞的状态。

5. 发明申请

US20050014129A1 Device and methods for detecting the response of a plurality of cells to at least one analyte of interest 有权
标题翻译：用于检测多个细胞对至少一种感兴趣分析物的响应的装置和方法
公开(公告)号：US20050014129A1
公开(公告)日：2005-01-20
申请号：US10483466
申请日：2002-08-06
申请人： David Cliffel , Franz Baudenbacher , John Wikswo , Sven Eklund , R. Balcarcel , Jonathan Gilligan
发明人： David Cliffel , Franz Baudenbacher , John Wikswo , Sven Eklund , R. Balcarcel , Jonathan Gilligan
IPC分类号： C12M1/34 , C12Q1/00 , C12Q1/68 , C12Q1/70 , G01F1/64 , G01N15/10 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G01N33/5005 , C12M41/32 , G01N33/5023 , G01N33/5038 , G01N33/5041 , G01N2015/1006 , Y10T436/115831
摘要： An apparatus and methods for detecting at least one analyte of interest either produced or consumed by a plurality of cell. In one embodiment of the present invention, the method includes the steps of providing a housing defining a chamber, placing a plurality of cells in the chamber, and simultaneously detecting at least two analytes of interest either produced or consumed by the plurality of cells in the chamber.
摘要翻译：一种用于检测由多个细胞产生或消耗的至少一种感兴趣分析物的装置和方法。在本发明的一个实施例中，该方法包括以下步骤：提供限定腔室的壳体，将多个细胞放置在腔室中，同时检测至少两种感兴趣的分析物，所述分析物是由多个细胞产生或消耗的房间。

6. 发明授权

US07713733B2 Device and methods for detecting the response of a plurality of cells to at least one analyte of interest 有权
标题翻译：用于检测多个细胞对至少一种感兴趣分析物的响应的装置和方法
公开(公告)号：US07713733B2
公开(公告)日：2010-05-11
申请号：US10483466
申请日：2002-08-06
申请人： David Cliffel , Franz J. Baudenbacher , John P. Wikswo , Sven Eklund , R. Robert Balcarcel , Jonathan M. Gilligan
发明人： David Cliffel , Franz J. Baudenbacher , John P. Wikswo , Sven Eklund , R. Robert Balcarcel , Jonathan M. Gilligan
IPC分类号： C12M1/22 , C12M3/00 , C12M1/34
CPC分类号： G01N33/5005 , C12M41/32 , G01N33/5023 , G01N33/5038 , G01N33/5041 , G01N2015/1006 , Y10T436/115831
摘要： An apparatus and methods for detecting at least one analyte of interest either produced or consumed by a plurality of cell. In one embodiment of the present invention, the method includes the steps of providing a housing defining a chamber, placing a plurality of cells in the chamber, and simultaneously detecting at least two analytes of interest either produced or consumed by the plurality of cells in the chamber.
摘要翻译：一种用于检测由多个细胞产生或消耗的至少一种感兴趣分析物的装置和方法。在本发明的一个实施例中，该方法包括以下步骤：提供限定腔室的壳体，将多个细胞放置在腔室中，同时检测至少两种感兴趣的分析物，所述分析物是由多个细胞产生或消耗的房间。

7. 发明授权

US5899642A Milling cutter and method of assembly 失效
标题翻译：铣刀及组装方法
公开(公告)号：US5899642A
公开(公告)日：1999-05-04
申请号：US940021
申请日：1997-09-29
申请人： Carl-Erik Berglow , Sven Eklund
发明人： Carl-Erik Berglow , Sven Eklund
IPC分类号： B23B29/03 , B23B31/11 , B23C5/10 , B23C5/28 , B23Q11/00 , B23Q11/10 , B23C5/26
CPC分类号： B23B31/11 , B23C5/10 , B23C5/28 , B23Q11/0042 , B23Q11/1023 , B23C2210/03 , Y02P70/171 , Y10T279/16 , Y10T407/192 , Y10T407/1924 , Y10T407/1948 , Y10T407/23 , Y10T407/27 , Y10T408/907
摘要： An end mill includes a shank, a pull rod having a first end connected to a front end of the shank, and a second end connected to an end mill head. The end mill head has a centering surface engageable with a centering surface formed on either the pull rod or shank. The end mill head includes a radially extending abutment surface engageable with a radial abutment surface formed on the shank.
摘要翻译：端铣刀包括柄，拉杆，其具有连接到柄的前端的第一端和连接到立铣刀头的第二端。端铣头具有可与形成在拉杆或柄上的定心表面接合的定心表面。端铣刀头包括可与形成在柄上的径向邻接表面接合的径向延伸的邻接表面。

8. 发明授权

US6053671A Metal cutting insert, and tool therefor, and method of mounting insert 失效
标题翻译：金属切削刀片及其刀具，以及安装刀片的方法
公开(公告)号：US6053671A
公开(公告)日：2000-04-25
申请号：US981286
申请日：1998-04-09
申请人： Robert Stedt , Sven Eklund , Bertrand Riviere
发明人： Robert Stedt , Sven Eklund , Bertrand Riviere
IPC分类号： B23C5/22 , B23C5/20
CPC分类号： B23C5/2221 , B23C2200/0422 , B23C2200/045 , B23C2200/125 , B23C2200/126 , B23C2200/167 , B23C2200/168 , B23C2210/168 , Y10T407/191 , Y10T407/1926 , Y10T407/1934 , Y10T407/20
摘要： A cutting tool, preferably for milling, includes a holder and a cutting insert mounted thereon. The holder includes a seat upon which the insert is mounted, and an upstanding wall structure against which an edge face of the insert is pressed. The edge face has upper and lower portions separated by a step. The upper portion is frustoconical and is pressed against an upper wall of the wall structure to frictionally resist rotation of the insert about the insert's center axis. The lower portion of the edge face is polygonal and is adapted to engage a lower wall of the wall structure at a location spaced radially inwardly from a location where the upper portion and upper wall make contact. The lower portion rotates into engagement with the lower wall in response to cutting forces acting on the insert, to create an interference relationship between the lower portion and lower wall which prevents further rotation of the insert.
摘要翻译： PCT No.PCT / SE96 / 00784 Sec。 371日期：1998年4月9日 102（e）1998年4月9日PCT PCT 1996年6月18日PCT公布。出版物WO97 / 00750 日期1997年1月9日优选用于铣削的切削工具包括安装在其上的保持器和切削刀片。保持器包括一个安装有插入件的座，以及直立的壁结构，使得插入件的边缘面被按压。边缘面具有由台阶分开的上部和下部。上部是截头圆锥形的并且被压靠在壁结构的上壁上以摩擦地抵抗插入件围绕插入件的中心轴的旋转。边缘面的下部是多边形的并且适于在与上部和上部壁接触的位置处径向向内间隔开的位置处接合壁结构的下壁。响应于作用在插入件上的切割力，下部旋转成与下壁接合，以在下部和下壁之间形成干涉关系，从而防止插入件进一步旋转。

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