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1. 发明授权

US5496697A Methods and apparatus for detecting the effect of cell affecting agents on living cells 失效
标题翻译：用于检测细胞影响剂对活细胞的影响的方法和装置
公开(公告)号：US5496697A
公开(公告)日：1996-03-05
申请号：US118094
申请日：1993-09-08
申请人： John W. Parce , Harden M. McConnell , Gillian M. K. Humphries , Karen M. Kercso , John C. Owicki , Josef E. Kercso
发明人： John W. Parce , Harden M. McConnell , Gillian M. K. Humphries , Karen M. Kercso , John C. Owicki , Josef E. Kercso
IPC分类号： C12M1/34 , C12Q1/04 , G01N33/50 , C12Q1/02 , C12Q1/70
CPC分类号： G01N33/5008 , C12M23/12 , C12M35/08 , Y10S435/817
摘要： Methods and apparatus are disclosed for detecting the effects of cell affecting agents on living cells. The method steps include providing living cells that are retained in a micro flow chamber. The micro flow chamber is adapted for either continuous or intermittent flow of solutions or suspensions in intimate contact with the cells. The solutions or suspensions, which contain a cell affecting agent, are then flowed in intimate contact with the cells and the pit is measured.
摘要翻译：公开了用于检测细胞影响剂对活细胞的影响的方法和装置。方法步骤包括提供保留在微流动室中的活细胞。微流动室适于与细胞紧密接触的连续或间歇流动的溶液或悬浮液。然后将含有细胞影响剂的溶液或悬浮液与细胞紧密接触流动并测量凹坑。

2. 发明授权

US5278048A Methods for detecting the effect of cell affecting agents on living cells 失效
标题翻译：检测细胞影响剂对活细胞的影响的方法
公开(公告)号：US5278048A
公开(公告)日：1994-01-11
申请号：US708121
申请日：1991-05-29
申请人： John W. Parce , Harden M. McConnell , Gillian M. K. Humphries , Karen M. Kercso , John C. Owicki , Josef E. Kercso
发明人： John W. Parce , Harden M. McConnell , Gillian M. K. Humphries , Karen M. Kercso , John C. Owicki , Josef E. Kercso
IPC分类号： C12M1/34 , G01N33/50 , C12Q1/02
CPC分类号： C12M35/08 , G01N33/5008 , Y10S435/817 , Y10S436/806
摘要： Methods are disclosed for detecting the effects of cell affecting agents on living cells. The method steps include providing living cells that are retained in a micro flow chamber. The micro flow chamber is adapted for either continuous or intermittent flow of solutions or suspensions in intimate contact with the cells. The solutions or suspensions, which contain a cell affecting agent, are then flowed in intimate contact with the cells and at least one effect of the cell affecting agent on the cells is measured by an appropriate detecting means, which is operatively associated with the micro flow chamber.
摘要翻译：公开了用于检测细胞影响剂对活细胞的作用的方法。方法步骤包括提供保留在微流动室中的活细胞。微流动室适于与细胞紧密接触的连续或间歇流动的溶液或悬浮液。然后将含有细胞影响剂的溶液或悬浮液与细胞紧密接触流动，并通过合适的检测手段测量细胞影响剂对细胞的至少一种作用，该检测手段与微量流可操作地相关联房间。

3. 发明授权

US4704353A Photoresponsive redox detection and discrimination 失效
标题翻译：光电氧化还原检测和歧视
公开(公告)号：US4704353A
公开(公告)日：1987-11-03
申请号：US604800
申请日：1984-04-27
申请人： Gillian M. K. Humphries , John W. Parce , Harden M. McConnell
发明人： Gillian M. K. Humphries , John W. Parce , Harden M. McConnell
IPC分类号： G01N21/00 , C12Q1/00 , G01N27/00 , G01N27/30 , G01N33/543 , G01N33/50 , G01N27/52 , G01N33/53
CPC分类号： G01N33/5438 , C12Q1/004 , G01N27/305 , Y10S435/966 , Y10S435/973 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/827 , Y10S436/904
摘要： Devices and methods are provided for making a plurality of determinations of the local (site-specific) redox state of a liquid system, by employing a photoresponsive element, which can be independently irradiated at different sites to provide independently detectable signals.
摘要翻译：提供了用于通过使用光响应元件多次确定液体系统的局部（位点特异性）氧化还原状态的装置和方法，所述光响应元件可以在不同位置独立地照射以提供独立可检测的信号。

4. 发明授权

US4883579A Photoresponsive redox detection and discrimination 失效
标题翻译：光电氧化还原检测和歧视
公开(公告)号：US4883579A
公开(公告)日：1989-11-28
申请号：US34036
申请日：1987-04-01
申请人： Gillian M. K. Humphries , John W. Parce , Harden M. McConnell
发明人： Gillian M. K. Humphries , John W. Parce , Harden M. McConnell
IPC分类号： C12Q1/00 , G01N27/30 , G01N33/543
CPC分类号： C12Q1/004 , G01N27/305 , G01N33/5438 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/827 , Y10S436/904
摘要： Devices and methods are provided for making a plurality of determinations of the local (site-specific) redox state of a liquid system, by employing a photoresponsive element, which can be independently irradiated at different sites to provide independently detectable signals.
摘要翻译：提供了用于通过使用光响应元件多次确定液体系统的局部（位点特异性）氧化还原状态的装置和方法，所述光响应元件可以在不同位置独立地照射以提供独立可检测的信号。

5. 发明授权

US4849330A Photoresponsive redox detection and discrimination 失效
公开(公告)号：US4849330A
公开(公告)日：1989-07-18
申请号：US730231
申请日：1985-05-03
申请人： Gillian M. K. Humphries , John W. Parce , Harden M. McConnell
发明人： Gillian M. K. Humphries , John W. Parce , Harden M. McConnell
IPC分类号： C12Q1/00 , G01N27/30 , G01N33/543
CPC分类号： C12Q1/004 , G01N27/305 , G01N33/5438 , Y10S435/966 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/827 , Y10S436/904
摘要： Devices and methods are provided for making a plurality of determinations of the local (site-specific) redox state of a liquid system, by employing a photoresponsive element, which can be independently irradiated at different sites to provide independently detectable signals.

6. 发明授权

US4591550A Device having photoresponsive electrode for determining analytes including ligands and antibodies 失效
标题翻译：具有用于测定包括配体和抗体在内的分析物的光响应电极的装置
公开(公告)号：US4591550A
公开(公告)日：1986-05-27
申请号：US597135
申请日：1984-04-05
申请人： Dean Hafeman , John W. Parce , Harden M. McConnell
发明人： Dean Hafeman , John W. Parce , Harden M. McConnell
IPC分类号： G01N33/53 , G01N21/27 , G01N27/30 , G01N27/416 , G01N33/543 , G01N27/07 , G01N33/50
CPC分类号： G01N27/327 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/00702 , Y10S435/817 , Y10S435/973 , Y10S436/806 , Y10S436/827
摘要： Photoresponsive devices, including a photoresponsive electrode, are provided and methods for their use to measure changes in environment at a site at or about the surface of the photoresponsive device. By employing a source of light for irradiating a site on the surface and means for biasing the photoresponsive electrode in relation to a counterelectrode, a variation in electrical signal can be related to a change in a medium in photoresponsive modulation relationship to the photoresponsive electrode surface.
摘要翻译：提供了光响应装置，包括光响应电极，以及用于测量光响应装置表面处或周围环境变化的方法。通过使用用于照射表面上的位置的光源和用于相对于反电极偏置光响应电极的装置，电信号的变化可以与光响应调制关系中的光响应电极表面的介质变化有关。

7. 发明授权

US5500188A Device for photoresponsive detection and discrimination 失效
标题翻译：用于光响应检测和辨别的装置
公开(公告)号：US5500188A
公开(公告)日：1996-03-19
申请号：US185492
申请日：1994-01-24
申请人： Dean G. Hafeman , John W. Parce , Harden M. McConnell
发明人： Dean G. Hafeman , John W. Parce , Harden M. McConnell
IPC分类号： G01N27/30 , G01N27/416 , G01N21/27 , G01N27/07
CPC分类号： G01N27/3273 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00702 , Y10S435/817 , Y10S436/806 , Y10S436/827
摘要： Photoresponsive devices including a photoresponsive electrode are provided, and methods for their use to measure changes in environment at a site at or about the surface of the photoresponsive device. By employing a source of light for irradiating a site on the surface and means for biasing the photoresponsive electrode in relation to a counterelectrode, a variation in electrical signal can be related to a change in a medium in photoresponsive modulation relationship to the photoresponsive electrode surface.
摘要翻译：提供了包括光响应电极的光响应装置，以及用于测量光响应装置表面处或周围环境变化的方法。通过使用用于照射表面上的位置的光源和用于相对于反电极偏置光响应电极的装置，电信号的变化可以与光响应调制关系中的光响应电极表面的介质变化有关。

8. 发明授权

US4737464A Solid-state optical assay imaging apparatus 失效
标题翻译：固态光学测定成像装置
公开(公告)号：US4737464A
公开(公告)日：1988-04-12
申请号：US780485
申请日：1985-09-26
申请人： Harden M. McConnell , Jonathan Briggs , John W. Parce
发明人： Harden M. McConnell , Jonathan Briggs , John W. Parce
IPC分类号： G01N21/25 , G01N21/27 , G01N21/00
CPC分类号： G01N21/253 , G01N21/272 , G01N21/6428 , G01N2201/0461 , Y10S436/805 , Y10S436/807 , Y10T436/11
摘要： An apparatus for determining a characteristic of a signal modulating component related to an analyte of interest at an assay site by measuring light modulated by the component. A light source uniformly illuminates the assay site and a reference site. The light is directed from the sites onto a group of memory cells on the surface of a random access memory. The memory cells will decay from a logical 1 to a logical 0 due to the light over a period of time which is a function of the intensity of the light and the reference voltage of the memory cells marking the difference between a 1 and a 0. The digital state of each of the memory cells in the group is measured a predetermined exposure time. The measured states of a group of memory cells corresponding to the assay site are compared to the memory cell states for a reference group. The measured states are then analyzed to determine a characteristic of the analyte.
摘要翻译：一种用于通过测量由该组分调制的光来确定在测定部位与感兴趣分析物相关的信号调节成分的特征的装置。光源均匀地照射了测定部位和参考部位。光从站点引导到随机存取存储器表面上的一组存储器单元上。存储器单元将由于在一段时间内的光而从逻辑1衰减到逻辑0，该时间段是光的强度和记录单元的参考电压的函数，标记1和0之间的差。在预定的曝光时间内测量组中的每个存储单元的数字状态。将对应于测定位点的一组存储器单元的测量状态与参考组的存储器单元状态进行比较。然后分析测量的状态以确定分析物的特征。

9. 发明授权

US4911794A Measuring with zero volume cell 失效
标题翻译：用零容量单元进行测量
公开(公告)号：US4911794A
公开(公告)日：1990-03-27
申请号：US65418
申请日：1987-06-18
申请人： John W. Parce , Robert F. Zuk
发明人： John W. Parce , Robert F. Zuk
IPC分类号： C12Q1/00 , G01N27/28 , G01N27/30 , G01N27/414 , G01N27/416
CPC分类号： G01N27/3271 , Y10S435/817 , Y10S436/806
摘要： Methods and apparatuses are described for determining the presence of an analyte in a sample suspected of containing the analyte. The method comprises contacting a concentrate of a determinable element capable of being detected by means of a semiconductive electrode with the electrode in the presence of a relatively large volume of an assay medium. The determinable element is present in the concentrate in the amount related to the amount of analyte present in the sample. The volume of the medium in diffusive communication with the concentrate is then reduced and the determinable element is detected by means of the effect that the determinable element has on the semiconductive electrode.
摘要翻译：描述了用于确定疑似含有分析物的样品中分析物的存在的方法和装置。该方法包括在相对较大体积的测定培养基的存在下使能够通过半导体电极检测的可测定元件的浓缩物与电极接触。浓缩物中可测量的元素以与样品中存在的分析物的量相关的量存在。然后减少与浓缩物扩散连通的介质的体积，并且通过可测定元件在半导体电极上具有的作用来检测可确定元件。

10. 发明授权

US5395503A Zero volume electrochemical cell 失效
标题翻译：零容电化学电池
公开(公告)号：US5395503A
公开(公告)日：1995-03-07
申请号：US129541
申请日：1993-09-29
申请人： John W. Parce , Robert F. Zuk
发明人： John W. Parce , Robert F. Zuk
IPC分类号： G01N27/28 , G01N27/416 , G01N27/327
CPC分类号： G01N27/327
摘要： Methods and apparatuses are described for determining the presence of an analyte in a sample suspected of containing the analyte. The method comprises contacting a concentrate of a determinable element capable of being detected by means of a semiconductive electrode with the electrode in the presence of a relatively large volume of an assay medium. The determinable element is present in the concentrate in the amount related to the amount of analyte present in the sample. The volume of the medium in diffusive communication with the concentrate is then reduced and the determinable element is detected by means of the effect that the determinable element has on the semiconductive electrode.
摘要翻译：描述了用于确定疑似含有分析物的样品中分析物的存在的方法和装置。该方法包括在相对较大体积的测定培养基的存在下使能够通过半导体电极检测的可测定元件的浓缩物与电极接触。浓缩物中可测量的元素以与样品中存在的分析物的量相关的量存在。然后减少与浓缩物扩散连通的介质的体积，并且通过可测定元件在半导体电极上具有的作用来检测可确定元件。

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