专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5939365A Lubricant with a higher molecular weight copolymer lube oil flow improver 失效
标题翻译：润滑剂具有较高分子量共聚物润滑油流动改进剂
公开(公告)号：US5939365A
公开(公告)日：1999-08-17
申请号：US771791
申请日：1996-12-20
申请人： John V. Redpath , Arunas T. Lapinas , David J. Martella , Albert Rossi , William M. Davis
发明人： John V. Redpath , Arunas T. Lapinas , David J. Martella , Albert Rossi , William M. Davis
IPC分类号： C10M101/00 , C10M145/14 , C10M157/00 , C10M169/04 , C10N20/04 , C10N30/02 , C10N40/04 , C10M157/10
CPC分类号： C10M157/00 , C10M169/04 , C10M2203/10 , C10M2203/1006 , C10M2203/102 , C10M2203/1025 , C10M2203/1045 , C10M2203/1065 , C10M2203/1085 , C10M2205/00 , C10M2205/022 , C10M2205/024 , C10M2205/04 , C10M2209/06 , C10M2209/084 , C10M2209/086 , C10N2240/00 , C10N2240/04 , C10N2240/042 , C10N2240/044 , C10N2240/046 , C10N2240/08 , C10N2240/10 , C10N2240/101 , C10N2240/104 , C10N2240/105 , C10N2240/106 , C10N2240/14 , C10N2240/22 , C10N2240/30 , C10N2240/50 , C10N2240/52 , C10N2240/54 , C10N2240/56 , C10N2240/58 , C10N2240/60 , C10N2240/66
摘要： A lubricant which comprises: a mineral oil basestock which has been dewaxed via catalytic cracking and/or catalytic isomerization; an alkylene-alkylene copolymer; and a lubricating oil flow improver formed from the reaction product of: (a) an unsaturated carboxy ester formed via the esterification of an unsaturated carboxylic acid or its corresponding anhydride with a monohydric aliphatic alcohol having an average carbon number of between about 10 to 18, the unsaturated carboxy ester having the formula: ##STR1## wherein R' is selected from the group consisting of hydrogen and COOR and wherein R is a C.sub.6 to C.sub.22 alkyl group; and (b) a monomer selected from the group consisting of(i) a vinyl ester having the formula: ##STR2## wherein R.sub.1 comprises an alkyl group containing from 1 to 18 carbon atoms;(ii) an olefin having the formula ##STR3## wherein R.sub.1 and R.sub.2 can independently be hydrogen, an alkyl having from 1 to 28 carbon atoms, or a substituted aryl group, provided both R.sub.1 and R.sub.2 are not hydrogen,the reaction product having a specific viscosity in the range between about 0.3 to 1.5, or a weight average molecular weight of between about 50,000 to 350,000 Daltons.
摘要翻译：一种润滑剂，其特征在于，包括：通过催化裂化和/或催化异构化脱蜡的矿物油基料; 亚烷基 - 亚烷基共聚物; 和由以下反应产物形成的润滑油流动改进剂：（a）通过不饱和羧酸或其相应的酸酐与平均碳数为约10至18的一元脂族醇的酯化形成的不饱和羧酸酯，所述不饱和羧酸酯具有下式：其中R'选自氢和COOR，并且其中R是C6至C22烷基; 和（b）选自（i）具有下式的乙烯基酯的单体：其中R 1包含含有1至18个碳原子的烷基; （ii）具有下式的烯烃：其中R 1和R 2可以独立地为氢，具有1至28个碳原子的烷基或取代的芳基，只要R1和R2都不为氢，反应产物的比粘度约0.3至1.5的范围，或重量平均分子量在约50,000至350,000道尔顿之间。

2. 发明申请

US20110258151A1 System and Method for Resolving Gamma-Ray Spectra 审中-公开
标题翻译：解决伽玛光谱的系统和方法
公开(公告)号：US20110258151A1
公开(公告)日：2011-10-20
申请号：US13011431
申请日：2011-01-21
申请人： Charles A. Gentile , Jason Perry , Stephen W. Langish , Kenneth Silber , William M. Davis , Dana Mastrovito
发明人： Charles A. Gentile , Jason Perry , Stephen W. Langish , Kenneth Silber , William M. Davis , Dana Mastrovito
IPC分类号： G06F15/18
CPC分类号： G01T1/167 , G01T3/00 , G01T7/00 , G01V5/0075 , G01V5/0083
摘要： A system for identifying radionuclide emissions is described. The system includes at least one processor for processing output signals from a radionuclide detecting device, at least one training algorithm run by the at least one processor for analyzing data derived from at least one set of known sample data from the output signals, at least one classification algorithm derived from the training algorithm for classifying unknown sample data, wherein the at least one training algorithm analyzes the at least one sample data set to derive at least one rule used by said classification algorithm for identifying at least one radionuclide emission detected by the detecting device.
摘要翻译：描述了用于识别放射性核素排放的系统。该系统包括用于处理来自放射性核素检测装置的输出信号的至少一个处理器，由至少一个处理器运行的至少一个训练算法，用于从输出信号分析从至少一组已知采样数据导出的数据，至少一个从用于分类未知样本数据的训练算法得出的分类算法，其中所述至少一个训练算法分析所述至少一个采样数据集以导出由所述分类算法使用的至少一个规则，用于识别由所述检测检测到的至少一个放射性核素发射设备。

3. 发明授权

US07125230B2 Valve with operation parameter set at assembly and pump using same 有权
标题翻译：阀门具有在组装和泵使用相同的操作参数
公开(公告)号：US07125230B2
公开(公告)日：2006-10-24
申请号：US10191913
申请日：2002-07-09
申请人： William M. Davis , Casey C. O'Connor , Ryan P. Michels
发明人： William M. Davis , Casey C. O'Connor , Ryan P. Michels
IPC分类号： F04B39/00 , F04B53/00
CPC分类号： F04B49/24 , F16K17/04 , Y10T29/49425 , Y10T137/0491 , Y10T137/2592 , Y10T137/6011 , Y10T137/7835
摘要： A valve is assembled by telescoping a first body component relative to a second body component until reaching a relative position that corresponds to a predetermined valve operation parameter, such as a valve opening pressure. The first body component is then fixed with respect to the second body component at the relative position, such as by laser welding. The present invention finds potential application as a cartridge valve for a pump, such as a pressure relief valve and/or pressure reduction valve. The relative positioning control over the body components de-sensitizes valve operation from variations in valve components, such as variations attributable to geometrical tolerances.
摘要翻译：通过将第一主体部件相对于第二主体部件伸缩组装直到到达对应于预定的阀操作参数（例如开阀压力）的相对位置来组装阀。然后，例如通过激光焊接，第一主体部件相对于第二主体部件在相对位置固定。本发明可以用作泵的排气阀，例如减压阀和/或减压阀。身体部件上的相对定位控制使得阀门部件的变化（例如由于几何公差引起的变化）使阀门操作变得敏感。

4. 发明授权

US5120322A Method and apparatus for treatment of fibrotic lesions 失效
标题翻译：用于治疗纤维化病变的方法和装置
公开(公告)号：US5120322A
公开(公告)日：1992-06-09
申请号：US538025
申请日：1990-06-13
申请人： William M. Davis , Milos Chvapil
发明人： William M. Davis , Milos Chvapil
IPC分类号： A61L26/00 , A61K31/195 , A61K31/275 , A61L29/00 , A61M25/00 , A61M29/02
CPC分类号： A61M25/1027 , A61K31/195 , A61K31/275 , A61M25/104 , A61M2025/1031 , A61M2025/105
摘要： A method of controlling scar formation in humans byapplying a force to tissue in an amount to create a wound;applying a lathyrogenic agent to the wound;forming the wound into a predetermined stationary or moveable beneficial configuration; andmaintaining the wound in the predetermined configuration and in contact with lathyrogenic agent during healing.
摘要翻译：一种通过向组织施加一定量的创造伤口来控制人体中瘢痕形成的方法; 向伤口施用淫羊藿剂; 将伤口形成预定的静止或可移动的有益结构; 并且将伤口保持在预定构型并且在愈合过程中与割草剂接触。

5. 发明授权

US4678780A Anti-spasmodic agents having a ring in the main chain 失效
标题翻译：抗痉挛剂在主链中具有环
公开(公告)号：US4678780A
公开(公告)日：1987-07-07
申请号：US923623
申请日：1986-10-27
申请人： William M. Davis
发明人： William M. Davis
IPC分类号： C07D295/088 , A61K31/55
CPC分类号： C07D295/088
摘要： A new class of anti-spasmodic compounds having two branch chains is provided. The compounds have the general formula: ##STR1## where R, X, m, n and p are defined hereinbelow.
摘要翻译：提供了一类新的具有两条支链的抗痉挛化合物。化合物具有以下通式：其中R，X，m，n和p在下文定义。

6. 发明授权

US5614387A Method of making stabilized enzyme compositions for nucleic acid amplification 失效
标题翻译：制备用于核酸扩增的稳定化酶组合物的方法
公开(公告)号：US5614387A
公开(公告)日：1997-03-25
申请号：US444547
申请日：1995-05-19
申请人： Nancy L. L. Shen , Daniel L. Kacian , James G. Putnam , William M. Davis
发明人： Nancy L. L. Shen , Daniel L. Kacian , James G. Putnam , William M. Davis
IPC分类号： C12N9/12 , C12N9/96 , C12N15/09 , C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C12N9/96 , C12N9/1241 , C12N9/1276 , C12Q1/6846 , Y10S435/81
摘要： Stabilized enzyme compositions for use in nucleic acid amplification. Compositions are provided for the stabilization of one or more enzymes in a single stabilized formulation. Additional compositions incorporate a dried, stabilized enzyme mixture together with necessary cofactors and enzyme substrates in a single container for use upon rehydration. Also disclosed are methods for making and using stabilized enzyme compositions and kits for nucleic acid amplification incorporating the disclosed compositions.
摘要翻译：用于核酸扩增的稳定化酶组合物。提供组合物用于在单一稳定的制剂中稳定一种或多种酶。另外的组合物将干燥的稳定的酶混合物与必需的辅因子和酶底物合并在单个容器中，用于补液。还公开了用于制备和使用稳定的酶组合物和用于掺入所公开的组合物的核酸扩增试剂盒的方法。

7. 再颁专利

USRE33907E Anti-spasmodic agents having a heterocyclic ring 失效
公开(公告)号：USRE33907E
公开(公告)日：1992-04-28
申请号：US394274
申请日：1989-08-15
申请人： William M. Davis
发明人： William M. Davis
IPC分类号： C07D207/08 , C07D207/12 , C07D211/20 , C07D211/54 , C07D239/26 , C07D239/38 , C07D249/08 , C07D249/12 , C07D265/30 , C07D279/12 , C07D451/02 , C07D451/04 , C07D453/02
CPC分类号： C07D207/08 , C07D207/12 , C07D211/20 , C07D211/54 , C07D239/26 , C07D239/38 , C07D249/08 , C07D249/12 , C07D265/30 , C07D279/12 , C07D451/02 , C07D451/04 , C07D453/02
摘要： A new class of anti-spasmodic thioester compounds having a heterocyclic ring containing the nitrogen atom of a secondary or tertiary amine or a bicycloheterocyclic ring system containing the nitrogen atom of a secondary or tertiary amine. These compounds have the general formula I ##STR1## wherein: =n is an integer from 0 to 2;R.sub.1 is aryl or cycloalkyl;=R.sub.2 is hydrogen or hydroxyl; andR.sub.3 is selected from the group consisting of heterocyclic containing the nitrogen atom of a secondary or tertiary amine to which an alkyl group having from 0 to 3 carbon atoms is bonded and no other hetero atoms are present in the ring structure; heterocyclic containing the nitrogen atom of a secondary or tertiary amine to which an alkyl group having from 0 to 3 carbon atoms is bonded and one or more hetero atoms selected from the group consisting of N, O and S are present in the ring structure; bicycloheterocyclic ring system containing the nitrogen atom of a secondary or tertiary amine to which an alkyl group having from 0 to 3 carbon atoms is bonded and no other hetero atoms are present in the ring system; and bicycloheterocyclic ring system containing the nitrogen atom of a secondary or tertiary amine to which an alkyl group having from 0 to 3 carbon atoms is bonded and one or more hetero atoms selected from the group consisting of N, O and S are present in the ring system.

8. 发明授权

US4957941A Anti-spasmdoic agents having an acetylenic bond 失效
标题翻译：具有炔属键的抗痉挛剂
公开(公告)号：US4957941A
公开(公告)日：1990-09-18
申请号：US463892
申请日：1990-01-09
申请人： William M. Davis
发明人： William M. Davis
IPC分类号： C07D295/084
CPC分类号： C07D295/084
摘要： A new class of anti-spasmodic compounds having two branch chains is provided. The compounds have the general formula: ##STR1## where Y is H or OH;j is an integer from 0 to 4;k is an integer from 0 to 4, and whereinm is an integer from 1 to 4;n is an integer from 1 to 4;p is an integer from 1 to 4; andX may be nonexistent or may be O, S, NH or CH.sub.2 or salts thereof, but when X is nonexistent the terminal group in which both the n-chain and the p-chain is a methyl group. ##STR2## The reaction was performed under reflux condensation. Following the reaction, which was usually complete within a few hours, the acid chlorides were vacuum distilled and reacted with a thiol compound as described above.The compounds of this invention are anti-muscarinic agents (cholinergic-muscarinic receptor antagonists) which inhibit the actions of acetylcholine on autonomic effectors innervated by postganglionic cholinergic nerves as well as on smooth muscle that lacks cholinergic innervation. Since a major component of parasympathetic control of smooth muscle occurs via muscarinic receptors, these compounds are effective as modifiers of smooth muscle activity.Thiphenamil hydrochloride has been shown to decrease spasm of the gastrointestinal tract, biliary tract, ureter and uterus without producing characteristic atropinic side effects on salivary and sweat glands, GI glands, the eye or the cardiovascular system. This invention results in compounds which are as efficacious as thiphenamil hydrochloride, or more so, in relaxing various smooth muscle systems while at the same time demonstrating thiphenamil hydrochloride's lack of associated side-effects.
摘要翻译：提供了一类新的具有两条支链的抗痉挛化合物。该化合物具有通式：其中Y是H或OH; j为0〜4的整数， k为0〜4的整数，m为1〜4的整数， n是1至4的整数; p是1至4的整数; 并且X可以不存在，或者可以是O，S，NH或CH 2或其盐，但是当X不存在其中n链和p链都是甲基的末端基团时。反应在回流冷凝下进行。反应通常在几小时内完成，如上所述，将酰氯真空蒸馏并与硫醇化合物反应。本发明的化合物是抑制乙酰胆碱对由神经节后胆碱能神经支配的自主神经作用者以及缺乏胆碱能神经支配的平滑肌的作用的抗毒蕈碱药（胆碱能 - 毒蕈碱受体拮抗剂）。由于平滑肌副交感神经控制的主要成分是通过毒蕈碱受体发生的，所以这些化合物作为平滑肌活性的调节剂是有效的。已经证明，盐酸泰而米米可以减少胃肠道，胆道，输尿管和子宫的痉挛，而不会对唾液腺和汗腺，胃腺，眼睛或心血管系统产生特征性的阿托品副作用。本发明产生的化合物与盐酸泰维必利素一样有效，或更倾向于在放松各种平滑肌系统的同时，同时显示出盐酸泰尼泊尔缺乏相关的副作用。

9. 发明授权

US4725593A Method of treating smooth muscle spasm 失效
标题翻译：治疗平滑肌痉挛的方法
公开(公告)号：US4725593A
公开(公告)日：1988-02-16
申请号：US853378
申请日：1986-04-15
申请人： William M. Davis
发明人： William M. Davis
IPC分类号： A61K31/265 , A61K31/54
CPC分类号： A61K31/265
摘要： A new method of treating a patient suffering smooth muscle spasm comprises administering to the patient an effective amount of anti-spasmodic compound having the general formula: ##STR1## where R is selected from the group consisting of: ##STR2## wherein W is CH.sub.2, NH, O or S, ##STR3## wherein Y is an alicyclic ring ring having 3-12 carbon atoms, and ##STR4## the total number of carbon atoms in R is equal to or less than 20. Furthermore, m is an integer from 1 to 4, n is an integer from 1 to 4, p is an integer from 1 to 4 and q is an integer from 1 to 4. X may be nonexistent or may be 0, S, NH or CH.sub.2 or salts thereof. However, when X is nonexistent the terminal group in both the n-chain and the p-chain is a methyl group provided that a is zero or 1 and when a is 1, X is selected from the group consisting of 0, S, and CH.sub.2 and n and p are integers from 1 to 4; and when a is 0 then X is nonexistent and n and p are integers from 1 to 4 and the terminal group in both the n-chain and the p-chain is methyl; and pharmaceutically acceptable salts thereof.
摘要翻译：治疗患有平滑肌痉挛的患者的新方法包括向患者施用有效量的具有以下通式的抗痉挛化合物：其中R选自：其中W是CH 2， NH，O或S，其中Y是具有3-12个碳原子的脂环族环，并且R中的总碳原子数等于或小于20.此外，m是 1至4，n为1至4的整数，p为1至4的整数，q为1至4的整数.X可以不存在或可以为0，S，NH或CH 2或其盐。然而，当X不存在时，n链和p链中的末端基团是甲基，条件是a为0或1，当a为1时，X选自0，S和 CH2和n和p是1至4的整数; 当a为0时，X不存在，n和p为1〜4的整数，n链和p链中的末端基为甲基; 及其药学上可接受的盐。

10. 发明授权

US4707480A Method for stabilizing a detrusor muscle while increasing detrusor muscle strength 失效
标题翻译：稳定逼尿肌同时增加逼尿肌强度的方法
公开(公告)号：US4707480A
公开(公告)日：1987-11-17
申请号：US783311
申请日：1985-10-03
申请人： William M. Davis
发明人： William M. Davis
IPC分类号： A61K31/265 , A61K31/21 , A61K31/445 , A61K31/535
CPC分类号： A61K31/265 , Y10S514/906
摘要： A method for inhibiting unplanned or premature detrusor muscle contractions while at the same time increasing the force of contraction of the detrusor muscle is provided. The method comprises administering to the patient a di-N-substituted aminoethyl ester of diphenylthioacetic acid having the formula: ##STR1## in which R represents a disubstituted amino radical of the group consisting of the diethylamino group, the morpholino group or the piperidino group.
摘要翻译：提供一种抑制计划外或过早的逼尿肌收缩同时增加逼尿肌收缩力的方法。该方法包括向患者施用具有下式的二-N-取代氨基乙基酯：其中R表示二乙氨基，吗啉代基或哌啶子基组中的二取代氨基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式