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1. 发明申请

US20080171345A1 BIOMARKERS OF TUBERCULOSIS THAT DISTINGUISH DISEASE CATEGORIES: USE AS SERODIAGNOSTIC ANTIGENS 有权
标题翻译：辨证性疾病的结核菌生物标志物：用作血清抗原
公开(公告)号：US20080171345A1
公开(公告)日：2008-07-17
申请号：US11837264
申请日：2007-08-10
申请人： John T. BELISLE , Mark J. Sartain , Suman Laal
发明人： John T. BELISLE , Mark J. Sartain , Suman Laal
IPC分类号： G01N33/554 , C07K14/00
CPC分类号： C07K14/35 , G01N33/5695
摘要： Mycobacterial proteins from culture filtrate or cytosol are disclosed as being useful B cell antigens for early diagnosis of mycobacterial disease, particularly in humans. These proteins include four that had not previously been recognized as B cell antigens (LppZ protein encoded by Mtb gene Rv3006; SodC protein encoded by Mtb gene Rv0432; BfrB protein encoded by Mtb gene Rv3841 and TrxC protein encoded byMtb gene Rv3914). Antigenic compositions include these proteins and/or peptide fragments thereof, in various combinations with each other or with one or more of a set of 10 additional Mtb proteins known to be antigens (in paricular early antigens. Methods and kits for using these antigenic composition for early diagnosis of mycobacterial infection and disease are also disclosed.
摘要翻译：公开了来自培养滤液或细胞溶质的分枝杆菌蛋白质作为用于早期诊断分枝杆菌病，特别是人类的有用的B细胞抗原。这些蛋白质包括以前未被认定为B细胞抗原的四种（Mtb基因Rv3006编码的LppZ蛋白;由Mtb基因Rv0432编码的SodC蛋白;由Mtb基因Rv3841编码的BfrB蛋白和由Mtb基因Rv3914编码的TrxC蛋白）。抗原组合物包括这些蛋白质和/或其肽片段，其彼此具有各种组合，或与已知为抗原的10种另外的Mtb蛋白质的一种或多种组合（在特异性早期抗原中）。使用这些抗原组合物的方法和试剂盒还公开了分枝杆菌感染和疾病的早期诊断。

2. 发明授权

US07776341B2 Biomarkers of tuberculosis that distinguish disease categories: use as serodiagnostic antigens 有权
标题翻译：结核病生物标志物区分疾病类别：用作血清诊断抗原
公开(公告)号：US07776341B2
公开(公告)日：2010-08-17
申请号：US11837264
申请日：2007-08-10
申请人： John T. Belisle , Mark J. Sartain , Suman Laal
发明人： John T. Belisle , Mark J. Sartain , Suman Laal
IPC分类号： A61K39/04 , A61K39/00 , A61K39/02
CPC分类号： C07K14/35 , G01N33/5695
摘要： Mycobacterial proteins from culture filtrate or cytosol are disclosed as being useful B cell antigens for early diagnosis of mycobacterial disease, particularly in humans. These proteins include four that had not previously been recognized as B cell antigens (LppZ protein encoded by Mtb gene Rv3006; SodC protein encoded by Mtb gene Rv0432; BfrB protein encoded by Mtb gene Rv3841 and TrxC protein encoded by Mtb gene Rv3914). Antigenic compositions include these proteins and/or peptide fragments thereof, in various combinations with each other or with one or more of a set of 10 additional Mtb proteins known to be antigens (in particular early antigens. Methods and kits for using these antigenic composition for early diagnosis of mycobacterial infection and disease are also disclosed.
摘要翻译：公开了来自培养滤液或细胞溶质的分枝杆菌蛋白质作为用于早期诊断分枝杆菌病，特别是人类的有用的B细胞抗原。这些蛋白质包括以前未被认定为B细胞抗原的四种（Mtb基因Rv3006编码的LppZ蛋白; Mtb基因Rv0432编码的SodC蛋白;由Mtb基因Rv3841编码的BfrB蛋白和由Mtb基因Rv3914编码的TrxC蛋白）。抗原组合物包括彼此各种组合的这些蛋白质和/或其肽片段，或与一组已知为抗原的10种另外的Mtb蛋白质（特别是早期抗原）中的一种或多种组合使用这些抗原组合物的方法和试剂盒还公开了分枝杆菌感染和疾病的早期诊断。

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