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1. 发明授权

US07338803B2 Method for increasing capacity in an automatic clinical analyzer by using modular reagent delivery means 有权
标题翻译：通过使用模块化试剂递送装置来增加自动临床分析仪的容量的方法
公开(公告)号：US07338803B2
公开(公告)日：2008-03-04
申请号：US10623355
申请日：2003-07-18
申请人： John Paul Mizzer , Steven Frye , William Jackson Devlin, Sr. , Allan Tit-Shing Chow
发明人： John Paul Mizzer , Steven Frye , William Jackson Devlin, Sr. , Allan Tit-Shing Chow
IPC分类号： G01N35/02
CPC分类号： G01N35/1081 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163
摘要： An automatic clinical analyzer in which the number of cuvette ports available for reaction vessels on a reaction carousel are 50% in a configuration using a single reagent storage areas; in a second configuration an additional reagent storage areas is employed and additional ones of the cuvette ports on reaction carousel are utilized, thereby significantly increasing throughput.
摘要翻译：一种自动临床分析仪，其中可用于反应转盘上的反应容器的比色皿端口的数量在使用单个试剂储存区域的构型中为50％; 在第二配置中，使用附加的试剂储存区域，并且利用反应转盘上的另外的比色皿端口，从而显着增加产量。

2. 发明授权

US5985672A Method and apparatus for pre-treating samples in an automatic chemical analyzer 失效
标题翻译：在自动化学分析仪中预处理样品的方法和设备
公开(公告)号：US5985672A
公开(公告)日：1999-11-16
申请号：US9015
申请日：1998-01-20
申请人： Joseph Edward Kegelman , John Paul Mizzer , Edward Anthony Nuzzaci , Allan Tit-Shing Chow
发明人： Joseph Edward Kegelman , John Paul Mizzer , Edward Anthony Nuzzaci , Allan Tit-Shing Chow
IPC分类号： G01N33/543 , G01N35/00 , G01N35/02 , G01N35/04
CPC分类号： G01N35/0098 , G01N2035/0453 , Y10T436/11 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/25 , Y10T436/2575
摘要： A pre-processor for use in performing heterogeneous immunoassays on samples for analytes in the sample employing concentrically positioned incubating and processing carousels. A single transfer station permits reaction vessels containing sample and reagents to be moved between the carousels. The samples are separated, washed and mixed on the processing carousel and incubated on the incubating carousel thus speeding up processing throughput.
摘要翻译：用于对样品中的分析物样品进行异质免疫测定的预处理器，采用同心位置的孵育和加工转盘。单个转运站允许含有样品和试剂的反应容器在转盘之间移动。将样品分离，洗涤并在加工转盘上混合，并在孵育转盘上孵育，从而加快加工量。

3. 发明申请

US20120227771A1 Apparatus, Systems, And Methods Adapted To Rinse And Dry Clinical Analyzer Sample Probes 有权
标题翻译：设备，系统和方法适用于清洗和干燥的临床分析样品探头
公开(公告)号：US20120227771A1
公开(公告)日：2012-09-13
申请号：US13510840
申请日：2010-11-17
申请人： Raymond Waterbury , Antoine Elias Haddad , John Paul Mizzer
发明人： Raymond Waterbury , Antoine Elias Haddad , John Paul Mizzer
IPC分类号： B08B3/02 , B08B5/02 , B08B7/04 , B08B5/04
CPC分类号： G01N35/1004
摘要： A rinsing and drying apparatus of a clinical analyzer probe drain station is provided. The rinsing and drying apparatus has a group of nozzles that are offset from a longitudinal axis of a probe passage and may be inclined and oriented to provide tangentially oriented fluid-jet trajectories exiting into the sample probe passage. The offset nozzles, nozzle orientation, and cavity geometrical features of the device permit the drying capacity of probe-impinging planar air-knife jets to be maximized by stabilizing local internal fluid movement to form a swirling (e.g., helical) gas flow field directed away from a drying region and toward a vacuum exhaust. The rinsing and drying apparatus eliminates rinse water re-circulated entrainment and up-wash (spitting) during the air-knife drying operation. Therefore, the rinsing and drying apparatus significantly reduces water carryout on sampling probes thereby reducing sample/reagent dilution.
摘要翻译：提供了一种临床分析仪探针漏极台的冲洗和干燥设备。冲洗和干燥装置具有一组从一个探测器通道的纵向轴线偏移，并且可以被倾斜，并且定向以提供切向定向的离开进入试样探针通道流体喷射轨迹喷嘴。该装置的偏移量的喷嘴，喷嘴的方向，和模腔的几何特征允许探针撞击平面气刀喷嘴的干燥能力，以通过稳定本地内部的流体运动，以形成旋流（例如，螺旋）气流引导远场被最大化从干燥区域并朝向真空排气。冲洗和干燥装置在气刀干燥操作期间消除冲洗水再循环的夹带和上洗（吐）。因此，冲洗和干燥装置显着减少取样探针上的水分，从而减少样品/试剂稀释。

4. 发明授权

US09063107B2 Apparatus, systems, and methods adapted to rinse and dry clinical analyzer sample probes 有权
标题翻译：适用于冲洗和干燥临床分析仪样品探针的装置，系统和方法
公开(公告)号：US09063107B2
公开(公告)日：2015-06-23
申请号：US13510840
申请日：2010-11-17
申请人： Raymond Waterbury , Antoine Elias Haddad , John Paul Mizzer
发明人： Raymond Waterbury , Antoine Elias Haddad , John Paul Mizzer
IPC分类号： B08B5/00 , B08B5/02 , B08B9/00 , B08B9/02 , G01N35/10
CPC分类号： G01N35/1004
摘要： A rinsing and drying apparatus of a clinical analyzer probe drain station is provided. The rinsing and drying apparatus has a group of nozzles that are offset from a longitudinal axis of a probe passage and may be inclined and oriented to provide tangentially oriented fluid-jet trajectories exiting into the sample probe passage. The offset nozzles, nozzle orientation, and cavity geometrical features of the device permit the drying capacity of probe-impinging planar air-knife jets to be maximized by stabilizing local internal fluid movement to form a swirling (e.g., helical) gas flow field directed away from a drying region and toward a vacuum exhaust. The rinsing and drying apparatus eliminates rinse water re-circulated entrainment and up-wash (spitting) during the air-knife drying operation. Therefore, the rinsing and drying apparatus significantly reduces water carryout on sampling probes thereby reducing sample/reagent dilution.
摘要翻译：提供临床分析仪探头排水站的冲洗和干燥装置。冲洗和干燥装置具有一组从探针通道的纵向轴线偏离的喷嘴，并且可以倾斜并定向以提供离开样品探针通道的切向定向的流体喷射轨迹。该装置的偏移喷嘴，喷嘴取向和腔体几何特征允许通过稳定局部内部流体运动来使探针冲击的平面气刀喷嘴的干燥能力最大化，以形成指向远离的旋转（例如，螺旋形）气流场从干燥区域到真空排气。冲洗和干燥装置在气刀干燥操作期间消除冲洗水再循环的夹带和上洗（吐）。因此，冲洗和干燥装置显着减少取样探针上的水分，从而减少样品/试剂稀释。

5. 发明授权

US5827744A Method and apparatus for cleaning a liquid dispensing probe 失效
标题翻译：清洗液体分配探针的方法和装置
公开(公告)号：US5827744A
公开(公告)日：1998-10-27
申请号：US893634
申请日：1997-07-11
申请人： James Brian Fose , Ching-Cherng Lee , John Paul Mizzer
发明人： James Brian Fose , Ching-Cherng Lee , John Paul Mizzer
IPC分类号： B08B3/04 , B08B9/02 , G01N35/10
CPC分类号： G01N35/1004 , B08B3/04 , B08B9/0327 , Y10T436/114998 , Y10T436/119163
摘要： A method for cleaning a liquid sample probe in which the probe is positioned within a washing chamber inside a wash body and a purging liquid solution is pumped through the probe into the chamber. A cleaning liquid solution may also be pumped into the chamber around the probe. Either or both liquids are subsequently vacuumed from the chamber drawing air through an annular gap between the probe and the wash body thereby creating a cleaning air flow between the exterior probe surface and the wash body. The cleaning air flow removes all cleaning liquid solution and/or purging liquid solution as the probe is removed from the wash body.
摘要翻译：用于清洗液体样本探针的方法，其中将探针定位在洗涤体内的洗涤室内和清洗液体溶液中，通过探针被泵送到腔室中。清洁液体溶液也可以泵送到探针周围的腔室中。随后，两个或两个液体从室抽吸空气通过探针和洗涤体之间的环形间隙，从而在外部探针表面和洗涤体之间产生清洁空气流。当探头从洗涤体中取出时，清洁空气流将去除所有清洁液体溶液和/或清洗液体溶液。

6. 发明授权

US6118541A Method to determine the effectiveness of a chemical mixing system 失效
标题翻译：确定化学混合系统有效性的方法
公开(公告)号：US6118541A
公开(公告)日：2000-09-12
申请号：US60034
申请日：1998-04-13
申请人： John Paul Mizzer , Ching-Cherng Lee
发明人： John Paul Mizzer , Ching-Cherng Lee
IPC分类号： G01N21/27 , G01N21/00
CPC分类号： G01N21/272
摘要： Confirming sufficient mixture uniformity between a reagent and liquid sample experiencing a kinetic reaction by comparing the amount of light absorbed within the mixture after the reaction begins with the amount of light absorbed within the solution at the completion of the reaction and requiring that the difference between measured amounts of absorbed light be less than a predetermined value.
摘要翻译：通过将反应开始后的混合物中吸收的光的量与反应完成后在溶液中吸收的光量进行比较，确认试剂和经受动力学反应的液体样品之间足够的混合均匀性，并要求测量吸收光的量小于预定值。

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