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    • 7. 发明授权
    • Substituted phenylalkyl-(piperazinyl or homopiperazinyl)alkyl-thiols and
-thiocarbamates useful for the treatment of immunological,
inflammatory, and allergic disorders
    • 可用于治疗免疫学,炎症和过敏性疾病的取代的苯基烷基 - (哌嗪基或高哌嗪基)烷基硫醇和硫代氨基甲酸酯
    • US4618677A
    • 1986-10-21
    • US668089
    • 1984-11-05
    • Karl D. HargraveJohn P. DevlinEdward A. Barsumian
    • Karl D. HargraveJohn P. DevlinEdward A. Barsumian
    • C07D243/08C07D295/088C07D241/38A61K31/495
    • C07D295/088C07D243/08
    • Compounds of the formula ##STR1## wherein R is hydrogen or ##STR2## A is alkyl of 1 to 8 carbon atoms; cycloalkyl of 3 to 7 carbon atoms; phenyl; or phenyl mono-, di- or tri-substituted independently with alkyl of 1 to 4 carbon atoms, halogen, trihalomethyl, alkoxy of 1 to 3 carbon atoms, carboxylic acyl of 1 to 3 carbon atoms, carboxyl, (alkoxy of 1 to 3 carbon atoms)carbonyl, nitro, cyano or di(alkyl of 1 to 3 carbon atoms)amino;R.sub.1, R.sub.2 and R.sub.3, are independently hydrogen, halogen, alkyl of 1 to 4 carbon atoms, trihalomethyl, nitro, cyano, di(alkyl of 1 to 4 carbon atoms)amino, (alkoxy of 1 to 4 carbon atoms)carbonyl, alkoxy of 1 to 4 carbon atoms or hydroxyl;R.sub.4 and R.sub.5 are independently hydrogen, alkyl of 1 to 4 carbon atoms, or phenyl;R.sub.6, R.sub.7, R.sub.8 and R.sub.9 are independently hydrogen or methyl;Y is --CH.sub.2 -- or --CH.sub.2 --CH.sub.2 --;j is 0 or 1;k and m are independently 0, 1, 2, or 3, their sum being no more than 6 and must be 0 when j is 1;n is 2, 3, or 4, with the proviso that n must be 3 or 4 when R.sub.1 is hydrogen or 2-methyl, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9 and R are each hydrogen and j, k, and m are each 0, and Y is --CH.sub.2 --; andnon-toxic, pharmaceutically acceptable acid addition salts thereof are useful for the treatment of immunological, inflammatory and allergic disorders.
    • 其中R是氢或者A是具有1至8个碳原子的烷基; 3至7个碳原子的环烷基; 苯基; 或独立地具有1至4个碳原子的烷基,卤素,三卤代甲基,1至3个碳原子的烷氧基,1至3个碳原子的羧基酰基,羧基(1至3个的烷氧基) 碳原子)羰基,硝基,氰基或二(1至3个碳原子的烷基)氨基; R1,R2和R3独立地是氢,卤素,1-4个碳原子的烷基,三卤甲基,硝基,氰基,二(1-4个碳原子的烷基)氨基,(1-4个碳原子的烷氧基)羰基,烷氧基 1至4个碳原子或羟基; R4和R5独立地是氢,1-4个碳原子的烷基或苯基; R6,R7,R8和R9独立地是氢或甲基; Y是-CH 2 - 或-CH 2 -CH 2 - ; j为0或1; k和m独立为0,1,2或3,它们的和不大于6,当j为1时必须为0; n为2,3或4,条件是当R1为氢或2-甲基时,n必须为3或4,R2,R3,R4,R5,R6,R7,R8,R9和R分别为氢和j ,k和m各自为0,Y为-CH 2 - ; 其无毒的药学上可接受的酸加成盐可用于治疗免疫学,炎性和过敏性疾病。
    • 8. 发明申请
    • EARPHONE ASSEMBLY
    • 耳机装配
    • US20120008814A1
    • 2012-01-12
    • US12833651
    • 2010-07-09
    • Michael Joseph AlwickerJohn P. DevlinMark Bui Breneman
    • Michael Joseph AlwickerJohn P. DevlinMark Bui Breneman
    • H04R25/00H05K13/00
    • H04R1/1058H04R1/1016H04R11/02
    • An earphone assembly for an in-ear listening device is disclosed. The earphone assembly has an inner housing comprising a nozzle, configured to receive a sleeve for placement into a user's ear, and a balanced armature motor assembly. The balanced armature motor assembly is mounted in the inner housing so as to form an acoustical seal between the inner housing and the balanced armature motor assembly. The earphone assembly also includes an outer housing configured to receive the inner housing. The inner housing can comprise a recess for receiving a paddle of the balanced armature motor assembly. Alternatively, the outer housing can be formed with a nozzle for receiving a sleeve for placement into a user's ear canal, and the inner housing can comprise a spout, which is received in a recess in the outer housing.
    • 公开了一种用于入耳式听音装置的耳机组件。 耳机组件具有包括喷嘴的内部壳体,该喷嘴被配置为接收用于放置在使用者耳朵中的套筒和平衡的电枢电动机组件。 平衡的电枢电动机组件安装在内壳体中,以在内壳体和平衡的电枢电动机组件之间形成声学密封。 耳机组件还包括被配置为容纳内壳体的外壳。 内壳体可以包括用于接收平衡电枢电动机组件的桨叶的凹部。 或者,外壳可以形成有用于接收用于放置在使用者的耳道中的套筒的喷嘴,并且内壳体可以包括容纳在外壳中的凹部中的喷口。
    • 10. 发明授权
    • Alkylarylketo acids
    • 烷基芳基酮酸
    • US5504244A
    • 1996-04-02
    • US166401
    • 1993-12-14
    • Karl D. HargraveJohn P. Devlin
    • Karl D. HargraveJohn P. Devlin
    • C07C59/76C07C59/90C07C205/56C07C229/42C07D257/04C07C69/76
    • C07D257/04C07C205/56C07C229/42C07C59/76C07C59/90
    • Disclosed are novel alkylarylketocarboxylic acids and 5-substituted tetrazoles represented by the formula ##STR1## wherein Z is aryl or an alkyl of the structure ##STR2## W is a carboxyl moiety or a tetrazole moiety bound to Z at the 5-position of the tetrazole;R.sub.1 is C.sub.4 -C.sub.12 alkyl where Z is aryl and X is oxygen or is C.sub.5 -C.sub.12 alkyl where Z is alkyl and where Z is aryl and X is a bond;R.sub.2 and R.sub.3 are each independently hydrogen, C.sub.1 -C.sub.4 alkyl, hydroxy, C.sub.1 -C.sub.4 alkoxy, halogen, trihalomethyl, nitro, cyano or C.sub.1 -C.sub.4 acyl;R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are each independently hydrogen or C.sub.1 -C.sub.4 alkyl or R.sub.4 and R.sub.6 or R.sub.5 and R.sub.7 can combine to form a carbocyclic ring;X is oxygen, or a bond at the ortho or para position;m is 0, 1 or 2; andn is 0 or 1, and nontoxic, pharmaceutically acceptable addition salts and carboxylic acid esters thereof.
    • 公开了新的烷基芳基酮羧酸和由下式表示的5-取代的四唑:其中Z是芳基或结构的烷基W是羧基部分或在四唑的5位与Z结合的四唑部分 ; R1是C4-C12烷基,其中Z是芳基,X是氧,或者是C5-C12烷基,其中Z是烷基,Z是芳基,X是一个键; R2和R3各自独立地为氢,C1-C4烷基,羟基,C1-C4烷氧基,卤素,三卤甲基,硝基,氰基或C1-C4酰基; R4,R5,R6和R7各自独立地为氢或C1-C4烷基或R4,R6或R5和R7可以结合形成碳环; X是氧,或邻位或对位的键; m为0,1或2; 和n为0或1,以及无毒的药学上可接受的加成盐和羧酸酯。