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1. 发明申请

US20120035642A1 CATHETER, A BALLOON CATHETER AND A METHOD AND APPARATUS FOR MONITORING THE TRANSVERSE CROSS-SECTION OF A STOMA 有权
标题翻译：导管，气囊导管以及用于监测STOMA横断面部分的方法和装置
公开(公告)号：US20120035642A1
公开(公告)日：2012-02-09
申请号：US13255195
申请日：2010-03-09
申请人： John O'dea , Adrian McHugh , Eoin Bambury
发明人： John O'dea , Adrian McHugh , Eoin Bambury
IPC分类号： A61M29/00
CPC分类号： A61B5/1076 , A61B5/42 , A61B5/4238 , A61B5/6853 , A61F5/0063 , A61F2005/002 , A61M25/10 , A61M25/1002 , A61M25/1018 , A61M25/10184 , A61M25/10187 , A61M2025/0002 , A61M2025/1086 , A61M2025/1088 , A61M2025/1093 , A61M2210/1064
摘要： A balloon catheter (1) comprises a catheter (2) and a balloon (6) located on the distal end of the catheter. A pair of stimulating electrodes (15) for receiving a constant current stimulating signal when the balloon (6) is inflated with an electrically conductive medium and a plurality of sensing electrodes (16) for producing voltage response signals are located on the catheter (2). The voltage response signals are indicative of the values of the transverse cross-sectional area of the balloon (6) adjacent the sensing electrodes (16). A first lumen
摘要翻译：气囊导管（1）包括导管（2）和位于导管远端的球囊（6）。一对刺激电极（15）位于导管（2）上，用于在气球（6）用导电介质充气时接收恒流刺激信号，并且多个感测电极（16）用于产生电压响应信号，。电压响应信号表示与感测电极（16）相邻的球囊（6）的横截面积的值。第一腔<9）容纳充气介质往上和离开球囊（6），第二腔（19）容纳导电线（18）到刺激和感测电极（15,16）。压力传感器（21）位于第二内腔（19）中的保护壳体（22）中，并且通过保护壳体（22）中的连通开口（26）并且通过连通口（24）连通导管（2），其具有球囊（6）的中空内部区域（7）。

2. 发明授权

US09131898B2 Catheter, a balloon catheter and a method and apparatus for monitoring the transverse cross-section of a stoma 有权
标题翻译：导管，气囊导管以及用于监测造口横截面的方法和装置
公开(公告)号：US09131898B2
公开(公告)日：2015-09-15
申请号：US13255195
申请日：2010-03-09
申请人： John O'Dea , Adrian McHugh , Eoin Bambury
发明人： John O'Dea , Adrian McHugh , Eoin Bambury
IPC分类号： A61M29/00 , A61B5/00 , A61B5/107 , A61M25/10 , A61M25/00
CPC分类号： A61B5/1076 , A61B5/42 , A61B5/4238 , A61B5/6853 , A61F5/0063 , A61F2005/002 , A61M25/10 , A61M25/1002 , A61M25/1018 , A61M25/10184 , A61M25/10187 , A61M2025/0002 , A61M2025/1086 , A61M2025/1088 , A61M2025/1093 , A61M2210/1064
摘要： A balloon catheter comprises a catheter and a balloon located on the distal end of the catheter. A pair of stimulating electrodes for receiving a constant current stimulating signal when the balloon is inflated with an electrically conductive medium and a plurality of sensing electrodes for producing voltage response signals are located on the catheter. The voltage response signals are indicative of the values of the transverse cross-sectional area of the balloon adjacent the sensing electrodes. A first lumen accommodates the inflating medium to and from the balloon, and a second lumen accommodates electrically conductive wires to the stimulating and sensing electrodes. A pressure sensing element is located in a protective housing in the second lumen, and communicates through a communicating opening in the protective housing and through a communicating port in the catheter with a hollow interior region of the balloon. The balloon catheter may also be provided with a guide wire engaging element for engaging a guide wire externally of the balloon catheter.
摘要翻译：气囊导管包括位于导管远端的导管和气囊。一对刺激电极，用于当气囊用导电介质充气时接收恒流刺激信号，并且多个用于产生电压响应信号的感测电极位于导管上。电压响应信号表示与感测电极相邻的球囊的横截面积的值。第一内腔容纳充气介质往返气囊，第二腔容纳导电线到刺激和感测电极。压力感测元件位于第二内腔中的保护壳体中，并且通过保护壳体中的连通开口并且通过导管中的连通口与气囊的中空内部区域连通。气囊导管还可以设置有用于接合球囊导管外部的导丝的导丝接合元件。

3. 发明申请

US20110295230A1 FLUID TRANSFER DEVICE AND AN ACTIVE SUBSTANCE CARTRIDGE FOR THE FLUID TRANSFER DEVICE, AND A METHOD FOR CONTROLLING THE PRESSURE AT WHICH AN ACTIVE SUBSTANCE IS DELIVERED TO A SUBJECT FROM A FLUID TRANSFER DEVICE 有权
标题翻译：流体传输装置和用于流体传输装置的活性物质盒，以及用于控制活性物质从流体传输装置传送到主体的压力的方法
公开(公告)号：US20110295230A1
公开(公告)日：2011-12-01
申请号：US13140587
申请日：2009-12-21
申请人： John O'Dea , Eoin Bambury
发明人： John O'Dea , Eoin Bambury
IPC分类号： A61M5/31 , B67D7/06
CPC分类号： A61M37/0015 , A61M5/282 , A61M5/425 , A61M2005/14252 , A61M2037/0023 , A61M2037/003 , A61M2037/0061
摘要： A micro-needle device comprising an active substance layer (3) having a plurality of active substance chambers (4) formed therein, a drive substance layer (9) having a plurality of drive substance chambers (10) formed therein and a needle support layer (5) having a plurality of micro-needles (6) extending therefrom. An activation layer (12) comprising a plurality of heating elements (14) for heating an expandable drive substance (11) located in the drive substance chambers (10) for in turn urging the second membrane (16) into the active substance chamber (4) for pressurising and urging an active substance (2) therefrom through the corresponding micro-needle (6). A plurality of membrane accommodating recesses (25) extend into the needle support layer (5) for accommodating the first membrane (15) as the active substance in the corresponding active substance chamber (10) is pressurised. A puncturing member (33) with a piercing point (35) extends into each membrane accommodating recess (25). A barrier grating (41) extends across each active substance chamber (4) for preventing contact between the second membrane (16) and the corresponding puncturing member (33).
摘要翻译：一种微针装置，包括具有形成在其中的多个活性物质室（4）的活性物质层（3），形成有多个驱动物质室（10）的驱动物质层（9）和针支撑层（5）具有从其延伸的多个微针（6）。一种激活层（12），包括多个用于加热位于所述驱动物质室（10）中的可膨胀驱动物质（11）的加热元件（14），从而将所述第二隔膜（16）推进所述活性物质室（4）），用于通过相应的微针（6）加压和推压活性物质（2）。随着相应的活性物质室（10）中的活性物质被加压，多个膜容纳凹部（25）延伸到针支撑层（5）中，用于容纳第一膜（15）。具有穿刺点（35）的穿刺构件（33）延伸到每个膜容纳凹部（25）中。屏障光栅（41）延伸穿过每个活性物质室（4），以防止第二膜（16）和相应的穿刺构件（33）之间的接触。

4. 发明授权

US09168364B2 Transfer device for transferring a substance between the device and a subject 有权
标题翻译：用于在物体和物体之间传送物质的转移装置
公开(公告)号：US09168364B2
公开(公告)日：2015-10-27
申请号：US13127287
申请日：2009-11-04
申请人： John O'Dea , Eoin Bambury
发明人： John O'Dea , Eoin Bambury
IPC分类号： A61M5/00 , A61M37/00 , A61B17/20 , A61B10/00
CPC分类号： A61M37/0015 , A61B17/205 , A61B2010/008 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0053 , A61M2037/0061
摘要： A micro-needle delivery device (1) comprises an active substance accommodating layer (17) having active substance accommodating chambers (20) therein, a drive substance accommodating layer (32) having drive substance accommodating chambers (35) therein aligned with the active substance accommodating chambers (20), an activating layer (45) having heating elements (48) aligned with the drive substance accommodating chambers (35) for heating a drive substance therein, and a micro-needle element (8) having a needle support layer (9) and a plurality of micro-needles (12) extending therefrom. A burstable first membrane (22) is located between and sealably secured to the micro-needle element (8) and to the active substance accommodating layer (17) for sealably closing the active substance accommodating chambers (20) at one end. A second stretchable membrane (30) is located between and sealably secured to the drive substance accommodating layer (32) and to the active substance accommodating layer (17) sealably closes the active substance accommodating chambers (20) at the other end, and the drive substance accommodating chambers (35). A third membrane (40) sealably closes the drive substance accommodating chambers (35).
摘要翻译：微针输送装置（1）包括其中具有活性物质容纳室（20）的活性物质容纳层（17），具有与活性物质对准的驱动物质容纳室（35）的驱动物质容纳层（32）容纳室（20），具有与用于加热其中的驱动物质的驱动物质容纳室（35）对准的加热元件（48）的活化层（45）和具有针支撑层的微针元件（8） 9）和从其延伸的多个微针（12）。可爆破的第一膜（22）位于微针元件（8）之间并且可密封地固定到活动物质容纳层（17）上，用于在一端密封地封闭活性物质容纳室（20）。第二可拉伸膜（30）位于驱动物质容纳层（32）之间并且可密封地固定在驱动物质容纳层（32）上并且活性物质容纳层（17）在另一端密封地封闭活性物质容纳室（20）物质容纳室（35）。第三膜（40）密封地封闭驱动物质容纳室（35）。

5. 发明申请

US20100298808A1 METHOD AND A DELIVERY DEVICE FOR ADMINISTERING AN ACTIVE SUBSTANCE TO A SUBJECT 审中-公开
标题翻译：用于管理主体的主体的方法和传送装置
公开(公告)号：US20100298808A1
公开(公告)日：2010-11-25
申请号：US12744786
申请日：2008-11-28
申请人： John O'Dea , Eoin Bambury
发明人： John O'Dea , Eoin Bambury
IPC分类号： A61M5/00 , A61M5/32 , A61M5/31
CPC分类号： A61M5/2046 , A61K9/0021 , A61K9/0024 , A61K9/0097 , A61M37/0015 , A61M37/0069 , A61M2037/0023 , A61M2037/0046 , A61M2205/0244
摘要： A delivery device (1) for administering an active substance to a subject transdermal̂ comprises a first plate member (7) having a plurality of first chambers (8) formed therein. Solid form structures (2) comprising the active substance and of conical shape having a pointed skin penetrating tip (5) are located in the first chambers (8). A second plate member (12) having a plurality of second chambers (16) comprising a driving substance (18) is secured to the first plate member (7) with a first membrane (20) of an expandable material sealably located between the respective first and second plate members (7,12). Expansion of the driving substance (18) in the second chambers (22) urges the first membrane (20) into the corresponding first chambers (8) for in turn urging the solid form structures (2) to penetrate through a second membrane (22) into the skin of the subject. A third plate member (24) comprises a plurality of electrically powered heating elements (28) aligned with the second chambers (22) for heating the driving substance (18) in the second chambers (16) for in turn expanding the driving substances (18) therein.
摘要翻译：用于向受试者透皮施用活性物质的递送装置（1）包括其中形成有多个第一室（8）的第一板构件（7）。包含活性物质和具有尖锐皮肤渗透尖端（5）的圆锥形状的固体形式结构（2）位于第一腔室（8）中。具有包括驱动物质（18）的多个第二腔室（16）的第二板构件（12）通过可膨胀材料的第一膜（20）固定到第一板构件（7），所述第一膜（20）可密封地位于相应的第一和第二板构件（7,12）。驱动物质（18）在第二腔室（22）中的膨胀将第一膜（20）推到相应的第一腔室（8）中，从而推动固体形式结构（2）穿透第二隔膜（22）进入主体的皮肤。第三板构件（24）包括与第二室（22）对准的多个电动加热元件（28），用于加热第二室（16）中的驱动物质（18），从而使驱动物质（18 ）。

6. 发明申请

US20110054395A1 SYSTEM AND A METHOD FOR INFLATING AN INFLATABLE ELEMENT WITH A LIQUID INFLATING MEDIUM AND A BALLOON CATHETER INFLATED BY THE SYSTEM AND METHOD 有权
标题翻译：系统和方法，用于通过系统和方法对液体介质和气泡导管进行充气的元件
公开(公告)号：US20110054395A1
公开(公告)日：2011-03-03
申请号：US12937082
申请日：2009-04-09
申请人： John O'Dea , Eoin Bambury
发明人： John O'Dea , Eoin Bambury
IPC分类号： A61M29/00
CPC分类号： A61B5/1076 , A61M25/10182 , A61M25/10186 , A61M25/10187 , A61M2025/1022 , A61M2025/1077 , A61M2205/3337
摘要： A system for inflating a balloon (8) of a balloon catheter (4) with a liquid inflating medium which removes air during inflation of the balloon (8) comprises a vertically mounted syringe (36) containing the liquid inflating medium for inflating the balloon (8). Air in the system is displaced into a return lumen (30) and a return line (46). Air drawn into the syringe (36) with the liquid inflating medium is trapped between a piston (39) of the syringe and a top surface of the liquid inflating medium in the syringe, and thereby separated from the liquid inflating medium. Re-inflating and deflating of the balloon continues until the level of air in the balloon, the flow and return lumens and the flow and return lines (44,45) has been reduced to a predefined level. Then, an accurate determination of the inflation pressure can be read from first and second pressure sensors (50,51; 52,53) on the return and flow lines, respectively. The balloon catheter may be used to determine the volume and transverse cross-sectional area of a lumen or vessel within which the balloon is inflated.
摘要翻译：用于在气囊（8）充气期间用液体充气介质充气气球导管（4）的气囊（8）的系统包括垂直安装的注射器（36），其包含用于使气囊膨胀的液体膨胀介质 8）。系统中的空气移动到返回管腔（30）和返回管线（46）中。用液体膨胀介质吸入注射器（36）的空气被捕获在注射器的活塞（39）和注射器中的液体膨胀介质的顶表面之间，从而与液体膨胀介质分离。球囊的再充气和放气继续进行，直到球囊中的空气，流量和回流腔以及流动和返回管线（44,45）的水平已经减小到预定水平。然后，可以分别从返回管线和流动管线上的第一和第二压力传感器（50,51; 52,53）读取充气压力的精确确定。球囊导管可用于确定气囊膨胀的管腔或血管的体积和横截面积。

7. 发明授权

US09358375B2 Fluid transfer device and an active substance cartridge for the fluid transfer device, and a method for controlling the pressure at which an active substance is delivered to a subject from a fluid transfer device 有权
标题翻译：用于流体输送装置的流体输送装置和活性物质盒，以及用于控制活性物质从流体输送装置输送到被检体的压力的方法
公开(公告)号：US09358375B2
公开(公告)日：2016-06-07
申请号：US13140587
申请日：2009-12-21
申请人： John O'Dea , Eoin Bambury
发明人： John O'Dea , Eoin Bambury
IPC分类号： A61M37/00 , A61M5/142 , A61M5/28 , A61M5/42
CPC分类号： A61M37/0015 , A61M5/282 , A61M5/425 , A61M2005/14252 , A61M2037/0023 , A61M2037/003 , A61M2037/0061
摘要： A micro-needle device comprising an active substance layer (3) having a plurality of active substance chambers (4) formed therein, a drive substance layer (9) having a plurality of drive substance chambers (10) formed therein and a needle support layer (5) having a plurality of micro-needles (6) extending therefrom. An activation layer (12) comprising a plurality of heating elements (14) for heating an expandable drive substance (11) located in the drive substance chambers (10) for in turn urging the second membrane (16) into the active substance chamber (4) for pressurizing and urging an active substance (2) therefrom through the corresponding micro-needle (6). A plurality of membrane accommodating recesses (25) extend into the needle support layer (5) for accommodating the first membrane (15) as the active substance in the corresponding active substance chamber (10) is pressurized. A puncturing member (33) with a piercing point (35) extends into each membrane accommodating recess (25). A barrier grating (41) extends across each active substance chamber (4) for preventing contact between the second membrane (16) and the corresponding puncturing member (33).
摘要翻译：一种微针装置，包括具有形成在其中的多个活性物质室（4）的活性物质层（3），形成有多个驱动物质室（10）的驱动物质层（9）和针支撑层（5）具有从其延伸的多个微针（6）。一种激活层（12），包括多个用于加热位于所述驱动物质室（10）中的可膨胀驱动物质（11）的加热元件（14），从而将所述第二隔膜（16）推进所述活性物质室（4）），用于通过相应的微针（6）加压和推压活性物质（2）。随着相应的活性物质室（10）中的活性物质被加压，多个膜容纳凹部（25）延伸到针支撑层（5）中，用于容纳第一膜（15）。具有穿刺点（35）的穿刺构件（33）延伸到每个膜容纳凹部（25）中。屏障光栅（41）延伸穿过每个活性物质室（4），以防止第二膜（16）和相应的穿刺构件（33）之间的接触。

8. 发明授权

US08486011B2 System and a method for inflating an inflatable element with a liquid inflating medium and a balloon catheter inflated by the system and method 有权
标题翻译：系统和方法，用于通过系统和方法使液体膨胀介质和气囊导管充气的可充气元件充气
公开(公告)号：US08486011B2
公开(公告)日：2013-07-16
申请号：US12937082
申请日：2009-04-09
申请人： John O'Dea , Eoin Bambury
发明人： John O'Dea , Eoin Bambury
IPC分类号： A61M29/00
CPC分类号： A61B5/1076 , A61M25/10182 , A61M25/10186 , A61M25/10187 , A61M2025/1022 , A61M2025/1077 , A61M2205/3337
摘要： A balloon of a balloon catheter is inflated with a liquid inflating medium by a syringe through a flow line. Air in the flow line and the balloon is displaced into a return line. The balloon is deflated by drawing the liquid inflating medium from the balloon along with the air in the return line into the syringe where the air is trapped in the syringe. The balloon is reinflated and deflated by the syringe until the level of air in the liquid inflating medium has been reduced to a predefined level. A first non-return valve and a second non-return valve are provided in the flow and return lines, so that the liquid inflating medium is prevented from flowing from the balloon to the syringe in the flow line and from the syringe to the balloon in the return line.
摘要翻译：气球导管的球囊通过注射器通过流动管线用液体充气介质充气。流线中的空气和气球被移入回流管线。将气囊中的液体充气介质与返回管路中的空气一起拉到注射器中，使空气被捕获在注射器中，使气囊收缩。气囊被注射器重新充气并放气，直到液体膨胀介质中的空气水平已经降低到预定水平。第一止回阀和第二止回阀设置在流动和返回管线中，使得防止液体膨胀介质从气囊流动到流动管线中的注射器和从注射器到气囊返回线。

9. 发明申请

US20120130207A1 MICRO-NEEDLE DEVICE AND APPARATUS AND A METHOD FOR APPLYING A MICRO-NEEDLE ELEMENT TO A SITE ON THE SKIN OF A SUBJECT 审中-公开
标题翻译：微针装置和装置以及将微针元件应用于主体皮肤上的现场的方法
公开(公告)号：US20120130207A1
公开(公告)日：2012-05-24
申请号：US13266248
申请日：2010-04-29
申请人： John O'dea , Eoin Bambury
发明人： John O'dea , Eoin Bambury
IPC分类号： A61B5/053 , A61B5/145 , A61M5/00 , A61B5/103
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0061 , A61M2205/13
摘要： A micro-needle device (3) comprises a micro-needle element (2) which is carried on a strap (14) and is securable around a limb of a subject by the strap (14) with the micro-needle element (2) located at a desired site. A pressure sensor (23) is located between the strap (14) and the micro-needle element (2) for detecting the pressure at which the micro-needle element (2) is urged into engagement with the skin of the subject. An adjustable clasp (18) secures the strap (14) and permits adjustment of the tension in the strap (14) for in turn adjusting the pressure with which the micro-needle element (2) is urged into engagement with the skin of the subject. An electronic control circuit located in a housing (26) mounted on the strap (14) monitors the pressure read by the pressure sensor (23) and operates three light emitting diodes (28,29,30) to indicate the pressures with which the micro-needle element (2) is urged into engagement with the skin of the subject, and also to indicate when the micro-needle element (2) is urged into engagement with the skin of the subject by the strap (14) with micro-needles (5) of the micro-needle element (2) penetrating the skin of the subject to a desired depth.
摘要翻译：微针装置（3）包括微针元件（2），所述微针元件（2）承载在带（14）上，并且通过所述带（14）与所述微针元件（2）可缠绕在受试者的肢体周围，位于所需的位置。压力传感器（23）位于带（14）和微针元件（2）之间，用于检测微针元件（2）被迫与受试者的皮肤接合的压力。可调扣环（18）固定带子（14）并且允许调节带子（14）中的张力，从而进一步调节微针元件（2）被推动与受试者的皮肤接合的压力。位于安装在带子（14）上的壳体（26）中的电子控制电路监测由压力传感器（23）读取的压力，并操作三个发光二极管（28,29,30），以指示微型 - 针头元件（2）被推动与被检体的皮肤接合，并且还指示微针元件（2）何时被带子（14）用微针推动与被检体的皮肤接合（2）的微针元件（5）穿透受试者的皮肤到期望的深度。

10. 发明申请

US20110264048A1 TRANSFER DEVICE FOR TRANSFERRING A SUBSTANCE BETWEEN THE DEVICE AND A SUBJECT 有权
标题翻译：用于传送设备和主体之间的物质的传送设备
公开(公告)号：US20110264048A1
公开(公告)日：2011-10-27
申请号：US13127287
申请日：2009-11-04
申请人： John O'dea , Eoin Bambury
发明人： John O'dea , Eoin Bambury
IPC分类号： A61M5/00
CPC分类号： A61M37/0015 , A61B17/205 , A61B2010/008 , A61M2037/0023 , A61M2037/003 , A61M2037/0038 , A61M2037/0053 , A61M2037/0061
摘要： A micro-needle delivery device (1) comprises an active substance accommodating layer (17) having active substance accommodating chambers (20) therein, a drive substance accommodating layer (32) having drive substance accommodating chambers (35) therein aligned with the active substance accommodating chambers (20), an activating layer (45) having heating elements (48) aligned with the drive substance accommodating chambers (35) for heating a drive substance therein, and a micro-needle element (8) having a needle support layer (9) and a plurality of micro-needles (12) extending therefrom. A burstable first membrane (22) is located between and sealably secured to the micro-needle element (8) and to the active substance accommodating layer (17) for sealably closing the active substance accommodating chambers (20) at one end. A second stretchable membrane (30) is located between and sealably secured to the drive substance accommodating layer (32) and to the active substance accommodating layer (17) sealably closes the active substance accommodating chambers (20) at the other end, and the drive substance accommodating chambers (35). A third membrane (40) sealably closes the drive substance accommodating chambers (35).
摘要翻译：微针输送装置（1）包括其中具有活性物质容纳室（20）的活性物质容纳层（17），具有与活性物质对准的驱动物质容纳室（35）的驱动物质容纳层（32）容纳室（20），具有与用于加热其中的驱动物质的驱动物质容纳室（35）对准的加热元件（48）的活化层（45）和具有针支撑层的微针元件（8） 9）和从其延伸的多个微针（12）。可爆破的第一膜（22）位于微针元件（8）之间并且可密封地固定到活动物质容纳层（17）上，用于在一端密封地封闭活性物质容纳室（20）。第二可拉伸膜（30）位于驱动物质容纳层（32）之间并且可密封地固定在驱动物质容纳层（32）上并且活性物质容纳层（17）在另一端密封地封闭活性物质容纳室（20）物质容纳室（35）。第三膜（40）密封地封闭驱动物质容纳室（35）。

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