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1. 发明授权

US6066673A Enzyme inhibitors 失效
标题翻译：酶抑制剂
公开(公告)号：US6066673A
公开(公告)日：2000-05-23
申请号：US41196
申请日：1998-03-12
申请人： John McMillan McIver , Todd Laurence Underiner , Timothy Bates
发明人： John McMillan McIver , Todd Laurence Underiner , Timothy Bates
IPC分类号： A61K8/30 , A61K20060101 , A61K8/00 , A61K8/42 , A61K8/49 , A61K8/86 , A61K31/155 , A61K31/167 , A61K31/216 , A61K31/505 , A61K31/77 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/12 , A61P43/00 , A61Q17/00 , C07C257/14 , C07C257/18 , C07C277/08 , C07C279/18 , C07D233/04 , C07D239/06 , C08G20060101 , C08G65/329 , C08G65/48 , C12N20060101
CPC分类号： C08G65/333 , A61K31/155 , A61K31/77 , A61K8/0208 , A61K8/0216 , A61K8/86 , A61Q19/00 , C07C257/14 , C07C257/18 , C07C279/18 , C08G65/3326 , A61K2800/92 , Y10S514/844 , Y10S514/846
摘要： The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in health, skin, hair, oral, beauty, and personal care applications.In particular, the present invention relates to compounds having the structure: ##STR1## and the tautomers, acceptable salts, and biohydrolyzable amides, esters, and imides thereof, wherein A, Q, n, P, L.sub.1, L.sub.2, L.sub.3, L.sub.4, Z, X, B.sub.1, and B.sub.2 are defined herein.
摘要翻译：本发明涉及可用于预防和治疗不良健康，皮肤，头发和口腔状况的化合物，组合物和方法。化合物，组合物和方法也广泛适用于健康，皮肤，头发，口腔，美容和个人护理用途。特别地，本发明涉及具有以下结构的化合物：和互变异构体，可接受的盐和可生物水解的酰胺，酯和酰亚胺，其中A，Q，n，P，L1，L2，L3，L4，Z，X ，B1和B2在本文中定义。

2. 发明授权

US08309788B2 Protease inhibitors in absorbent articles 有权
标题翻译：吸收制品中的蛋白酶抑制剂
公开(公告)号：US08309788B2
公开(公告)日：2012-11-13
申请号：US12358697
申请日：2009-01-23
申请人： Francis James Rourke , Scott Edward Osborne , Donald Carroll Roe , Todd Laurence Underiner , John McMillan McIver , Timothy Bates
发明人： Francis James Rourke , Scott Edward Osborne , Donald Carroll Roe , Todd Laurence Underiner , John McMillan McIver , Timothy Bates
IPC分类号： A61F13/15
CPC分类号： A61B5/441 , A61L15/44 , A61L2300/434
摘要： The invention provides an absorbent article, at least a portion of which has a protease inhibitor incorporated therein to decrease the activity of proteases that may otherwise initiate or contribute to inflammation of the skin of a wearer of the article resulting in skin irritation or dermatitis. The article can further comprise a delivery system for releasably containing and delivering the protease inhibitor to at least a portion of the skin of the wearer. The delivery system can comprise a skin care composition and at least a portion of the composition, including the protease inhibitor, is automatically transferred from the article to the wearer's skin without manual intervention during normal usage of the article to form a defense against protease activity. Most preferably, repeated application of similarly treated articles to the wearer's skin provides an available source from which the protease inhibitor continuously transfers onto the skin over time and accumulates to provide a proactive defense against protease activity for the reduction or prevention of skin irritation or dermatitis due to proteolytic enzymes.
摘要翻译：本发明提供一种吸收制品，其至少一部分具有并入其中的蛋白酶抑制剂以降低蛋白酶的活性，否则其可引起或促成造成皮肤刺激或皮炎的制品佩戴者的皮肤炎症。该制品还可包括用于将蛋白酶抑制剂可释放地包含并递送至穿戴者皮肤的至少一部分的递送系统。递送系统可以包含皮肤护理组合物，并且包括蛋白酶抑制剂在内的组合物的至少一部分在制品的正常使用期间被自动地从制品转移到穿着者的皮肤，而无需人工干预，以形成抗蛋白酶活性的防御。最优选地，将类似处理的物品重复应用于穿着者的皮肤提供了可用的来源，蛋白酶抑制剂从该蛋白酶抑制剂随时间连续转移到皮肤上并积聚以提供主动防御蛋白酶活性，以减少或预防皮肤刺激或皮炎到蛋白水解酶。

3. 发明授权

US06211186B1 Enzyme Inhibitors 失效
标题翻译：酶抑制剂
公开(公告)号：US06211186B1
公开(公告)日：2001-04-03
申请号：US09504444
申请日：2000-02-16
申请人： John McMillan McIver , Todd Laurence Underiner , Timothy Bates
发明人： John McMillan McIver , Todd Laurence Underiner , Timothy Bates
IPC分类号： A61K31505
CPC分类号： C08G65/333 , A61K8/0208 , A61K8/0216 , A61K8/86 , A61K31/155 , A61K31/77 , A61K2800/92 , A61Q19/00 , C07C257/14 , C07C257/18 , C07C279/18 , C08G65/3326 , Y10S514/844 , Y10S514/846
摘要： The present invention relates to compounds, compositions, and methods which are useful for the prevention and treatment of adverse health, skin, hair, and oral conditions. The compounds, compositions, and methods are also widely applicable for use in health, skin, hair, oral, beauty, and personal care applications. In particular, the present invention relates to compounds having the structure: and the tautomers, acceptable salts, and biohydrolyzable amides, esters, and imides thereof, wherein A, Q, n, P, L1, L2, L3, L4, Z, X, B1, and B2 are defined herein.
摘要翻译：本发明涉及可用于预防和治疗不良健康，皮肤，头发和口腔状况的化合物，组合物和方法。化合物，组合物和方法也广泛适用于健康，皮肤，头发，口腔，美容和个人护理用途。特别地，本发明涉及具有以下结构的化合物：和互变异构体，可接受的盐和其中A，Q，n，P，L 1，L 2，L 3，L 4，Z，X，B 1和B 2定义为本发明的生物可水解酰胺，酯和酰亚胺。

4. 发明申请

US20090286769A1 COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS USING NON-NATURALLY OCCURRING PROSTAGLANDINS 有权
标题翻译：使用非自然生成PROSTAGLANDIN处理头发损失的组合物和方法
公开(公告)号：US20090286769A1
公开(公告)日：2009-11-19
申请号：US12535513
申请日：2009-08-04
申请人： Mitchell Anthony DeLong , John McMillan McIver , Robert Scott Youngquist
发明人： Mitchell Anthony DeLong , John McMillan McIver , Robert Scott Youngquist
IPC分类号： A61K31/5575 , A61P17/14
CPC分类号： A61K8/49 , A61K8/365 , A61K8/37 , A61K8/4986 , A61K31/19 , A61K31/192 , A61K31/381 , A61K31/428 , A61K31/5575 , A61K31/559 , A61K45/06 , A61Q7/00
摘要： A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.
摘要翻译：用于治疗哺乳动物脱发的方法使用含有前列腺素F类似物的组合物。组合物可以局部施用于皮肤。组合物可以阻止脱发，逆转脱发，并促进毛发生长。

5. 发明申请

US20080188505A1 Regulation of Mammalian Hair Growth 有权
标题翻译：哺乳动物毛发生长调节
公开(公告)号：US20080188505A1
公开(公告)日：2008-08-07
申请号：US12056377
申请日：2008-03-27
申请人： John Erich Oblong , Sara Johnson McPhail , Shannon Christine McArthur , Charles Carson Bascom , David Joseph Eickhoff , John McMillan McIver
发明人： John Erich Oblong , Sara Johnson McPhail , Shannon Christine McArthur , Charles Carson Bascom , David Joseph Eickhoff , John McMillan McIver
IPC分类号： A61K36/82 , A61K31/155 , A61K31/54 , A61Q5/00 , A61K31/19 , A61K31/05 , A61K31/56
CPC分类号： A61Q19/00 , A61K8/347 , A61K8/40 , A61K8/43 , A61K8/4926 , A61K8/63 , A61K31/155 , A61K31/353 , A61K31/7048 , A61K36/82 , A61K45/06 , A61Q1/02 , A61Q7/02 , A61Q15/00 , A61K2300/00
摘要： The present invention relates to a topical skin care composition containing a safe and effective amount of a skin care active comprising agmatine, and its salt; a safe and effective amount of a first additional skin care active selected from the group consisting of BHT or BHA, hexamidine, cetyl pyridinium chloride, green tea catechins, phytosterols, ursolic acid, compounds derived from plant extracts, their salts and derivatives; and a dermatologically acceptable carrier for the agmatine composition.The present invention also relates to methods of using such agmatine compositions to regulate hair growth and the condition of mammalian skin. Said methods generally comprise the step of topically applying the composition to the skin of a mammal needing such treatment, a safe and effective amount of such compositions.
摘要翻译：本发明涉及含有安全有效量的含有丁胺及其盐的护肤活性物质的局部皮肤护理组合物; 安全有效量的选自BHT或BHA，己脒，十六烷基吡啶鎓氯化物，绿茶儿茶素，植物甾醇，熊果酸，植物提取物衍生的化合物，其盐和衍生物的第一另外的护肤活性物质; 和用于胍丁胺组合物的皮肤病学可接受的载体。本发明还涉及使用这种丁酰胺组合物调节毛发生长和哺乳动物皮肤状况的方法。所述方法通常包括将组合物局部施用于需要这种治疗的哺乳动物的皮肤，安全和有效量的这种组合物的步骤。

6. 发明授权

US07407987B2 Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins 有权
标题翻译：使用C16-C20芳族四氢前列腺素治疗脱发的组合物和方法
公开(公告)号：US07407987B2
公开(公告)日：2008-08-05
申请号：US11565297
申请日：2006-11-30
申请人： Mitchell Anthony deLong , John McMillan McIver , Robert Scott Youngquist
发明人： Mitchell Anthony deLong , John McMillan McIver , Robert Scott Youngquist
IPC分类号： A61K31/215 , A61K31/33 , A61K31/38 , A61K31/41
CPC分类号： A61Q7/00 , A61K8/365 , A61K8/46 , A61K31/5575
摘要： A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.
摘要翻译：用于治疗哺乳动物脱发的方法使用含有前列腺素F类似物的组合物。组合物可以局部施用于皮肤。组合物可以阻止脱发，逆转脱发，并促进毛发生长。

7. 发明授权

US08541466B2 Compositions and methods for treating hair loss using non-naturally occurring prostaglandins 有权
公开(公告)号：US08541466B2
公开(公告)日：2013-09-24
申请号：US12535513
申请日：2009-08-04
申请人： Mitchell Anthony DeLong , John McMillan McIver , Robert Scott Youngquist
发明人： Mitchell Anthony DeLong , John McMillan McIver , Robert Scott Youngquist
IPC分类号： A61K31/16 , A61K31/165 , A61K31/21 , A61K31/215 , A61K31/33 , A61K31/38 , A61K31/41
CPC分类号： A61K8/49 , A61K8/365 , A61K8/37 , A61K8/4986 , A61K31/19 , A61K31/192 , A61K31/381 , A61K31/428 , A61K31/5575 , A61K31/559 , A61K45/06 , A61Q7/00
摘要： A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.

8. 发明授权

US06723717B1 Sulfur-containing thyroxane derivatives and their use as hair growth promotors 失效
标题翻译：含硫甲状腺素衍生物及其作为毛发生长促进剂的用途
公开(公告)号：US06723717B1
公开(公告)日：2004-04-20
申请号：US09980404
申请日：2001-11-30
申请人： Robert Scott Youngquist , John McMillan McIver
发明人： Robert Scott Youngquist , John McMillan McIver
IPC分类号： A61K31535
CPC分类号： C07D295/096 , A61K8/46 , A61K8/49 , A61K8/4913 , A61Q7/00 , C07C317/40 , C07C323/37 , C07C323/41 , C07C323/42
摘要： The present disclosure describes novel compounds of formula (A), wherein R1-R12, X and Y have the meanings given in the specification and compositions containing them which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The compounds described herein are cardiac-sparing.
摘要翻译：本公开内容描述了式（A）的新化合物，其中R1-R12，X和Y具有本说明书中给出的含义和含有它们的组合物，其特别用于治疗哺乳动物的脱发，包括阻止和/或逆转脱发并促进头发生长。本文所述的化合物是心脏保存的。

9. 发明授权

US6121272A Bidentate metalloprotease inhibitors 失效
标题翻译：二齿金属蛋白酶抑制剂
公开(公告)号：US6121272A
公开(公告)日：2000-09-19
申请号：US918318
申请日：1997-08-26
申请人： Neil Gregory Almstead , Biswanath De , Rimma Sandler Bradley , Garry Steven Garrett , John Emory Marlin, II , John McMillan McIver , Zhe Wang , Yetunde Olabisi Taiwo
发明人： Neil Gregory Almstead , Biswanath De , Rimma Sandler Bradley , Garry Steven Garrett , John Emory Marlin, II , John McMillan McIver , Zhe Wang , Yetunde Olabisi Taiwo
IPC分类号： A23G4/00 , A61K8/00 , A61K8/49 , A61K31/395 , A61K31/40 , A61K31/4439 , A61K31/445 , A61K31/454 , A61K31/5377 , A61P1/02 , A61P9/00 , A61P17/00 , A61P19/08 , A61P27/02 , A61P29/00 , A61P43/00 , A61Q11/00 , C07D207/36 , C07D207/48 , C07D211/96 , C07D213/16 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14
CPC分类号： C07D401/04 , C07D207/48 , C07D211/96 , C07D401/14 , C07D417/06 , C07D417/14
摘要： The invention provides compounds which are useful as inhibitors of metalloproteases, and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the present invention relates to a compound having a structure according to Formula (I) ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable alkoxyamide, ester, acyloxyamide, or imide thereof. Also disclosed are compounds, pharmaceutical compositions and methods of treating diseases characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.
摘要翻译：本发明提供了可用作金属蛋白酶抑制剂的化合物，其有效治疗以这些酶的过量活性为特征的病症。特别地，本发明涉及具有如权利要求中所述的式（I）结构的化合物或其旋光异构体，非对映异构体或其对映异构体或其药学上可接受的盐或生物可水解的烷氧基酰胺，酯，酰氧基酰胺，或其酰亚胺。还公开了使用这些化合物或含有它们的药物组合物治疗以金属蛋白酶活性为特征的疾病的化合物，药物组合物和方法。

10. 发明授权

US5840678A Liquid detergents containing a peptide trifluoromethyl ketone 失效
标题翻译：含有三氟甲基酮的液体洗涤剂
公开(公告)号：US5840678A
公开(公告)日：1998-11-24
申请号：US719665
申请日：1996-09-25
申请人： Regine Labeque , John McMillan McIver , Christiaan Arthur J.K. Thoen
发明人： Regine Labeque , John McMillan McIver , Christiaan Arthur J.K. Thoen
IPC分类号： C11D3/32 , C11D3/37 , C11D3/386
CPC分类号： C11D3/38663 , C11D3/32 , C11D3/3719
摘要： Aqueous liquid detergent compositions are described which comprise a proteolytic enzyme wherein the proteolytic activity is reversibly inhibited by a peptide trifluoromethyl ketone.
摘要翻译：描述了含有蛋白水解酶的水性液体洗涤剂组合物，其中蛋白水解活性被肽三氟甲基酮可逆地抑制。

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