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1. 发明授权

US6162844A Method and composition for incorporating radiation-absorbing agents into polymers 有权
标题翻译：将辐射吸收剂掺入聚合物中的方法和组合物
公开(公告)号：US6162844A
公开(公告)日：2000-12-19
申请号：US469680
申请日：1999-12-22
申请人： John Martin Lally , Deborah Jean Mulcahy , Achim Muller , Beat Muller , Bernhard Seiferling , Friedrich Stockinger
发明人： John Martin Lally , Deborah Jean Mulcahy , Achim Muller , Beat Muller , Bernhard Seiferling , Friedrich Stockinger
IPC分类号： G02C7/04 , B29C39/02 , B29C39/24 , C08F2/44 , G02B1/04 , G02B1/10 , C08L29/04 , C09B62/00 , D06P3/58
CPC分类号： C08F2/44 , G02B1/043 , Y10S525/937
摘要： A method of incorporating radiation-absorbing agents (i.e., dyes) into polymeric materials. A preferred method involves crosslinking or polymerizing a polymerizable or crosslinkable material in the presence of a polymeric dye. A preferred product is a tinted contact lens comprising poly(vinyl alcohol). The methods offer advantages in reduced fabrication cycles, reduced extractables, elimination of post-polymerization activation steps, elimination of post-polymerization extraction steps and reduced scrap and costs associated with lens handling.
摘要翻译：将辐射吸收剂（即染料）掺入聚合材料中的方法。优选的方法包括在聚合染料存在下交联或聚合可聚合的或可交联的材料。优选的产品是包含聚（乙烯醇）的着色隐形眼镜。该方法在减少制造周期，降低的可萃取物，消除后聚合活化步骤，消除后聚合萃取步骤以及降低的废料和与透镜处理相关的成本方面具有优势。

2. 发明授权

US6149692A Method and composition for incorporating radiation-absorbing agents into polymers 有权
标题翻译：将辐射吸收剂掺入聚合物中的方法和组合物
公开(公告)号：US6149692A
公开(公告)日：2000-11-21
申请号：US141128
申请日：1998-08-27
申请人： John Martin Lally , Deborah Jean Mulcahy , Achim Muller , Beat Muller , Bernhard Seiferling , Friedrich Stockinger
发明人： John Martin Lally , Deborah Jean Mulcahy , Achim Muller , Beat Muller , Bernhard Seiferling , Friedrich Stockinger
IPC分类号： C08F290/04 , D06P1/00 , D06P3/58 , D06P5/20 , G02B1/04 , G02C7/02 , G02C7/04
CPC分类号： G02B1/043 , C08F290/04 , D06P1/0064 , D06P3/58 , D06P5/2005
摘要： A method of incorporating dyes into polymeric materials. The method involved contacting a functionalized dye with a high molecular weight crosslinkable polymer precursor, dispensing the solution into a mold and applying radiation, thereby forming a molded article having dye covalently bonded to the polymer backbone. A preferred product is a visibility tinted disposable contact lens comprising poly(vinyl alcohol). Various embodiments of the innovative method offer advantages in reduced fabrication cycles, reduced extractables, elimination of post-polymerization activation steps, elimination of post-polymerization extraction steps and reduced scrap and costs associated with lens handling.
摘要翻译：将染料掺入聚合物材料的方法。该方法包括使官能化染料与高分子量可交联聚合物前体接触，将溶液分配到模具中并施加辐射，从而形成具有共价键合到聚合物主链上的染料的模制品。优选的产品是包括聚（乙烯醇）的可见度着色的一次性隐形眼镜。创新方法的各种实施方案在减少制造周期，减少的可萃取物，消除后聚合活化步骤，消除后聚合萃取步骤以及降低的废料以及与透镜处理相关的成本方面提供了优点。

3. 发明授权

US6149842A Methods and compositions for manufacturing tinted ophthalmic lenses 有权
标题翻译：用于制造有色眼镜的方法和组合物
公开(公告)号：US6149842A
公开(公告)日：2000-11-21
申请号：US191063
申请日：1998-11-12
申请人： John Martin Lally , Friedrich Stockinger , Charlotte Lynn Cooper , Achim Muller , Deborah Jean Mulcahy , Bernhard Seiferling
发明人： John Martin Lally , Friedrich Stockinger , Charlotte Lynn Cooper , Achim Muller , Deborah Jean Mulcahy , Bernhard Seiferling
IPC分类号： B29C35/02 , B29D11/00
CPC分类号： B29D11/00317 , B29C35/02
摘要： The invention relates to a process for the manufacture of tinted ophthalmic moldings comprising the steps of(a) providing a water soluble polymer precursor having crosslinkable or polymerizable groups;(b) providing a pigment dispersion comprising an inorganic or organic pigment and a dispersing agent;(c) mixing the metal phthalocyanine dye or pigment with the polymer precursor to form a tinted prepolymerization mixture,(d) dispensing the tinted prepolymerization mixture into a mold,(e) applying radiation to the tinted prepolymerization mixture in the mold, thereby crosslinking or polymerizing the polymer precursor and entrapping the dye or pigment within the polymeric network of the resultant ophthalmic molding, and(f) opening the mold so that the ophthalmic molding can be removed from the mold.According to the process, tinted ophthalmic moldings, particularly full-body tinted soft contact lenses having improved properties, are prepared with an improved efficiency.
摘要翻译：本发明涉及一种制造有色眼用模制品的方法，包括以下步骤：（a）提供具有可交联或可聚合基团的水溶性聚合物前体; （b）提供包含无机或有机颜料和分散剂的颜料分散体; （c）将金属酞菁染料或颜料与聚合物前体混合以形成着色的预聚合混合物，（d）将着色的预聚合混合物分配到模具中，（e）向模具中的着色预聚合混合物施加辐射，从而交联或使聚合物前体聚合并将染料或颜料捕获到所得眼用模制品的聚合物网络内，和（f）打开模具，使得可以将模具从模具中移出。根据该方法，以提高的效率制备着色眼用模制品，特别是具有改进性能的全身有色软触角镜。

4. 发明授权

US6156244A Storage-stable hydrogels 有权
标题翻译：储存稳定的水凝胶
公开(公告)号：US6156244A
公开(公告)日：2000-12-05
申请号：US180588
申请日：1998-11-12
申请人： Achim Muller , Beat Muller , Bernhard Seiferling , Iris Leder
发明人： Achim Muller , Beat Muller , Bernhard Seiferling , Iris Leder
IPC分类号： G02C7/04 , B29D11/00 , C08F8/00 , G02B1/04 , C08F8/12
CPC分类号： G02B1/043 , C08F8/12 , C08F2800/10 , C08F2810/20
摘要： The present invention relates to a process for the preparation of storage-stable hydrogel mouldings, the storage stability of which can be established by controlled hydrolysis. At the same time as the sotrage stability is established, the hydrogel is sterilised in its final packaging, and the salt concentration of the aqueous phase is adjusted preferably to a physiological range.
摘要翻译： PCT No.PCT / EP97 / 02477。 371日期：1998年11月12日 102（e）日期1998年11月12日PCT提交1997年5月15日PCT公布。公开号WO97 / 44687 日期1997年11月27日本发明涉及一种制备储存稳定型水凝胶模塑制品的方法，其储存稳定性可通过可控制的水解来建立。在稳定性稳定的同时，将水凝胶在其最终包装中灭菌，并将水相的盐浓度优选调节至生理范围。

5. 发明申请

US20080249381A1 Combined Apparatus For Measuring the Blood Glucose Level From an Ocular Fluid 审中-公开
标题翻译：用于从眼液测量血糖水平的组合仪器
公开(公告)号：US20080249381A1
公开(公告)日：2008-10-09
申请号：US11570628
申请日：2005-06-13
申请人： Achim Muller , Peter Herbrechtsmeier , Bernhard Seiferling , Wolfgang Hofmann
发明人： Achim Muller , Peter Herbrechtsmeier , Bernhard Seiferling , Wolfgang Hofmann
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/0071 , A61B5/1455 , A61B5/1486 , A61B5/6821
摘要： A combined apparatus for measuring the blood glucose level from an ocular fluid comprises a hand-held fluorescence photometer (D1) for determining the glucose level of the ocular fluid and a device (D2) for the amperometric or photometric determination of the blood glucose level. The fluorescence photometer (D1) comprises: first irradiating means (7,8,10) for providing a pilot beam (1) for irradiation of the eye (3) in order to excite a first fluorescence comprising a first wavelength band; first detecting means (8,9,12,13) for measuring the intensity of the of the pupil fluorescence within the first wavelength band; second irradiating means (17,18,21) for providing a measurement beam (5) for irradiation of the eye in order to excite an ocular sensor (4) to emit a second fluorescence comprising a second wavelength band; second detecting means (18,19,20,22,23,24,25) for measuring the intensity of the second fluorescence within the second wavelength band. The first and second irradiating means are arranged such that the measurement beam irradiates the eye under a predetermined angle (a) between 0° and 90° and at a predetermined distance from the pilot beam.
摘要翻译：用于测量来自眼液的血糖水平的组合装置包括用于确定眼液的葡萄糖水平的手持荧光光度计（D 1）和用于血糖的电流或光度测定的装置（D 2）水平。荧光光度计（D 1）包括：第一照射装置（7,8,10），用于提供用于照射眼睛（3）的引导光束（1），以便激发包括第一波长带的第一荧光; 第一检测装置（8,9,12,13），用于测量第一波长带内的瞳孔荧光的强度; 第二照射装置（17,18,21），用于提供用于照射眼睛的测量光束（5），以激发眼睛传感器（4）以发射包括第二波长带的第二荧光; 用于测量第二波长带内的第二荧光的强度的第二检测装置（18,19,20,22,23,24,25）。第一和第二照射装置被布置成使得测量光束以0°至90°之间的预定角度（a）照射眼睛并且距离导向光束预定距离。

6. 发明授权

US5712356A Cross-linkable copolymers and hydrogels 失效
标题翻译：可交联的共聚物和水凝胶
公开(公告)号：US5712356A
公开(公告)日：1998-01-27
申请号：US339384
申请日：1994-11-14
申请人： Harald Bothe , Achim Muller , Bernhard Seiferling , Sharla Borghorst , John Golby , Peter Hagmann , Peter Herbrechtsmeier , Otto Kretzschmar
发明人： Harald Bothe , Achim Muller , Bernhard Seiferling , Sharla Borghorst , John Golby , Peter Hagmann , Peter Herbrechtsmeier , Otto Kretzschmar
IPC分类号： G02C7/04 , C08F8/00 , C08F16/08 , C08F16/14 , C08F20/26 , C08F20/52 , C08F26/00 , C08F216/08 , C08F216/14 , C08F218/02 , C08F218/04 , C08F220/04 , C08F220/06 , C08F220/28 , C08F220/56 , C08F226/06 , C08F226/10 , C08F246/00 , C08F293/00 , C08F299/00 , G02B1/04 , C08F220/18 , C08F224/00 , C08F226/02 , C08F228/02
CPC分类号： C08F226/06 , C08F293/005 , C08F8/14 , G02B1/043 , C08F226/10 , C08F2800/10 , C08F2800/20 , C08F2810/20 , C08F2810/50
摘要： The present invention describes novel statistical copolymers and the preparation and possible uses thereof. Copolymers are described that are water-soluble and cross-linkable and that comprise the copolymerisation product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond.
摘要翻译：本发明描述了新的统计共聚物及其制备及其可能用途。描述了共聚物是水溶性和可交联的，并且包含基本上由乙烯基内酰胺（a）和至少一种另外的不同类型的乙烯基单体（b）组成的单体混合物的共聚产物，所述另外的乙烯基单体（b）选自的疏水性，亲水性和功能性的乙烯基单体，其中单体以统计分布的结构单元的形式存在于共聚物中，并且如果官能的乙烯基单体作为共聚物中的结构单元存在，则该结构单元在适当的情况下，用反应性乙烯基单体（c）改性，反应性乙烯基单体（c）与保持其乙烯基基团并形成共价键的官能乙烯基单体的结构单元连接。

7. 发明授权

US6113817A Molding processes 失效
标题翻译：成型工艺
公开(公告)号：US6113817A
公开(公告)日：2000-09-05
申请号：US47041
申请日：1998-03-24
申请人： Peter Herbrechtsmeier , Karl Baur , Roger Biel , John Golby , Roland Hauck , Peter Hagmann , Axel Heinrich , Otto Kretzschmar , Anette Lang , Achim Muller , Thomas Schulz , Bernhard Seiferling , Werner Steffan
发明人： Peter Herbrechtsmeier , Karl Baur , Roger Biel , John Golby , Roland Hauck , Peter Hagmann , Axel Heinrich , Otto Kretzschmar , Anette Lang , Achim Muller , Thomas Schulz , Bernhard Seiferling , Werner Steffan
IPC分类号： B29D11/00
CPC分类号： B29D11/0023 , B08B9/00 , B29D11/00259 , B08B3/02
摘要： Efficient and consistent processes for manufacturing moldings, especially ophthalmic lenses such as contact lenses. The processes comprises a series of improvements, including improvements in the areas of conditions for dispensing liquid prepolymer into lens molds, male and female mold mating, reusable molds, mold cleaning, lens separation from molds (demolding), lens handling, and in-line inspection. Cyclic series of processing steps are also disclosed. Additionally, an improved molding tool is disclosed, with the molding tool including a male mold housing and a female mold housing, each of which have disposed therein a plurality of mold halves.
摘要翻译：用于制造模制品的高效且一致的工艺，特别是诸如隐形眼镜的眼镜。这些方法包括一系列改进，包括将液体预聚物分配到透镜模具中的条件的改进，阳模和阴模配合，可重复使用的模具，模具清洁，与模具分离的透镜（脱模），透镜处理和在线检查。还公开了循环系列的处理步骤。此外，公开了一种改进的模制工具，其中模制工具包括阳模壳体和阴模壳体，每个模具壳体中设置有多个半模。

8. 发明授权

US6042756A Process for the manufacture of moulded articles that are partly colored or have regions of different colors 失效
标题翻译：用于制造部分着色或具有不同颜色区域的模制品的方法
公开(公告)号：US6042756A
公开(公告)日：2000-03-28
申请号：US875341
申请日：1997-07-30
申请人： Achim Muller , Bernhard Seiferling , Axel Heinrich
发明人： Achim Muller , Bernhard Seiferling , Axel Heinrich
IPC分类号： G02C7/04 , B29C31/10 , B29C35/08 , B29C39/02 , B29C39/12 , B29C39/24 , B29D11/00 , B29K105/24 , B29L11/00
CPC分类号： B29C43/021 , B29C35/0888 , B29C39/12 , B29C39/24 , B29C43/34 , B29D11/00048 , B29C2043/3433 , B29C31/10 , B29K2105/0002 , B29L2011/0016
摘要： For the fast and rational manufacture of moulded articles, specifically contact lenses, that are partly colored or have regions of different colors, by the casting process, measured amounts of two or more crosslinkable materials of different colors are introduced into the casting mould in the uncrosslinked stated unmixed and, after closing the casting mould, are crosslinked together. By suitably controlling the introduction of the different crosslinkable materials with regard to location and/or time the merging of the colors and the transitions between the colors in the contact lens are influenced in a controlled manner.
摘要翻译： PCT No.PCT / EP96 / 00244 Sec。 371日期1997年7月30日 102（e）日期1997年7月30日PCT 1996年1月22日PCT PCT。公开号WO96 / 23648 日期1996年8月8日为了通过铸造工艺快速合理地制造模制品，特别是部分着色或具有不同颜色区域的隐形眼镜，将两种或更多种不同颜色的可交联材料的测量量引入在未交联的未混合的模具中，并且在关闭铸模之后，将其模制在一起。通过适当地控制不同的可交联材料在位置和/或时间上的引入，可以以受控的方式影响颜色的合并和隐形眼镜中的颜色之间的转变。

9. 发明授权

US5936052A Cross-linkable copolymers and hydrogels 失效
公开(公告)号：US5936052A
公开(公告)日：1999-08-10
申请号：US942097
申请日：1997-10-01
申请人： Harald Bothe , Achim Muller , Bernhard Seiferling , Sharla Borghorst , John Golby , Peter Hagmann , Peter Herbrechtsmeier , Otto Kretzschmar
发明人： Harald Bothe , Achim Muller , Bernhard Seiferling , Sharla Borghorst , John Golby , Peter Hagmann , Peter Herbrechtsmeier , Otto Kretzschmar
IPC分类号： G02C7/04 , C08F8/00 , C08F16/08 , C08F16/14 , C08F20/26 , C08F20/52 , C08F26/00 , C08F216/08 , C08F216/14 , C08F218/02 , C08F218/04 , C08F220/04 , C08F220/06 , C08F220/28 , C08F220/56 , C08F226/06 , C08F226/10 , C08F246/00 , C08F293/00 , C08F299/00 , G02B1/04 , C08F26/08
CPC分类号： C08F226/06 , C08F293/005 , C08F8/14 , G02B1/043 , C08F226/10 , C08F2800/10 , C08F2800/20 , C08F2810/20 , C08F2810/50
摘要： The present invention describes novel statistical copolymers and the preparation and possible uses thereof. Copolymers are described that are water-soluble and cross-linkable and that comprise the copolymerization product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond.

10. 发明授权

US5871675A Crosslinked tinted polymers 失效
标题翻译：交联着色聚合物
公开(公告)号：US5871675A
公开(公告)日：1999-02-16
申请号：US875532
申请日：1997-09-18
申请人： Achim Muller , Thomas Pohlmann , Bernhard Seiferling
发明人： Achim Muller , Thomas Pohlmann , Bernhard Seiferling
IPC分类号： G02B7/04 , B29D11/00 , C08F8/00 , C08F16/06 , C08F226/06 , C08J3/24 , G02B1/04 , G02B1/10 , G02B1/12 , C07C43/00 , C08F224/00 , C08G63/91
CPC分类号： G02B1/043 , C08F8/00 , C08F8/12 , C08F8/30 , C08F226/10 , C08F2800/20 , C08F2810/20 , C08F2810/30 , C08F2810/50
摘要： The invention relates to a novel process for the production of tinted mouldings, in particular tinted contact lenses, in which a crosslinkable tinted polymer comprising units containing a crosslinkable group and units containing a reactive dye radical is crosslinked in solution, and to tinted mouldings, in particular tinted contact lenses, obtainable by this process. The present invention likewise relates to novel crosslinkable tinted polymers comprising units containing a crosslinkable group and units containing a reactive dye radical which can be employed in the novel process, in particular derivatives of a polyvinyl alcohol having a molecular weight of at least about 2000, to crosslinked tinted polymers, either homopolymers or copolymers, made from these novel crosslinkable tinted polymers containing a reactive dye radical, a process for the preparation of the novel crosslinkable tinted polymers comprising units containing a crosslinkable group and units containing a reactive dye radical and the homopolymers and copolymers obtainable therefrom, to tinted mouldings made from said homopolymers or copolymers, in particular tinted contact lenses made from these homopolymers or copolymers, and to a process for the production of tinted contact lenses using said homopolymers or copolymers.
摘要翻译： PCT No.PCT / EP96 / 00252 Sec。 371日期：1997年9月18日 102（e）1997年9月18日PCT PCT 1996年1月23日PCT公布。公开号WO96 / 24076 日期1996年8月8日本发明涉及一种生产有色成型品，特别是着色隐形眼镜的新方法，其中包含含有可交联基团的单元的交联着色聚合物和含有活性染料基团的单元在溶液中交联，用于通过该方法获得的有色成型品，特别是有色隐形眼镜。本发明同样涉及包含可交联基团的单元的新型交联着色聚合物和可用于新方法的反应性染料基团的单元，特别是分子量至少为约2000的聚乙烯醇的衍生物，至交联着色聚合物，均聚物或共聚物，由含有活性染料基团的这些新型可交联着色聚合物制成，制备包含可交联基团的单元的新交联着色聚合物的方法和含有活性染料基团的单元和均聚物和可从其获得的共聚物到由所述均聚物或共聚物制成的着色模制品，特别是由这些均聚物或共聚物制成的着色隐形眼镜，以及使用所述均聚物或共聚物生产着色隐形眼镜的方法。

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