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1. 发明授权

US07071330B2 Process for carbapenem synthesis 失效
标题翻译：碳青霉烯合成方法
公开(公告)号：US07071330B2
公开(公告)日：2006-07-04
申请号：US10466876
申请日：2002-01-11
申请人： John M. Williams , Renato Skerlj
发明人： John M. Williams , Renato Skerlj
IPC分类号： C07D477/20
CPC分类号： C07D477/20 , C07D477/02 , C07D487/04 , Y02P20/55
摘要： A process for synthesizing a compound represented by formula I: or a pharmaceutically acceptable salt thereof, wherein deprotection is conducted using a prereduced metal catalyst is disclosed.
摘要翻译：公开了一种合成式I化合物或其药学上可接受的盐的方法，其中使用预还原的金属催化剂进行脱保护。

2. 发明授权

US08661760B2 Wind resistant tile roofing system 有权
标题翻译：防风瓦屋面系统
公开(公告)号：US08661760B2
公开(公告)日：2014-03-04
申请号：US13742187
申请日：2013-01-15
申请人： John M. Williams , Albert L. Galloup
发明人： John M. Williams , Albert L. Galloup
IPC分类号： E04D1/34
CPC分类号： E04D1/34 , E04D2001/3411 , E04D2001/3458 , E04D2001/3494
摘要： An integral strip and fastener installation system is provided for light weight slate and tile roofing systems installed with a single overlap between each row or course of tile. A specialized fastener hook is formed with one or more lateral projections or wings installed underneath one or more slate tiles to anchor the fastener to the roof at least in part by the weight of the overlying tiles. This anchoring supports and reinforces the open mouth of the hook against deflection from high winds and thereby enables the hook to hold a tile securely under high wind loads.
摘要翻译：提供一体的条带和紧固件安装系统，用于在每行或每个瓦片之间安装有单个重叠的轻质板岩和瓦面屋顶系统。一种专门的紧固钩形成有一个或多个横向突起或翼，其安装在一个或多个板岩砖下面，至少部分地通过重叠的瓦片的重量将紧固件锚定到屋顶。这种锚定支撑并加强了钩子的敞开的口部，防止了从大风中的偏转，从而使得钩子能够在高风荷载下牢固地固定瓦片。

3. 发明授权

US08518999B2 Modulators of TNF-αsignaling 有权
标题翻译： TNF-α信号调节剂
公开(公告)号：US08518999B2
公开(公告)日：2013-08-27
申请号：US11292325
申请日：2005-12-01
申请人： Scott F. Sneddon , John L. Kane , Bradford H. Hirth , Fred Vinick , Shuang Qiao , Sharon R. Nahill , John M. Williams , Hans-Peter Biemann
发明人： Scott F. Sneddon , John L. Kane , Bradford H. Hirth , Fred Vinick , Shuang Qiao , Sharon R. Nahill , John M. Williams , Hans-Peter Biemann
IPC分类号： A61K31/16 , A61K31/4174 , A61K31/436 , A61K31/395 , A61K45/06 , A61P37/06 , C07C233/00 , C07D233/54
CPC分类号： A61K31/53 , C07D233/64 , C07D401/14 , C07D403/14
摘要： The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be represented by the following structural formulas:
摘要翻译：本发明提供了作为TNF-α信号调节剂的化合物及其用于治疗患有TNF-α介导病症的患者的方法。该化合物可以由以下结构式表示：

4. 发明申请

US20130180201A1 Wind Resistant Tile Roofing System 有权
标题翻译：防风瓦屋面系统
公开(公告)号：US20130180201A1
公开(公告)日：2013-07-18
申请号：US13742187
申请日：2013-01-15
申请人： John M. Williams , Albert L. Galloup
发明人： John M. Williams , Albert L. Galloup
IPC分类号： E04D1/34
CPC分类号： E04D1/34 , E04D2001/3411 , E04D2001/3458 , E04D2001/3494
摘要： An integral strip and fastener installation system is provided for light weight slate and tile roofing systems installed with a single overlap between each row or course of tile. A specialized fastener hook is formed with one or more lateral projections or wings installed underneath one or more slate tiles to anchor the fastener to the roof at least in part by the weight of the overlying tiles. This anchoring supports and reinforces the open mouth of the hook against deflection from high winds and thereby enables the hook to hold a tile securely under high wind loads.
摘要翻译：提供一体的条带和紧固件安装系统，用于在每行或每个瓦片之间安装有单个重叠的轻质板岩和瓦面屋顶系统。一种专门的紧固钩形成有一个或多个横向突起或翼，其安装在一个或多个板岩砖下面，至少部分地通过重叠的瓦片的重量将紧固件锚定到屋顶。这种锚定支撑并加强了钩子的敞开的口部，防止了从大风中的偏转，从而使得钩子能够在高风荷载下牢固地固定瓦片。

5. 发明授权

US07926307B1 Double sided polypropylene knit loop fabric 有权
标题翻译：双面聚丙烯编织圈布
公开(公告)号：US07926307B1
公开(公告)日：2011-04-19
申请号：US11416343
申请日：2006-05-02
申请人： John M. Williams
发明人： John M. Williams
IPC分类号： D04B7/12
CPC分类号： D04B1/02
摘要： A double sided polypropylene knit loop fabric comprises at least one and preferably both of the inner and outer loops comprised of polypropylene yarn forming cantilevered loops from a knit fabric. Polypropylene has many different characteristics than those of cotton or cotton blends. Accordingly, by making at least one of the loops, if not both of the loops, and the tie yarn out at least substantially, if not principally, polypropylene, a fabric can be produced which has different characteristics than a cotton fabric of similar construction.
摘要翻译：双面聚丙烯编织圈织物包括由针织织物形成悬臂环的聚丙烯纱线组成的至少一个，优选两个内圈和外圈。聚丙烯具有许多不同于棉或棉混纺的特性。因此，通过使至少一个环（如果不是两个环）和连接纱至少基本上（即使不是主要地）聚丙烯，也可以生产出具有与类似结构的棉织物不同的特性的织物。

6. 发明授权

US07145002B2 Crystalline forms of carbapenem antibiotics and methods of preparation 有权
标题翻译：碳青霉烯类抗生素的结晶形式及其制备方法
公开(公告)号：US07145002B2
公开(公告)日：2006-12-05
申请号：US10485319
申请日：2002-09-20
申请人： Karel M. J. Brands , Raymond Cvetovich , Louis S. Crocker , Michael D. Ward , Amar J. Mahajan , Robert M. Wenslow , John M. Williams , Daniel R. Sidler , Charles Orella , Elizabeth S. Fisher , Ronald Jobson
发明人： Karel M. J. Brands , Raymond Cvetovich , Louis S. Crocker , Michael D. Ward , Amar J. Mahajan , Robert M. Wenslow , John M. Williams , Daniel R. Sidler , Charles Orella , Elizabeth S. Fisher , Ronald Jobson
IPC分类号： C07D477/20
CPC分类号： C07D477/20
摘要： A process for preparing a crystalline, carbapenem monosodium salt of formula IIa: characterized by the steps a) adding about 10 to 30% of an organic solvent to an aqueous solution of the carbapenem, b) cooling the resulting solution to less than −5° C., c) adjusting the pH using a solution containing an acid in an organic solvent to give the appropriate pH for crystallization, and d) crystallizing the compound by adding methanol, and a C2-5 alcohol at between −5 and −25° C.
摘要翻译：制备式IIa的结晶碳青霉烯单钠盐的方法，其特征在于以下步骤：a）向碳青霉烯的水溶液中加入约10至30％的有机溶剂，b）将所得溶液冷却至小于-5℃ c）c）使用在有机溶剂中含有酸的溶液调节pH以得到适当的结晶pH，和d）通过加入甲醇和C 2-5醇来使化合物结晶在-5和-25℃之间

7. 发明授权

US06504027B1 Decarboxylation process for synthesizing carbapenem antibiotics 有权
标题翻译：合成碳青霉烯类抗生素的方法
公开(公告)号：US06504027B1
公开(公告)日：2003-01-07
申请号：US09487044
申请日：2000-01-19
申请人： John M. Williams , Karel M. J. Brands , Renato T. Skerlj , Peter Houghton
发明人： John M. Williams , Karel M. J. Brands , Renato T. Skerlj , Peter Houghton
IPC分类号： C07D47720
CPC分类号： C07D477/20 , C07D477/02
摘要： A process for the direct crystallization of a compound of the formula I: or a pharmaceutically acceptable salt thereof, is disclosed, wherein R1 and R2 represent H, C1-10 alkyl, aryl or heteroaryl, or substituted C1-10 alkyl, aryl or heteroaryl and X+ represents a charge balancing group, comprising extracting a solution containing a crude compound of formula I or Ia: or a pharmaceutically acceptable salt thereof, wherein each X+ is a charge balancing group, and R1 and R2 are as described above with a C4-10 alcohol, collecting and crystallizing the resulting aqueous phase to produce a crystalline compound of formula I.
摘要翻译：公开了用于直接结晶式I化合物或其药学上可接受的盐的方法，其中R 1和R 2表示H，C 1-10烷基，芳基或杂芳基或取代的C 1-10烷基，芳基或杂芳基并且X +表示电荷平衡基团，其包括提取含有式I或Ia的粗化合物或其药学上可接受的盐的溶液，其中每个X +是电荷平衡基团，并且R 1和R 2如上所述与C 4- 10酒精，收集和结晶所得水相以产生式I的结晶化合物。

8. 发明授权

US5952323A Carbapenem antibiotic 失效
标题翻译：碳青霉烯类抗生素
公开(公告)号：US5952323A
公开(公告)日：1999-09-14
申请号：US64426
申请日：1998-04-22
申请人： Jeffrey A. Zimmerman , John M. Williams , Paul A. Bergquist , Lisa M. DiMichele , David C. DuBost , Michael J. Kaufman , Daniel R. Sidler , William A. Hunke
发明人： Jeffrey A. Zimmerman , John M. Williams , Paul A. Bergquist , Lisa M. DiMichele , David C. DuBost , Michael J. Kaufman , Daniel R. Sidler , William A. Hunke
IPC分类号： A61K31/40 , C07D20060101 , C07D477/20 , C07D207/16 , C07D403/12
CPC分类号： C07D477/20
摘要： A pharmaceutical composition is disclosed which contains a compound of formula I: ##STR1## or a pharmaceutically acceptable salt, prodrug or hydrate thereof, in the stabilized form and/or in combination with a carbon dioxide source.
摘要翻译：公开了一种药物组合物，其含有稳定形式的和/或与二氧化碳源组合的式I化合物或其药学上可接受的盐，前药或水合物。

9. 发明授权

US5358516A Implantable electrophysiology lead and method of making 失效
标题翻译：植入式电生理学导论和制作方法
公开(公告)号：US5358516A
公开(公告)日：1994-10-25
申请号：US988998
申请日：1992-12-11
申请人： David J. Myers , John M. Williams
发明人： David J. Myers , John M. Williams
IPC分类号： A61N1/05 , H01B3/44 , H01B7/282 , A61N5/04
CPC分类号： A61N1/05 , H01B3/445 , H01B7/2825
摘要： An implantable lead in the form of an electrical conductor wire having an insulating layer of impervious plastic surrounding the surface of the electrical conductor wire and further having an exterior surface covering of porous PTFE. The impervious plastic insulating layer is preferably a thermoplastic and most preferably a thermoplastic fluoropolymer such as ETFE, FEP or PFA. The exterior surface covering of porous PTFE offers improved flexibility and biocompatibility in comparison to conventional lead wires having silicone exterior surfaces, while the impervious plastic insulating layer prevents loss of insulating integrity resulting from wetting out of the porous PTFE exterior surface by body fluids. Methods of making the implantable lead are also described.
摘要翻译：电导体线形式的可植入引线，其具有围绕电导体线表面的不透水塑料的绝缘层，并且还具有覆盖多孔PTFE的外表面。不透水的塑料绝缘层优选为热塑性，最优选热塑性含氟聚合物，例如ETFE，FEP或PFA。与具有硅氧烷外表面的常规引线相比，多孔PTFE的外表面覆盖物提供了改进的柔性和生物相容性，而不透水塑料绝缘层防止了由体液润湿多孔PTFE外表面导致的绝缘完整性损失。还描述了制造可植入引线的方法。

10. 发明授权

US4962935A Apparatus for playing a racquet and ball game in a confined space 失效
标题翻译：在狭窄的空间里玩球拍和球赛的装置
公开(公告)号：US4962935A
公开(公告)日：1990-10-16
申请号：US183185
申请日：1988-02-16
申请人： John M. Williams
发明人： John M. Williams
IPC分类号： A63B61/00 , A63B67/00 , A63B71/02 , A63C19/00
CPC分类号： A63B67/002 , A63C19/00
摘要： An apparatus for playing a racquet and ball game in a confined space comprises an enclosed playing arena having a generally rectangular playing area; upright walls surrounding said playing area; a roof extending over said playing arena and extending between opposed upper regions of the walls; and a pair of upright spaced substantially parallel barriers. The barriers extend transversely of the playing area to divide the playing area into two substantially equal player's zones. The player's zones each include a ball service boundary marked on and extending transverely of each of the player's zone. An upper edge of each of the barriers is spaced from the roof.
摘要翻译： PCT No.PCT / AU87 / 00173 Sec。 371日期：1988年3月14日 102（e）1988年3月14日PCT Filted 1987年6月16日PCT公布。第WO87 / 07519号公报日期为1987年12月17日。在密闭空间中玩球拍和球赛的装置包括具有大致矩形的游戏区域的封闭游乐场; 围绕所述游乐区的直立墙壁; 在所述游戏区域上延伸并在壁的相对的上部区域之间延伸的屋顶; 以及一对直立间隔开的基本上平行的挡板。障碍物横向延伸到游戏区域，将游戏区域分成两个基本相等的玩家区域。玩家的区域各自包括在玩家的每个区域上标记并延伸的球服务边界。每个障碍物的上边缘与屋顶间隔开。

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