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1. 发明授权

US08562555B2 Fluid exchange system for controlled and localized irrigation and aspiration 有权
标题翻译：用于控制和局部灌溉和抽吸的流体交换系统
公开(公告)号：US08562555B2
公开(公告)日：2013-10-22
申请号：US11458185
申请日：2006-07-18
申请人： John M. MacMahon , Thomas G. Goff , Brian K. Courtney
发明人： John M. MacMahon , Thomas G. Goff , Brian K. Courtney
IPC分类号： A61M1/00 , A61M3/00 , A61M31/00 , A61M5/00 , A61M25/00
CPC分类号： A61M1/0058 , A61M1/0009 , A61M1/0064 , A61M1/0068
摘要： The control of fluid introduction into and out of body conduits such as vessels, is of great concern in medicine. As the development of more particular treatments to vessels and organs continues it is apparent that controlled introduction and removal of fluids is necessary. Fluid delivery and removal from such sites, usually referred to as irrigation and aspiration, using fluid exchange devices that control also need to be considerate of potential volume and/or pressure in a vessel or organ are described together with catheter and lumen configurations to achieve the fluid exchange. The devices include several electrically or mechanically controlled embodiments and produce both controlled and localized flow with defined volume exchange ratios for fluid management. The applications in medicine include diagnostic, therapeutic, imaging, and uses for the introduction or removal of concentrations of emboli within body cavities.
摘要翻译：液体导入和流出体液导管如血管的控制在医学上是非常关注的。随着对血管和器官的更特殊的治疗的发展继续，显然需要控制引入和去除流体。与导管和管腔配置一起描述使用控制的流体交换装置（通常称为灌注和抽吸）的流体递送和移除也需要考虑容器或器官中的潜在体积和/或压力，以实现流体交换。这些装置包括几个电气或机械控制的实施例，并产生具有限定的用于流体管理的体积交换比的受控和局部流。药物中的应用包括用于引入或去除体腔内栓塞浓度的诊断，治疗，成像和用途。

2. 发明授权

US07530976B2 Fluid exchange system for controlled and localized irrigation and aspiration 失效
标题翻译：用于控制和局部灌溉和抽吸的流体交换系统
公开(公告)号：US07530976B2
公开(公告)日：2009-05-12
申请号：US10903521
申请日：2004-07-30
申请人： John M. MacMahon , Thomas G. Goff , Brian K. Courtney
发明人： John M. MacMahon , Thomas G. Goff , Brian K. Courtney
IPC分类号： A61M5/178 , A61M31/00
CPC分类号： A61M1/0058 , A61M1/0009 , A61M1/0064 , A61M1/0068
摘要： The control of fluid introduction into and out of body conduits such as vessels, is of great concern in medicine. As the development of more particular treatments to vessels and organs continues it is apparent that controlled introduction and removal of fluids is necessary. Fluid delivery and removal from such sites, usually referred to as irrigation and aspiration, using fluid exchange devices that control also need to be considerate of potential volume and/or pressure in the vessel or organ are described together with catheter and lumen configurations to achieve the fluid exchange. The devices include several electrically or mechanically controlled embodiments and produce both controlled and localized flow with defined volume exchange ratios for fluid management. The applications in medicine include diagnostic, therapeutic, imaging, and uses for the introduction or removal of concentrations of emboli within body cavities.
摘要翻译：液体导入和流出体液导管如血管的控制在医学上是非常关注的。随着对血管和器官的更特殊的治疗的发展继续，显然需要控制引入和去除流体。与导管和管腔配置一起描述使用控制的流体交换装置（通常称为灌注和抽吸）的流体输送和移除也需要考虑容器或器官中的潜在体积和/或压力，以实现流体交换。这些装置包括几个电气或机械控制的实施例，并产生具有限定的用于流体管理的体积交换比的受控和局部流。药物中的应用包括用于引入或去除体腔内栓塞浓度的诊断，治疗，成像和用途。

3. 发明授权

US07108677B2 Embolization protection system for vascular procedures 有权
标题翻译：血管手术栓塞保护系统
公开(公告)号：US07108677B2
公开(公告)日：2006-09-19
申请号：US09872068
申请日：2001-05-31
申请人： Brian K. Courtney , John M. MacMahon , Thomas G. Goff
发明人： Brian K. Courtney , John M. MacMahon , Thomas G. Goff
IPC分类号： A61M29/00
CPC分类号： A61B17/22 , A61B17/22031 , A61B2017/22067 , A61B2017/22082 , A61B2017/22084 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： Apparatus and methods are described for effective removal of emboli or harmful fluids during vascular procedures, such as angiography, balloon angioplasty, stent deployment, laser angioplasty, atherectomy, intravascular ultrasonography and other therapeutic and diagnostic procedures. A catheter with an occluder mounted at its distal end creates an occlusion proximal to the lesion. The catheter provides a pathway for introducing a treatment catheter. Prior to, during or subsequent to the procedure, suction is activated to establish retrograde flow to remove emboli from the site. Additionally, a thin catheter with a distal fluid ejection nozzle maybe introduced distal to the treatment site to rinse emboli from the treatment site. The suction flow and/or ejected fluid flow may be varied in a pulsatile manner to simulate regular blood flow and/or perturb settled emboli into being captured that may otherwise not be collected. The method establishes a protective environment before any devices enter the site to be treated.
摘要翻译：描述了用于在血管手术（例如血管造影术，球囊血管成形术，支架展开，激光血管成形术，粥样斑块切除术，血管内超声检查和其他治疗和诊断程序）的血管手术中有效去除栓塞或有害流体的装置和方法。具有安装在其远端的封堵器的导管在损伤附近产生闭塞。导管提供用于引入治疗导管的途径。在手术之前，期间或之后，吸力被激活以建立逆行流动以从现场除去栓塞。此外，具有远端液体喷射嘴的薄导管可以在治疗部位的远端引入，以从治疗部位冲洗栓塞。抽吸流体和/或排出的流体流动可以以脉动方式变化，以模拟正常血液流动和/或扰乱沉积的栓塞，从而可能不被收集。该方法在任何设备进入待处理场所之前建立保护环境。

4. 发明授权

US06878128B2 Fluid exchange system for controlled and localized irrigation and aspiration 失效
标题翻译：用于控制和局部灌溉和抽吸的流体交换系统
公开(公告)号：US06878128B2
公开(公告)日：2005-04-12
申请号：US10819409
申请日：2004-04-06
申请人： John M. MacMahon , Thomas G. Goff , Brian K. Courtney
发明人： John M. MacMahon , Thomas G. Goff , Brian K. Courtney
IPC分类号： A61B17/22 , A61B17/00 , A61M1/00 , A61M25/00 , A61M5/178 , A61M3/00 , A61M5/00
CPC分类号： A61M1/0058 , A61M1/0009 , A61M1/0064 , A61M1/0068
摘要： The control of fluid introduction into and out of body conduits such as vessels, is of great concern in medicine. As the development of more particular treatments to vessels and organs continues it is apparent that controlled introduction and removal of fluids is necessary. Fluid delivery and removal from such sites, usually referred to as irrigation and aspiration, using fluid exchange devices that control also need to be considerate of potential volume and/or pressure in the vessel or organ are described together with catheter and lumen configurations to achieve the fluid exchange. The devices include several electrically or mechanically controlled embodiments and produce both controlled and localized flow with defined volume exchange ratios for fluid management. The applications in medicine include diagnostic, therapeutic, imaging, and uses for the introduction or removal of concentrations of emboli within body cavities.
摘要翻译：液体导入和流出体液导管如血管的控制在医学上是非常关注的。随着对血管和器官的更特殊的治疗的发展继续，显然需要控制引入和去除流体。与导管和管腔配置一起描述使用控制的流体交换装置（通常称为灌注和抽吸）的流体输送和移除也需要考虑容器或器官中的潜在体积和/或压力，以实现流体交换。这些装置包括几个电气或机械控制的实施例，并产生具有限定的用于流体管理的体积交换比的受控和局部流。药物中的应用包括用于引入或去除体腔内栓塞浓度的诊断，治疗，成像和用途。

5. 发明授权

US08435225B2 Embolization protection system for vascular procedures 有权
标题翻译：血管手术栓塞保护系统
公开(公告)号：US08435225B2
公开(公告)日：2013-05-07
申请号：US10903523
申请日：2004-07-30
申请人： Brian K. Courtney , John M. MacMahon , Thomas G. Goff
发明人： Brian K. Courtney , John M. MacMahon , Thomas G. Goff
IPC分类号： A61M31/00 , A61M29/00 , A61F11/00
CPC分类号： A61K9/2846 , A61K9/2866 , A61K9/4891 , A61K31/7068
摘要： Apparatus and methods are described for effective removal of emboli or harmful fluids during therapeutic and diagnostic vascular procedures, such as angiography, balloon angioplasty, stent deployment, laser angioplasty, atherectomy, and intravascular ultrasonography. A catheter with an occluder mounted at its distal end creates an occlusion proximal to the lesion and provides a pathway for introducing a treatment catheter. Prior to, during or subsequent to the procedure, suction is activated to establish retrograde flow to remove emboli from the site. Additionally, a thin catheter with a distal fluid ejection nozzle may be introduced distal to the treatment site to rinse emboli from the treatment site. The suction flow and/or ejected fluid flow may be varied in a pulsatile manner to simulate regular blood flow and/or perturb settled emboli into being captured that may otherwise not be collected. The method establishes a protective environment before any devices enter the treatment site.
摘要翻译：描述了用于在治疗和诊断血管手术（例如血管造影，球囊血管成形术，支架展开，激光血管成形术，粥样斑块切除术和血管内超声检查）期间有效去除栓塞或有害流体的装置和方法。具有安装在其远端的封堵器的导管在损伤附近产生闭塞并且提供用于引入治疗导管的通路。在手术之前，期间或之后，吸力被激活以建立逆行流动以从现场除去栓塞。此外，具有远端液体喷射嘴的薄导管可以在处理部位的远端被引入以从治疗部位冲洗栓子。抽吸流体和/或排出的流体流动可以以脉动方式变化，以模拟正常的血液流动和/或扰动沉积的栓塞被捕获，否则可能不被收集。该方法在任何设备进入治疗部位之前建立保护环境。

6. 发明授权

US06827701B2 Fluid exchange system for controlled and localized irrigation and aspiration 失效
公开(公告)号：US06827701B2
公开(公告)日：2004-12-07
申请号：US10198718
申请日：2002-07-17
申请人： John M. MacMahon , Thomas G. Goff , Brian K. Courtney
发明人： John M. MacMahon , Thomas G. Goff , Brian K. Courtney
IPC分类号： A61M5178
CPC分类号： A61M1/0058 , A61M1/0009 , A61M1/0064 , A61M1/0068
摘要： The control of fluid introduction into and out of body conduits such as vessels, is of great concern in medicine. As the development of more particular treatments to vessels and organs continues it is apparent that controlled introduction and removal of fluids is necessary. Fluid delivery and removal from such sites, usually referred to as irrigation and aspiration, using fluid exchange devices that control also need to be considerate of potential volume and/or pressure in the vessel or organ are described together with catheter and lumen configurations to achieve the fluid exchange. The devices include several electrically or mechanically controlled embodiments and produce both controlled and localized flow with defined volume exchange ratios for fluid management. The applications in medicine include diagnostic, therapeutic, imaging, and uses for the introduction or removal of concentrations of emboli within body cavities.

7. 发明申请

US20140336506A1 DEVICE AND METHODS FOR DELIVERY AND TRANSFER OF TEMPORARY RADIOPAQUE ELEMENT 审中-公开
标题翻译：用于递送和传送临时放射性元素的装置和方法
公开(公告)号：US20140336506A1
公开(公告)日：2014-11-13
申请号：US14450103
申请日：2014-08-01
申请人： Thomas G. Goff
发明人： Thomas G. Goff
IPC分类号： A61M25/10 , A61B19/00
CPC分类号： A61M25/10 , A61B90/39 , A61B2090/3966 , A61B2090/3983 , A61F2/24 , A61F2/2427 , A61M25/0108 , A61M29/02 , A61M2025/1031 , A61M2025/1075 , A61M2025/1079 , A61M2025/1086 , A61M2025/1088 , A61M2025/1095
摘要： A device for the transfer of radiopaque material within the body comprises a valvuloplasty or other balloon coated with the radiopaque material. The balloon is inflated in the aortic valve for marking the site of an aortic annulus to enable accurate placement of prosthetic valves under fluoroscopic imaging.
摘要翻译：用于在体内转移不透射线材料的装置包括用不透射线材料涂覆的瓣膜成形术或其它球囊。气囊在主动脉瓣中充气，用于标记主动脉瓣环的位置，以使得能够在荧光镜成像下准确地放置人工瓣膜。

8. 发明申请

US20140144445A1 Substantially Constant Positive Airway Pressure Systems and Methods for Treating Sleep Apnea, Snoring, and Other Respiratory Disorders 审中-公开
标题翻译：基本上恒定的正气道压力系统和治疗睡眠呼吸暂停，打鼾和其他呼吸系统疾病的方法
公开(公告)号：US20140144445A1
公开(公告)日：2014-05-29
申请号：US12986808
申请日：2011-01-07
申请人： NATHANIEL L BOWDITCH , Thomas G. Goff
发明人： NATHANIEL L BOWDITCH , Thomas G. Goff
IPC分类号： A61M16/20 , A61M16/06 , A61M16/08 , A61M16/00
CPC分类号： A61M16/208 , A61M16/0066 , A61M16/0084 , A61M16/024 , A61M16/06 , A61M16/0683 , A61M16/16 , A61M16/161 , A61M2016/0021 , A61M2016/0033 , A61M2205/3331 , A61M2205/3365 , A61M2205/3368 , A61M2205/50 , A61M2205/8206 , A61M2205/8237 , A61M2209/088
摘要： Substantially constant positive airway pressure systems and methods mediate the variations in pressures that occur within a conventional CPAP mask during inhalation and exhalation cycles, and thereby reduce discomfort.
摘要翻译：基本上恒定的正气道压力系统和方法介导在吸入和呼气循环期间在常规CPAP掩模内发生的压力变化，从而减少不适。

9. 发明授权

US08327846B2 Positive airway pressure system with head position control 有权
标题翻译：气道正压控制系统
公开(公告)号：US08327846B2
公开(公告)日：2012-12-11
申请号：US13244834
申请日：2011-09-26
申请人： Nathaniel L. Bowditch , Thomas G. Goff , Tarmigan Casebolt
发明人： Nathaniel L. Bowditch , Thomas G. Goff , Tarmigan Casebolt
IPC分类号： A61M16/00
CPC分类号： A61M16/0003 , A61M16/00 , A61M16/0051 , A61M16/0057 , A61M16/0069 , A61M16/024 , A61M16/0616 , A61M16/0683 , A61M16/0875 , A61M16/202 , A61M16/204 , A61M2016/0027 , A61M2205/3303 , A61M2205/332 , A61M2205/3331 , A61M2205/3355 , A61M2205/42 , A61M2205/52 , A61M2205/70 , A61M2205/8206 , A61M2205/8218 , A61M2205/8262 , A61M2209/088 , A61M2210/06 , A61M2230/005 , A61M2230/62 , A61M2230/63
摘要： The invention is directed to a positive airway pressure (PAP) system with a head mounted harness assembly with a housing and a head position sensor located within or secured to the housing that detects the position of a patient's head, and communicates this head position information to a controller of the system which may be disposed within the housing having the position sensor or a second housing. The controller varies the output pressure of the pressure source, e.g. a rotary compressor, based, at least in part, on the head position information provided by the head position sensor. In a preferred embodiment, the position sensor is an accelerometer.
摘要翻译：本发明涉及一种具有头部安装的线束组件的正气道压力（PAP）系统，其具有壳体和位于壳体内或固定到壳体上的头部位置传感器，其检测患者头部的位置，并将该头部位置信息传递到该系统的控制器可以设置在具有位置传感器或第二壳体的壳体内。控制器改变压力源的输出压力，例如旋转压缩机，至少部分地基于由头部位置传感器提供的头部位置信息。在优选实施例中，位置传感器是加速度计。

10. 发明申请

US20140005576A1 SHOCK WAVE BALLOON CATHETER WITH MULTIPLE SHOCK WAVE SOURCES 有权
公开(公告)号：US20140005576A1
公开(公告)日：2014-01-02
申请号：US13534658
申请日：2012-06-27
申请人： John Adams , Thomas G. Goff , Doug Hakala
发明人： John Adams , Thomas G. Goff , Doug Hakala
IPC分类号： A61B17/22
CPC分类号： A61B18/1492 , A61B17/2202 , A61B17/22022 , A61B17/22029 , A61B17/2251 , A61B17/320725 , A61B18/00 , A61B2017/22024 , A61B2017/22025 , A61B2017/22051 , A61B2017/22058 , A61B2017/22061 , A61B2017/22062 , A61B2017/22098
摘要： An apparatus includes a balloon adapted to be placed adjacent a calcified region of a body. The balloon is inflatable with a liquid. The apparatus further includes a shock wave generator within the balloon that produces shock waves that propagate through the liquid for impinging upon the calcified region adjacent the balloon. The shock wave generator includes a plurality of shock wave sources distributed within the balloon.

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