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1. 发明授权

US6083953A 2- (2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3- propanediol derivative 失效
标题翻译： 2-（2-氨基-1,6-二氢-6-氧代 - 嘌呤-9-基）甲氧基-1,3-丙二醇衍生物
公开(公告)号：US6083953A
公开(公告)日：2000-07-04
申请号：US812991
申请日：1997-03-04
申请人： John Joseph Nestor , Scott William Womble , Hans Maag
发明人： John Joseph Nestor , Scott William Womble , Hans Maag
IPC分类号： A61K31/522 , C07D473/00 , C07D473/18 , A61K31/52
CPC分类号： C07D473/00
摘要： The L-monovaline ester derived from 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol and its pharmaceutically acceptable salts are of value as antiviral agents with improved absorption.
摘要翻译：衍生自2-（2-氨基-1,6-二氢-6-氧代 - 嘌呤-9-基）甲氧基-1,3-丙二醇的L-单缬氨酸酯及其药学上可接受的盐具有改进的抗病毒剂的价值吸收。

2. 发明授权

US5856481A 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative 失效
标题翻译： 2-（2-氨基-1,6-二氢-6-氧代 - 嘌呤-9-基）甲氧基-1,3-丙二醇衍生物
公开(公告)号：US5856481A
公开(公告)日：1999-01-05
申请号：US812989
申请日：1997-03-04
申请人： John Joseph Nestor , Hans Maag
发明人： John Joseph Nestor , Hans Maag
IPC分类号： A61K31/522 , C07D473/00 , C07D473/18 , C07F7/18
CPC分类号： C07D473/00
摘要： The L-monovaline ester derived from 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol and its pharmaceutically acceptable salts are of value as antiviral agents with improved absorption.
摘要翻译：衍生自2-（2-氨基-1,6-二氢-6-氧代 - 嘌呤-9-基）甲氧基-1,3-丙二醇的L-单缬氨酸酯及其药学上可接受的盐具有改善的抗病毒剂的价值吸收。

3. 发明授权

US5543414A Achiral amino acid acyl esters of ganciclovir and its derivatives 失效
标题翻译：更昔洛韦及其衍生物的非手性氨基酸酰基酯
公开(公告)号：US5543414A
公开(公告)日：1996-08-06
申请号：US282142
申请日：1994-07-28
申请人： John J. Nestor , Scott W. Womble , Hans Maag
发明人： John J. Nestor , Scott W. Womble , Hans Maag
IPC分类号： C07D473/16 , A61K31/52 , A61K31/522 , A61P31/12 , A61P31/22 , C07D473/00 , C07D473/18 , C07D473/32 , C07D473/40
CPC分类号： C07D473/00
摘要： Compounds of the Formula I ##STR1## wherein X is hydrogen, chloro, amino or hydroxy; R.sup.1 is an achiral amino acid acyl residue with a tertiary .alpha.-carbon atom. Preferred achiral amino acid acyl residues have the formula ##STR2## wherein each R.sup.2 is alkyl with 1 to 6 carbon atoms, cycloalkyl with 3 to 5 carbon atoms, or benzyl; or the two R.sup.2 groups link together to form a polymethylene group with 3 to 9 carbon atoms, and pharmaceutically acceptable salts thereof are antiviral agents with improved absorption. Intermediates for the preparation of the compounds of Formula I are also described.
摘要翻译：式I的化合物其中X是氢，氯，氨基或羟基; R1是具有叔碳原子的非手性氨基酸酰基残基。优选的非手性氨基酸酰基残基具有式“IMAGE”，其中每个R 2是具有1至6个碳原子的烷基，具有3至5个碳原子的环烷基或苄基; 或两个R 2基团连接在一起形成具有3至9个碳原子的多亚甲基，其药学上可接受的盐是具有改善的吸收的抗病毒剂。还描述了制备式I化合物的中间体。

4. 发明授权

US5449664A Antiviral agents 失效
标题翻译：抗病毒剂
公开(公告)号：US5449664A
公开(公告)日：1995-09-12
申请号：US808968
申请日：1991-12-16
申请人： Julien P. H. Verheyden , Hans Maag , Ernest J. Prisbe
发明人： Julien P. H. Verheyden , Hans Maag , Ernest J. Prisbe
IPC分类号： A61K9/127 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , A61K31/70 , C07H19/00
CPC分类号： C07H19/06 , A61K9/127 , C07H19/10 , C07H19/16 , C07H19/20 , Y10S514/934
摘要： Nucleoside compounds of the formula ##STR1## wherein: B is a purine or a pyrimidine;X and X' are H, OH or F, provided that at least one is H;Y and Y' are H, OH, OCH.sub.3 or F, provided that at least one is H;Y' and Z together form a cyclic phosphate ester, provided that Y is H; orZ is ##STR2## where n is zero, one, two or three; and Z' is N.sub.3 or OCH.sub.3 ; provided that when X' and Y' are OH and Z' is N.sub.3, B is not cytosine, andwhen X' and Y' are OH and Z' is OCH.sub.3, B is not uracil, adenine or cytosine;and the pharmaceutically acceptable esters, ethers and salts thereof, have been found to have potent antiviral activity with a high therapeutic ratio.
摘要翻译：式IMA的核苷化合物其中：B是嘌呤或嘧啶; X和X'是H，OH或F，条件是至少一个是H; Y和Y'是H，OH，OCH 3或F，条件是至少一个是H; Y'和Z一起形成环状磷酸酯，条件是Y是H; 或Z为，其中n为零，一，二或三; Z'为N 3或OCH 3; 条件是当X'和Y'为OH且Z'为N 3时，B不是胞嘧啶，当X'和Y'为OH且Z'为OCH 3时，B不是尿嘧啶，腺嘌呤或胞嘧啶; 已经发现其药学上可接受的酯，醚和盐具有高治疗比的有效的抗病毒活性。

5. 发明授权

US4650883A Hexahydro-3-fluoro-4-octenyl-2H-cyclopenta[.beta.]furan-2-ones 失效
标题翻译：六氢-3-氟-4-辛烯基-2H-环戊二烯并呋喃-2-酮
公开(公告)号：US4650883A
公开(公告)日：1987-03-17
申请号：US773914
申请日：1985-09-09
申请人： George W. Holland , Perry Rosen , Hans Maag
发明人： George W. Holland , Perry Rosen , Hans Maag
IPC分类号： C07D307/935 , C07D307/937 , C07F7/18 , C07D307/93
CPC分类号： C07D307/935 , C07D307/937 , C07F7/1856
摘要： The prostacyclins 7-fluoro-6,9-epoxy-16-substituted-15-hydroxyprost-[4 or 5,13]-dienoic acids and esters useful as anti-secretory agents, blood pressure lowering agents, anti-ulcerogenic agents, anti-hypertensive agents, bronchodilation agents and for combating gastro-hyperacidity and as anti-blood platelet aggregating agents.
摘要翻译：前列腺素7-氟-6,9-环氧-16-取代-15-羟基 - [4或5,13] - 二烯酸和酯可用作抗分泌剂，降血压剂，抗溃疡剂，抗 - 高血压药，支气管扩张剂和抗胃酸过多作为抗血小板聚集剂。

6. 发明授权

US07361648B2 Heterocyclylakylamines as muscarinic receptor antagonists 失效
标题翻译：杂环辛胺作为毒蕈碱受体拮抗剂
公开(公告)号：US07361648B2
公开(公告)日：2008-04-22
申请号：US11508581
申请日：2006-08-22
申请人： Charles Alois Dvorak , Lawrence Emerson Fisher , Keena Lynn Green , Ralph New Harris, III , Hans Maag , Anthony Prince , David Bruce Repke , Russell Stephen Stabler
发明人： Charles Alois Dvorak , Lawrence Emerson Fisher , Keena Lynn Green , Ralph New Harris, III , Hans Maag , Anthony Prince , David Bruce Repke , Russell Stephen Stabler
IPC分类号： A61K31/395 , A61K31/553 , A61K31/55
CPC分类号： C07D207/27 , A61K31/55 , A61K31/551 , A61K31/553 , C07D211/76 , C07D223/10 , C07D225/02 , C07D239/10 , C07D241/08 , C07D243/04 , C07D243/08 , C07D265/10 , C07D267/06 , C07D267/10 , C07D267/22 , C07D279/06 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D411/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR5, and the other substituents are as defined in the specification; and prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
摘要翻译：本发明涉及通常为毒蕈碱性M2 / M3受体拮抗剂并由式I表示的化合物：其中X，Y和Z为O，S或NR 5，其它取代基为在规范中定义; 和前药，各异构体，异构体的外消旋或非外消旋混合物及其药学上可接受的盐或溶剂合物。本发明还涉及含有这些化合物的药物组合物及其用作治疗剂的方法。

7. 发明授权

US06667301B2 Heterocyclylalkylamines as muscarinic receptor antagonists 有权
标题翻译：杂环烷基胺作为毒蕈碱受体拮抗剂
公开(公告)号：US06667301B2
公开(公告)日：2003-12-23
申请号：US09862286
申请日：2001-05-22
申请人： Charles Alois Dvorak , Lawrence Emerson Fisher , Keena Lynn Green , Ralph New Harris, III , Hans Maag , Anthony Prince , David Bruce Repke , Russell Stephen Stabler
发明人： Charles Alois Dvorak , Lawrence Emerson Fisher , Keena Lynn Green , Ralph New Harris, III , Hans Maag , Anthony Prince , David Bruce Repke , Russell Stephen Stabler
IPC分类号： C07D24108
CPC分类号： C07D207/27 , A61K31/55 , A61K31/551 , A61K31/553 , C07D211/76 , C07D223/10 , C07D225/02 , C07D239/10 , C07D241/08 , C07D243/04 , C07D243/08 , C07D265/10 , C07D267/06 , C07D267/10 , C07D267/22 , C07D279/06 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D411/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein X, Y, and Z are O, S or NR5, and the other substituents are as defined in the specification; and prodrugs, individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
摘要翻译：本发明涉及通常为毒蕈碱性M2 / M3受体拮抗剂并由式I表示的化合物：其中X，Y和Z为O，S或NR 5，其它取代基如说明书中所定义; 和前药，各异构体，异构体的外消旋或非外消旋混合物及其药学上可接受的盐或溶剂合物。本发明还涉及含有这些化合物的药物组合物及其用作治疗剂的方法。

8. 发明授权

US5840891A 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative 失效
标题翻译： 2-（2-氨基-1,6-二氢-6-氧代 - 嘌呤-9-基）甲氧基-1,3-丙二醇衍生物
公开(公告)号：US5840891A
公开(公告)日：1998-11-24
申请号：US812990
申请日：1997-03-04
申请人： John J. Nestor, Jr. , Hans Maag
发明人： John J. Nestor, Jr. , Hans Maag
IPC分类号： A61K31/522 , C07D473/00 , C07D473/18 , A61K31/52
CPC分类号： C07D473/00
摘要： The L-monovaline ester derived from 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol and its pharmaceutically acceptable salts are of value as antiviral agents with improved absorption.
摘要翻译：衍生自2-（2-氨基-1,6-二氢-6-氧代 - 嘌呤-9-基）甲氧基-1,3-丙二醇的L-单缬氨酸酯及其药学上可接受的盐具有改进的抗病毒剂的价值吸收。

9. 发明授权

US5122074A Flourescent lamp holder mount 失效
标题翻译：荧光灯支架安装
公开(公告)号：US5122074A
公开(公告)日：1992-06-16
申请号：US794950
申请日：1991-11-20
申请人： Hans Maag , Gino J. Ciancanelli
发明人： Hans Maag , Gino J. Ciancanelli
IPC分类号： H01R33/08
CPC分类号： H01R33/0845
摘要： A one-piece, molded plastic spring clip, which is substantially inverted U-shape in cross-section, has a bight portion including an opening receiving a screw threaded fastener to attach the clip to the rear surface of a lamp holder so that the screw threaded fastener does not extend from the clip through a headed flange portion of a lamp holder to provide a liquid conduit which could potentially short the lamp. The clip is provided with legs extending from either side of the bight and each leg has a pair of spaced, parallel wing portions extending outwardly from its associated leg to expand when inserted through the mounting plate. The wing portions provide vertical shoulders to seat the lamp holder on a vertical support in conjunction with a compressible coil spring provided on the opposite side of the mounting panel or vertical support between the headed flange and support to exert pressure on the clip shoulders against the rear of the mounting panel. A second non-compressible lamp holder is provided for the opposite end of the lamp on a second mounting panel. A one-piece, molded plastic spring clip is also provided for mounting the second lamp holder in a similar fashion, but is provided with flanges extending outwardly from the bottom of each leg, parallel to the bight portion so that the lamp will exert an axial force on the clip under the spring pressure of the compressible spring associated with the other lamp holder to clamp it to the front surface of the second mounting panel.
摘要翻译：横截面为大致倒U形的单件模制塑料弹簧夹具有弯曲部分，该弯曲部分包括接纳螺纹紧固件的开口，以将夹子附接到灯座的后表面，使得螺钉螺纹紧固件不从夹子延伸穿过灯座的头部凸缘部分，以提供可能使灯短路的液体导管。该夹具设置有从弯曲部的任一侧延伸的腿部，并且每个腿部具有一对间隔开的平行的翼部分，其从相关的腿部向外延伸，以在插入穿过安装板时膨胀。机翼部分提供垂直的肩部以将灯座安置在垂直支撑件上，与设置在安装面板的相对侧上的可压缩螺旋弹簧或头部凸缘和支撑件之间的垂直支撑件相结合，以将压力施加在夹子肩部抵靠后部的安装面板。在第二安装面板上为第二不可压缩的灯座设置用于灯的相对端。还提供了一体成型的塑料弹簧夹，用于以类似的方式安装第二灯座，但是设置有从每个腿的底部向外平行于弯曲部分向外延伸的凸缘，使得灯将施加轴向在与另一个灯座相关联的可压缩弹簧的弹簧压力下将夹子夹紧在第二安装面板的前表面上。

10. 发明授权

US07981914B2 Tetrazole-substituted aryl amide derivatives and uses thereof 有权
标题翻译：四唑取代的芳基酰胺衍生物及其用途
公开(公告)号：US07981914B2
公开(公告)日：2011-07-19
申请号：US12286643
申请日：2008-10-01
申请人： Daisy Joe Du Bois , Todd Richard Elworthy , Hans Maag , Sunil Sahdeo
发明人： Daisy Joe Du Bois , Todd Richard Elworthy , Hans Maag , Sunil Sahdeo
IPC分类号： A61K31/44 , C07D207/04
CPC分类号： C07D257/04 , C07D401/10 , C07D403/10 , C07D405/12 , C07D409/10
摘要： Compounds of the formula: wherein R1, R2, Ar1, Ar2, and n are as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.
摘要翻译：下式的化合物：其中R1，R2，Ar1，Ar2和n如本文所定义。还提供了药物组合物，使用方法和制备本发明化合物的方法。

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