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1. 发明授权

US5866553A Polynucleotide vaccine for papillomavirus 失效
标题翻译：乳头瘤病毒的多核苷酸疫苗
公开(公告)号：US5866553A
公开(公告)日：1999-02-02
申请号：US750810
申请日：1996-12-17
申请人： John J. Donnelly , Margaret A. Liu , Douglas Martinez , Donna L. Montgomery
发明人： John J. Donnelly , Margaret A. Liu , Douglas Martinez , Donna L. Montgomery
IPC分类号： C12N15/09 , A61K39/12 , A61K48/00 , A61P31/12 , A61P37/04 , C07H21/04 , C07K14/025 , C12N15/00 , C12N15/37 , C12R1/92 , A01N43/04
CPC分类号： C12N7/00 , C07K14/005 , A61K48/00 , C12N2710/20022
摘要： DNA constructs encoding papilloma virus gene products, capable of being expressed upon direct introduction into animal tissues, are novel prophylactic pharmaceuticals which can provide immune protection against infection by papilloma virus.
摘要翻译： PCT No.PCT / US95 / 06915 Sec。 371日期：1996年12月17日 102（e）日期1996年12月17日PCT归档1995年6月1日PCT公布。公开号WO96 / 00583 日期1996年1月11日编码能够直接引入动物组织中表达的乳头状瘤病毒基因产物的DNA构建体是可以提供针对乳头状瘤病毒感染的免疫保护的新型预防药物。

2. 发明授权

US06653125B2 Synthetic hepatitis C genes 失效
标题翻译：合成丙型肝炎基因
公开(公告)号：US06653125B2
公开(公告)日：2003-11-25
申请号：US09194949
申请日：2000-02-17
申请人： John J. Donnelly , Margaret A. Liu , John W. Shiver , Tong-Ming Fu
发明人： John J. Donnelly , Margaret A. Liu , John W. Shiver , Tong-Ming Fu
IPC分类号： C12N1579
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , A61K2039/53 , C12N2770/24222
摘要： The present invention relates to polynucleotides comprising a DNA sequence encoding an HCV protein and fragments thereof that contain codons optimized for expression in a vertebrate host. Uses of the polynucleotides include eliciting an immune response specifically recognizing HCV.
摘要翻译：本发明涉及包含编码HCV蛋白的DNA序列的多核苷酸及其片段，其含有在脊椎动物宿主中表达的优化的密码子。多核苷酸的用途包括引发特异性识别HCV的免疫应答。

3. 发明授权

US09365885B2 High-throughput complement-mediated antibody-dependent and opsonic bactericidal assays 有权
标题翻译：高通量补体介导的抗体依赖和调理杀菌测定
公开(公告)号：US09365885B2
公开(公告)日：2016-06-14
申请号：US12816534
申请日：2010-06-16
申请人： Puiying Annie Mak , George Santos , Jeffrey Eugene Janes , John J. Donnelly
发明人： Puiying Annie Mak , George Santos , Jeffrey Eugene Janes , John J. Donnelly
IPC分类号： C12Q1/00 , A01N63/00 , C12Q1/18
CPC分类号： C12Q1/18
摘要： The disclosure provides methods and kits for performing automated high-throughput assays to measure bactericidal activity in samples, such as plasma or sera from vaccinated subjects to evaluate the efficacy of vaccines against bacterial pathogens. The method combines obligatory linear-range data analysis, plate sealing and liquid volume handling for all assay steps to provide an automated, high-throughput measurement of bactericidal activity with favorable inter-assay and inter-operator variability.
摘要翻译：本公开提供用于进行自动化高通量测定以测量样品（例如来自接种受试者的血浆或血清）中的杀菌活性以评估疫苗对细菌病原体的功效的方法和试剂盒。该方法结合强制线性范围数据分析，板密封和液体体积处理，用于所有测定步骤，以提供有效的测定间和操作员间变异性的自动化，高通量的杀菌活性测量。

4. 发明授权

US08097243B2 Microparticle-based transfection and activation of dendritic cells 有权
标题翻译：基于微粒的树突状细胞的转染和活化
公开(公告)号：US08097243B2
公开(公告)日：2012-01-17
申请号：US12755266
申请日：2010-04-06
申请人： John J. Donnelly , Kimberly S. Denis-Mize , Gary S. Ott
发明人： John J. Donnelly , Kimberly S. Denis-Mize , Gary S. Ott
IPC分类号： A61K48/00 , C12N15/63 , C12N5/0783 , C12N5/0784
CPC分类号： C12N15/87 , A61K2039/5154 , C12N5/0639 , C12N2510/00
摘要： The present invention provides an effective method for the transfection of dendritic cells by non-viral methods. The present invention provides this benefit by incubating dendritic cells and a specified transfection agent. The transfection agent comprises a polynucleotide and microparticles, with the microparticles being comprised of biodegradable polymer and cationic detergent. The dendritic cells and transfection agent are incubated for a time sufficient to transfect the dendritic cells with the polynucleotide.
摘要翻译：本发明提供了通过非病毒方法转染树突状细胞的有效方法。本发明通过孵育树突状细胞和特定转染剂来提供这种益处。转染剂包含多核苷酸和微粒，微粒由可生物降解的聚合物和阳离子洗涤剂组成。将树状细胞和转染剂孵育足以用多核苷酸转染树突状细胞的时间。

5. 发明授权

US07713739B1 Microparticle-based transfection and activation of dendritic cells 失效
标题翻译：基于微粒的树突状细胞的转染和活化
公开(公告)号：US07713739B1
公开(公告)日：2010-05-11
申请号：US09715902
申请日：2000-11-17
申请人： John J. Donnelly , Kimberly S. Denis-Mize , Gary S. Ott
发明人： John J. Donnelly , Kimberly S. Denis-Mize , Gary S. Ott
IPC分类号： C12N15/64 , C12N15/63 , C12N5/10
CPC分类号： C12N15/87 , A61K2039/5154 , C12N5/0639 , C12N2510/00
摘要： The present invention provides an effective method for the transfection of dendritic cells by non-viral methods. The present invention provides this benefit by incubating dendritic cells and a specified transfection agent. The transfection agent comprises a polynucleotide and microparticles, with the microparticles being comprised of biodegradable polymer and cationic detergent. The dendritic cells and transfection agent are incubated for a time sufficient to transfect the dendritic cells with the polynucleotide.
摘要翻译：本发明提供了通过非病毒方法转染树突状细胞的有效方法。本发明通过孵育树突状细胞和特定转染剂来提供这种益处。转染剂包含多核苷酸和微粒，微粒由可生物降解的聚合物和阳离子洗涤剂组成。将树状细胞和转染剂孵育足以用多核苷酸转染树突状细胞的时间。

6. 发明授权

US5086994A Oscillating and continuous motion gear drive assembly 失效
标题翻译：振动和连续运动齿轮传动组件
公开(公告)号：US5086994A
公开(公告)日：1992-02-11
申请号：US592255
申请日：1990-10-03
申请人： John J. Donnelly , Bruno J. Germano
发明人： John J. Donnelly , Bruno J. Germano
IPC分类号： B64C25/50 , F16H19/08 , F16H27/08
CPC分类号： F16H19/08 , B64C25/50 , F16H27/08 , Y10T74/19605 , Y10T74/19874
摘要： The present invention pertains to a gear drive assembly that will allow components that are not capable of continuous rotation to be coupled to a component that is capable of continuous rotation. The drive gear assembly includes a drive gear component which is actually comprised of two gear sectors, one used to mesh and drive a driven gear directly and the other used to drive the driven gear in a reverse direction through a reversing cluster gear arrangement. The drive gear sectors are arranged so that when one sector is coupled and driving the driven gear, the other sector is decoupled, and vice-versa. Gear jamming is prevented by properly timing the coupling and decoupling of the drive gear sectors with the driven gear and the reversing cluster gear arrangement. In addition, where gear teeth pairs clash during coupling, provision is made to allow one gear tooth of the clashing pair to deflect and allow passage of the other gear tooth to the proper position. Therefore, the gear drive assembly of the present invention permits constant rotary motion of the drive gear component in either direction while resulting in an oscillating motion of the driven gear component.
摘要翻译：本发明涉及一种齿轮传动组件，其将允许不能够连续旋转的部件联接到能够连续旋转的部件。驱动齿轮组件包括实际上由两个齿轮部分组成的驱动齿轮部件，一个用于直接啮合和驱动从动齿轮的驱动齿轮部件，另一个用于通过反向的集群齿轮装置沿相反方向驱动从动齿轮。驱动齿轮扇区被布置成使得当一个扇区联接并且驱动从动齿轮时，另一个扇区被解耦，反之亦然。通过适当地定时驱动齿轮扇区与从动齿轮和反向组合齿轮装置的耦合和解耦来防止齿轮阻塞。此外，当齿轮齿配对在联接期间碰撞时，设置允许碰撞对的一个齿轮齿偏转并允许另一齿轮齿通过适当的位置。因此，本发明的齿轮传动组件允许驱动齿轮部件在任一方向上恒定的旋转运动，同时导致从动齿轮部件的摆动运动。

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