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1. 发明授权

US06492411B1 Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation 失效
标题翻译：用于治疗炎症的取代的吡唑基苯磺酰胺
公开(公告)号：US06492411B1
公开(公告)日：2002-12-10
申请号：US10125325
申请日：2002-04-17
申请人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H. Docter , Stella S Yu
发明人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H. Docter , Stella S Yu
IPC分类号： A61P2900
CPC分类号： C07D403/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D405/04 , C07D409/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: wherein R2 is selected from hydrido, alkyl, haloalkyl, alkoxycarbonyl, cyano, cyanoalkyl, carboxyl, aminocarbonyl, alkylaminocarbonyl, cycloalkylaminocarbonyl, arylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl, aralkoxycarbonylalkylaminocarbonyl, aminocarbonylalkyl, alkoxycarbonylcyanoalkenyl and hydroxyalkyl; wherein R3 is selected from hydrido, alkyl, cyano, hydroxyalkyl, cycloalkyl, alkylsulfonyl and halo; and wherein R4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl, carboxyl, cycloalkyl, alkylamino, dialkylamino, alkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino; provided R2 and R3 are not both hydrido; further provided that R2 is not carboxyl or methyl when R3 is hydrido and when R4 is phenyl; further provided that R4 is not triazolyl when R2 is methyl; further provided that R4 is not aralkenyl when R2 is carboxyl, aminocarbonyl or ethoxycarbonyl; further provided that R4 is not phenyl when R2 is methyl and R3 is carboxyl; and further provided that R4 is not unsubstituted thienyl when R2 is trifluoromethyl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式II定义：其中R2选自氢化，烷基，卤代烷基，烷氧基羰基，氰基，氰基烷基，羧基，氨基羰基，烷基氨基羰基，环烷基氨基羰基，芳基氨基羰基，羧基烷基氨基羰基，羧基烷基，芳烷氧基羰基烷基氨基羰基，氨基羰基烷基，烷氧基羰基氰基烯基和羟烷基。其中R 3选自氢，烷基，氰基，羟基烷基，环烷基，烷基磺酰基和卤素; 并且其中R 4选自芳烯基，芳基，环烷基，环烯基和杂环; 其中R 4在可取代位置任选被一个或多个选自卤素，烷硫基，烷基磺酰基，氰基，硝基，卤代烷基，烷基，羟基，烯基，羟基烷基，羧基，环烷基，烷基氨基，二烷基氨基，烷氧基羰基，氨基羰基，烷氧基，卤代烷氧基，氨磺酰基，杂环和氨基; 只要R2和R3都不是氢的; 进一步提供当R 3是氢的时，当R 4是苯基时，R 2不是羧基或甲基; 进一步提供当R 2是甲基时，R 4不是三唑基; 进一步提供当R 2是羧基时，R 4不是芳烯基，氨基羰基或乙氧基羰基; 进一步提供，当R 2是甲基且R 3是羧基时，R 4不是苯基; 并且进一步提供当R 2是三氟甲基时，R 4不是未取代的噻吩基; 或其药学上可接受的盐。

2. 发明授权

US06413960B1 Substituted pyrazolyl benzenesulfonamides for the treatment of asthma 失效
标题翻译：用于治疗哮喘的取代的吡唑基苯磺酰胺
公开(公告)号：US06413960B1
公开(公告)日：2002-07-02
申请号：US09609011
申请日：2000-05-30
申请人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H. Docter , Stella S Yu
发明人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H. Docter , Stella S Yu
IPC分类号： A61P1106
CPC分类号： C07D405/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D409/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: wherein R2 is selected from hydrido, alkyl, haloalkyl, alkoxycarbonyl, cyano, cyanoalkyl, carboxyl, aminocarbonyl, alkylaminocarbonyl, cycloalkylaminocarbonyl, arylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl, aralkoxycarbonylalkylaminocarbonyl, aminocarbonylalkyl, alkoxycarbonylcyanoalkenyl and hydroxyalkyl; wherein R3 is selected from hydrido, alkyl, cyano, hydroxyalkyl, cycloalkyl, alkylsulfonyl and halo; and wherein R4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl, carboxyl, cycloalkyl, alkylamino, dialkylamino, alkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino; provided R2 and R3 are not both hydrido; further provided that R2 is not carboxyl or methyl when R3 is hydrido and when R4 is phenyl; further provided that R4 is not triazolyl when R2 is methyl; further provided that R4 is not aralkenyl when R2 is carboxyl, aminocarbonyl or ethoxycarbonyl; further provided that R4 is not phenyl when R2 is methyl and R3 is carboxyl; and further provided that R4 is not unsubstituted thienyl when R2 is trifluoromethyl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式II定义：其中R2选自氢化，烷基，卤代烷基，烷氧基羰基，氰基，氰基烷基，羧基，氨基羰基，烷基氨基羰基，环烷基氨基羰基，芳基氨基羰基，羧基烷基氨基羰基，羧基烷基，芳烷氧基羰基烷基氨基羰基，氨基羰基烷基，烷氧基羰基氰基烯基和羟烷基。其中R 3选自氢，烷基，氰基，羟基烷基，环烷基，烷基磺酰基和卤素; 并且其中R 4选自芳烯基，芳基，环烷基，环烯基和杂环; 其中R 4在可取代位置任选被一个或多个选自卤素，烷硫基，烷基磺酰基，氰基，硝基，卤代烷基，烷基，羟基，烯基，羟基烷基，羧基，环烷基，烷基氨基，二烷基氨基，烷氧基羰基，氨基羰基，烷氧基，卤代烷氧基，氨磺酰基，杂环和氨基; 只要R2和R3都不是氢的; 进一步提供当R 3是氢的时，当R 4是苯基时，R 2不是羧基或甲基; 进一步提供当R 2是甲基时，R 4不是三唑基; 进一步提供当R 2是羧基时，R 4不是芳烯基，氨基羰基或乙氧基羰基; 进一步提供，当R 2是甲基且R 3是羧基时，R 4不是苯基; 并且进一步提供当R 2是三氟甲基时，R 4不是未取代的噻吩基; 或其药学上可接受的盐。

3. 发明授权

US6156781A Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation 有权
标题翻译：用于治疗炎症的取代的吡唑基苯磺酰胺
公开(公告)号：US6156781A
公开(公告)日：2000-12-05
申请号：US449076
申请日：1999-11-24
申请人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H. Docter , Stella S Yu
发明人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H. Docter , Stella S Yu
IPC分类号： A61K31/415 , A61P11/06 , A61P17/06 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04 , A61P17/07
CPC分类号： C07D405/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D409/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein R.sup.2 is selected from hydrido, alkyl, haloalkyl, alkoxycarbonyl, cyano, cyanoalkyl, carboxyl, aminocarbonyl, alkylaminocarbonyl, cycloalkylaminocarbonyl, arylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl, aralkoxycarbonylalkylaminocarbonyl, aminocarbonylalkyl, alkoxycarbonylcyanoalkenyl and hydroxyalkyl; wherein R.sup.3 is selected from hydrido, alkyl, cyano, hydroxyalkyl, cycloalkyl, alkylsulfonyl and halo; and wherein R.sup.4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R.sup.4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl, carboxyl, cycloalkyl, alkylamino, dialkylamino, alkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino; provided R.sup.2 and R.sup.3 are not both hydrido; further provided that R.sup.2 is not carboxyl or methyl when R.sup.3 is hydrido and when R.sup.4 is phenyl; further provided that R.sup.4 is not triazolyl when R.sup.2 is methyl; further provided that R.sup.4 is not aralkenyl when R.sup.2 is carboxyl, aminocarbonyl or ethoxycarbonyl; further provided that R.sup.4 is not phenyl when R.sup.2 is methyl and R.sup.3 is carboxyl; and further provided that R.sup.4 is not unsubstituted thienyl when R.sup.2 is trifluoromethyl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式II定义：其中R2选自氢化，烷基，卤代烷基，烷氧基羰基，氰基，氰基烷基，羧基，氨基羰基，烷基氨基羰基，环烷基氨基羰基，芳基氨基羰基，羧基烷基氨基羰基，羧基烷基，芳烷氧基羰基烷基氨基羰基，氨基羰基烷基，烷氧基羰基氰基烯基和羟烷基。其中R 3选自氢，烷基，氰基，羟基烷基，环烷基，烷基磺酰基和卤素; 并且其中R 4选自芳烯基，芳基，环烷基，环烯基和杂环; 其中R 4在可取代位置任选被一个或多个选自卤素，烷硫基，烷基磺酰基，氰基，硝基，卤代烷基，烷基，羟基，烯基，羟基烷基，羧基，环烷基，烷基氨基，二烷基氨基，烷氧基羰基，氨基羰基，烷氧基，卤代烷氧基，氨磺酰基，杂环和氨基; 只要R2和R3都不是氢的; 进一步提供当R 3是氢的时，当R 4是苯基时，R 2不是羧基或甲基; 进一步提供当R 2是甲基时，R 4不是三唑基; 进一步提供当R 2是羧基时，R 4不是芳烯基，氨基羰基或乙氧基羰基; 进一步提供，当R 2是甲基且R 3是羧基时，R 4不是苯基; 并且进一步提供当R 2是三氟甲基时，R 4不是未取代的噻吩基; 或其药学上可接受的盐。

4. 发明授权

US06951949B2 Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation 有权
公开(公告)号：US06951949B2
公开(公告)日：2005-10-04
申请号：US10700019
申请日：2003-11-03
申请人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H. Docter , Stella S Yu
发明人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H. Docter , Stella S Yu
IPC分类号： C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D495/04
CPC分类号： C07D409/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: wherein R2 is selected from hydrido, alkyl, haloalkyl, alkoxycaronyl, cyano, cyanoalkyl, carboxyl, aminocaronyl, alkylaminocarbonyl, cycloalklaminocarbonyl, arylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl, aralkoxycarbonylalkylaminocarbonyl, amioncarbonylalkyl, alkoxycarbonylcyanoalkenyl and hydroxyalkyl; wherein R3 is selected from hydrido, alkyl, cyano, hydroxyalkyl, cycloalkyl, alkylsulfonyl and halo; and wherein R4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R4 is optionally substituted at a substitutable position with one or more radicals selected from halo alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl, carboxyl, cycloalkyl, alkylamino, dialkylamino, alkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino; provided R2 and R3 are not both hydrido; further provided that R2 is not carboxyl or methyl when R3 is hydrido and when R4 is phenyl; further provided that R4 is not triazolyl when R2 is methyl; further provided that R4 is not arakenyl when R2 is carboxyl, aminocarbonyl or ethoxycarbonyl; further provided that R4 is not phenyl when R2 is methyl and R3 is carboxyl; and further provided that R4 is not unsubstituted thienyl when R2 is trifluoromethyl; or a pharmaceutically-acceptable salt thereof.

5. 发明授权

US06586603B1 Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation 失效
公开(公告)号：US06586603B1
公开(公告)日：2003-07-01
申请号：US10274679
申请日：2002-10-21
申请人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R. Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H Docter , Stella S Yu
发明人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R. Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H Docter , Stella S Yu
IPC分类号： C07D23112
CPC分类号： C07D403/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D405/04 , C07D409/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: wherein R2 is selected from hydrido, alkyl, haloalkyl, alkoxycarbonyl, cyano, cyanoalkyl, carboxyl, aminocarbonyl, alkylaminocarbonyl, cycloalkylaminocarbonyl, arylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl, aralkoxycarbonylalkylaminocarbonyl, aminocarbonylalkyl, alkoxycarbonylcyanoalkenyl and hydroxyalkyl; wherein R3 is selected from hydrido, alkyl, cyano, hydroxyalkyl, cycloalkyl, alkylsulfonyl and halo; and wherein R4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl, carboxyl, cycloalkyl, alkylamino, dialkylamino, alkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino; provided R2 and R3 are not both hydrido; further provided that R2 is not carboxyl or methyl when R3 is hydrido and when R4 is phenyl; further provided that R4 is not triazolyl when R2 is methyl; further provided that R4 is not aralkenyl when R2 is carboxyl, aminocarbonyl or ethoxycarbonyl; further provided that R4 is not phenyl when R2 is methyl and R3 is carboxyl; and further provided that R4 is not unsubstituted thienyl when R2 is trifluoromethyl; or a pharmaceutically-acceptable salt thereof.

6. 发明授权

US06716991B1 Process for preparing a substituted pyrazolyl benzenesulfonamide for the treatment of inflammation 失效
标题翻译：制备用于治疗炎症的取代的吡唑基苯磺酰胺的方法
公开(公告)号：US06716991B1
公开(公告)日：2004-04-06
申请号：US10378781
申请日：2003-03-04
申请人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H. Doctor , Stella S Yu
发明人： John J Talley , Thomas D Penning , Paul W Collins , Donald J Rogier, Jr. , James W Malecha , Julie M Miyashiro , Stephen R Bertenshaw , Ish K Khanna , Matthew J Graneto , Roland S Rogers , Jeffery S Carter , Stephen H. Doctor , Stella S Yu
IPC分类号： C07D23112
CPC分类号： C07D409/04 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/54 , C07D401/04 , C07D403/04 , C07D405/04 , C07D495/04
摘要： A class of pyrazolyl benzenesulfonamide compounds is descrbed for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: wherein R2 is selected from hydrido, alkyl, haloalkyl, alkoxycarbonyl, cyano, cyanoalkyl, carboxyl, aminocarbonyl, alkylaminocarbonyl, cycloalkylaminocarbonyl, arylaminocarbonyl, carboxyalkylaminocarbonyl, carboxyalkyl, aralkoxycarbonylalkylaminocarbonyl, aminocarbonylalkyl, alkoxycarbonylcyanoalkenyl and hydroxyalkyl; wherein R3 is selected from hydrido, alkyl, cyano, hydroxyalkyl, cycloalkyl, alkylsulforyl and halo; and wherein R4 is selected from aralkenyl, aryl, cycloalkyl, cycloalkenyl and heterocyclic; wherein R4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfonyl, cyano, nitro, haloalkyl, alkyl, hydroxyl, alkenyl, hydroxyalkyl, carboxy, cycloalkyl, alkylamino, dialkylamino, alkoxycarbonyl, aminocarbonyl, alkoxy, haloalkoxy, sulfamyl, heterocyclic and amino; provided R2 and R3 are not both hydrido; further provided that R2 is not carboxyl or methyl when R3 is hydrido and when R4 is phenyl; further provided that R4 is not triazolyl when R2 is methyl; further provided that R4 is not aralkenyl when R2 is carboxyl, aminocarbonyl or ethoxycarbonyl; further provided that R4 is not phenyl when R2 is methyl and R3 is carboxyl; and further provided that R4 is not unsubstituted thienyl when R2 is trifluoromethyl; or a pharmceutically-acceptable salt thereof.
摘要翻译：描述了一类吡唑基苯磺酰胺化合物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由式II定义：其中R 2选自氢化，烷基，卤代烷基，烷氧基羰基，氰基，氰基烷基，羧基，氨基羰基，烷基氨基羰基，环烷基氨基羰基，芳基氨基羰基，羧基烷基氨基羰基，羧基烷基，芳烷氧基羰基烷基氨基羰基，氨基羰基烷基，烷氧羰基氰基烯基和羟烷基其中R 3选自氢，烷基，氰基，羟基烷基，环烷基，烷基磺酰基和卤素; 其中R 4选自芳烯基，芳基，环烷基，环烯基和杂环; 其中R 4在可取代的位置任选被一个或多个选自卤素，烷硫基，烷基磺酰基，氰基，硝基，卤代烷基，烷基，羟基，烯基，羟基烷基，羧基，环烷基，烷基氨基，二烷基氨基，烷氧基羰基，氨基羰基，烷氧基，卤代烷氧基，氨磺酰基，杂环和氨基; 条件是R 2和R 3都不是氢的; 进一步提供当R 3是氢的时，当R 4是苯基时，R 2不是羧基或甲基; 进一步提供当R 2是甲基时，R 4不是三唑基; 进一步提供当R 2是羧基时，R 4不是芳烯基，氨基羰基或乙氧基羰基; 进一步提供当R 2是甲基且R 3是羧基时，R 4不是苯基; 并且进一步提供当R 2为三氟甲基时R 4为未取代的噻吩基; 或其药学上可接受的盐。

7. 发明授权

US06274590B1 Method of treating skin related conditions 失效
标题翻译：治疗皮肤相关病症的方法
公开(公告)号：US06274590B1
公开(公告)日：2001-08-14
申请号：US09661719
申请日：2000-09-14
申请人： John J. Talley , Stephen R Bertenshaw , Paul W Collins , Thomas D. Penning , David B. Reitz , Roland S Rogers
发明人： John J. Talley , Stephen R Bertenshaw , Paul W Collins , Thomas D. Penning , David B. Reitz , Roland S Rogers
IPC分类号： A61K31381
CPC分类号： C07D307/38 , A61K31/341 , A61K31/365 , C07D307/58 , C07D333/16 , C07D333/18 , C07D333/28 , C07D333/38 , C07D409/04
摘要： A class of 3,4-diaryl substituted thiophene, derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: wherein Y is S; wherein X is one or two substituents selected from hydrido, halo, lower alkoxycarbonyl and carboxyl; wherein R2 and R3 are independently aryl or heteroaryl; and wherein R2 and R3 are optionally substituted with one or more radicals selected from sulfamyl, alkylsulfonyl, halo, lower alkoxy and lower alkyl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：一类3,4-二芳基取代的噻吩，其衍生物和类似物，含有它们的药物组合物和使用它们治疗炎症和炎症相关疾病的方法。特别感兴趣的化合物由式I定义：其中Y是S; 其中X是一个或两个选自氢，卤素，低级烷氧基羰基和羧基的取代基; 其中R2和R3独立地是芳基或杂芳基; 并且其中R2和R3任选地被一个或多个选自亚磺酰基，烷基磺酰基，卤素，低级烷氧基和低级烷基的基团取代; 或其药学上可接受的盐。

8. 发明授权

US06599934B1 3,4-diaryl thiopenes and analogs thereof having use as antiinflammatory agents 失效
标题翻译：具有用作抗炎剂的3,4-二芳基呋喃及其类似物
公开(公告)号：US06599934B1
公开(公告)日：2003-07-29
申请号：US09711737
申请日：2000-11-13
申请人： John J. Talley , Stephen R Bertenshaw , Paul W Collins , Thomas D. Penning , David B. Reitz , Roland S Rogers
发明人： John J. Talley , Stephen R Bertenshaw , Paul W Collins , Thomas D. Penning , David B. Reitz , Roland S Rogers
IPC分类号： C07D30702
CPC分类号： C07D307/38 , A61K31/341 , A61K31/365 , C07D307/58 , C07D333/16 , C07D333/18 , C07D333/28 , C07D333/38 , C07D409/04
摘要： A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: wherein Y is selected from O, S and NR1; wherein R1 is selected from hydrido and lower alkyl; wherein X is one or two substituent selected from hydrido, halo, lower alkoxycarbonyl and carboxyl; wherein R2 and R3 are independently aryl or heteroaryl; and wherein R2 and R3 are optionally substituted at a substitutable position with one or more radicals selected from sulfamyl, alkylsulfonyl, halo, lower alkoxy and lower alkyl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：一类3,4-二芳基取代的噻吩，呋喃和吡咯衍生物及其类似物，含有它们的药物组合物和使用它们治疗炎症和炎症相关疾病的方法。特别感兴趣的化合物由式I定义：其中Y选自O，S和NR1; 其中R1选自氢和低级烷基; 其中X是一个或两个选自氢，卤素，低级烷氧基羰基和羧基的取代基; 其中R2和R3独立地是芳基或杂芳基; 并且其中R2和R3任选在可取代的位置被一个或多个选自磺酰胺基，烷基磺酰基，卤素，低级烷氧基和低级烷基的基团取代; 或其药学上可接受的盐。

9. 发明授权

US06492413B2 3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents 失效
标题翻译：具有用作抗炎剂的3,4-二芳基噻吩及其类似物
公开(公告)号：US06492413B2
公开(公告)日：2002-12-10
申请号：US09528934
申请日：2000-03-20
申请人： John J. Talley , Stephen R Bertenshaw , Paul W Collins , Thomas D. Penning , David B. Reitz , Roland S Rogers
发明人： John J. Talley , Stephen R Bertenshaw , Paul W Collins , Thomas D. Penning , David B. Reitz , Roland S Rogers
IPC分类号： A61K314025
CPC分类号： C07D307/38 , A61K31/341 , A61K31/365 , C07D307/58 , C07D333/16 , C07D333/18 , C07D333/28 , C07D333/38 , C07D409/04
摘要： A class of 3,4-diaryl substituted thiophene, furan and pyrrole derivatives and analogs thereof, pharmaceutical compositions containing them and methods of using them to treat inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: wherein Y is selected from O, S and NR1; wherein R1 is selected from hydrido and lower alkyl; wherein X is one or two substituent selected from hydrido, halo, lower alkoxycarbonyl and carboxyl; wherein R2 and R3 are independently aryl or heteroaryl; and wherein R2 and R3 are optionally substituted at a substitutable position with one or more radicals selected from sulfamyl, alkylsulfonyl, halo, lower alkoxy and lower alkyl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：一类3,4-二芳基取代的噻吩，呋喃和吡咯衍生物及其类似物，含有它们的药物组合物和使用它们治疗炎症和炎症相关疾病的方法。特别感兴趣的化合物由式I定义：其中Y选自O，S和NR1; 其中R1选自氢和低级烷基; 其中X是一个或两个选自氢，卤素，低级烷氧基羰基和羧基的取代基; 其中R2和R3独立地是芳基或杂芳基; 并且其中R2和R3任选在可取代的位置被一个或多个选自磺酰胺基，烷基磺酰基，卤素，低级烷氧基和低级烷基的基团取代; 或其药学上可接受的盐。

10. 发明授权

US06426360B1 4,5-substituted imidazolyl compounds for the treatment of inflammation 失效
标题翻译：用于治疗炎症的4,5-取代的咪唑基化合物
公开(公告)号：US06426360B1
公开(公告)日：2002-07-30
申请号：US09571033
申请日：2000-05-15
申请人： Richard M Weier , Paul W Collins , Michael A Stealey , Thomas E Barta , Renee M Huff
发明人： Richard M Weier , Paul W Collins , Michael A Stealey , Thomas E Barta , Renee M Huff
IPC分类号： A01N4350
CPC分类号： C07D233/64 , C07D233/84 , C07D233/88 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04
摘要： A class of compounds is described for treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula wherein R1 is selected from lower alkyl, lower haloalkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower alkenyloxyalkyl, mercapto, lower alkylcarbonyl, lower haloalkylcarbonyl, phenylcarbonyl, lower aralkylcarbonyl, lower aralkenyl, lower aryloxyalkyl, lower aralkyloxyalkyl, lower arylsulfonyl, lower aralkylsulfonyl, lower arylthioalkyl, lower heteroarylalkylthioalkyl, and heteroaryl selected from 2-thienyl, 2-furyl, 3-furyl, 2-pyridyl, 4-pyridyl and 2-benzofuryl; wherein R2 and R3 are independently selected from heteroaryl, cycloalkyl and aryl, wherein the heteroaryl, cycloalkyl and aryl radicals are substituted at a substitutable position with one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, aminosulfonyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower alkoxyalkyl, lower haloalkoxy, amino, lower alkylamino, phenylamino and nitro; and wherein R4 is selected from hydrido, lower alkyl and acyl; or a pharmaceutically-acceptable salt thereof.
摘要翻译：描述了一类化合物用于治疗炎症和炎症相关疾病。特别感兴趣的化合物由通式Ⅵ所定义：R1选自低级烷基，低级卤代烷基，低级羟烷基，低级烷氧基烷基，低级烯氧基烷基，巯基，低级烷基羰基，低级卤代烷基羰基，苯基羰基，低级芳烷基羰基，低级芳烯基，低级芳氧基烷基，低级芳烷氧基烷基，芳基磺酰基，低级芳烷基磺酰基，低级芳基硫代烷基，低级杂芳基烷硫基烷基和选自2-噻吩基，2-呋喃基，3-呋喃基，2-吡啶基，4-吡啶基和2-苯并呋喃基的杂芳基。其中R2和R3独立地选自杂芳基，环烷基和芳基，其中杂芳基，环烷基和芳基在可取代的位置被一个或多个选自氢，卤代，低级烷硫基，低级烷基亚磺酰基，低级烷基磺酰基，氨基磺酰基，低级烷基，氰基，羧基，低级烷氧基羰基，低级卤代烷基，羟基，低级烷氧基，低级羟基烷基，低级烷氧基烷基，低级卤代烷氧基，氨基，低级烷基氨基，苯基氨基和硝基。并且其中R 4选自氢，低级烷基和酰基; 或其药学上可接受的盐。

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