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1. 发明授权

US09481880B2 Methods of genome installation in a recipient host cell 有权
标题翻译：基因组安装在受体宿主细胞中的方法
公开(公告)号：US09481880B2
公开(公告)日：2016-11-01
申请号：US12598414
申请日：2008-05-01
申请人： John I. Glass , Nina Alperovich , Clyde A. Hutchison, III , Carole Lartigue , Charles E. Merryman , Sanjay Vashee , J. Craig Venter
发明人： John I. Glass , Nina Alperovich , Clyde A. Hutchison, III , Carole Lartigue , Charles E. Merryman , Sanjay Vashee , J. Craig Venter
IPC分类号： C12N15/10 , C12N15/74
CPC分类号： C12N15/10 , C12N15/1079 , C12N15/74
摘要： The presently disclosed invention relates to methods of installing a genome isolated from one species (the donor) into suitably prepared cells of a second species (the recipient). Introduction of the donor genetic material into the recipient host cell effectively converts the recipient host cell into a new cell that, as a result of the operation of the donated genetic material, is functionally classified as belonging to the genus and species of the donor genetic material.
摘要翻译：本公开的本发明涉及将从一个物种（供体）分离的基因组安装到适当制备的第二物种（受体）的细胞中的方法。将供体遗传物质引入受体宿主细胞有效地将受体宿主细胞转化为新的细胞，由于所捐赠的遗传物质的操作，功能上被归类为供体遗传物质的属和物种。

2. 发明申请

US20110045592A1 METHODS OF GENOME INSTALLATION IN A RECIPIENT HOST CELL 有权
标题翻译：在接受宿主细胞中的基因组安装方法
公开(公告)号：US20110045592A1
公开(公告)日：2011-02-24
申请号：US12598414
申请日：2008-05-01
申请人： John I. Glass , Nina Alperovich , Clyde A. Hutchison, III , Carole Lartigue , Charles E. Merryman , Sanjay Vashee , J. Craig Venter
发明人： John I. Glass , Nina Alperovich , Clyde A. Hutchison, III , Carole Lartigue , Charles E. Merryman , Sanjay Vashee , J. Craig Venter
IPC分类号： C12N15/74
CPC分类号： C12N15/10 , C12N15/1079 , C12N15/74
摘要： The presently disclosed invention relates to methods of installing a genome isolated from one species (the donor) into suitably prepared cells of a second species (the recipient). Introduction of the donor genetic material into the recipient host cell effectively converts the recipient host cell into a new cell that, as a result of the operation of the donated genetic material, is functionally classified as belonging to the genus and species of the donor genetic material.
摘要翻译：本公开的本发明涉及将从一个物种（供体）分离的基因组安装到适当制备的第二物种（受体）的细胞中的方法。将供体遗传物质引入受体宿主细胞有效地将受体宿主细胞转化为新的细胞，由于所捐赠的遗传物质的操作，功能上被归类为供体遗传物质的属和物种。

3. 发明授权

US09273310B2 Methods for cloning and manipulating genomes 有权
标题翻译：克隆和操纵基因组的方法
公开(公告)号：US09273310B2
公开(公告)日：2016-03-01
申请号：US12718911
申请日：2010-03-05
申请人： Gwynedd A. Benders , John I. Glass , Clyde A. Hutchison, III , Carole Lartigue , Sanjay Vashee , Mikkel A. Algire , Hamilton O. Smith , Charles E. Merryman , Vladimir N. Noskov , Ray-Yuan Chuang , Daniel G. Gibson , J. Craig Venter
发明人： Gwynedd A. Benders , John I. Glass , Clyde A. Hutchison, III , Carole Lartigue , Sanjay Vashee , Mikkel A. Algire , Hamilton O. Smith , Charles E. Merryman , Vladimir N. Noskov , Ray-Yuan Chuang , Daniel G. Gibson , J. Craig Venter
IPC分类号： C12N15/09 , C12N15/10
CPC分类号： C12N15/905 , C12N15/10 , C12N15/1031 , C12N15/1079 , C12N15/1093 , C12N15/81
摘要： Compositions and methods are disclosed herein for cloning a donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells.
摘要翻译：本文公开了用于在异源宿主细胞中克隆供体基因组的组合物和方法。在一个实施方案中，可以在宿主细胞内进一步修饰供体基因组。修饰或未修饰的基因组可以进一步从宿主细胞中分离并转移到受体细胞。本文公开的方法可以用于在更容易处理的宿主细胞中改变来自难治性供体细胞的供体基因组。

4. 发明申请

US20110053272A1 METHODS FOR CLONING AND MANIPULATING GENOMES 有权
标题翻译：克隆和操纵基因的方法
公开(公告)号：US20110053272A1
公开(公告)日：2011-03-03
申请号：US12718911
申请日：2010-03-05
申请人： Gwynedd A. Benders , John I. Glass , Clyde A. Hutchison, III , Carole Lartigue , Sanjay Vashee , Mikkel A. Algire , Hamilton O. Smith , Charles E. Merryman , Vladimir N. Noskov , Ray-Yuan Chuang , Daniel G. Gibson , J. Craig Venter
发明人： Gwynedd A. Benders , John I. Glass , Clyde A. Hutchison, III , Carole Lartigue , Sanjay Vashee , Mikkel A. Algire , Hamilton O. Smith , Charles E. Merryman , Vladimir N. Noskov , Ray-Yuan Chuang , Daniel G. Gibson , J. Craig Venter
IPC分类号： C12N15/74 , C12N15/82 , C12N15/85 , C12N1/21 , C12N1/15 , C12N1/19 , C12N5/10
CPC分类号： C12N15/905 , C12N15/10 , C12N15/1031 , C12N15/1079 , C12N15/1093 , C12N15/81
摘要： Compositions and methods are disclosed herein for cloning a donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells.
摘要翻译：本文公开了用于在异源宿主细胞中克隆供体基因组的组合物和方法。在一个实施方案中，可以在宿主细胞内进一步修饰供体基因组。修饰或未修饰的基因组可以进一步从宿主细胞中分离并转移到受体细胞。本文公开的方法可用于在更容易处理的宿主细胞中改变来自难治性供体细胞的供体基因组。

5. 发明授权

US09267132B2 Methods for cloning and manipulating genomes 有权
标题翻译：克隆和操纵基因组的方法
公开(公告)号：US09267132B2
公开(公告)日：2016-02-23
申请号：US12783489
申请日：2010-05-19
申请人： Gwynedd A. Benders , John I. Glass , Clyde A. Hutchison , Carole Lartigue , Sanjay Vashee , Mikkel A. Algire , Hamilton O. Smith , Charles E. Merryman , Vladimir N. Noskov , Ray-Yuan Chuang , Daniel G. Gibson , J. Craig Venter
发明人： Gwynedd A. Benders , John I. Glass , Clyde A. Hutchison , Carole Lartigue , Sanjay Vashee , Mikkel A. Algire , Hamilton O. Smith , Charles E. Merryman , Vladimir N. Noskov , Ray-Yuan Chuang , Daniel G. Gibson , J. Craig Venter
IPC分类号： C12N15/10
CPC分类号： C12N15/81 , C12N15/10 , C12N15/102 , C12N15/1031 , C12N15/1079 , C12N15/1093
摘要： Compositions and methods are disclosed herein for cloning a synthetic or a semi-synthetic donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells.
摘要翻译：本文公开了在异源宿主细胞中克隆合成或半合成供体基因组的组合物和方法。在一个实施方案中，可以在宿主细胞内进一步修饰供体基因组。修饰或未修饰的基因组可以进一步从宿主细胞中分离并转移到受体细胞。本文公开的方法可以用于在更容易处理的宿主细胞中改变来自难治性供体细胞的供体基因组。

6. 发明申请

US20110053273A1 METHODS FOR CLONING AND MANIPULATING GENOMES 有权
标题翻译：克隆和操纵基因的方法
公开(公告)号：US20110053273A1
公开(公告)日：2011-03-03
申请号：US12783489
申请日：2010-05-19
申请人： Gwynedd A. Benders , John I. Glass , Clyde A. Hutchison , Carole Lartigue , Sanjay Vashee , Mikkel A. Algire , Hamilton O. Smith , Charles E. Merryman , Vladimir N. Noskov , Ray-Yuan Chuang , Daniel G. Gibson , J. Craig Venter
发明人： Gwynedd A. Benders , John I. Glass , Clyde A. Hutchison , Carole Lartigue , Sanjay Vashee , Mikkel A. Algire , Hamilton O. Smith , Charles E. Merryman , Vladimir N. Noskov , Ray-Yuan Chuang , Daniel G. Gibson , J. Craig Venter
IPC分类号： C12N15/87 , C12N1/21
CPC分类号： C12N15/81 , C12N15/10 , C12N15/102 , C12N15/1031 , C12N15/1079 , C12N15/1093
摘要： Compositions and methods are disclosed herein for cloning a synthetic or a semi-synthetic donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells.
摘要翻译：本文公开了在异源宿主细胞中克隆合成或半合成供体基因组的组合物和方法。在一个实施方案中，可以在宿主细胞内进一步修饰供体基因组。修饰或未修饰的基因组可以进一步从宿主细胞中分离并转移到受体细胞。本文公开的方法可用于在更容易处理的宿主细胞中改变来自难治性供体细胞的供体基因组。

7. 发明授权

US09434974B2 Installation of genomes or partial genomes into cells or cell-like systems 有权
标题翻译：将基因组或部分基因组安装到细胞或细胞样系统中
公开(公告)号：US09434974B2
公开(公告)日：2016-09-06
申请号：US11644713
申请日：2006-12-22
申请人： John I. Glass , Lei Young , Carole Lartigue , Nacyra Assad-Garcia , Hamilton O. Smith , Clyde A. Hutchison , J. Craig Venter
发明人： John I. Glass , Lei Young , Carole Lartigue , Nacyra Assad-Garcia , Hamilton O. Smith , Clyde A. Hutchison , J. Craig Venter
IPC分类号： C12N15/74 , C12N15/63 , C12N15/10 , C12R1/35 , C12P21/02
CPC分类号： C12P21/02 , C12N2510/00
摘要： A method is provided for introducing a genome into a cell or cell-like system. The introduced genome may occur in nature, be manmade with or without automation, or may be a hybrid of naturally occurring and manmade materials. The genome is obtained outside of a cell with minimal damage. Materials such as a proteins, RNAs, polycations, nucleoid condensation proteins, or gene translation systems may accompany the genome. The genome is installed into a naturally occurring cell or into a manmade cell-like system. A cell-like system or synthetic cell resulting from the practice of the provided method may be designed and used to yield gene-expression products, such as desired proteins. By enabling the synthesis of cells or cell-like systems comprising a wide variety of genomes, accompanying materials and membrane types, the provided method makes possible a broader field of experimentation and bioengineering than has been available using prior art methods.
摘要翻译：提供了将基因组导入细胞或细胞样系统的方法。引入的基因组可以在自然界中发生，在有或没有自动化的情况下是人造的，或者可以是天然存在的和人造的材料的混合物。基因组以最小的损伤在细胞外获得。材料如蛋白质，RNAs，聚阳离子，核仁缩合蛋白或基因翻译系统可能伴随着基因组。将基因组安装到天然存在的细胞或人造细胞样系统中。可以设计并使用由所提供的方法的实践产生的细胞样系统或合成细胞来产生基因表达产物，例如所需的蛋白质。通过实现包含各种各样的基因组，伴随材料和膜类型的细胞或细胞样系统的合成，所提供的方法可能比使用现有技术方法可用的更广泛的实验和生物工程领域。

8. 发明申请

US20070269862A1 Installation of genomes or partial genomes into cells or cell-like systems 有权
标题翻译：将基因组或部分基因组安装到细胞或细胞样系统中
公开(公告)号：US20070269862A1
公开(公告)日：2007-11-22
申请号：US11644713
申请日：2006-12-22
申请人： John Glass , Lei Young , Carole Lartigue , Nacyra Assad-Garcia , Hamilton Smith , Clyde Hutchison , J. Venter
发明人： John Glass , Lei Young , Carole Lartigue , Nacyra Assad-Garcia , Hamilton Smith , Clyde Hutchison , J. Venter
IPC分类号： C12N15/87 , C12N5/06 , C12P21/04
CPC分类号： C12P21/02 , C12N2510/00
摘要： A method is provided for introducing a genome into a cell or cell-like system. The introduced genome may occur in nature, be manmade with or without automation, or may be a hybrid of naturally occurring and manmade materials. The genome is obtained outside of a cell with minimal damage. Materials such as a proteins, RNAs, polycations, nucleoid condensation proteins, or gene translation systems may accompany the genome. The genome is installed into a naturally occurring cell or into a manmade cell-like system. A cell-like system or synthetic cell resulting from the practice of the provided method may be designed and used to yield gene-expression products, such as desired proteins. By enabling the synthesis of cells or cell-like systems comprising a wide variety of genomes, accompanying materials and membrane types, the provided method makes possible a broader field of experimentation and bioengineering than has been available using prior art methods.
摘要翻译：提供了将基因组导入细胞或细胞样系统的方法。引入的基因组可以在自然界中发生，在有或没有自动化的情况下是人造的，或者可以是天然存在的和人造的材料的混合物。基因组以最小的损伤在细胞外获得。材料如蛋白质，RNAs，聚阳离子，核仁缩合蛋白或基因翻译系统可能伴随着基因组。将基因组安装到天然存在的细胞或人造细胞样系统中。可以设计并使用由所提供的方法的实践产生的细胞样系统或合成细胞来产生基因表达产物，例如所需的蛋白质。通过实现包含各种各样的基因组，伴随材料和膜类型的细胞或细胞样系统的合成，所提供的方法可能比使用现有技术方法可用的更广泛的实验和生物工程领域。

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