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1. 发明授权

US08486457B2 Compositions that treat or inhibit pathological conditions associated with inflammatory response 失效
标题翻译：治疗或抑制与炎症反应相关的病理状况的组合物
公开(公告)号：US08486457B2
公开(公告)日：2013-07-16
申请号：US10532388
申请日：2003-10-20
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Gary Darland , Robert Lerman , Daniel O. Lukaczer , DeAnn J. Liska , Terrence Howell
IPC分类号： A01N65/00
CPC分类号： A61K36/185 , A61K31/122 , A61K36/53 , A61K2300/00
摘要： A natural formulation of compounds that would to modulate inflammation is disclosed. The formulation would also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively in target cells. The compositions containing at least one fraction isolated or derived from hops. Other embodiments relate to combinations of components, including at least one fraction isolated or derived from hops, tryptanthrin and conjugates thereof, rosemary, an extract or compound derived from rosemary, a triterpene species, or a diterpene lactone or derivatives or conjugates thereof.
摘要翻译：公开了将调节炎症的化合物的天然制剂。该制剂还可抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并在靶细胞中选择性抑制炎症反应。所述组合物含有至少一个分离或衍生自啤酒花的级分。其它实施方案涉及组分的组合，包括至少一种分离或衍生自啤酒花的蛋白质，色胺及其缀合物，迷迭香，源自迷迭香的提取物或化合物，三萜类物质或二萜内酯或其衍生物或缀合物。

2. 发明授权

US08263139B2 Protein kinase modulation by hops and Acacia products 有权
标题翻译：蛋白激酶调制由啤酒花和相思产品
公开(公告)号：US08263139B2
公开(公告)日：2012-09-11
申请号：US11501393
申请日：2006-08-09
申请人： Matthew L. Tripp , John G. Babish , Linda M. Pacioretty , Jeffrey S. Bland , Amy J. Hall , Veera Konda , Anu Desai
发明人： Matthew L. Tripp , John G. Babish , Linda M. Pacioretty , Jeffrey S. Bland , Amy J. Hall , Veera Konda , Anu Desai
IPC分类号： A61K36/00
CPC分类号： A61K36/185 , A61K31/12 , A61K36/48 , A61K45/06 , A61K2300/00
摘要： Botanical compounds to modulate kinase activity are disclosed. The compounds and methods disclosed also inhibit expression of COX-2, inhibit synthesis of prostaglandins selectively in target cells, and inhibit inflammatory response selectively. The compositions contain at least one fraction isolated or derived from hops or Acacia.
摘要翻译：公开了调节激酶活性的植物化合物。所公开的化合物和方法还抑制COX-2的表达，在靶细胞中选择性抑制前列腺素的合成，并且选择性地抑制炎症反应。组合物含有至少一个分离或衍生自啤酒花或金合欢的馏分。

3. 发明授权

US07914831B2 Synergistic anti-inflammatory pharmaceutical compositions and related methods using curcuminoids or methylxanthines 有权
标题翻译：协同抗炎药物组合物和使用姜黄素或甲基黄嘌呤的相关方法
公开(公告)号：US07914831B2
公开(公告)日：2011-03-29
申请号：US10789817
申请日：2004-02-27
申请人： John G. Babish , Matthew L. Tripp , Jeffrey S. Bland
发明人： John G. Babish , Matthew L. Tripp , Jeffrey S. Bland
IPC分类号： A01N65/00 , A01N43/90 , A01N37/00 , A01N35/00 , A61K36/00 , A61K31/52 , A61K31/19 , A61K31/12
CPC分类号： A61K31/522 , A61K31/12 , A61K31/19 , A61K36/185 , A61K36/9066 , A61K45/06 , A61K2300/00
摘要： The invention provides compositions containing a fraction isolated or derived from hops and a methylxanthine. The invention additionally provides compositions containing a fraction derived from hops and a curcuminoid. The invention also provides methods of using such compositions to reduce inflammation.
摘要翻译：本发明提供了含有从啤酒花和甲基黄嘌呤中分离或衍生的级分的组合物。本发明另外提供了含有源自啤酒花和姜黄素的级分的组合物。本发明还提供了使用这种组合物减少炎症的方法。

4. 发明申请

US20100184857A1 ANTI-INFLAMMATORY PHARMACEUTICAL COMPOSITIONS FOR REDUCING INFLAMMATION AND THE TREATMENT OR PREVENTION OF GASTRIC TOXICITY 有权
标题翻译：用于减少炎症和治疗或预防胃肠毒性的抗炎药物组合物
公开(公告)号：US20100184857A1
公开(公告)日：2010-07-22
申请号：US12564174
申请日：2009-09-22
申请人： John G. Babish , Matthew L. Tripp , Jeffrey S. Bland , Terrence Howell , Gary K. Darland , Robert H. Lerman , Daniel O. Lukaczer
发明人： John G. Babish , Matthew L. Tripp , Jeffrey S. Bland , Terrence Howell , Gary K. Darland , Robert H. Lerman , Daniel O. Lukaczer
IPC分类号： A61K31/122 , A61K31/215
CPC分类号： A61K31/12 , A61K31/192 , A61K36/185 , A61K2300/00
摘要： The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
摘要翻译：本发明提供啤酒花（Humulus lupulus）提取物或其衍生物，其用于预防性和/或治疗性地对胃和/或肠的溃疡型障碍进行治疗。溃疡性疾病可以是化学诱导型，环境诱导型，感染诱导型和/或应激诱导型。本发明还提供了包含活力量的啤酒花提取物或其衍生物与止痛化合物和/或抗炎化合物组合的药物组合物。本发明进一步提供啤酒花提取物或其衍生物的使用，显着减少和/或治疗性地治疗胃和/或肠的溃疡形成型疾病。

5. 发明授权

US07736677B2 Xanthohumol and tetrahydro-isoalpha acid based protein kinase modulation cancer treatment 失效
标题翻译：黄酮和四氢异恶唑酸蛋白激酶调节癌症治疗
公开(公告)号：US07736677B2
公开(公告)日：2010-06-15
申请号：US11820568
申请日：2007-06-20
申请人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Amy Hall , Linda M. Pacioretty , Anu Desai
发明人： Matthew L. Tripp , John G. Babish , Jeffrey S. Bland , Veera Konda , Amy Hall , Linda M. Pacioretty , Anu Desai
IPC分类号： A01N65/00
CPC分类号： A61K31/12 , A61K31/122 , A61K36/185 , A61K36/53 , A61K2300/00
摘要： Compounds and methods for protein kinase modulation for cancer treatment are disclosed. The compounds and methods disclosed are based on xanthohumol or isoxantohumol, or tetrahydro-isoalpha acids commonly found in hops.
摘要翻译：公开了用于癌症治疗的蛋白激酶调节的化合物和方法。所公开的化合物和方法基于黄曲霉醇或异山梨醇或通常在啤酒花中发现的四氢异α-酸。

6. 发明授权

US07666449B2 Anti-inflammatory pharmaceutical compositions for reducing inflammation and the treatment or prevention of gastric toxicity 有权
标题翻译：用于减少炎症和治疗或预防胃毒性的抗炎药物组合物
公开(公告)号：US07666449B2
公开(公告)日：2010-02-23
申请号：US11355145
申请日：2006-02-15
申请人： John G. Babish , Matthew L. Tripp , Jeffrey S. Bland , Terrence Howell , Gary K. Darland , Robert H. Lerman , Daniel O. Lukaczer
发明人： John G. Babish , Matthew L. Tripp , Jeffrey S. Bland , Terrence Howell , Gary K. Darland , Robert H. Lerman , Daniel O. Lukaczer
IPC分类号： A01N65/00
CPC分类号： A61K31/12 , A61K31/192 , A61K36/185 , A61K2300/00
摘要： The invention provides hops (Humulus lupulus) extracts or derivatives thereof for use in treating a patient prophylactically and/or therapeutically for ulcerogenic-type disorders of the stomach and/or intestines. The ulcerogenic disorders can be of the type chemically induced, environmentally-induced, infection-induced, and/or stress-induced. The invention also provides a pharmaceutical composition comprising an active amount of hops extracts or derivatives thereof, in combination with an analgesic compound and/or an anti-inflammatory compound. The invention further provides for use of hops extracts or derivatives thereof, significantly reducing and/or therapeutically treating ulcerogenic-type disorders of the stomach and/or intestines.
摘要翻译：本发明提供啤酒花（Humulus lupulus）提取物或其衍生物，其用于预防性和/或治疗性地对胃和/或肠的溃疡型障碍进行治疗。溃疡性疾病可以是化学诱导型，环境诱导型，感染诱导型和/或应激诱导型。本发明还提供了包含活力量的啤酒花提取物或其衍生物与止痛化合物和/或抗炎化合物组合的药物组合物。本发明进一步提供啤酒花提取物或其衍生物的使用，显着减少和/或治疗性地治疗胃和/或肠的溃疡形成型疾病。

7. 发明申请

US20090274778A1 Compositions Exhibiting Inhibition Of Cyclooxygenase-2 审中-公开
标题翻译：组合物展示环氧合酶-2的抑制
公开(公告)号：US20090274778A1
公开(公告)日：2009-11-05
申请号：US11667614
申请日：2005-11-14
申请人： John G. Babish
发明人： John G. Babish
IPC分类号： A61K36/00 , A61K31/19 , A61K31/01 , A61P3/00
CPC分类号： A61K45/06 , A61K31/12 , A61K2300/00
摘要： The invention provides a method of treating diabetes by administering to an individual having diabetes a composition containing a hops extract. In a particular embodiment, an individual having diabetes can be administered a composition comprising a first component selected from the group consisting of alpha acids and beta acids, essential oils, fats and waxed, with the proviso that the first component and second component are not the same compound. The invention additional provides a method of treating diabetes by administering to an individual having diabetes a composition comprising a first component selected from a curcuminoid and a second component selected from an alpha acid and a beta acid.
摘要翻译：本发明提供了通过向具有糖尿病的个体施用含有啤酒花提取物的组合物来治疗糖尿病的方法。在一个具体实施方案中，可以给患有糖尿病的个体施用包含选自由α酸和β酸组成的组的第一组分，精油，脂肪和蜡状物的组合物，条件是第一组分和第二组分不是相同的化合物。本发明另外提供了一种通过向具有糖尿病的个体施用组合物来治疗糖尿病的组合物，所述组合物包含选自姜黄素和选自α酸和β酸的第二组分的第一组分。

8. 发明授权

US06733793B2 Oral composition with insulin-like activities and methods of use 失效
标题翻译：具有胰岛素样活性的口服组合物和使用方法
公开(公告)号：US06733793B2
公开(公告)日：2004-05-11
申请号：US10163254
申请日：2002-06-04
申请人： Linda M. Pacioretty , John G. Babish
发明人： Linda M. Pacioretty , John G. Babish
IPC分类号： A61K3324
CPC分类号： A61K31/28 , A23L33/10 , A23L33/16 , A23V2002/00 , A61K31/185 , A61K31/385 , A61K33/24 , Y10S514/866 , Y10S514/904 , Y10S514/905 , Y10S514/909 , A61K2300/00 , A23V2250/1636 , A23V2250/026 , A23V2250/0644 , A23V2250/1586 , A23V2250/0612
摘要： An orally administered, novel dietary supplement or therapeutic composition capable of insulin-like activity in animals, preferably humans, is provided. Contained in the composition are therapeutically effective amounts of vanadyl sulfate, alpha-lipoic acid, taurine, and chromium carnitine. The composition is preferably orally administered on a daily basis for at least about 4 weeks and can be used by normal, healthy individuals as well as diabetics.
摘要翻译：提供了一种口服给药的新型膳食补充剂或能够在动物，优选人类中具有胰岛素样活性的治疗组合物。组合物中含有治疗有效量的硫酸氧钒，α-硫辛酸，牛磺酸和铬肉碱。组合物优选每天口服给药至少约4周，并且可由正常健康个体以及糖尿病患者使用。

9. 发明授权

US06629835B2 Combinations of diterpene triepoxide lactones and ditepene lactones or triterpenes for synergistic inhibition of cyclooxygenase-2 失效
公开(公告)号：US06629835B2
公开(公告)日：2003-10-07
申请号：US09920339
申请日：2001-08-01
申请人： John G. Babish , Terrence Howell , Linda Pacioretty
发明人： John G. Babish , Terrence Howell , Linda Pacioretty
IPC分类号： A61K3578
CPC分类号： A61K31/365 , A61K47/54 , Y10S514/825 , Y10S514/885 , Y10S514/886 , A61K31/34 , A61K2300/00
摘要： A novel formulation is provided that serves to inhibit the inflammatory response in animals. The formulation comprises, as a first component an effective amount of a diterpene triepoxide lactone species and an effective amount of a second component selected from the group consisting of a diterpene lactone species and a triterpene species or derivatives thereof, and provides synergistic anti-inflammatory effects in response to physical or chemical injury or abnormal immune stimulation due to a biological agent or unknown etiology.

10. 发明授权

US5496703A Indirect immunoassay for dioxinlike compounds 失效
标题翻译：二恶英类化合物的间接免疫测定
公开(公告)号：US5496703A
公开(公告)日：1996-03-05
申请号：US132164
申请日：1993-10-05
申请人： John G. Babish , Sakina El-Tom , Xinfang Ma , Goeffrey Wheelock
发明人： John G. Babish , Sakina El-Tom , Xinfang Ma , Goeffrey Wheelock
IPC分类号： G01N33/15 , G01N33/53 , G01N33/566 , G01N33/567 , C12Q1/02
CPC分类号： G01N33/5308 , G01N33/566 , G01N33/567 , G01N2430/40 , Y10S435/97 , Y10S435/975 , Y10S436/807 , Y10S436/809
摘要： This invention relates to the determination of in vivo exposure to dioxinlike compounds and the in vitro quantitation of dioxinlike compounds based on protein tyrosine phosphorylation as mediated by the Ah receptor. The extent of protein tyrosine phosphorylation is determined by monoclonal antibodies to protein tyrosine phosphate. The amount and nature of protein tyrosylphosphate is quantitatively related to the in vivo or in vitro concentration of dioxin to which animals or cells were exposed. This method permits detection of dioxinlike compounds at concentrations in the parts per trillion and parts per billion range.
摘要翻译：本发明涉及二恶英类化合物的体内暴露的测定以及基于由Ah受体介导的蛋白质酪氨酸磷酸化的二恶英样化合物的体外定量。蛋白质酪氨酸磷酸化的程度由磷酸蛋白酪氨酸的单克隆抗体决定。蛋白酪蛋白磷酸盐的量和性质与动物或细胞暴露于二恶英的体内或体外浓度定量相关。该方法允许以每万亿分之几和十亿分之几的浓度检测二恶英类化合物。

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