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1. 发明申请

US20110086061A1 Cancer Detection Methods and Reagents 审中-公开
标题翻译：癌症检测方法和试剂
公开(公告)号：US20110086061A1
公开(公告)日：2011-04-14
申请号：US12967719
申请日：2010-12-14
申请人： John Forsyth Russell Robertson , Catherine Rosamund Louise Graves , Michael Rawling Price , Frances Margaret Price
发明人： John Forsyth Russell Robertson , Catherine Rosamund Louise Graves , Michael Rawling Price , Frances Margaret Price
IPC分类号： A61K39/00 , A61K39/12 , A61P35/00 , A61P37/04
CPC分类号： G01N33/57484
摘要： The present invention comprises methods and compositions for detecting cancer in an individual comprising autoantibodies to cancer-associated antigens. Specifically, the present invention comprises methods and compositions for detecting autoantibodies to cancer-associated antigen in a bodily fluid as well as use of said autoantibodies as a means to detect the presence of cancer-associated antigens.
摘要翻译：本发明包括用于检测个体中癌症的方法和组合物，其包括与癌症相关抗原的自身抗体。具体地，本发明包括用于检测体液中与癌症相关抗原的自身抗体以及使用所述自身抗体作为检测癌症相关抗原存在的手段的方法和组合物。

2. 发明授权

US07205117B1 Cancer detection method and reagents 有权
标题翻译：癌症检测方法和试剂
公开(公告)号：US07205117B1
公开(公告)日：2007-04-17
申请号：US09857739
申请日：2001-06-08
申请人： John Forsyth Russell Robertson , Catherine Rosemund Graves , Michael Rawling Price , Frances Margaret Price
发明人： John Forsyth Russell Robertson , Catherine Rosemund Graves , Michael Rawling Price , Frances Margaret Price
IPC分类号： G01N33/53
CPC分类号： G01N33/57484 , G01N33/564 , G01N33/574
摘要： Sensitive and specific methods are provided for use in detecting the presence of cancer marker proteins in the body fluids of a mammal. Also provided are autoantibodies for use in these methods and immortalized cells, which are a source of the autoantibodies.
摘要翻译：提供敏感和具体的方法用于检测哺乳动物体液中癌症标志物蛋白质的存在。还提供了用于这些方法的自身抗体和作为自身抗体来源的永生化细胞。

3. 发明授权

US08592169B2 Tumour marker proteins and uses thereof 有权
标题翻译：肿瘤标记蛋白及其用途
公开(公告)号：US08592169B2
公开(公告)日：2013-11-26
申请号：US10534773
申请日：2003-11-13
申请人： John Forsyth Russell Robertson , Catherine Rosamund Louise Graves
发明人： John Forsyth Russell Robertson , Catherine Rosamund Louise Graves
IPC分类号： G01N33/574
CPC分类号： G01N33/6854 , C07K1/36 , G01N33/564 , G01N33/57488 , G01N2800/24
摘要： The invention relates to tumor marker proteins and their preparation from fluids from one or more cancer patients, wherein said fluids are those which collect in a body cavity or space which is naturally occurring or which is the result of cancer or medical intervention for cancer. The invention also relates to preparation of tumor marker proteins from excretions taken from patients with cancer. The tumor marker proteins are useful as immunoassay reagents in the detection of cancer-associated anti-tumor marker autoantibodies.
摘要翻译：本发明涉及肿瘤标志物蛋白及其来自一种或多种癌症患者的流体的制备，其中所述流体是收集在天然存在的体腔或空间中的那些，或者是癌症或癌症的医学干预的结果。本发明还涉及从患有癌症的排泄物中制备肿瘤标志物蛋白质。肿瘤标记蛋白可用作检测癌症相关抗肿瘤标志物自身抗体中的免疫测定试剂。

4. 发明授权

US08722339B2 Immunoassay methods 有权
标题翻译：免疫测定方法
公开(公告)号：US08722339B2
公开(公告)日：2014-05-13
申请号：US11814516
申请日：2006-05-26
申请人： John Forsyth Russell Robertson , Anthony Barnes , Andrea Murray , Caroline Chapman
发明人： John Forsyth Russell Robertson , Anthony Barnes , Andrea Murray , Caroline Chapman
IPC分类号： G01N33/53
CPC分类号： G01N33/574 , G01N33/564 , G01N2800/102 , G01N2800/52
摘要： The invention relates to a method of detecting a disease state or disease susceptibility in a mammalian subject which comprises detecting an antibody in a test sample comprising a bodily fluid from said mammalian subject wherein said antibody is a biological marker of a disease state or disease susceptibility, the method comprising: (a) contacting said test sample with a plurality of different amounts of an antigen specific for said antibody, (b) detecting the amount of specific binding between said antibody and said antigen, (c) plotting or calculating a curve of the amount of said specific binding versus the amount of antigen for each amount of antigen used in step (a) and (d) determining the presence or absence of said disease state or disease susceptibility based upon the amount of specific binding between said antibody and said antigen at each different antigen concentration used.
摘要翻译：本发明涉及检测哺乳动物受试者的疾病状态或疾病易感性的方法，其包括检测包含来自所述哺乳动物受试者的体液的测试样品中的抗体，其中所述抗体是疾病状态或疾病易感性的生物标志物，所述方法包括：（a）使所述测试样品与多种不同量的所述抗体特异性抗原接触，（b）检测所述抗体与所述抗原之间的特异性结合量，（c）绘制或计算所述特异性结合量相对于步骤（a）和（d）中使用的每种抗原量的抗原量，基于所述抗体与所述抗体的特异性结合量，确定所述疾病状态或疾病易感性的存在或不存在抗原在各种不同抗原浓度下使用。

5. 发明申请

US20080305476A1 Immunoassay Methods 有权
标题翻译：免疫测定方法
公开(公告)号：US20080305476A1
公开(公告)日：2008-12-11
申请号：US11814516
申请日：2006-05-26
申请人： John Forsyth Russell Robertson , Anthony Barnes , Andrea Murray , Caroline Chapman
发明人： John Forsyth Russell Robertson , Anthony Barnes , Andrea Murray , Caroline Chapman
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/574 , G01N33/564 , G01N2800/102 , G01N2800/52
摘要： The invention relates to a method of detecting a disease state or disease susceptibility in a mammalian subject which comprises detecting an antibody in a test sample comprising a bodily fluid from said mammalian subject wherein said antibody is a biological marker of a disease state or disease susceptibility, the method comprising: (a) contacting said test sample with a plurality of different amounts of an antigen specific for said antibody, (b) detecting the amount of specific binding between said antibody and said antigen, (c) plotting or calculating a curve of the amount of said specific binding versus the amount of antigen for each amount of antigen used in step (a) and (d) determining the presence or absence of said disease state or disease susceptibility based upon the amount of specific binding between said antibody and said antigen at each different antigen concentration used.
摘要翻译：本发明涉及检测哺乳动物受试者的疾病状态或疾病易感性的方法，其包括检测包含来自所述哺乳动物受试者的体液的测试样品中的抗体，其中所述抗体是疾病状态或疾病易感性的生物标志物，所述方法包括：（a）使所述测试样品与多种不同量的所述抗体特异性抗原接触，（b）检测所述抗体与所述抗原之间的特异性结合量，（c）绘制或计算所述特异性结合量相对于步骤（a）和（d）中使用的每种抗原量的抗原量，基于所述抗体与所述抗体的特异性结合量，确定所述疾病状态或疾病易感性的存在或不存在抗原在各种不同抗原浓度下使用。

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