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1. 发明授权

US06426313B2 Polymeric supported catalysts for olefin polymerization 有权
标题翻译：用于烯烃聚合的聚合载体催化剂
公开(公告)号：US06426313B2
公开(公告)日：2002-07-30
申请号：US09277339
申请日：1999-03-26
申请人： John F. Walzer, Jr. , Anthony J. Dias , Jean M J Frechet , Stephen B. Roscoe
发明人： John F. Walzer, Jr. , Anthony J. Dias , Jean M J Frechet , Stephen B. Roscoe
IPC分类号： B01J3100
CPC分类号： C08F10/00 , C08F4/65908 , C08F4/65912 , C08F4/65927 , C08F4/65916
摘要： The described invention provides a low fouling, high particle density polymerization process and an olefin polymerization cocatalyst activator composition comprising a cross-linked polymer bead having a surface area of from about 1 to 20 m2/g to which are bound a plurality of non-coordinating anions, where the polymeric support comprises ligands covalently bound to the central metal or metalloid atoms of said anions, and an effective number of cationic species to achieve a balanced charge. The invention also provides an olefin polymerization catalyst compositions comprising the reaction product of a) the foregoing cocatalyst activator, and b) an organometallic transition metal compound having ancillary ligands, at least one labile ligand capable of abstraction by protonation and at least one labile ligand into which an olefinic monomer can insert for polymerization. In a preferred embodiment, the polymeric support has a surface area of ≦10 m2/g and is particularly suitable for use with high activity organometallic, transition metal catalyst compounds.
摘要翻译：所述发明提供低结垢，高密度聚合方法和烯烃聚合助催化剂活化剂组合物，其包含表面积为约1至20m 2 / g的交联聚合物珠粒，其结合了多个非配位的阴离子，其中聚合物载体包含与所述阴离子的中心金属或准金属原子共价结合的配体和有效数量的阳离子物质以实现平衡电荷。本发明还提供了一种烯烃聚合催化剂组合物，其包含a）前述助催化剂活化剂的反应产物，和b）具有辅助配体的有机金属过渡金属化合物，至少一个能够通过质子化引发抽出的不稳定配体和至少一种不稳定配体，烯烃单体可以插入聚合。在优选的实施方案中，聚合物载体的表面积为= 10m 2 / g，特别适用于高活性有机金属过渡金属催化剂化合物。

2. 发明授权

US6100214A Polymeric supported catalysts for olefin polymerization 失效
标题翻译：用于烯烃聚合的聚合载体催化剂
公开(公告)号：US6100214A
公开(公告)日：2000-08-08
申请号：US092752
申请日：1998-06-05
申请人： John F. Walzer, Jr. , Anthony J. Dias , Jean M J Frechet , Stephen B. Roscoe
发明人： John F. Walzer, Jr. , Anthony J. Dias , Jean M J Frechet , Stephen B. Roscoe
IPC分类号： C08F4/02 , C08F4/619 , C08F4/6192 , C08F4/64 , C08F4/642 , C08F4/643 , C08F4/659 , C08F4/6592 , C08F10/00 , C08F210/16 , B01J31/00 , B01J37/00 , C08F4/44 , C08F4/60
CPC分类号： C08F10/00 , C08F210/16 , C08F4/61908 , C08F4/6192 , C08F4/65908 , C08F4/65922 , Y10S526/943
摘要： The described invention provides a low fouling, high particle density polymerization process and an olefin polymerization catalyst composition comprising the reaction product of a) an organic polymeric support i) having a surface area of from about 1 to 10 m.sup.2 /g and ii) functionalized with an acidic proton-containing ammonium salt of a non-coordinating anion, and b) an organometallic transition metal compound having ancillary ligands, at least one labile ligand capable of abstraction by protonation by said ammonium salt and at least one labile ligand into which an olefinic monomer can insert for polymerization. In a preferred embodiment, the polymeric support has a surface area of .ltoreq.10 m.sup.2 /g and is particularly suitable for use with high activity organometallic, transition metal catalyst compounds.
摘要翻译：所述发明提供低结垢，高颗粒密度聚合方法和烯烃聚合催化剂组合物，其包含a）有机聚合物载体i）的反应产物，其表面积为约1-10m 2 / g，和ii）用非配位阴离子的含酸性质子的铵盐，以及b）具有辅助配体的有机金属过渡金属化合物，至少一个能够被所述铵盐质子化而被抽出的不稳定配体和至少一个不稳定的配体，烯属单体可插入聚合。在优选的实施方案中，聚合物载体的表面积为= 10m 2 / g，特别适用于高活性有机金属过渡金属催化剂化合物。

3. 发明申请

US20120301911A1 Rapid Detection of Molds that Produce Glucose Oxidase 有权
标题翻译：快速检测产生葡萄糖氧化酶的模具
公开(公告)号：US20120301911A1
公开(公告)日：2012-11-29
申请号：US13515856
申请日：2010-12-21
申请人： Stephen B. Roscoe , Michael J. Svarovsky , Stephanie J. Moeller
发明人： Stephen B. Roscoe , Michael J. Svarovsky , Stephanie J. Moeller
IPC分类号： G01N21/78
CPC分类号： C12Q1/04 , C12Q1/045 , C12Q1/26 , C12Q1/54
摘要： Methods and kits are disclosed for detecting microorganisms that produce glucose oxidase. The method includes providing a culture medium and a hydrogen peroxide indicating reagent comprising a chromogenic substrate that can provide a detectable chromogenic reaction indicating the presence of a microorganism that produces glucose oxidase, and additional methods are disclosed for differentiating microorganisms by the detection of an additional chromogenic reaction.
摘要翻译：公开了用于检测产生葡萄糖氧化酶的微生物的方法和试剂盒。该方法包括提供培养基和过氧化氢指示试剂，其包含可产生可产生葡萄糖氧化酶的微生物存在的可检测的生色反应的显色底物，并且公开了用于通过检测另外的显色性来分化微生物的另外的方法反应。

4. 发明授权

US07294742B2 Ring-opened azlactone initiators for atom transfer radical polymerization 有权
标题翻译：用于原子转移自由基聚合的开环吖内酯引发剂
公开(公告)号：US07294742B2
公开(公告)日：2007-11-13
申请号：US11081218
申请日：2005-03-16
申请人： Duane D. Fansler , Kevin M. Lewandowski , Babu N. Gaddam , Steven M. Heilmann , Larry R. Krepski , Stephen B. Roscoe , Michael S. Wendland
发明人： Duane D. Fansler , Kevin M. Lewandowski , Babu N. Gaddam , Steven M. Heilmann , Larry R. Krepski , Stephen B. Roscoe , Michael S. Wendland
IPC分类号： C07C229/20 , C07F4/00
CPC分类号： C08F2/38 , C08F4/00 , C08F4/04 , C08F4/40 , C08F220/14 , C08F265/04 , C08F291/00 , C08F293/005
摘要： Initiators for atom transfer radical polymerizations are described. The initiators have an azlactone or ring-opened azlactone moiety to provide telechelic (co)polymers.
摘要翻译：描述了原子转移自由基聚合的引发剂。引发剂具有吖内酯或开环的吖内酯部分以提供遥爪（共）聚合物。

5. 发明授权

US06245700B1 Transparent microspheres 有权
标题翻译：透明微球
公开(公告)号：US06245700B1
公开(公告)日：2001-06-12
申请号：US09362323
申请日：1999-07-27
申请人： Kenton D. Budd , Toshihiro Kasai , Stephen B. Roscoe , Chikafumi Yokoyama , John E. Bailey
发明人： Kenton D. Budd , Toshihiro Kasai , Stephen B. Roscoe , Chikafumi Yokoyama , John E. Bailey
IPC分类号： C03C1202
CPC分类号： C03C12/02 , C03C1/00 , C03C3/062 , Y10S977/775 , Y10S977/776 , Y10T428/2982
摘要： Transparent solid microspheres that contain titania plus alumina, zirconia, and/or silica in a total content of at least about 75% by weight, based on the total weight of the solid microspheres, wherein the total content of alumina, zirconia, and titania is greater than the content of silica.
摘要翻译：基于固体微球的总重量，含有总重量至少约75重量％的二氧化钛加氧化铝，氧化锆和/或二氧化硅的透明固体微球，其中氧化铝，氧化锆和二氧化钛的总含量为大于二氧化硅的含量。

6. 发明授权

US09096883B2 Microbiological systems and methods of fluid sample analysis 有权
标题翻译：微生物系统和流体样品分析方法
公开(公告)号：US09096883B2
公开(公告)日：2015-08-04
申请号：US12808317
申请日：2008-12-18
申请人： Stephen B. Roscoe , Manjiri T. Kshirsagar , Cynthia D. Zook
发明人： Stephen B. Roscoe , Manjiri T. Kshirsagar , Cynthia D. Zook
IPC分类号： C12Q1/24 , C12Q1/04
CPC分类号： C12Q1/10 , C12M25/06 , C12M41/36 , C12Q1/04 , C12Q1/06 , C12Q1/24 , G01N2333/245 , Y02A50/54
摘要： Methods and systems for detecting the presence of a target microorganism in a liquid sample are provided. Methods comprise the steps of passing the liquid sample through a surface filter, placing the surface filter into contact with a culture device, incubating the culture device for a period of time and detecting the presence of a target microorganism. Methods may be used with an automated detection system.
摘要翻译：提供了用于检测液体样品中目标微生物的存在的方法和系统。方法包括使液体样品通过表面过滤器，使表面过滤器与培养装置接触，培养培养装置一段时间并检测目标微生物的存在的步骤。方法可以与自动检测系统一起使用。

7. 发明申请

US20130230876A1 METHODS AND COMPOSITIONS TO DETECT A BIOLOGICAL ACTIVITY 有权
标题翻译：检测生物活性的方法和组合物
公开(公告)号：US20130230876A1
公开(公告)日：2013-09-05
申请号：US13883620
申请日：2011-10-28
申请人： Stephen B. Roscoe , Kurt J. Halverson , Jesse D. Miller , Stephanie J. Moeller , Jason W. Bjork
发明人： Stephen B. Roscoe , Kurt J. Halverson , Jesse D. Miller , Stephanie J. Moeller , Jason W. Bjork
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , C12Q1/04
摘要： Compositions that comprise water, a first indicator reagent that can be converted by a first biological activity to a first biological derivative, and a plurality of particles are provided. The first indicator reagent can comprise a fluorogenic enzyme substrate having a fluorophore selected from the group consisting of umbelliferone, 7-aminocoumarin, β-naphthylamine, β-naphthol, fluorescein, resorufin, 9H-(1,3-dichloro-9,9-dimethyl acridin-2-one), rhodamine 110, a derivative of any of the foregoing fluorophores, and a combination of any of the foregoing fluorophores. The particles are capable of receiving and retaining the first biological derivative from an aqueous liquid. The first biological derivative can be indicative of a microorganism. The compositions further can comprise a gelling agent. Methods of using the compositions to detect the presence or absence of a microorganism in a sample are also provided.
摘要翻译：提供了包含水，可以通过第一生物活性转化为第一生物衍生物的第一指示剂试剂和多个颗粒的组合物。第一指示剂可以包括具有选自伞形酮，7-氨基香豆素，β-萘胺，β-萘酚，荧光素，再次吸收的9H-（1,3-二氯-9,9-四氢 - 二甲基吖啶-2-酮），罗丹明110，任何前述荧光团的衍生物，以及任何上述荧光团的组合。颗粒能够从水性液体中接收和保留第一生物衍生物。第一种生物衍生物可以指示微生物。组合物还可以包含胶凝剂。还提供了使用组合物来检测样品中微生物的存在或不存在的方法。

8. 发明申请

US20100151553A1 METHOD OF DETECTION OF BIOANALYTES BY ACOUSTO-MECHANICAL DETECTION SYSTEMS COMPRISING THE ADDITION OF LIPOSOMES 审中-公开
标题翻译：通过包含脂质体添加剂的机械检测系统检测生物质的方法
公开(公告)号：US20100151553A1
公开(公告)日：2010-06-17
申请号：US12521611
申请日：2007-12-28
申请人： Jason W. Bjork , Samuel J. Gason , Michael C. Palazzotto , Stephen B. Roscoe
发明人： Jason W. Bjork , Samuel J. Gason , Michael C. Palazzotto , Stephen B. Roscoe
IPC分类号： C12N13/00
CPC分类号： G01N33/54373 , G01N29/022 , G01N29/30 , G01N2291/0255 , G01N2291/0256 , G01N2291/0422 , G01N2291/0423
摘要： Methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g., a surface acoustic wave sensor such as, e.g., a shear horizontal surface acoustic wave sensor (e.g., a LSH-SAW sensor). The detection of the target biological analytes in sample material are enhanced by contacting the target biological analyte and/or the sensor surface with liposomes that amplify the sensor sensitivity by (1) modifying the rheological properties of the fluid near the sensor surface; (2) changing the mass attached to the surface; and/or (3) modifying the dielectric properties of the fluid near the sensor surface, the sensor surface itself and/or any intervening layers on the sensor surface.
摘要翻译：公开了使用由传感器产生的声 - 机械能来检测样品材料内的目标生物分析物的方法。声机械能可以使用诸如例如剪切水平声表面波传感器（例如LSH-SAW传感器）的表面声波传感器的声 - 机械传感器来提供。通过使目标生物分析物和/或传感器表面与通过（1）修改传感器表面附近的流体的流变特性来扩大传感器灵敏度的脂质体接触来增强样品材料中目标生物分析物的检测; （2）改变附着在表面上的质量; 和/或（3）修改传感器表面附近的流体的介电特性，传感器表面本身和/或传感器表面上的任何中间层。

9. 发明授权

US07687176B2 Fuel cell 有权
标题翻译：燃料电池
公开(公告)号：US07687176B2
公开(公告)日：2010-03-30
申请号：US11008826
申请日：2004-12-10
申请人： Stephen B. Roscoe , Neal A. Rakow , Radoslav Atanasoski , Eric R. Jackson , John H. Thomas, III , Lester H. McIntosh, III
发明人： Stephen B. Roscoe , Neal A. Rakow , Radoslav Atanasoski , Eric R. Jackson , John H. Thomas, III , Lester H. McIntosh, III
IPC分类号： H01M2/02 , H01M8/00 , H01M4/00
CPC分类号： H01M8/0247 , H01M8/023 , H01M8/04007 , H01M8/0432 , H01M8/04559 , H01M8/04589 , H01M8/04619 , H01M8/1007 , H01M8/241
摘要： A fuel cell comprising a membrane electrode assembly, and an IR transmissive window for thermographic analysis of a surface of the membrane electrode assembly is described. The test fuel cell provides a method of monitoring a fuel cell, and capturing a thermographic profile of said fuel cell with an IR detector array, while simultaneously measuring the electrochemical output of the cell, including current, voltages and half cell potentials.
摘要翻译：描述了包括膜电极组件和用于热电影分析膜片电极组件的表面的IR透射窗的燃料电池。测试燃料电池提供监测燃料电池的方法，以及用IR检测器阵列捕获所述燃料电池的热成像图，同时测量电池的电化学输出，包括电流，电压和半电池电位。

10. 发明授权

US07635452B2 System, kit, and method for measuring membrane diffusion 失效
标题翻译：用于测量膜扩散的系统，试剂盒和方法
公开(公告)号：US07635452B2
公开(公告)日：2009-12-22
申请号：US10669276
申请日：2003-09-24
申请人： Stephen B. Roscoe , Neal A. Rakow , Michael L. Husberg , Lester H. McIntosh, III
发明人： Stephen B. Roscoe , Neal A. Rakow , Michael L. Husberg , Lester H. McIntosh, III
IPC分类号： G01N33/00
CPC分类号： B01L3/5025 , G01N13/00 , G01N33/15 , G01N2013/003 , G01N2015/086
摘要： A system for measuring diffusion of a compound across a membrane generally comprises a membrane held between a first base having a plurality of outwardly extending hollow projections and a second base fastened to the first base and having a plurality of recessed tapered openings therein adapted to engage the plurality of hollow projections. Methods for measuring membrane diffusion using such systems are included. The system components are also provided in kit form.
摘要翻译：用于测量化合物穿过膜的扩散的系统通常包括保持在具有多个向外延伸的中空突出部的第一基座和固定到第一基座的第二基座之间并具有多个凹入的锥形开口的膜，其中适于接合多个中空突起。包括使用这种系统测量膜扩散的方法。系统组件也以套件形式提供。

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