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1. 发明授权

US08920402B2 Thrombectomy and soft debris removal device 有权
标题翻译：血栓切除术和软切除装置
公开(公告)号：US08920402B2
公开(公告)日：2014-12-30
申请号：US11871908
申请日：2007-10-12
申请人： John E. Nash , Greg Walters , Dennis M. Sauro , Mark Eberhardt , William T. Fisher , Douglas G. Evans
发明人： John E. Nash , Greg Walters , Dennis M. Sauro , Mark Eberhardt , William T. Fisher , Douglas G. Evans
IPC分类号： A61M25/00 , A61B17/3207
CPC分类号： A61B17/320758 , A61B17/320783 , A61B2017/00685 , A61B2017/320733 , A61B2017/320741 , A61B2017/320766 , A61B2217/005
摘要： A device suitable for removing material from a living being is provided, featuring at least an aspiration pump, powered by a motor. The aspiration pump and any optional infusate pump preferably feature a helical pumping mechanism, and operate at a high rate of rotation, thereby ensuring adequate pumping performance and flexibility. The helical pumping mechanism may be a helical coiled wire about a central core tube. The helical coil wire, whether together with, or independent of, the core tube, may be rotated to cause a pumping action. Additionally, a narrow crossing profile is maintained, ensuring that the device may reach more tortuous regions of the vasculature. In one embodiment, the system comprises a wire-guided mono-rail catheter with a working head mounted on a flexible portion of the catheter that can laterally displace away from the guide wire to facilitate thrombus removal. The working head may be operated to separate and move away from the guide wire to come within a closer proximity of the obstructive material to more effectively remove it from the vessel.
摘要翻译：提供一种适用于从活体中去除材料的装置，其特征在于至少一个由马达驱动的抽吸泵。抽吸泵和任何可选的输注泵优选地具有螺旋泵送机构，并且以高转速进行操作，从而确保了足够的泵送性能和灵活性。螺旋泵送机构可以是围绕中心芯管的螺旋卷绕的线。螺旋线圈线，无论是与芯管一起，还是独立于芯管，可以旋转以引起泵送动作。另外，保持狭窄的横截面，确保装置可能达到脉管系统的更曲折的区域。在一个实施例中，系统包括导线单轨导管，其具有安装在导管的柔性部分上的工作头，所述工作头能横向移位远离引导线以促进血栓移除。工作头可以被操作以分离并远离引导线进入更靠近阻塞物质的位置，以更有效地将其从容器中移出。

2. 发明授权

US07976528B2 Thrombectomy and soft debris removal device 有权
标题翻译：血栓切除术和软切除装置
公开(公告)号：US07976528B2
公开(公告)日：2011-07-12
申请号：US12705332
申请日：2010-02-12
申请人： John E. Nash , Greg Walters , Dennis M. Sauro , Mark Eberhart , William T. Fisher , Douglas G. Evans
发明人： John E. Nash , Greg Walters , Dennis M. Sauro , Mark Eberhart , William T. Fisher , Douglas G. Evans
IPC分类号： A61M31/00 , A61M25/00
CPC分类号： A61B17/32037 , A61B17/320783 , A61B2017/00685 , A61B2017/22039 , A61B2017/22067 , A61B2017/22084 , A61M1/0058 , A61M1/0066 , A61M1/101 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0082 , A61M25/10 , A61M2025/0177 , A61M2025/0183 , A61M2025/1052
摘要： A device suitable for removing material from a living being is provided, featuring an infusate pump, and an aspiration pump, both powered by a motor. The aspiration pump and infusate pump preferably feature a helical pumping mechanism, and operate at a high rate of rotation, thereby ensuring adequate pumping performance and flexibility. Additionally, a narrow crossing profile is maintained, ensuring that the device may reach more tortuous regions of the vasculature. In one embodiment, the system comprises a wire-guided mono-rail catheter with a working head mounted on a flexible portion of the catheter that can laterally displace away from the guide wire to facilitate thrombus removal. The working head may be operated to separate and move away from the guide wire to come within a closer proximity of the obstructive material to more effectively remove it from the vessel.
摘要翻译：提供了一种适用于从活体中去除材料的装置，其特征在于具有输注泵和吸引泵，两者都由马达驱动。抽吸泵和输注泵优选地具有螺旋泵送机构，并且以高转速进行操作，从而确保足够的泵送性能和柔性。另外，保持狭窄的横截面，确保装置可能达到脉管系统的更曲折的区域。在一个实施例中，系统包括导线单轨导管，其具有安装在导管的柔性部分上的工作头，所述工作头可横向移位远离导丝以促进血栓移除。工作头可以被操作以分离并远离引导线进入更靠近阻塞物质的位置，以更有效地将其从容器中移出。

3. 发明申请

US20100145259A1 THROMBECTOMY AND SOFT DEBRIS REMOVAL DEVICE 有权
标题翻译：镜像和软件去除设备
公开(公告)号：US20100145259A1
公开(公告)日：2010-06-10
申请号：US12705332
申请日：2010-02-12
申请人： John E. Nash , Greg Walters , Dennis M. Sauro , Mark Eberhart , William T. Fisher , Douglas G. Evans
发明人： John E. Nash , Greg Walters , Dennis M. Sauro , Mark Eberhart , William T. Fisher , Douglas G. Evans
IPC分类号： A61B17/22
CPC分类号： A61B17/32037 , A61B17/320783 , A61B2017/00685 , A61B2017/22039 , A61B2017/22067 , A61B2017/22084 , A61M1/0058 , A61M1/0066 , A61M1/101 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0082 , A61M25/10 , A61M2025/0177 , A61M2025/0183 , A61M2025/1052
摘要： A device suitable for removing material from a living being is provided, featuring an infusate pump, and an aspiration pump, both powered by a motor. The aspiration pump and infusate pump preferably feature a helical pumping mechanism, and operate at a high rate of rotation, thereby ensuring adequate pumping performance and flexibility. Additionally, a narrow crossing profile is maintained, ensuring that the device may reach more tortuous regions of the vasculature. In one embodiment, the system comprises a wire-guided mono-rail catheter with a working head mounted on a flexible portion of the catheter that can laterally displace away from the guide wire to facilitate thrombus removal. The working head may be operated to separate and move away from the guide wire to come within a closer proximity of the obstructive material to more effectively remove it from the vessel.
摘要翻译：提供了一种适用于从活体中去除材料的装置，其特征在于具有输注泵和吸引泵，两者都由马达驱动。抽吸泵和输注泵优选地具有螺旋泵送机构，并且以高转速进行操作，从而确保足够的泵送性能和柔性。另外，保持狭窄的横截面，确保装置可能达到脉管系统的更曲折的区域。在一个实施例中，系统包括导线单轨导管，其具有安装在导管的柔性部分上的工作头，所述工作头可横向移位远离导丝以促进血栓移除。工作头可以被操作以分离并远离引导线进入更靠近阻塞物质的位置，以更有效地将其从容器中移出。

4. 发明授权

US07666161B2 Thrombectomy and soft debris removal device 有权
标题翻译：血栓切除术和软切除装置
公开(公告)号：US07666161B2
公开(公告)日：2010-02-23
申请号：US11751443
申请日：2007-05-21
申请人： John E. Nash , Greg Walters , Dennis M. Sauro , Mark Eberhart , William T. Fisher , Douglas G. Evans
发明人： John E. Nash , Greg Walters , Dennis M. Sauro , Mark Eberhart , William T. Fisher , Douglas G. Evans
IPC分类号： A61B17/20 , A61B17/22 , A61M25/00
CPC分类号： A61B17/32037 , A61B17/320783 , A61B2017/00685 , A61B2017/22039 , A61B2017/22067 , A61B2017/22084 , A61M1/0058 , A61M1/0066 , A61M1/101 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0082 , A61M25/10 , A61M2025/0177 , A61M2025/0183 , A61M2025/1052
摘要： A device suitable for removing material from a living being is provided, featuring an infusate pump, and an aspiration pump, both powered by a motor. The aspiration pump and infusate pump preferably feature a helical pumping mechanism, and operate at a high rate of rotation, thereby ensuring adequate pumping performance and flexibility. Additionally, a narrow crossing profile is maintained, ensuring that the device may reach more tortuous regions of the vasculature. In one embodiment, the system comprises a wire-guided mono-rail catheter with a working head mounted on a flexible portion of the catheter that can laterally displace away from the guide wire to facilitate thrombus removal. The working head may be operated to separate and move away from the guide wire to come within a closer proximity of the obstructive material to more effectively remove it from the vessel.
摘要翻译：提供了一种适用于从活体中去除材料的装置，其特征在于具有输注泵和吸引泵，两者都由马达驱动。抽吸泵和输注泵优选地具有螺旋泵送机构，并且以高转速进行操作，从而确保足够的泵送性能和柔性。另外，保持狭窄的横截面，确保装置可能达到脉管系统的更曲折的区域。在一个实施例中，系统包括导线单轨导管，其具有安装在导管的柔性部分上的工作头，所述工作头可横向移位远离导丝以促进血栓移除。工作头可以被操作以分离并远离引导线进入更靠近阻塞物质的位置，以更有效地将其从容器中移出。

5. 发明申请

US20080097298A1 Catheter for conducting a procedure within a lumen, duct or organ of a living being 失效
标题翻译：导管用于在内腔，导管或器官内进行手术
公开(公告)号：US20080097298A1
公开(公告)日：2008-04-24
申请号：US11465767
申请日：2006-08-18
申请人： William T. Fisher , David E. Yaeger , John E. Nash , Douglas G. Evans
发明人： William T. Fisher , David E. Yaeger , John E. Nash , Douglas G. Evans
IPC分类号： A61M25/08 , A61M25/00
CPC分类号： A61M25/0147 , A61B17/320758 , A61B2017/00367 , A61B2017/22038 , A61M25/005 , A61M25/0069 , A61M25/0082 , A61M25/0138 , A61M2025/0183
摘要： In an embodiment, the invention provides a catheter suitable for use in performing a procedure within a vessel, lumen or organ of a living having a distal end which is steerable, such as upon the application of compression. The catheter may be of the over the wire type, or alternatively may be a rapid exchange catheter. The catheter may provide for a rotating element which may be used to open a clogged vessel, or alternatively to provide information about adjacent tissues, such as may be generated by imaging or guiding arrangements using tissue detection systems known in the art, e.g., ultrasound, optical coherence reflectometry, etc. For rapid exchange catheters having a rotating element, there is provided an offset drive assembly to allow the rotary force to be directed from alongside the guidewire to a location coaxial to and over the guidewire.
摘要翻译：在一个实施方案中，本发明提供了一种适用于在具有可转向的远端（例如在施加压缩）的血管，内腔或器官内进行手术的导管。导管可以是导线类型，或者可以是快速交换导管。导管可以提供可用于打开堵塞的容器的旋转元件，或者替代地提供关于相邻组织的信息，例如可以通过使用本领域已知的组织检测系统的成像或引导装置来产生，例如超声波，光学相干反射测量法等。对于具有旋转元件的快速交换导管，设置有偏移驱动组件，以允许旋转力从导丝线旁边引导到与导线同轴并位于导线上方的位置。

6. 发明申请

US20130244856A1 Centrifuge 有权
公开(公告)号：US20130244856A1
公开(公告)日：2013-09-19
申请号：US13766528
申请日：2013-02-13
申请人： John E. Nash , William T. Fisher , Douglas G. Evans
发明人： John E. Nash , William T. Fisher , Douglas G. Evans
IPC分类号： B04B1/18
CPC分类号： B04B11/04 , A61M1/3693 , A61M1/3696 , B01D21/262 , B01D21/34 , B01D2221/10 , B04B1/02 , B04B1/14 , B04B1/18 , B04B5/0407 , B04B5/0442 , B04B7/08 , B04B2005/0485
摘要： Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.

7. 发明授权

US07674253B2 Catheter for conducting a procedure within a lumen, duct or organ of a living being 失效
公开(公告)号：US07674253B2
公开(公告)日：2010-03-09
申请号：US11465767
申请日：2006-08-18
申请人： William T. Fisher , David E. Yaeger , John E. Nash , Douglas G. Evans
发明人： William T. Fisher , David E. Yaeger , John E. Nash , Douglas G. Evans
IPC分类号： A61M25/00
CPC分类号： A61M25/0147 , A61B17/320758 , A61B2017/00367 , A61B2017/22038 , A61M25/005 , A61M25/0069 , A61M25/0082 , A61M25/0138 , A61M2025/0183
摘要： In an embodiment, the invention provides a catheter suitable for use in performing a procedure within a vessel, lumen or organ of a living having a distal end which is steerable, such as upon the application of compression. The catheter may be of the over the wire type, or alternatively may be a rapid exchange catheter. The catheter may provide for a rotating element which may be used to open a clogged vessel, or alternatively to provide information about adjacent tissues, such as may be generated by imaging or guiding arrangements using tissue detection systems known in the art, e.g., ultrasound, optical coherence reflectometry, etc. For rapid exchange catheters having a rotating element, there is provided an offset drive assembly to allow the rotary force to be directed from alongside the guidewire to a location coaxial to and over the guidewire.

8. 发明授权

US08721626B2 Catheter for conducting a procedure within a lumen, duct or organ of a living being 失效
标题翻译：导管用于在内腔，导管或器官内进行手术
公开(公告)号：US08721626B2
公开(公告)日：2014-05-13
申请号：US12719768
申请日：2010-03-08
申请人： William T. Fisher , David E. Yaeger , John E. Nash , Douglas G. Evans
发明人： William T. Fisher , David E. Yaeger , John E. Nash , Douglas G. Evans
IPC分类号： A61M25/00
CPC分类号： A61M25/0147 , A61B17/320758 , A61B2017/00367 , A61B2017/22038 , A61M25/005 , A61M25/0069 , A61M25/0082 , A61M25/0138 , A61M2025/0183
摘要： In an embodiment, the invention provides a catheter suitable for use in performing a procedure within a vessel, lumen or organ of a living having a distal end which is steerable, such as upon the application of compression. The catheter may be of the over the wire type, or alternatively may be a rapid exchange catheter. The catheter may provide for a rotating element which may be used to open a clogged vessel, or alternatively to provide information about adjacent tissues, such as may be generated by imaging or guiding arrangements using tissue detection systems known in the art, e.g., ultrasound, optical coherence reflectometry, etc. For rapid exchange catheters having a rotating element, there is provided an offset drive assembly to allow the rotary force to be directed from alongside the guidewire to a location coaxial to and over the guidewire.
摘要翻译：在一个实施方案中，本发明提供了一种适用于在具有可转向的远端（例如在施加压缩）的血管，内腔或器官内进行手术的导管。导管可以是导线类型，或者可以是快速交换导管。导管可以提供可用于打开堵塞的容器的旋转元件，或者替代地提供关于相邻组织的信息，例如可以通过使用本领域已知的组织检测系统的成像或引导装置来产生，例如超声波，光学相干反射测量法等。对于具有旋转元件的快速交换导管，设置有偏移驱动组件，以允许旋转力从导丝线旁边引导到与导线同轴并位于导线上方的位置。

9. 发明申请

US20100228152A1 Catheter for conducting a procedure within a lumen, duct or organ of a living being 失效
标题翻译：导管用于在内腔，导管或器官内进行手术
公开(公告)号：US20100228152A1
公开(公告)日：2010-09-09
申请号：US12719768
申请日：2010-03-08
申请人： William T. FISHER , David E. Yaeger , John E. Nash , Douglas G. Evans
发明人： William T. FISHER , David E. Yaeger , John E. Nash , Douglas G. Evans
IPC分类号： A61M25/09 , A61M25/00
CPC分类号： A61M25/0147 , A61B17/320758 , A61B2017/00367 , A61B2017/22038 , A61M25/005 , A61M25/0069 , A61M25/0082 , A61M25/0138 , A61M2025/0183
摘要： In an embodiment, the invention provides a catheter suitable for use in performing a procedure within a vessel, lumen or organ of a living having a distal end which is steerable, such as upon the application of compression. The catheter may be of the over the wire type, or alternatively may be a rapid exchange catheter. The catheter may provide for a rotating element which may be used to open a clogged vessel, or alternatively to provide information about adjacent tissues, such as may be generated by imaging or guiding arrangements using tissue detection systems known in the art, e.g., ultrasound, optical coherence reflectometry, etc. For rapid exchange catheters having a rotating element, there is provided an offset drive assembly to allow the rotary force to be directed from alongside the guidewire to a location coaxial to and over the guidewire.
摘要翻译：在一个实施方案中，本发明提供了一种适用于在具有可转向的远端（例如在施加压缩）的血管，内腔或器官内进行手术的导管。导管可以是导线类型，或者可以是快速交换导管。导管可以提供可用于打开堵塞的容器的旋转元件，或者替代地提供关于相邻组织的信息，例如可以通过使用本领域已知的组织检测系统的成像或引导装置来产生，例如超声波，光学相干反射测量法等。对于具有旋转元件的快速交换导管，设置有偏移驱动组件，以允许旋转力从导丝线旁边引导到与导线同轴并位于导线上方的位置。

10. 发明申请

US20090234327A1 Transmyocardial revascularization system and method of use 审中-公开
标题翻译：心肌血运重建系统及其使用方法
公开(公告)号：US20090234327A1
公开(公告)日：2009-09-17
申请号：US12321132
申请日：2009-01-14
申请人： Douglas G. Evans , John E. Nash
发明人： Douglas G. Evans , John E. Nash
IPC分类号： A61B18/18 , A61M31/00
CPC分类号： A61F2/82 , A61B2017/00247 , A61B2018/00392 , A61F2/2493
摘要： A transmyocardial revascularization system including a plurality of inserts formed of a material to elicit a healing response in tissue of the myocardium and deployment instruments and associated components for deploying the inserts into the wall of the myocardium. The inserts are arranged to be disposed within respective lumens or channels in the wall of the myocardium. The inserts can take various forms, e.g., be solid members, tubular members, or porous members, and may be resorbable, partially resorbable or non-resorbable. In some embodiments the inserts are arranged to be left in place within the channels in the wall of the myocardium to result in plural lumens which enable blood to flow therethrough and into contiguous capillaries. The deployment instruments are arranged to pierce the tissue of the myocardium from either the endocardium or the epicardium to insert the inserts into the myocardium, depending on the particular deployment instrument used. The deployment instruments may make use of a stabilizing device to stabilize them during the procedure of inserting the inserts into the myocardium. A controller may also be provided as part of the system to coordinate the operation of the deployment instrument with the cardiac cycle. The formation of the lumens can be achieved either by the inserts or by some other means, such as a piercing tip or an energy applicator forming a portion of the instrument. The inserts may include one or more of pharmaceuticals, biologically active agents, radiopaque materials, etc.
摘要翻译：一种经心肌血运重建系统，其包括由材料组成的多个插入物，以在心肌的组织中引发愈合反应，以及用于将插入物部署到心肌壁上的相关组件。插入件布置成设置在心肌壁中相应的腔或通道内。插入件可以采取各种形式，例如是实心构件，管状构件或多孔构件，并且可以是可再吸收的，部分可再吸收的或不可再吸收的。在一些实施例中，插入物被布置成在心肌壁中的通道内留在适当的位置，以产生多个流明，使得血液能够流过并流入相邻的毛细血管。根据所使用的特定部署仪器，这些展开装置被设置成从心内膜或心外膜刺穿心肌的组织以将插入物插入心肌。在将插入物插入心肌的过程中，展开装置可以利用稳定装置来稳定它们。还可以提供控制器作为系统的一部分，以协调部署仪器与心动周期的操作。腔的形成可以通过插入件或通过其它手段实现，例如刺穿尖端或形成器械的一部分的能量施加器。插入物可以包括一种或多种药物，生物活性剂，不透射线材料等。

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