专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090181005A1 NUCLEIC ACID ENCODING PROTEINS INVOLVED IN PROTEIN DEGRADATION, PRODUCTS AND METHODS RELATED THERETO 失效
标题翻译：涉及蛋白质降解的产品和方法涉及的核酸编码蛋白
公开(公告)号：US20090181005A1
公开(公告)日：2009-07-16
申请号：US12397468
申请日：2009-03-04
申请人： John C. Reed , Shu-ichi Matsuzawa
发明人： John C. Reed , Shu-ichi Matsuzawa
IPC分类号： A61K38/46 , C12N9/96
CPC分类号： C07K14/00 , C07K14/47 , C07K2319/00 , C12N9/88 , C12Y401/01017
摘要： In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPS) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein. Also provided are compositions and methods for targeting the destruction of selected polypeptides in eukaryotic cells based on the ubiquitin-independent mechanism by which ornithine decarboxylase is degraded by the 26S proteasome.
摘要翻译：根据本发明，提供了新型的Siah介导的降解蛋白（SMDPS）和/或SCF-复合蛋白（SCP）。还公开了编码这种蛋白质的核酸序列和使用其的测定法。本发明SMDP和/或SCP可以以各种方式使用，例如用于在治疗组合物中生产抗SMDP和/或SCP抗体，以及使用这种蛋白质和/或抗体进行药物筛选的方法，功能基因组学等应用。还提供了表达本发明蛋白质的转基因非人哺乳动物。还提供了基于鸟氨酸脱羧酶被26S蛋白酶体降解的泛素非依赖性机制，靶向真核细胞中所选多肽的破坏的组合物和方法。

2. 发明授权

US07504253B2 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereof 失效
标题翻译：涉及蛋白质降解的核酸编码蛋白质，与其有关的产品和方法
公开(公告)号：US07504253B2
公开(公告)日：2009-03-17
申请号：US11441688
申请日：2006-05-25
申请人： John C. Reed , Shu-ichi Matsuzawa
发明人： John C. Reed , Shu-ichi Matsuzawa
IPC分类号： C12N5/00 , C07H17/00 , C12P14/44
CPC分类号： C07K14/00 , C07K14/47 , C07K2319/00 , C12N9/88 , C12Y401/01017
摘要： In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein. Also provided are compositions and methods for targeting the destruction of selected polypeptides in eukaryotic cells based on the ubiquitin-independent mechanism by which ornithine decarboxylase is degraded by the 26S proteasome.
摘要翻译：根据本发明，提供了新型的Siah介导的降解蛋白（SMDP）和/或SCF-复合蛋白（SCP）。还公开了编码这种蛋白质的核酸序列和使用其的测定法。本发明SMDP和/或SCP可以以各种方式使用，例如用于在治疗组合物中生产抗SMDP和/或SCP抗体，以及使用这种蛋白质和/或抗体进行药物筛选的方法，功能基因组学等应用。还提供了表达本发明蛋白质的转基因非人哺乳动物。还提供了基于鸟氨酸脱羧酶被26S蛋白酶体降解的泛素非依赖性机制，靶向真核细胞中所选多肽的破坏的组合物和方法。

3. 发明申请

US20080254510A1 NUCLEIC ACID ENCODING PROTEINS INVOLVED IN PROTEIN DEGRADATION, PRODUCTS AND METHODS RELATED THERETO 失效
标题翻译：涉及蛋白质降解的产品和方法涉及的核酸编码蛋白
公开(公告)号：US20080254510A1
公开(公告)日：2008-10-16
申请号：US12132565
申请日：2008-06-03
申请人： John C. Reed , Shu-ichi Matsuzawa
发明人： John C. Reed , Shu-ichi Matsuzawa
IPC分类号： C12P21/04 , C12N15/11 , C12N15/00 , C12N5/06 , C07H21/00 , G01N33/00 , C07K14/00
CPC分类号： C07K14/47 , C07K14/00 , Y10T436/143333
摘要： In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein.
摘要翻译：根据本发明，提供了新型的Siah介导的降解蛋白（SMDP）和/或SCF-复合蛋白（SCP）。还公开了编码这种蛋白质的核酸序列和使用其的测定法。本发明SMDP和/或SCP可以以各种方式使用，例如用于在治疗组合物中生产抗SMDP和/或SCP抗体，以及使用这种蛋白质和/或抗体用于药物筛选的方法，功能基因组学等应用。还提供了表达本发明蛋白质的转基因非人哺乳动物。

4. 发明授权

US06638734B1 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto 失效
标题翻译：涉及蛋白质降解的核酸编码蛋白质，与其有关的产品和方法
公开(公告)号：US06638734B1
公开(公告)日：2003-10-28
申请号：US09591694
申请日：2000-06-09
申请人： John C. Reed , Shu-ichi Matsuzawa
发明人： John C. Reed , Shu-ichi Matsuzawa
IPC分类号： C12P206
CPC分类号： C07K14/00
摘要： In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein.
摘要翻译：根据本发明，提供了新型的Siah介导的降解蛋白（SMDP）和/或SCF-复合蛋白（SCP）。还公开了编码这种蛋白质的核酸序列和使用其的测定法。本发明SMDP和/或SCP可以以各种方式使用，例如用于在治疗组合物中生产抗SMDP和/或SCP抗体，以及使用这种蛋白质和/或抗体进行药物筛选的方法，功能基因组学等应用。还提供了表达本发明蛋白质的转基因非人哺乳动物。

5. 发明授权

US07982002B2 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto 失效
标题翻译：涉及蛋白质降解的核酸编码蛋白质，与其有关的产品和方法
公开(公告)号：US07982002B2
公开(公告)日：2011-07-19
申请号：US12397468
申请日：2009-03-04
申请人： John C. Reed , Shu-ichi Matsuzawa
发明人： John C. Reed , Shu-ichi Matsuzawa
IPC分类号： C07K14/00
CPC分类号： C07K14/00 , C07K14/47 , C07K2319/00 , C12N9/88 , C12Y401/01017
摘要： In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPS) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein. Also provided are compositions and methods for targeting the destruction of selected polypeptides in eukaryotic cells based on the ubiquitin-independent mechanism by which ornithine decarboxylase is degraded by the 26S proteasome.
摘要翻译：根据本发明，提供了新型的Siah介导的降解蛋白（SMDPS）和/或SCF-复合蛋白（SCP）。还公开了编码这种蛋白质的核酸序列和使用其的测定法。本发明SMDP和/或SCP可以以各种方式使用，例如用于在治疗组合物中生产抗SMDP和/或SCP抗体，以及使用这种蛋白质和/或抗体进行药物筛选的方法，功能基因组学等应用。还提供了表达本发明蛋白质的转基因非人哺乳动物。还提供了基于鸟氨酸脱羧酶被26S蛋白酶体降解的泛素非依赖性机制，靶向真核细胞中所选多肽的破坏的组合物和方法。

6. 发明授权

US07390656B2 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto 失效
标题翻译：涉及蛋白质降解的核酸编码蛋白质，与其有关的产品和方法
公开(公告)号：US07390656B2
公开(公告)日：2008-06-24
申请号：US11441861
申请日：2006-05-26
申请人： John C. Reed , Shu-ichi Matsuzawa
发明人： John C. Reed , Shu-ichi Matsuzawa
IPC分类号： C12N5/00 , C07H21/02
CPC分类号： C07K14/47 , C07K14/00 , Y10T436/143333
摘要： In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein.
摘要翻译：根据本发明，提供了新型的Siah介导的降解蛋白（SMDP）和/或SCF-复合蛋白（SCP）。还公开了编码这种蛋白质的核酸序列和使用其的测定法。本发明SMDP和/或SCP可以以各种方式使用，例如用于在治疗组合物中生产抗SMDP和/或SCP抗体，以及使用这种蛋白质和/或抗体用于药物筛选的方法，功能基因组学等应用。还提供了表达本发明蛋白质的转基因非人哺乳动物。

7. 发明授权

US07087386B2 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto 失效
公开(公告)号：US07087386B2
公开(公告)日：2006-08-08
申请号：US10679246
申请日：2003-10-02
申请人： John C. Reed , Shu-ichi Matsuzawa
发明人： John C. Reed , Shu-ichi Matsuzawa
IPC分类号： C12Q1/68 , C12P21/06 , C07H21/02
CPC分类号： C07K14/47 , C07K14/00 , Y10T436/143333
摘要： In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein.

8. 发明申请

US20060234288A1 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto 失效
公开(公告)号：US20060234288A1
公开(公告)日：2006-10-19
申请号：US11441861
申请日：2006-05-26
申请人： John Reed , Shu-ichi Matsuzawa
发明人： John Reed , Shu-ichi Matsuzawa
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/64
CPC分类号： C07K14/47 , C07K14/00 , Y10T436/143333
摘要： In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein.

9. 发明申请

US20070042463A1 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereof 失效
标题翻译：涉及蛋白质降解的核酸编码蛋白质，与其有关的产品和方法
公开(公告)号：US20070042463A1
公开(公告)日：2007-02-22
申请号：US11441688
申请日：2006-05-25
申请人： John Reed , Shu-ichi Matsuzawa
发明人： John Reed , Shu-ichi Matsuzawa
IPC分类号： C12P21/06 , C12N9/88 , C07H21/04
CPC分类号： C07K14/00 , C07K14/47 , C07K2319/00 , C12N9/88 , C12Y401/01017
摘要： In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or SCPs can be employed in a variety of ways, for example, for the production of anti-SMDP and/or SCP antibodies thereto, in therapeutic compositions, and methods employing such proteins and/or antibodies for drug screening, functional genomics and other applications. Also provided are transgenic non-human mammals that express the invention protein. Also provided are compositions and methods for targeting the destruction of selected polypeptides in eukaryotic cells based on the ubiquitin-independent mechanism by which ornithine decarboxylase is degraded by the 26S proteasome.
摘要翻译：根据本发明，提供了新型的Siah介导的降解蛋白（SMDP）和/或SCF-复合蛋白（SCP）。还公开了编码这种蛋白质的核酸序列和使用其的测定法。本发明SMDP和/或SCP可以以各种方式使用，例如用于在治疗组合物中生产抗SMDP和/或SCP抗体，以及使用这种蛋白质和/或抗体进行药物筛选的方法，功能基因组学等应用。还提供了表达本发明蛋白质的转基因非人哺乳动物。还提供了基于鸟氨酸脱羧酶被26S蛋白酶体降解的泛素非依赖性机制，靶向真核细胞中所选多肽的破坏的组合物和方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式