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1. 发明授权

US5087873A Non-invasive, high resolution detection of electrical currents and electrochemical impedances at spaced localities along a pipeline 失效
公开(公告)号：US5087873A
公开(公告)日：1992-02-11
申请号：US690290
申请日：1991-04-24
申请人： John C. Murphy , Glenn S. Hartong , Ralph F. Cohn , Patrick J. Moran
发明人： John C. Murphy , Glenn S. Hartong , Ralph F. Cohn , Patrick J. Moran
IPC分类号： G01N17/02 , G01V3/06
CPC分类号： G01V3/06 , G01N17/02
摘要： Electrical current distribution in the soil surrounding a buried pipeline is detected by applying an AC electrical potential between the pipe and a buried electrode spaced from the pipe. The magnetic field at spaced localities along the pipe arising from currents transverse to the pipe is detected. Additionally, a potential containing a plurality of alternating frequencies is similarly applied to the pipe and the magnetic field induced by the resulting electrical current both along the pipe and transversely of the pipe is detected. The magnetic field is detected by correlation discrimination at spaced locations along the pipe and across the spectrum of the impressed frequencies. The detected data is used to determine the capacitance and resistance of the soil/pipe interface at localities along the pipe and to generate impedance plots which indicate characteristics of that interface.

2. 发明授权

US5126654A Non-invasive, high resolution detection of electrical currents and electrochemical impedances at spaced localities along a pipeline 失效
标题翻译：沿管道的间隔地点的电流和电化学阻抗的非侵入式高分辨率检测
公开(公告)号：US5126654A
公开(公告)日：1992-06-30
申请号：US504100
申请日：1990-04-02
申请人： John C. Murphy , Glenn S. Hartong , Ralph F. Cohn , Patrick J. Moran
发明人： John C. Murphy , Glenn S. Hartong , Ralph F. Cohn , Patrick J. Moran
IPC分类号： G01N17/00 , G01N17/02 , G01R27/20 , G01V3/04
CPC分类号： G01V3/04 , G01N17/02 , G01R27/20
摘要： Electrical current distribution in the soil surrounding a buried pipeline is detected by applying an AC electrical potential between the pipe and a buried electrode spaced from the pipe. The magnetic field at spaced localities along the pipe arising from currents transverse to the pipe is detected. Additionally, a potential containing a plurality of alternating frequencies is similarly applied to the pipe and the magnetic field induced by the resulting electrical current both along the pipe and transversely of the pipe is detected. The magnetic field is detected by correlation discrimination at spaced locations along the pipe and across the spectrum of the impressed frequencies. The detected data is used to determine the capacitance and resistance of the soil/pipe interface at localities along the pipe and to generate impedance plots which indicate characteristics of that interface.
摘要翻译：通过在管道和与管道间隔开的埋地电极之间施加交流电位来检测埋在管道周围土壤中的电流分布。检测出沿横向于管道的电流产生的沿管道间隔的位置处的磁场。此外，包含多个交变频率的电位类似地应用于管道，并且检测由沿着管道和横向于管道的所得电流引起的磁场。磁场通过沿着管道的间隔位置并且穿过外加的频率的频谱上的相关鉴别来检测。检测到的数据用于确定沿着管道的地点的土壤/管道界面的电容和电阻，并产生指示该界面特征的阻抗图。

3. 发明申请

US20090035222A1 Techniques for Identifying Molecular Structures and Treating Cell Types Lining a Body Lumen Using Fluorescence 有权
标题翻译：识别分子结构和处理细胞类型的技术使用荧光衬里体液
公开(公告)号：US20090035222A1
公开(公告)日：2009-02-05
申请号：US12252436
申请日：2008-10-16
申请人： Igal Madar , John C. Murphy
发明人： Igal Madar , John C. Murphy
IPC分类号： A61K49/00
CPC分类号： A61B1/041 , A61B5/0071 , A61B5/073 , A61B2018/00982 , A61B2560/0468 , A61B2562/0233 , A61B2562/162 , A61K41/0057 , A61K41/0071 , A61K49/0013 , A61N1/327 , A61N5/062
摘要： Techniques for detecting fluorescence emitted by molecular constituents in a wall of a body lumen include introducing an autonomous solid support into the body lumen. Cells in a lumen wall of the body lumen are illuminated by a light source mounted to the solid support with a wavelength that excites a particular fluorescent signal. A detector mounted to the solid support detects whether illuminated cells emit the particular fluorescent signal. If the particular fluorescent signal is detected from the illuminated cells, then intensity or position in the lumen wall of the detected fluorescent signal, or both, is determined. These techniques allow the information collected by the capsule to support diagnosis and therapy of GI cancer and other intestinal pathologies and syndromes. For example, these techniques allow diagnostic imaging using endogenous and exogenous fluoroprobes, treating diseased sites by targeted release of drug with or without photoactivation, and determining therapeutic efficacy.
摘要翻译：用于检测体腔内的分子成分发出的荧光的技术包括将自主固体支持物引入体腔。体腔管腔壁中的细胞由安装在固体支持物上的光源照射，激发特定荧光信号的波长。安装到固体支架上的检测器检测照射的细胞是否发射特定的荧光信号。如果从照射的细胞检测到特定的荧光信号，则确定检测到的荧光信号或两者的管腔壁中的强度或位置。这些技术允许胶囊收集的信息支持GI癌症和其他肠道病理学和综合征的诊断和治疗。例如，这些技术允许使用内源和外源性荧光探针进行诊断成像，通过靶向释放具有或不具有光活化的药物来治疗患病部位，并确定治疗功效。

4. 发明授权

US4625521A Liquid nitrogen distribution system 失效
标题翻译：液氮分配系统
公开(公告)号：US4625521A
公开(公告)日：1986-12-02
申请号：US733055
申请日：1985-05-13
申请人： John C. Murphy , Robert H. Swinderman
发明人： John C. Murphy , Robert H. Swinderman
IPC分类号： B01D8/00 , F17C13/00
CPC分类号： F17C13/001 , B01D8/00 , B64G2007/005 , F17C2221/014 , F17C2221/017 , F17C2223/0161 , F17C2225/0169 , F17C2227/0114 , F17C2227/0135 , F17C2250/01
摘要： Apparatus for providing a simulated space environment for the testing of articles under low temperature conditions comprising a liquid nitrogen head tank, liquid nitrogen subcooler pumps, a liquid nitrogen subcooler coil, a liquid nitrogen head tank makeup pumps, a low pressure liquid nitrogen storage tank, a high pressure liquid nitrogen storage tank, a liquid nitrogen transfer pump, a vacuum chamber and thermal simulation heat exchanger shrouds contained within the vacuum chamber. Appropriate internal and external piping connects these components so that the apparatus can be operated both in a subcooled pressurized closed loop system as well as in a gravity convection system. While liquid nitrogen in this apparatus will produce a stable uniform temperature of -297.degree. F. within the shroud containing the article to be tested, other liquids with similar low temperature characteristics may be used. A requirement for such liquids when used as a circulating medium with the apparatus herein is that the boiling point thereof at one atmosphere will produce the required test operating temperature.
摘要翻译：一种用于提供用于在低温条件下测试物品的模拟空间环境的装置，包括液氮罐，液氮过冷器泵，液氮过冷器线圈，液氮头罐补充泵，低压液氮储存罐，真空室内容纳的高压液氮储罐，液氮输送泵，真空室和热模拟热交换器罩。适当的内部和外部管道连接这些组件，使得设备可以在过冷加压闭环系统以及重力对流系统中操作。虽然该装置中的液氮将在包含待测试物品的护罩内产生-297°F的稳定的均匀温度，但是可以使用具有相似低温特性的其它液体。当用作本文设备的循环介质时，对这种液体的要求是其在一个大气压下的沸点将产生所需的测试工作温度。

5. 发明授权

US5959452A Lorentz force magnetometer having a resonator 失效
标题翻译：洛伦兹力磁力计具有谐振器
公开(公告)号：US5959452A
公开(公告)日：1999-09-28
申请号：US943735
申请日：1997-10-03
申请人： Robert B. Givens , John C. Murphy , Dennis K. Wickenden , Robert Osiander , Thomas J. Kistenmacher
发明人： Robert B. Givens , John C. Murphy , Dennis K. Wickenden , Robert Osiander , Thomas J. Kistenmacher
IPC分类号： G01R33/028 , G01R33/02
CPC分类号： G01R33/028
摘要： The invention consists, in one embodiment, of a resonator such as a conductive bar supported by two wires placed at the nodal points of the fundamental resonance frequency. The wires also supply current of this frequency to the resonator. In the presence of a magnetic field, the Lorentz force causes the resonator to vibrate. The amplitude of this vibration is proportional to a vector component of the magnetic field. The motion of the resonator is detected using one of a number of possible methods including optical beam deflection. The invention has a sensitivity of at least 1 nT, comparable to that of a commercial fluxgate magnetometer, and a dynamic range exceeding 80 dB.
摘要翻译：本发明在一个实施例中包括诸如由放置在基本共振频率的节点处的两根电线支撑的导电棒的谐振器。电线还将该频率的电流提供给谐振器。在存在磁场的情况下，洛伦兹力使谐振器振动。该振动的振幅与磁场的矢量分量成比例。使用包括光束偏转的多种可能方法中的一种来检测谐振器的运动。本发明具有至少1nT的灵敏度，与商业磁通门磁强计相当，并且动态范围超过80dB。

6. 发明授权

US4184768A Self-calibrating photoacoustic apparatus for measuring light intensity and light absorption 失效
标题翻译：用于测量光强度和光吸收的自校准光声装置
公开(公告)号：US4184768A
公开(公告)日：1980-01-22
申请号：US848706
申请日：1977-11-04
申请人： John C. Murphy , Leonard C. Aamodt
发明人： John C. Murphy , Leonard C. Aamodt
IPC分类号： G01N21/17 , G01J3/42 , G01J1/56
CPC分类号： G01N21/1702
摘要： Pulsed light and readily measurable pulsed electrical energy are independently applied to a solid black, conductive sample in a gas-filled photoacoustic cell, each causing the black sample to heat. The heating of the black sample causes a pressure wave in the cell, which can be detected and measured. By adjusting the pulsed electrical energy, the pressure wave resulting from the pulsed electrical energy can be made to relate to the pressure wave resulting from the pulsed light in a predetermined manner. The pulsed light input intensity can then be measured in electrical units based on the measurable input of the electrical energy pulses. In this manner, the invention can be used as a radiometer. A second application for the present apparatus is in calibrating photoacoustic spectroscopy (PAS) cells. The PAS cell can be self-calibrated by discontinuing the light pulses and relating the pressure wave output to the electrical energy pulse input. The measurement then of light absorption in a test sample, which need be neither black nor conductive, can be made in absolute energy units based on the self-calibration relationship.
摘要翻译：脉冲光和容易测量的脉冲电能独立地施加到气体填充的光声单元中的固体黑色导电样品，每个导致黑色样品加热。黑色样品的加热导致电池中的压力波，这可以被检测和测量。通过调节脉冲电能，可以使由脉冲电能产生的压力波以与预定方式的脉冲光产生的压力波相关。然后可以基于电能脉冲的可测量输入以电单元测量脉冲光输入强度。以这种方式，本发明可以用作辐射计。本设备的第二个应用是校准光声光谱（PAS）单元。可以通过停止光脉冲并将压力波输出与电能脉冲输入相关联来对PAS单元进行自校准。基于自校准关系，可以以绝对能量单位进行测量样品中不需要黑色或不导电的测试样品的测量。

7. 发明授权

US4041722A Impact resistant tank for cryogenic fluids 失效
标题翻译：用于低温流体的耐冲击罐
公开(公告)号：US4041722A
公开(公告)日：1977-08-16
申请号：US617109
申请日：1975-09-26
申请人： John Terlesky , Hugh Emil Muller , John C. Murphy , Harold F. Honath
发明人： John Terlesky , Hugh Emil Muller , John C. Murphy , Harold F. Honath
IPC分类号： F17C3/02 , F17C3/06
CPC分类号： F17C3/022 , F17C2201/0109 , F17C2201/0119 , F17C2201/032 , F17C2201/052 , F17C2203/012 , F17C2203/0329 , F17C2203/0341 , F17C2203/0345 , F17C2203/0379 , F17C2203/0607 , F17C2203/0631 , F17C2203/0639 , F17C2203/0648 , F17C2203/0678 , F17C2205/0176 , F17C2205/0332 , F17C2209/228 , F17C2221/033 , F17C2223/0161 , F17C2223/033 , F17C2227/0135 , F17C2227/0178 , F17C2227/0304 , F17C2250/0413 , F17C2250/0439 , F17C2260/011 , F17C2260/036 , F17C2260/042 , F17C2270/0147 , F17C2270/016 , Y10S220/901
摘要： An impact resistant tank for storing cryogenic fluids, includes an inner metal tank having a metal side wall and a metal bottom and a concrete outer wall around the inner metal wall and having reinforcement therein to resist impact loads thereon, and to serve as a secondary containment for the cryogenic fluid.
摘要翻译：一种用于储存低温流体的抗冲击罐，包括内金属罐，其具有金属侧壁和金属底部以及围绕内金属壁的混凝土外壁，并且在其中具有加强件以抵抗其上的冲击载荷，并用作二级容纳物用于低温流体。

8. 发明授权

US07653429B2 Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence 有权
标题翻译：用于识别分子结构和使用荧光处理衬里体腔的细胞类型的技术
公开(公告)号：US07653429B2
公开(公告)日：2010-01-26
申请号：US12252436
申请日：2008-10-16
申请人： Igal Madar , John C. Murphy
发明人： Igal Madar , John C. Murphy
IPC分类号： A61B6/00
CPC分类号： A61B1/041 , A61B5/0071 , A61B5/073 , A61B2018/00982 , A61B2560/0468 , A61B2562/0233 , A61B2562/162 , A61K41/0057 , A61K41/0071 , A61K49/0013 , A61N1/327 , A61N5/062
摘要： Techniques for detecting fluorescence emitted by molecular constituents in a wall of a body lumen include introducing an autonomous solid support into the body lumen. Cells in a lumen wall of the body lumen are illuminated by a light source mounted to the solid support with a wavelength that excites a particular fluorescent signal. A detector mounted to the solid support detects whether illuminated cells emit the particular fluorescent signal. If the particular fluorescent signal is detected from the illuminated cells, then intensity or position in the lumen wall of the detected fluorescent signal, or both, is determined. These techniques allow the information collected by the capsule to support diagnosis and therapy of GI cancer and other intestinal pathologies and syndromes. For example, these techniques allow diagnostic imaging using endogenous and exogenous fluoroprobes, treating diseased sites by targeted release of drug with or without photoactivation, and determining therapeutic efficacy.
摘要翻译：用于检测体腔内的分子成分发出的荧光的技术包括将自主固体支持物引入体腔。体腔管腔壁中的细胞由安装在固体支持物上的光源照射，激发特定荧光信号的波长。安装到固体支架上的检测器检测照射的细胞是否发射特定的荧光信号。如果从照射的细胞检测到特定的荧光信号，则确定检测到的荧光信号或两者的管腔壁中的强度或位置。这些技术允许胶囊收集的信息支持GI癌症和其他肠道病理学和综合征的诊断和治疗。例如，这些技术允许使用内源和外源性荧光探针进行诊断成像，通过靶向释放具有或不具有光活化的药物来治疗患病部位，并确定治疗功效。

9. 发明授权

US07515953B2 Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence 有权
标题翻译：用于识别分子结构和使用荧光处理衬里体腔的细胞类型的技术
公开(公告)号：US07515953B2
公开(公告)日：2009-04-07
申请号：US10633446
申请日：2003-08-01
申请人： Igal Madar , John C. Murphy
发明人： Igal Madar , John C. Murphy
IPC分类号： A61B6/00
CPC分类号： A61B1/041 , A61B5/0071 , A61B5/073 , A61B2018/00982 , A61B2560/0468 , A61B2562/0233 , A61B2562/162 , A61K41/0057 , A61K41/0071 , A61K49/0013 , A61N1/327 , A61N5/062
摘要： Techniques for detecting fluorescence emitted by molecular constituents in a wall of a body lumen include introducing an autonomous solid support into the body lumen. Cells in a lumen wall of the body lumen are illuminated by a light source mounted to the solid support with a wavelength that excites a particular fluorescent signal. A detector mounted to the solid support detects whether illuminated cells emit the particular fluorescent signal. If the particular fluorescent signal is detected from the illuminated cells, then intensity or position in the lumen wall of the detected fluorescent signal, or both, is determined. These techniques allow the information collected by the capsule to support diagnosis and therapy of GI cancer and other intestinal pathologies and syndromes. For example, these techniques allow diagnostic imaging using endogenous and exogenous fluoroprobes, treating diseased sites by targeted release of drug with or without photoactivation, and determining therapeutic efficacy.
摘要翻译：用于检测体腔内的分子成分发出的荧光的技术包括将自主固体支持物引入体腔。体腔管腔壁中的细胞由安装在固体支持物上的光源照射，激发特定荧光信号的波长。安装到固体支架上的检测器检测照射的细胞是否发射特定的荧光信号。如果从照射的细胞检测到特定的荧光信号，则确定检测到的荧光信号或两者的管腔壁中的强度或位置。这些技术允许胶囊收集的信息支持GI癌症和其他肠道病理学和综合征的诊断和治疗。例如，这些技术允许使用内源和外源性荧光探针进行诊断成像，通过靶向释放具有或不具有光活化的药物来治疗患病部位，并确定治疗功效。

10. 发明授权

US06337627B1 System of providing medical treatment 有权
标题翻译：提供医疗的制度
公开(公告)号：US06337627B1
公开(公告)日：2002-01-08
申请号：US09699183
申请日：2000-10-27
申请人： Robert J. Von Gutfeld , James F. Ziegler , Scott J. McAllister , James H. Anderson , John C. Murphy , Matthias D. Ziegler
发明人： Robert J. Von Gutfeld , James F. Ziegler , Scott J. McAllister , James H. Anderson , John C. Murphy , Matthias D. Ziegler
IPC分类号： G08B1314
CPC分类号： A61B5/06 , A61B5/062 , G01V15/00
摘要： The invention describes methods for locating a treatment device disposed within a living body by means of magnetic fields that are produced by Barkhausen jumps, principally from amorphous tag wires with high permeability that exhibit reentrant flux reversal. When wires of this type are attached to concealed treatment devices such as catheters, interrogation or scanning of the tag wire by a low frequency ac magnetic field affords an accurate means for locating the treatment devices using a sensor coil to detect the magnetic field signal from the wire locating tag. The strength of the field detected by the position of a sensor coil with respect to the locator tag is used to determine the location of the tag. A favorable signal to noise detection ration is obtained as the signal emitted by the wire is at a very high frequency compared to that of the frequency of the interrogation field.
摘要翻译：本发明描述了通过由Barkhausen跳跃产生的磁场来定位设置在生物体内的治疗装置的方法，主要是来自呈现出可重入通量反转的高磁导率的非晶标签线。当这种类型的导线连接到诸如导管的隐蔽处理装置时，通过低频交流磁场对标签线的询问或扫描提供了使用传感器线圈来定位处理装置的精确装置，以检测来自电线定位标签。使用传感器线圈相对于定位器标签的位置检测的场强度来确定标签的位置。获得有利的信噪比检测比例，因为与线询问频率相比，由线发出的信号处于非常高的频率。

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