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1. 发明授权

US07745780B2 Multiplex data acquisition modes for ion mobility-mass spectrometry 有权
标题翻译：用于离子迁移率 - 质谱的多重数据采集模式
公开(公告)号：US07745780B2
公开(公告)日：2010-06-29
申请号：US12123163
申请日：2008-05-19
申请人： John A. McLean , David H. Russell , Thomas F. Egan , Michael V. Ugarov , J. Albert Schultz
发明人： John A. McLean , David H. Russell , Thomas F. Egan , Michael V. Ugarov , J. Albert Schultz
IPC分类号： H01J49/00
CPC分类号： G01N33/6851 , B82Y30/00 , G01N27/622 , H01J49/0031 , H01J49/004
摘要： A method and apparatus for multiplexed data acquisition for gas-phase ion mobility coupled with mass spectrometry is described. Ion packets are injected into an ion mobility drift chamber at a rate faster than the ion mobility separation arrival time distribution. The convoluted arrival time distributions thus generated are deconvoluted by a mass spectrometer and post-processing algorithms.
摘要翻译：描述了一种与质谱耦合的气相离子迁移多路复用数据采集方法和装置。离子包以比离子迁移率分离到达时间分布更快的速率注入离子迁移率漂移室。由此产生的复杂到达时间分布由质谱仪和后处理算法解卷积。

2. 发明申请

US20090101810A1 MULTIPLEX DATA ACQUISITION MODES FOR ION MOBILITY-MASS SPECTROMETRY 有权
标题翻译：用于离子移动质谱分析的多重数据采集模式
公开(公告)号：US20090101810A1
公开(公告)日：2009-04-23
申请号：US12123163
申请日：2008-05-19
申请人： John A. McLean , David H. Russell , Thomas F. Egan , Michael V. Ugarov , J. Albert Schultz
发明人： John A. McLean , David H. Russell , Thomas F. Egan , Michael V. Ugarov , J. Albert Schultz
IPC分类号： B01D59/44
CPC分类号： G01N33/6851 , B82Y30/00 , G01N27/622 , H01J49/0031 , H01J49/004
摘要： A method and apparatus for multiplexed data acquisition for gas-phase ion mobility coupled with mass spectrometry is described. Ion packets are injected into an ion mobility drift chamber at a rate faster than the ion mobility separation arrival time distribution. The convoluted arrival time distributions thus generated are deconvoluted by a mass spectrometer and post-processing algorithms.
摘要翻译：描述了一种与质谱耦合的气相离子迁移多路复用数据采集方法和装置。离子包以比离子迁移率分离到达时间分布更快的速率注入离子迁移率漂移室。由此产生的复杂到达时间分布由质谱仪和后处理算法解卷积。

3. 发明授权

US07388197B2 Multiplex data acquisition modes for ion mobility-mass spectrometry 有权
标题翻译：用于离子迁移率 - 质谱的多重数据采集模式
公开(公告)号：US07388197B2
公开(公告)日：2008-06-17
申请号：US11191666
申请日：2005-07-27
申请人： John A. McLean , David H. Russell , Thomas F. Egan , Michael V. Ugarov , J. A. Schultz
发明人： John A. McLean , David H. Russell , Thomas F. Egan , Michael V. Ugarov , J. A. Schultz
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： G01N33/6851 , B82Y30/00 , G01N27/622 , H01J49/0031 , H01J49/004
摘要： A method and apparatus for multiplexed data acquisition for gas-phase ion mobility coupled with mass spectrometry is described. Ion packets are injected into an ion mobility drift chamber at a rate faster than the ion mobility separation arrival time distribution. The convoluted arrival time distributions thus generated are deconvoluted by a mass spectrometer and post-processing algorithms.
摘要翻译：描述了一种与质谱耦合的气相离子迁移多路复用数据采集方法和装置。离子包以比离子迁移率分离到达时间分布更快的速率注入离子迁移率漂移室。由此产生的复杂到达时间分布由质谱仪和后处理算法解卷积。

4. 发明授权

US07081617B2 Gas-phase purification of biomolecules by ion mobility for patterning microarrays and protein crystal growth 失效
标题翻译：通过离子迁移率生物分子的气相纯化用于图案化微阵列和蛋白质晶体生长
公开(公告)号：US07081617B2
公开(公告)日：2006-07-25
申请号：US11038834
申请日：2005-01-20
申请人： John A. McLean , David H. Russell , J. Albert Schultz
发明人： John A. McLean , David H. Russell , J. Albert Schultz
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： G01N27/622 , B82Y30/00 , C30B7/00 , C30B23/00 , C30B29/58 , H01J49/00
摘要： A method and device for the gas-phase separation of ionic biomolecules including peptide, and protein or inorganic cluster ions or nanoparticles by ion mobility and for depositing them intact on a surface in a spatially addressable manner is described. The surface onto which the proteins are deposited can be modified for the purpose of constructing microarrays of biologically relevant materials or for promoting the growth of highly ordered protein crystals.
摘要翻译：描述了通过离子迁移率气相分离离子生物分子（包括肽）和蛋白质或无机簇离子或纳米颗粒并用空间可寻址方式在表面上完整沉积它们的方法和装置。为了构建生物相关材料的微阵列或促进高度有序的蛋白质晶体的生长，可以修饰其上沉积有蛋白质的表面。

5. 发明授权

US07282706B2 Advanced optics for rapidly patterned laser profiles in analytical spectrometry 有权
标题翻译：用于分析光谱法中快速图案化激光轮廓的高级光学元件
公开(公告)号：US07282706B2
公开(公告)日：2007-10-16
申请号：US11056852
申请日：2005-02-11
申请人： David H. Russell , John A. McLean
发明人： David H. Russell , John A. McLean
IPC分类号： G21K5/10 , H01J37/08 , G21G5/00
CPC分类号： H01J49/164
摘要： The present invention is directed to a novel arrangement of optical devices for the rapid patterning of laser profiles used for desorption and/or ionization sources in analytical mass spectrometry. Specifically, the new optical arrangement provides for a user-defined laser pattern at the sample target that can be quickly changed (on a microsecond timescale) to different dimensions (or shapes) for subsequent laser firings.
摘要翻译：本发明涉及用于在分析质谱法中用于解吸和/或电离源的激光轮廓的快速图案化的光学装置的新型布置。具体地说，新的光学布置提供了可以将样品目标的用户定义的激光图案快速地（微秒级）改变为不同尺寸（或形状）以用于随后的激光发射。

6. 发明申请

US20080263005A1 FRAMEWORK FOR THE DYNAMIC GENERATION OF A SEARCH ENGINE SITEMAP XML FILE 失效
标题翻译：搜索引擎站点XML文件的动态生成框架
公开(公告)号：US20080263005A1
公开(公告)日：2008-10-23
申请号：US11737563
申请日：2007-04-19
申请人： John A. McLean , Walfrey Ng , Danny Yuan
发明人： John A. McLean , Walfrey Ng , Danny Yuan
IPC分类号： G06F19/00
CPC分类号： G06F17/30864 , G06F17/30896 , G06Q30/02
摘要： The present invention relates to a method for the generation of a Sitemap XML file. The method comprises retrieving input parameter values and determining at least one target entity (an online retail store) within a target environment (a retailer) for which a search engine sitemap definition page will be generated and rendering the sitemap definition page for the determined target entity. The rendered content being further evaluated and ordered according to predetermined priority algorithms. The method further comprises outputting the rendered sitemap definition page, where if the output sitemap definition page exceeds a predetermined size, the output sitemap definition page is divided into smaller segments and an index file is generated and associated with the segmented output sitemap definition page files. Caching functionality (to enhance operational performance) and access control functionality (for controlling the rendering of sitemaps) is further provided within aspects of the present invention.
摘要翻译：本发明涉及生成Sitemap XML文件的方法。该方法包括检索输入参数值并确定目标环境（零售商）内的至少一个目标实体（零售店），为此目标环境（零售商）将为其生成搜索引擎站点定义页面，并为确定的目标实体呈现站点地图定义页面。渲染的内容根据预定的优先级算法被进一步评估和排序。该方法还包括输出所渲染的网站地图定义页面，其中如果输出站点定义页面超过预定大小，输出站点定义页面被划分成较小的段，并且生成索引文件并与分段的输出站点定义页面文件相关联。进一步在本发明的方面提供缓存功能（以增强操作性能）和访问控制功能（用于控制站点地图的呈现）。

7. 发明授权

US6166379A Direct injection high efficiency nebulizer for analytical spectrometry 失效
标题翻译：直接喷射高效雾化器，用于分析光谱
公开(公告)号：US6166379A
公开(公告)日：2000-12-26
申请号：US57198
申请日：1998-04-08
申请人： Akbar Montaser , John A. McLean , Jerold M. Kacsir
发明人： Akbar Montaser , John A. McLean , Jerold M. Kacsir
IPC分类号： G01N21/71 , G01N21/73 , H01J49/04 , H01J49/12 , G01J3/10
CPC分类号： H01J49/105 , G01N21/714 , H01J49/045
摘要： A simple, relatively low-cost direct injection high efficiency nebulizer (DIHEN) is suitable for argon inductively coupled plasma (Ar ICP) spectrometry. The DIHEN may be operated at solution uptake rates of 1-100 .mu.L/min. Analytical performance indices for the DIHEN and fundamental characteristics of the aerosol produced are obtained using an ICP mass spectrometer (ICPMS) and a 2-dimensional phase Doppler particle analyzer (2D PDPA), respectively. Results are compared to those obtained with a conventional crossflow pneumatic nebulizer (PN), equipped with a Scott-type spray chamber. Droplet sizes and velocities produced with the DIHEN are smaller than those reported for the direct injection nebulizer (DIN). The DIHEN offers optimal sensitivity at low injector gas flow rates (approx. 0.25 L/min) and high RF power (approx. 1.5 kW). For the 17 elements tested, detection limits (ppt) and sensitivities achieved with the DIHEN (at 85 .mu.L/min) are similar to or better than those obtained on the same instrument using the PN (at 1 mL/min). However, because the primary aerosol is injected directly into the plasma, oxide-to-metal ion ratios (MO.sup.+ /M.sup.+) are high as in the case of the DIN. The utility of the DIHEN for the analysis of small volume samples is demonstrated by microscale flow injection analysis (.mu.FIA) of Cr bound to human lung DNA. Detection of Cr at the femtogram level is feasible.
摘要翻译：一种简单，成本较低的直喷高效雾化器（DIHEN）适用于氩感应耦合等离子体（Ar ICP）光谱测定。 DIHEN可以溶液吸收速率为1-100μL/ min。使用ICP质谱仪（ICPMS）和二维相位多普勒粒子分析仪（2D PDPA）分别获得DIHEN的分析性能指标和产生的气溶胶的基本特征。将结果与使用装备有Scott型喷雾室的常规横流式气动雾化器（PN）获得的结果进行比较。使用DIHEN产生的液滴尺寸和速度小于直接喷射雾化器（DIN）报告的尺寸和速度。 DIHEN在低喷射器气体流量（约0.25L / min）和高RF功率（约1.5kW）下提供最佳灵敏度。对于测试的17个元素，用DIHEN（85μL/ min）实现的检测限（ppt）和灵敏度与使用PN（1mL / min）在同一仪器上获得的检测限（ppt）和灵敏度相似或更好。然而，由于主气溶胶直接注入等离子体，所以与DIN的情况相比，氧化物与金属的离子比（MO + / M +）高。通过对人肺DNA结合的Cr的微量流注射分析（μFIA）证明了DIHEN用于小体积样品分析的效用。检测在血压水平的Cr是可行的。

8. 发明授权

US08086948B2 Framework for the dynamic generation of a search engine sitemap XML file 失效
标题翻译：用于动态生成搜索引擎sitemap XML文件的框架
公开(公告)号：US08086948B2
公开(公告)日：2011-12-27
申请号：US11737563
申请日：2007-04-19
申请人： John A. McLean , Walfrey Ng , Danny Yuan
发明人： John A. McLean , Walfrey Ng , Danny Yuan
IPC分类号： G06F19/00
CPC分类号： G06F17/30864 , G06F17/30896 , G06Q30/02
摘要： The present invention relates to a method for the generation of a Sitemap XML file. The method comprises retrieving input parameter values and determining at least one target entity (an online retail store) within a target environment (a retailer) for which a search engine sitemap definition page will be generated and rendering the sitemap definition page for the determined target entity. The rendered content being further evaluated and ordered according to predetermined priority algorithms. The method further comprises outputting the rendered sitemap definition page, where if the output sitemap definition page exceeds a predetermined size, the output sitemap definition page is divided into smaller segments and an index file is generated and associated with the segmented output sitemap definition page files. Caching functionality (to enhance operational performance) and access control functionality (for controlling the rendering of sitemaps) is further provided within aspects of the present invention.
摘要翻译：本发明涉及生成Sitemap XML文件的方法。该方法包括检索输入参数值并确定目标环境（零售商）内的至少一个目标实体（零售店），为此目标环境（零售商）将为其生成搜索引擎站点定义页面，并为确定的目标实体呈现站点地图定义页面。渲染的内容根据预定的优先级算法被进一步评估和排序。该方法还包括输出所渲染的网站地图定义页面，其中如果输出站点定义页面超过预定大小，输出站点定义页面被划分成较小的段，并且生成索引文件并与分段的输出站点定义页面文件相关联。进一步在本发明的方面提供缓存功能（以增强操作性能）和访问控制功能（用于控制站点地图的呈现）。

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