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1. 发明授权

US06861419B2 Substituted 1, 4-thiazepine and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效
标题翻译：取代的1,4-硫氮杂和类似物作为半胱天冬酶和凋亡诱导剂的活化剂及其用途
公开(公告)号：US06861419B2
公开(公告)日：2005-03-01
申请号：US09836548
申请日：2001-04-18
申请人： John A. Drewe , Sui Xiong Cai , Emma Jane Shelton , Joane Litvak , David Sperandio , Jeffrey R. Spencer , Martin Sendzik
发明人： John A. Drewe , Sui Xiong Cai , Emma Jane Shelton , Joane Litvak , David Sperandio , Jeffrey R. Spencer , Martin Sendzik
IPC分类号： A61P35/00 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/04 , C07D417/14 , C07D513/04 , C07D513/14 , A61K31/55 , C07D281/02
CPC分类号： C07D417/14 , C07D281/06 , C07D281/10 , C07D405/04 , C07D417/04 , C07D513/04 , C07D513/14
摘要： The present invention is directed to substituted 1,4-thiazepine and analogs thereof, represented by the general Formula I: wherein the dashed lines, A1, A2, A3, X1 and R1 are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of capases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译：本发明涉及由通式I表示的取代的1,4-硫氮杂和其类似物：其中虚线A 1，A 2，A 3，X 1和R 3， 1>。本发明还涉及发现具有式I的化合物是抑制剂的活化剂和凋亡诱导剂。因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于诱导异常细胞发生不受控制的生长和扩散的各种临床病症中的细胞死亡。

2. 发明授权

US06562854B2 Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders 失效
公开(公告)号：US06562854B2
公开(公告)日：2003-05-13
申请号：US09874412
申请日：2001-06-04
申请人： Timothy J. Church , Neil Scott Cutshall , Anthony R. Gangloff , Thomas E. Jenkins , Martin S. Linsell , Joane Litvak , Kenneth D. Rice , Jeffrey R. Spencer , Vivian R. Wang
发明人： Timothy J. Church , Neil Scott Cutshall , Anthony R. Gangloff , Thomas E. Jenkins , Martin S. Linsell , Joane Litvak , Kenneth D. Rice , Jeffrey R. Spencer , Vivian R. Wang
IPC分类号： A61K314184
CPC分类号： C07D231/12 , A61F5/445 , C07D233/56 , C07D235/20 , C07D249/08 , C07D401/14 , C07D403/14 , C07D413/06 , C07D413/14 , C07D471/04 , C07F7/0812
摘要： Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis, as well as other types of immunomediated inflammatory disorders, such as rheumatoid arthritis, conjunctivitis and inflammatory bowel disease, various dermatological conditions, as well as certain viral conditions. The compounds comprise potent and selective inhibitors of the mast cell protease tryptase. The compositions for treating these conditions include oral, inhalant, topical and parenteral preparations as well as devices comprising such preparations.

3. 发明授权

US08143287B2 Thrombopoietin mimetics 有权
标题翻译：血小板生成素模拟物
公开(公告)号：US08143287B2
公开(公告)日：2012-03-27
申请号：US12853800
申请日：2010-08-10
申请人： Jeffrey R. Spencer , Juha Punnonen
发明人： Jeffrey R. Spencer , Juha Punnonen
IPC分类号： A61K31/454 , A61K31/4152 , C07D401/02 , C07D231/46
CPC分类号： C07D231/46 , C07D401/12
摘要： The invention relates to compounds and their use in the treatment of thrombocytopenia resulting from diseases or conditions such as immune thrombocytopenic purpura, cancer chemotherapy, surgery, bone marrow or stem cell transplantation, radiation injury or treatment, chronic viral infection, and pancytopenia. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods for treating such diseases or conditions in a mammal, including a human, by administering to such mammal an effective amount of a selected thrombopoietin receptor agonist.
摘要翻译：本发明涉及化合物及其在治疗由免疫性血小板减少性紫癜，癌症化疗，手术，骨髓或干细胞移植，放射性损伤或治疗，慢性病毒感染和全血细胞减少等疾病或病症引起的血小板减少症中的用途。本发明进一步涉及含有本发明化合物和组合物的药物组合物，以及通过向该哺乳动物施用有效量的选择的血小板生成素受体激动剂来治疗哺乳动物（包括人）中的这些疾病或病症的方法。

4. 发明授权

US07786159B2 Thrombopoietin mimetics 失效
标题翻译：血小板生成素模拟物
公开(公告)号：US07786159B2
公开(公告)日：2010-08-31
申请号：US11948955
申请日：2007-11-30
申请人： Jeffrey R. Spencer , Juha Punnonen
发明人： Jeffrey R. Spencer , Juha Punnonen
IPC分类号： A61K31/4152 , C07D231/46
CPC分类号： C07D231/46 , C07D401/12
摘要： The invention relates to compounds and their use in the treatment of thrombocytopenia resulting from diseases or conditions such as immune thrombocytopenic purpura, cancer chemotherapy, surgery, bone marrow or stem cell transplantation, radiation injury or treatment, chronic viral infection, and pancytopenia. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods for treating such diseases or conditions in a mammal, including a human, by administering to such mammal an effective amount of a selected thrombopoietin receptor agonist.
摘要翻译：本发明涉及化合物及其在治疗由免疫性血小板减少性紫癜，癌症化疗，手术，骨髓或干细胞移植，放射性损伤或治疗，慢性病毒感染和全血细胞减少等疾病或病症引起的血小板减少症中的用途。本发明进一步涉及含有本发明化合物和组合物的药物组合物，以及通过向该哺乳动物施用有效量的选择的血小板生成素受体激动剂来治疗哺乳动物（包括人）中的这些疾病或病症的方法。

5. 发明授权

US5721338A Inhibitors of oligosaccharyl transferase 失效
公开(公告)号：US5721338A
公开(公告)日：1998-02-24
申请号：US568486
申请日：1995-12-07
申请人： Barbara Imperiali , Jeffrey R. Spencer , Tamara L. Hendrickson
发明人： Barbara Imperiali , Jeffrey R. Spencer , Tamara L. Hendrickson
IPC分类号： A61K38/00 , C07K7/06 , C12P19/26 , C07K5/02 , A61K38/12 , C07K5/037
CPC分类号： C07K7/06 , C12P19/26 , A61K38/00
摘要： The present invention provides novel inhibitors of oligosaccharyl transferase, methods for producing Glc.sub.3 Man.sub.9 (GlcNAc).sub.2 -P-P-Dol, and methods for producing glycopeptides.

6. 发明申请

US20080139621A1 Thrombopoietin Mimetics 失效
标题翻译：血小板生成素模拟物
公开(公告)号：US20080139621A1
公开(公告)日：2008-06-12
申请号：US11948955
申请日：2007-11-30
申请人： Jeffrey R. Spencer , Juha Punnonen
发明人： Jeffrey R. Spencer , Juha Punnonen
IPC分类号： A61K31/4152 , C07D401/10 , C07D231/46 , A61P9/00 , A61P25/00 , A61K31/454
CPC分类号： C07D231/46 , C07D401/12
摘要： The invention relates to compounds and their use in the treatment of thrombocytopenia resulting from diseases or conditions such as immune thrombocytopenic purpura, cancer chemotherapy, surgery, bone marrow or stem cell transplantation, radiation injury or treatment, chronic viral infection, and pancytopenia. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods for treating such diseases or conditions in a mammal, including a human, by administering to such mammal an effective amount of a selected thrombopoietin receptor agonist.
摘要翻译：本发明涉及化合物及其在治疗由免疫性血小板减少性紫癜，癌症化疗，手术，骨髓或干细胞移植，放射性损伤或治疗，慢性病毒感染和全血细胞减少等疾病或病症引起的血小板减少症中的用途。本发明进一步涉及含有本发明化合物和组合物的药物组合物，以及通过向该哺乳动物施用有效量的选择的血小板生成素受体激动剂来治疗哺乳动物（包括人）中的这些疾病或病症的方法。

7. 发明授权

US5994502A Inhibitors of oligosaccharyl transferase 失效
标题翻译：寡糖基转移酶抑制剂
公开(公告)号：US5994502A
公开(公告)日：1999-11-30
申请号：US914494
申请日：1997-08-19
申请人： Barbara Imperiali , Jeffrey R. Spencer , Tamara L. Hendrickson
发明人： Barbara Imperiali , Jeffrey R. Spencer , Tamara L. Hendrickson
IPC分类号： A61K38/00 , C07K7/06 , C12P19/26 , C07K1/14 , C07K5/02 , C07K5/037
CPC分类号： C07K7/06 , C12P19/26 , A61K38/00
摘要： The present invention provides novel inhibitors of oligosaccharyl transferase, methods for producing Glc.sub.3 Man.sub.9 (GlcNAc).sub.2 --P--P--Dol, and methods for producing glycopeptides.
摘要翻译：本发明提供了寡糖基转移酶的新型抑制剂，用于产生Glc3Man9（GlcNAc）2-P-P-Dol的方法和生产糖肽的方法。

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