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1. 发明申请

US20080097709A1 APPARATUS AND METHOD FOR RANGINGS AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS 有权
标题翻译：通过并行检测光谱仪的低相干干涉LCI和光学相干TOMOGRAPHY OCT信号的范围和噪声降低的装置和方法
公开(公告)号：US20080097709A1
公开(公告)日：2008-04-24
申请号：US11956129
申请日：2007-12-13
申请人： Johannes de Boer , Guillermo Tearney , Brett Bouma
发明人： Johannes de Boer , Guillermo Tearney , Brett Bouma
IPC分类号： G01R25/04
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：通过检测并行的一组光谱带来增加光学相干断层扫描和低相干干涉测量（“LCI”）信号的灵敏度的装置和方法，每个频带是光频率的唯一组合。 LCI宽带宽源分为N个频谱带。 N个光谱带被单独检测和处理，以使信噪比增加N倍。每个光谱带由单独的光检测器检测并被放大。对于每个光谱带，信号通过模拟电子装置在信号带周围进行带通滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献减小了等于光谱带数的因子。信号保持不变。喷射噪声的降低增加了系统的动态范围和灵敏度。

2. 发明申请

US20080094637A1 APPARATUS AND METHOD FOR RANGING AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS 有权
公开(公告)号：US20080094637A1
公开(公告)日：2008-04-24
申请号：US11956079
申请日：2007-12-13
申请人： Johannes de Boer , Guillermo Tearney , Brett Bouma
发明人： Johannes de Boer , Guillermo Tearney , Brett Bouma
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02044 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.

3. 发明申请

US20060279742A1 Apparatus, method and system for performing phase-resolved optical frequency domain imaging 有权
标题翻译：用于执行相位分辨光学频域成像的装置，方法和系统
公开(公告)号：US20060279742A1
公开(公告)日：2006-12-14
申请号：US11445990
申请日：2006-06-01
申请人： Guillermo Tearney , Brett Bouma , Johannes De Boer , Benjamin Vakoc , Seok-Hyun Yun
发明人： Guillermo Tearney , Brett Bouma , Johannes De Boer , Benjamin Vakoc , Seok-Hyun Yun
IPC分类号： G01B11/02
CPC分类号： A61B5/0073 , A61B5/0066 , A61B2560/0223 , G01B9/02091 , G01N21/45 , G01N21/4795 , G01N21/49
摘要： Apparatus, system and method are provided which utilize signals received from a reference and a sample. In particular, a radiation is provided which includes at least one first electromagnetic radiation directed to the sample and at least one second electromagnetic radiation directed to the reference. A frequency of the radiation varies over time. An interference can be detected between at least one third radiation associated with the first radiation and at least one fourth radiation associated with the second radiation. It is possible to obtain a particular signal associated with at least one phase of at least one frequency component of the interference, and compare the particular signal to at least one particular information. Further, it is possible to receive at least one portion of the radiation and provide a further radiation, such that the particular signal can be calibrated based on the further signal.
摘要翻译：提供了使用从参考和样本接收的信号的装置，系统和方法。特别地，提供辐射，其包括指向样品的至少一个第一电磁辐射和指向参考的至少一个第二电磁辐射。辐射的频率随时间而变化。可以在与第一辐射相关联的至少一个第三辐射与与第二辐射相关联的至少一个第四辐射之间检测干扰。可以获得与干扰的至少一个频率分量的至少一个相位相关联的特定信号，并将特定信号与至少一个特定信息进行比较。此外，可以接收辐射的至少一部分并提供另外的辐射，使得可以基于另外的信号来校准特定信号。

4. 发明申请

US20050018201A1 Apparatus and method for ranging and noise reduction of low coherence interferometry lci and optical coherence tomography oct signals by parallel detection of spectral bands 有权
标题翻译：用于低相干干涉测量lci和光学相干断层扫描Oct信号的测距和降噪的装置和方法通过频谱带的并行检测
公开(公告)号：US20050018201A1
公开(公告)日：2005-01-27
申请号：US10501276
申请日：2003-01-24
申请人： Johannes de Boer , Guillermo Tearney , Brett Bouma
发明人： Johannes de Boer , Guillermo Tearney , Brett Bouma
IPC分类号： G01B9/02 , G01N21/47
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus, method, logic arrangement and storage medium are provided for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source can be split into N spectral bands. The N spectral bands can be individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band may be detected by a separate photo detector and amplified. For each spectral band, the signal can be band p3 filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is likely reduced by a factor equal to the number of spectral bands, while the signal amplitude can remain the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.
摘要翻译：提供装置，方法，逻辑布置和存储介质，用于通过检测光谱带的并行组来提高光学相干断层扫描和低相干干涉测量（“LCI”）信号的检测灵敏度，每个频带是光频率的唯一组合。 LCI宽带宽源可以分为N个光谱带。可以单独地检测和处理N个频谱带，以使信噪比增加N倍。每个频谱带可以由单独的光检测器检测并被放大。对于每个频谱带，信号可以通过模拟电子装置在信号频带附近进行p3滤波，并且被数字化，或者，信号可以被数字化并且在软件中进行带通滤波。结果，对信号的散粒噪声贡献可能降低等于光谱带数的因子，而信号幅度可以保持相同。喷射噪声的降低增加了系统的动态范围和灵敏度。

5. 发明申请

US20080100837A1 APPARATUS AND METHOD FOR RANGING AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS 有权
公开(公告)号：US20080100837A1
公开(公告)日：2008-05-01
申请号：US11955834
申请日：2007-12-13
申请人： Johannes de Boer , Guillermo Tearney , Brett Bouma
发明人： Johannes de Boer , Guillermo Tearney , Brett Bouma
IPC分类号： G01J3/28
CPC分类号： G01B9/02007 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02008 , G01B9/0201 , G01B9/02032 , G01B9/02044 , G01B9/02045 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45 , G01N21/4795
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.

6. 发明申请

US20080094613A1 APPARATUS AND METHOD FOR RANGING AND NOISE REDUCTION OF LOW COHERENCE INTERFEROMETRY LCI AND OPTICAL COHERENCE TOMOGRAPHY OCT SIGNALS BY PARALLEL DETECTION OF SPECTRAL BANDS 有权
公开(公告)号：US20080094613A1
公开(公告)日：2008-04-24
申请号：US11955961
申请日：2007-12-13
申请人： Johannes de Boer , Guillermo Tearney , Brett Bouma
发明人： Johannes de Boer , Guillermo Tearney , Brett Bouma
IPC分类号： G01N21/00
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , A61B5/7257 , G01B9/02044 , G01B9/02079 , G01B9/0209 , G01B9/02091 , G01B2290/45
摘要： Apparatus and method for increasing the sensitivity in the detection of optical coherence tomography and low coherence interferometry (“LCI”) signals by detecting a parallel set of spectral bands, each band being a unique combination of optical frequencies. The LCI broad bandwidth source is split into N spectral bands. The N spectral bands are individually detected and processed to provide an increase in the signal-to-noise ratio by a factor of N. Each spectral band is detected by a separate photo detector and amplified. For each spectral band the signal is band pass filtered around the signal band by analog electronics and digitized, or, alternatively, the signal may be digitized and band pass filtered in software. As a consequence, the shot noise contribution to the signal is reduced by a factor equal to the number of spectral bands. The signal remains the same. The reduction of the shot noise increases the dynamic range and sensitivity of the system.

7. 发明申请

US20060114473A1 Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample 有权
标题翻译：用于通过同时照射和检测样品上的多个点来执行光学成像的装置，装置，内窥镜，导管和方法
公开(公告)号：US20060114473A1
公开(公告)日：2006-06-01
申请号：US11288994
申请日：2005-11-29
申请人： Guillermo Tearney , Johannes de Boer , Brett Bouma
发明人： Guillermo Tearney , Johannes de Boer , Brett Bouma
IPC分类号： G01B9/02
CPC分类号： G02B23/2469 , A61B5/0066 , A61B5/0073 , A61B5/6852 , G01B9/02001 , G01B9/02091 , G02B21/0032 , G02B21/0056 , G02B23/2453 , G02B23/26
摘要： Devices, arrangements, endoscopes, catheters and methods adapted to propagate at least one electro-magnetic radiation are provided. In particular, a waveguide apparatus specifically configured may be utilized to split the electro-magnetic radiation into a plurality of beams that are intended to illuminate a biological sample, and impart a unique associated characteristic unto each of the beams. The beams may be intended to illuminate a biological sample at distinct locations, and impart a unique associated characteristic unto each of the beams. In addition, a control apparatus may be provided which is configured to control at least one of the fibers and which can be input to the fibers so as to modify the unique associated characteristics of the beams being propagated along the fibers, and thereby modify the characteristics of the distinct locations on the sample.
摘要翻译：提供了适于传播至少一个电磁辐射的装置，布置，内窥镜，导管和方法。特别地，可以使用专门配置的波导装置将电磁辐射分割成旨在照射生物样品的多个光束，并且向每个光束赋予独特的相关特征。光束可以用于在不同的位置照射生物样品，并且赋予每个光束唯一的相关特征。此外，可以提供控制装置，其被配置为控制光纤中的至少一个并且可以输入到光纤，以便改变沿着光纤传播的光束的独特相关特性，从而改变特性的样品上不同的位置。

8. 发明申请

US20120035527A1 PHOTOCHEMICAL TISSUE BONDING 审中-公开
标题翻译：化学组织结合
公开(公告)号：US20120035527A1
公开(公告)日：2012-02-09
申请号：US12681313
申请日：2008-10-02
申请人： Guillermo Tearney , Brett Bouma , Robert W. Redmond , Irene E. Kochevar
发明人： Guillermo Tearney , Brett Bouma , Robert W. Redmond , Irene E. Kochevar
IPC分类号： A61B18/18
CPC分类号： A61N5/062 , A61F2/062 , A61F2/82 , A61L27/3604 , A61L27/50 , A61L31/005 , A61L31/14 , A61N5/0601
摘要： The exemplary embodiments of the present invention provides exemplary methods for adhering biological membranes to luminal anatomical structures using photosensitizing agents and electromagnetic energy. The exemplary embodiments of the present invention also provides method for stabilizing luminal anatomical structures. Further, exemplary embodiments of the present invention provide arrangements for coupling to a luminal anatomical structure.
摘要翻译：本发明的示例性实施例提供了使用光敏剂和电磁能将生物膜粘附到管腔解剖结构的示例性方法。本发明的示例性实施例还提供了用于稳定管腔解剖结构的方法。此外，本发明的示例性实施例提供了耦合到管腔解剖结构的布置。

9. 发明申请

US20080021275A1 METHODS AND SYSTEMS FOR OPTICAL IMAGING OR EPITHELIAL LUMINAL ORGANS BY BEAM SCANNING THEREOF 有权
标题翻译：通过光束扫描对光学成像或上传光学仪器的方法和系统
公开(公告)号：US20080021275A1
公开(公告)日：2008-01-24
申请号：US11625135
申请日：2007-01-19
申请人： Guillermo Tearney , Milen Shishkov , Brett Bouma , Benjamin Vakoc , Norman Nishioka
发明人： Guillermo Tearney , Milen Shishkov , Brett Bouma , Benjamin Vakoc , Norman Nishioka
IPC分类号： A61B1/00
CPC分类号： A61B5/0084 , A61B5/0062 , A61B5/0066 , A61B5/0068 , A61B5/6852 , A61B5/7271 , G06T7/0012 , G06T2207/10056 , G06T2207/10101
摘要： Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.
摘要翻译：提供了布置，装置，系统和系统以获得至少一个管腔或中空样品中的至少一个部分的数据。该装置，系统或装置可以（可通过患者的嘴部或鼻子中的至少一个插入），例如，第一光学装置可以被配置为收发至少一个电磁（例如，可见）第二布置可以至少部分地包围第一布置。此外，第三布置可被配置为被致动以将第一布置定位在管腔或中空样品内的预定位置处，第一布置可以是被配置为补偿由第二布置和/或第三布置引起的至少一个像差（例如，散光），第二布置可以包括使引导布置能够插入到其中的至少一个部分，可以提供另一种布置其被配置为测量所述至少一个部分内的压力，所述数据可以包括所述第一装置的位置和/或取向与r 对于管腔或空心样品。

10. 发明申请

US20070282403A1 METHODS AND SYSTEMS FOR PROVIDING ELECTROMAGNETIC RADIATION TO AT LEAST ONE PORTION OF A SAMPLE USING CONFORMAL LASER THERAPY PROCEDURES 审中-公开
标题翻译：使用一致的激光治疗方法提供电镜至少一个样品的电磁辐射的方法和系统
公开(公告)号：US20070282403A1
公开(公告)日：2007-12-06
申请号：US11670043
申请日：2007-02-01
申请人： Guillermo Tearney , Milen Shishkov , Brett Bouma , Benjamin Vakoc
发明人： Guillermo Tearney , Milen Shishkov , Brett Bouma , Benjamin Vakoc
IPC分类号： A61N5/06 , A61B18/18
CPC分类号： A61B18/24 , A61B5/0066 , A61B2017/00066 , A61B2017/22051 , A61B2018/2272
摘要： According one exemplary embodiment of the present invention, method and system can be provided for applying a laser radiation to at least one portion of a biological structure. For example, a beam of the laser radiation can be provided to the portion, whereas a cross-sectional area of the beam is at most about 1/10th of an entire area of the at least one portion. The beam can be applied to the portion (a) based on a predetermined pattern, (b) while modulating a wavelength of the laser radiation, and/or (c) while monitoring a depth of the application of the laser radiation.
摘要翻译：根据本发明的一个示例性实施例，可以提供用于将激光辐射施加到生物结构的至少一部分的方法和系统。例如，可以向该部分提供激光辐射束，而光束的横截面积至多为至少一部分的整个区域的大约1/10。可以基于预定图案将光束施加到部分（a），（b）同时调制激光辐射的波长，和/或（c）同时监视激光辐射的施加深度。

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