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1. 发明授权

US5183939A Process for the racemization of optically active 1-aryl-alkylamines 失效
标题翻译：光活性1-芳基 - 氨基甲酸酯的制备方法
公开(公告)号：US5183939A
公开(公告)日：1993-02-02
申请号：US796109
申请日：1991-11-21
申请人： Johannes R. Jansen , Martin Littmann
发明人： Johannes R. Jansen , Martin Littmann
IPC分类号： C07B55/00 , C07C209/66 , C07C209/68 , C07C209/82 , C07C209/88 , C07C211/27 , C07C211/29 , C07C211/30 , C07C217/58
CPC分类号： C07C209/68 , C07B2200/07
摘要： A new process for the racemization of optically active 1-aryl-alkylamines of the formula (I) ##STR1## in which Ar represents optionally substituted aryl andR represents alkyl,which is characterized in that compounds of the formula (I) which largely have the R- or S-configuration at the carbon atom marked by * are reacted with metal alkoxides in dimethyl sulphoxide, optionally in the presence of appropriate alcohols, at temperatures between 0.degree. C. and 200.degree. C.
摘要翻译：用于使式（I）的光学活性1-芳基 - 烷基胺外消旋化的新方法其中Ar表示任选取代的芳基，R表示烷基，其特征在于式（I）化合物在0℃和200℃之间的温度下，在由*标记的碳原子上大部分具有R-或S-构型的金属醇盐在二甲基亚砜中任选地在适当的醇存在下与二甲基亚砜反应。

2. 发明申请

US20100190995A1 PROCESS FOR PREPARING CYANIMINO-1,3-THIAZOLIDINES 有权
标题翻译：制备CYANIMINO-1,3-THIAZOLIDINES的方法
公开(公告)号：US20100190995A1
公开(公告)日：2010-07-29
申请号：US12677462
申请日：2008-09-02
申请人： Norbert Lui , Klaus Jelich , Martin Littmann , Klaus Lorenz , Brice Lecorre
发明人： Norbert Lui , Klaus Jelich , Martin Littmann , Klaus Lorenz , Brice Lecorre
IPC分类号： C07D277/18
CPC分类号： C07D277/18
摘要： The present invention relates to a process for preparing cyanimino-1,3-thiazolidines, which are important building blocks for the preparation of crop protection active ingredients and pharmaceuticals, by the following scheme: where A is an alkali metal and X represents an acid radical.
摘要翻译：本发明涉及制备氰氨基-1,3-噻唑烷的方法，它们是制备作物保护活性成分和药物的重要结构单元，其方法如下：其中A为碱金属，X为酸基。

3. 发明授权

US08785673B2 Method for producing 2-chloroallyl thiocyanate and 2-chloroallyl isothiocyanate 失效
标题翻译：硫氰酸2-氯烯丙酯和异硫氰酸2-氯烯丙酯的方法
公开(公告)号：US08785673B2
公开(公告)日：2014-07-22
申请号：US14113739
申请日：2012-04-24
申请人： Thomas Himmler , Matthias Decker , Ralf Dunkel , Peter Gerdes , Martin Littmann , Norbert Lui , Albert Schnatterer
发明人： Thomas Himmler , Matthias Decker , Ralf Dunkel , Peter Gerdes , Martin Littmann , Norbert Lui , Albert Schnatterer
IPC分类号： C07C331/22
CPC分类号： C07C331/22
摘要： A process is described for producing 2-chloroallyl isothiocyanate from 2,3-dichloro-1-propene by reacting the 2,3-dichloro-1-propene with a thiocyanate in the presence of a phase transfer catalyst, without diluent or in the presence of up to 15 percent by weight based on 2,3-dichloropropene and simultaneously in the presence of an excess of from 10 to 200 mol percent of 2,3-dichloro-1-propene based on the thiocyanate. A process starting from 1,2,3-trichloropropane is also described.
摘要翻译：描述了通过2,3-二氯-1-丙烯通过在相转移催化剂存在下使2,3-二氯-1-丙烯与硫氰酸酯反应而无稀释剂或在存在下进行的制备2-氯烯丙基异硫氰酸酯的方法基于2,3-二氯丙烯高达15重量％，同时在过量的10至200摩尔％的基于硫氰酸盐的2,3-二氯-1-丙烯的存在下。还描述了从1,2,3-三氯丙烷开始的方法。

4. 发明授权

US6034278A Method for producing optically active 1-phenylethylamines 失效
标题翻译：光学活性1-苯基乙胺的制备方法
公开(公告)号：US6034278A
公开(公告)日：2000-03-07
申请号：US194719
申请日：1998-12-17
申请人： Walter Merz , Martin Littmann , Udo Kraatz , Christoph Mannheims
发明人： Walter Merz , Martin Littmann , Udo Kraatz , Christoph Mannheims
IPC分类号： C07B53/00 , C07C209/88 , C07C211/27 , C07C211/29 , C07C209/00
CPC分类号： C07C209/88
摘要： The invention concerns a new method for producing optically active 1-phenylethylamines, wherein (a) racemic 1-phenylethylamines are reacted with (S)-(-)-N-phenylcarbamate lactic acid in the presence of an aliphatic or aromatic hydrocarbon and in the presence of a lower aliphatic alcohol, wherein the reaction components are measured so that for every mole of racemic amine, between 0.25 and 0.5 mole of (S)-(-)-N-phenylcarbamate lactic acid are present, the reaction mixture is then concentrated at a liquid-phase temperature of up to 40.degree. C., the resulting solid product is separated, treated with diluted, aqueous alkaline lye in the presence of a hydrocarbon, and the respective (R)-amine is isolated by distillation from the organic phase, and if necessary, (b) the mother liquor remaining after the separation of the solid product is reacted in the presence of a lower aliphatic alcohol with (S)-(-)-N-phenylcarbamate lactic acid, wherein the reaction components are measured so that the molar quantity of (S)-(-)-N-phenylcarbamate lactic acid is twice as great as the quantity of (R)-amine still remaining in the mother liquor, the reaction mixture is then concentrated at a liquid-phase temperature of up to 40.degree. C., the resulting solid product is separated and the (S)-amine is isolated by distillation from the mother liquor.
摘要翻译： PCT No.PCT / EP97 / 02988第 371日期1998年12月17日第 102（e）日期1998年12月17日PCT提交1997年6月9日PCT公布。公开号WO97 / 49665 PCT 日期1997年12月31日本发明涉及一种用于制备光学活性1-苯基乙胺的新方法，其中（a）外消旋1-苯乙基胺与（S） - （ - ） - N-苯基氨基甲酸酯乳酸在脂肪族或芳族烃和低级脂族醇的存在下，其中测量反应组分，使得对于每摩尔外消旋胺，存在0.25至0.5摩尔（S） - （ - ） - N-苯基氨基甲酸酯乳酸，然后将反应混合物在高达40℃的液相温度下浓缩，分离得到的固体产物，在烃存在下用稀释的碱性碱水溶液处理，分离出（R） - 胺（b）将固体产物分离后剩余的母液在低级脂族醇与（S） - （ - ） - N-苯基氨基甲酸酯乳酸的存在下反应，其中测量反应组分 d，使得（S） - （ - ） - N-苯基氨基甲酸酯乳酸的摩尔量是母液中残留的（R） - 胺的量的两倍，然后将反应混合物以液 - 相温度高达40℃，分离得到的固体产物，并通过蒸馏从母液中分离出（S） - 胺。

5. 发明授权

US5126454A Process for the preparation of sulphonylisoureas 失效
标题翻译：制备硫代烟酸钠的方法
公开(公告)号：US5126454A
公开(公告)日：1992-06-30
申请号：US561641
申请日：1990-08-01
申请人： Reinhard Lantzsch , Klaus-Helmut Muller , Martin Littmann
发明人： Reinhard Lantzsch , Klaus-Helmut Muller , Martin Littmann
IPC分类号： C07D251/14 , A01N47/42 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/52 , C07D251/42 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D521/00
CPC分类号： C07D239/42 , C07D239/47 , C07D239/52 , C07D521/00
摘要： A process for the preparation of a sulphonylisourea of the formula ##STR1## in which R.sup.1 is an optionally substituted radical selected from the group consisting of alkyl, aralkyl, aryl and heteroaryl,R.sup.2 is alkyl or aralkyl,R.sup.3 is hydrogen, halogen or in each case optionally substituted alkyl or alkoxy,R.sup.4 is hydrogen, halogen or in each case optionally substituted alkyl or alkoxy andZ is nitrogen or a CH grouping,which comprises reacting an isourea of the formula ##STR2## with a sulphonyl halide of the formulaR.sup.1 --SO.sub.2 --X (III)in whichX is halogen,in the presence of an acid acceptor at a temperature between about -20.degree. C. and +50.degree. C. Some of the compounds II are new.
摘要翻译：制备式（I）的磺酰基异脲的方法，其中R 1是选自烷基，芳烷基，芳基和杂芳基的任选取代的基团，R 2是烷基或芳烷基，R 3是氢，卤素或者在每种情况下是任选取代的烷基或烷氧基，R 4是氢，卤素或在每种情况下是任选取代的烷基或烷氧基，Z是氮或CH基团，其包括使式（VI）的异脲与磺酰基在酸受体的存在下，在约-20℃至+ 50℃的温度下，其中X为卤素的式R 1 -SO 2 -X（III）的卤化物。一些化合物II是新的。

6. 发明授权

US08835645B2 Process for preparing cyanimino-1,3-thiazolidines 有权
标题翻译：制备氰氨基-1,3-噻唑烷的方法
公开(公告)号：US08835645B2
公开(公告)日：2014-09-16
申请号：US12677462
申请日：2008-09-02
申请人： Norbert Lui , Klaus Jelich , Martin Littmann , Klaus Lorenz , Brice Lecorre
发明人： Norbert Lui , Klaus Jelich , Martin Littmann , Klaus Lorenz , Brice Lecorre
IPC分类号： C07D277/06 , C07D277/18
CPC分类号： C07D277/18
摘要： The present invention relates to a process for preparing cyanimino-1,3-thiazolidines, which are important building blocks for the preparation of crop protection active ingredients and pharmaceuticals, by the following scheme: where A is an alkali metal and X represents an acid radical.
摘要翻译：本发明涉及制备氰氨基-1,3-噻唑烷的方法，它们是制备作物保护活性成分和药物的重要结构单元，其方法如下：其中A为碱金属，X为酸基。

7. 发明申请

US20140107367A1 METHOD FOR PRODUCING 2-CHLOROALLYL THIOCYANATE AND 2-CHLOROALLYL ISOTHIOCYANATE 失效
标题翻译：生产2-氯苯甲酸和2-氯代异硫氰酸酯的方法
公开(公告)号：US20140107367A1
公开(公告)日：2014-04-17
申请号：US14113739
申请日：2012-04-24
申请人： Thomas Himmler , Matthias Decker , Ralf Dunkel , Peter Gerdes , Martin Littmann , Norbert Lui , Albert Schnatterer
发明人： Thomas Himmler , Matthias Decker , Ralf Dunkel , Peter Gerdes , Martin Littmann , Norbert Lui , Albert Schnatterer
IPC分类号： C07C331/22
CPC分类号： C07C331/22
摘要： A process is described for producing 2-chloroallyl isothiocyanate from 2,3-dichloro-1-propene by reacting the 2,3-dichloro-1-propene with a thiocyanate in the presence of a phase transfer catalyst, without diluent or in the presence of up to 15 percent by weight based on 2,3-dichloropropene and simultaneously in the presence of an excess of from 10 to 200 mol percent of 2,3-dichloro-1-propene based on the thiocyanate. A process starting from 1,2,3-trichloropropane is also described.
摘要翻译：描述了通过2,3-二氯-1-丙烯通过在相转移催化剂存在下使2,3-二氯-1-丙烯与硫氰酸酯反应而无稀释剂或在存在下进行的制备2-氯烯丙基异硫氰酸酯的方法基于2,3-二氯丙烯高达15重量％，同时在过量的10至200摩尔％的基于硫氰酸盐的2,3-二氯-1-丙烯的存在下。还描述了从1,2,3-三氯丙烷开始的方法。

8. 发明授权

US4988829A Process for the preparation of 2-(4-chlorophenylethyl)-2-tert.-butyl-oxirane 失效
标题翻译： 2-（4-氯苯乙基）-2-叔丁基 - 环氧乙烷的制备方法
公开(公告)号：US4988829A
公开(公告)日：1991-01-29
申请号：US373770
申请日：1989-06-30
申请人： Paul Fiedler , Martin Littmann , Manfred Lenthe , Achim Noak , Gerd Siekmann
发明人： Paul Fiedler , Martin Littmann , Manfred Lenthe , Achim Noak , Gerd Siekmann
IPC分类号： C07D303/08
CPC分类号： C07D303/08
摘要： A process for making the known fungicide intermediate 2-(4-chlorophenyl ethyl)-2-tert.-butyloxirane of the formula ##STR1## comprising (a) mixing a solution of trimethylsulphonium bromide of the formula(CH.sub.3).sub.3 S.sup..sym. Br.sup..crclbar. (II) in a methanol/toluene mixture with preheated toluene and simultaneously distilling off a methanol/toluene mixture at a temperature between 65.degree. and 110.degree. C. until a suspension having a solids content between 10 and 70% by weight is formed, and(b) reacting the suspension of trimethylsulphonium bromide in toluene thus obtained with 1-(4-chlorophenyl)-4,4-dimethylpentan-3-one of the formula ##STR2## in the presence of solid potassium hydroxide, diethylene glycol and water at a temperature between 20.degree. and 120.degree. C., the amounts of the reaction components being such that per mole of 1-(4-chlorophenyl)-4,4-dimethylpentan-3-one of the formula (III) there are presentbetween 1 and 2 moles of trimethylsulphonium bromide of the formula (II),between 2 and 3 moles of solid potassium hydroxide and alsobetween 0.1 and 10% by weight of diethylene glycol and between 0.5 and 12% by weight of water, relative to 1-(4-chlorophenyl)-4,4-dimethylpentan-3-one of the formula (III).
摘要翻译：制备已知的杀真菌剂中间体式（I）的2-（4-氯苯基乙基）-2-叔丁基环氧乙烷的方法包括（a）将式（CH3）3S的三甲基锍溴化物 +）Br（ - ）（II）的甲醇/甲苯混合物中，同时在65-110℃的温度下蒸馏除去甲醇/甲苯混合物，直到固体含量为10至70％，并且（b）使由此获得的甲苯中的三甲基锍溴化物的悬浮液与式（III）的1-（4-氯苯基）-4,4-二甲基戊-3-酮在存在固体氢氧化钾，二甘醇和水，温度在20℃至120℃之间，反应组分的量使得每摩尔1-（4-氯苯基）-4,4-二甲基戊-3-酮为式（III）中存在1至2摩尔式（II）的三甲基锍溴化物，2至3小时固体氢氧化钾和0.1至10重量％的二甘醇和0.5至12重量％的水相对于式（I）的1-（4-氯苯基）-4,4-二甲基戊-3-酮，（三）。

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