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1. 发明授权

US06815217B2 Use of check surfaces for identifying disturbing samples in a detection procedure 失效
标题翻译：在检测程序中使用检查表面识别干扰样品
公开(公告)号：US06815217B2
公开(公告)日：2004-11-09
申请号：US09463547
申请日：2000-01-21
申请人： Johann Karl , Helmut Lenz , Friedemann Krause , Peter Finckh , Hans Hornauer , Johann Berger
发明人： Johann Karl , Helmut Lenz , Friedemann Krause , Peter Finckh , Hans Hornauer , Johann Berger
IPC分类号： G01N33553
CPC分类号： G01N33/54366 , C12Q1/6834 , Y10S435/805 , Y10S435/81 , Y10S435/962 , Y10S435/973 , Y10S435/974
摘要： A solid phase with at least one test area is described which contains reagents for the detection of at least one analyte in a sample, wherein the solid phase additionally comprises at least one control area for the detection of interfering reactions.
摘要翻译：描述了具有至少一个测试区域的固相，其包含用于检测样品中至少一种分析物的试剂，其中所述固相还包含用于检测干扰反应的至少一个控制区域。

2. 发明授权

US07229771B2 Polyethylene glycol-derivatized biomolecules and their use in heterogeneous detection methods 失效
标题翻译：聚乙二醇衍生的生物分子及其在异种检测方法中的应用
公开(公告)号：US07229771B2
公开(公告)日：2007-06-12
申请号：US09184043
申请日：1998-11-02
申请人： Hans Hornauer , Peter Sluka , Johann Karl , Helmut Lenz , Wolfgang Mutter
发明人： Hans Hornauer , Peter Sluka , Johann Karl , Helmut Lenz , Wolfgang Mutter
IPC分类号： G01N33/53 , G01N33/543 , G01N33/545 , G01N33/547 , C07K1/10
CPC分类号： G01N33/54353 , G01N33/54306 , G01N33/54393 , Y10S530/812
摘要： The use of polyalkylene oxide modified reagents is disclosed in a method for the detection of an analyte or in suitable reagent kits for such methods.
摘要翻译：在用于检测分析物的方法或用于这种方法的合适的试剂盒中公开了使用聚环氧烷改性的试剂。

3. 发明授权

US6153393A Elimination of interference in diagnostic methods by peptides comprising D-amino acids 失效
标题翻译：通过包含D-氨基酸的肽消除对诊断方法的干扰
公开(公告)号：US6153393A
公开(公告)日：2000-11-28
申请号：US210040
申请日：1998-12-11
申请人： Christoph Seidel , Helmut Lenz , Johann Karl , Beatus Ofenloch-Hahnle , Ursula Klause , Elke Faatz
发明人： Christoph Seidel , Helmut Lenz , Johann Karl , Beatus Ofenloch-Hahnle , Ursula Klause , Elke Faatz
IPC分类号： G01N33/531 , C07K7/00 , G01N33/53 , G01N33/543 , A61K38/00 , A61K38/04 , C12N15/09
CPC分类号： G01N33/54393 , G01N33/5306 , Y10S435/962
摘要： The invention concerns the use of peptides which are comprised essentially of D-amino acids to eliminate interference in diagnostic methods, a method for eliminating interference in diagnostic methods by peptides which are comprised essentially of D-amino acids as well as a reagent that eliminates interference containing at least one peptide which is comprised essentially of D-amino acids.
摘要翻译：本发明涉及使用基本上由D-氨基酸组成的肽以消除诊断方法的干扰，用于消除基本上由D-氨基酸组成的肽的诊断方法的干扰的方法以及消除干扰的试剂含有至少一种基本上由D-氨基酸组成的肽。

4. 发明授权

US10663538B2 Monitoring of a temporal change in a magnetic field in a magnetic resonance device 有权
公开(公告)号：US10663538B2
公开(公告)日：2020-05-26
申请号：US15700124
申请日：2017-09-09
申请人： Wolfgang Bielmeier , Gerhard Brinker , Swen Campagna , Nikolaus Demharter , Bernd Erbe , Matthias Gebhardt , Helmut Lenz , Jürgen Nistler , Dominik Paul , Carsten Prinz , Gudrun Ruyters , Stephan Stöcker , Markus Vester
发明人： Wolfgang Bielmeier , Gerhard Brinker , Swen Campagna , Nikolaus Demharter , Bernd Erbe , Matthias Gebhardt , Helmut Lenz , Jürgen Nistler , Dominik Paul , Carsten Prinz , Gudrun Ruyters , Stephan Stöcker , Markus Vester
IPC分类号： G01R33/24 , G01R33/385 , G01R33/28
摘要： A method for monitoring a temporal change in a magnetic field in a magnetic resonance device, as well as an evaluation unit, a magnetic resonance device, and a computer program product for performing the method are provided. The method provides that a position-dependent magnetic field distribution that is produced by the plurality of gradient coils is provided with a plurality of monitoring points. In addition, time-dependent gradient values of the plurality of gradient coils are ascertained. Based on position-dependent magnetic field distribution and the time-dependent gradient values, the temporal change in the magnetic field is ascertained. The temporal change in the magnetic field is monitored by comparing the temporal change in the magnetic field with at least one limit value.

5. 发明申请

US20180074138A1 MONITORING OF A TEMPORAL CHANGE IN A MAGNETIC FIELD IN A MAGNETIC RESONANCE DEVICE 审中-公开
公开(公告)号：US20180074138A1
公开(公告)日：2018-03-15
申请号：US15700124
申请日：2017-09-09
申请人： Wolfgang Bielmeier , Gerhard Brinker , Swen Campagna , Nikolaus Demharter , Bernd Erbe , Matthias Gebhardt , Helmut Lenz , Jürgen Nistler , Dominik Paul , Carsten Prinz , Gudrun Ruyters , Stephan Stöcker , Markus Vester
发明人： Wolfgang Bielmeier , Gerhard Brinker , Swen Campagna , Nikolaus Demharter , Bernd Erbe , Matthias Gebhardt , Helmut Lenz , Jürgen Nistler , Dominik Paul , Carsten Prinz , Gudrun Ruyters , Stephan Stöcker , Markus Vester
IPC分类号： G01R33/24 , G01R33/385 , G01R33/28
CPC分类号： G01R33/24 , G01R33/288 , G01R33/385
摘要： A method for monitoring a temporal change in a magnetic field in a magnetic resonance device, as well as an evaluation unit, a magnetic resonance device, and a computer program product for performing the method are provided. The method provides that a position-dependent magnetic field distribution that is produced by the plurality of gradient coils is provided with a plurality of monitoring points. In addition, time-dependent gradient values of the plurality of gradient coils are ascertained. Based on position-dependent magnetic field distribution and the time-dependent gradient values, the temporal change in the magnetic field is ascertained. The temporal change in the magnetic field is monitored by comparing the temporal change in the magnetic field with at least one limit value.

6. 发明授权

US08664007B2 Immune complex-specific antibodies for increased sensitivity in immunoassay array tests 有权
标题翻译：免疫复合物特异性抗体，用于在免疫测定阵列测试中提高灵敏度
公开(公告)号：US08664007B2
公开(公告)日：2014-03-04
申请号：US11260938
申请日：2005-10-28
申请人： Ursula Klause , Helmut Lenz , Christine Markert-Hahn
发明人： Ursula Klause , Helmut Lenz , Christine Markert-Hahn
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , G01N33/6854
摘要： The invention concerns a method for determining antigen-specific antibodies of a particular immunoglobulin class in a sample by means of an immunoassay in an array format in which various binding partners Bnx are bound on different discrete areas on a support where Bnx in each case contain the various antigens that are able to specifically bind to the antibodies to be detected, by incubating the support with the sample and a binding partner B2 which carries a label and subsequently detecting the label on the respective discrete areas wherein B2 specifically binds antibodies of a certain immunoglobulin class that have been bound in an antigen-specific manner.
摘要翻译：本发明涉及通过以阵列格式的免疫测定来测定样品中特定免疫球蛋白类别的抗原特异性抗体的方法，其中各种结合配偶体Bnx结合在支架上的不同离散区域上，其中每种情况下Bnx包含能够通过将载体与样品一起孵育的各种抗原和携带标记的结合伴侣B2，随后检测各个离散区域上的标记，其中B2特异性结合某种免疫球蛋白的抗体已经以抗原特异性方式结合的类。

7. 发明申请

US20080012636A1 Electric Amplifier and Method for the Control Thereof 有权
标题翻译：电动放大器及其控制方法
公开(公告)号：US20080012636A1
公开(公告)日：2008-01-17
申请号：US11629442
申请日：2005-06-14
申请人： Helmut Lenz
发明人： Helmut Lenz
IPC分类号： H03F1/36
CPC分类号： G01R33/3852
摘要： A method for controlling an electric amplifier is provided. The method includes monitoring a closed-loop control signal of a regulator, which triggers an end stage of the amplifier; adjusting the closed-loop control signal as a function of an output signal of the end stage; comparing the closed-loop control signal with a reference signal; triggering the end stage when an amplitude limit value and a period length limit value are exceeded or undershot by the amplitude value and period length value, respectively, of the closed-loop control signal; and blocking an input side and/or the regulator when the end stage is triggered.
摘要翻译：提供了一种用于控制电放大器的方法。该方法包括监视调节器的闭环控制信号，其触发放大器的末级; 根据终端的输出信号调整闭环控制信号; 将闭环控制信号与参考信号进行比较; 当分别超过或低于闭环控制信号的振幅值和周期长度值的振幅限制值和周期长度限制值时，触发结束级; 并且当终端被触发时阻塞输入侧和/或调节器。

8. 发明申请

US20070262892A1 Method for generating a modulator input signal and premodulator 失效
标题翻译：用于产生调制器输入信号和预调制器的方法
公开(公告)号：US20070262892A1
公开(公告)日：2007-11-15
申请号：US11784047
申请日：2007-04-05
申请人： Helmut Lenz
发明人： Helmut Lenz
IPC分类号： H03M3/00
CPC分类号： H03F3/2173
摘要： A method for generating at least one modulator input signal from at least one regulator signal is provided. The method comprising: generating at least one dither signal based on the periodic output of elements of a discrete dither sequence of the basic form DF=0, 1, 2 . . . 2(m−n)−1; and adding the at least one dither signal to the regulator signal. The regulator signal comprises a digital regulator signal with a length of m bits, and the modulator input signal comprises a digital modulator input signal with a length of n bits, where m>n.
摘要翻译：提供了一种用于从至少一个调节器信号产生至少一个调制器输入信号的方法。该方法包括：基于基本形式DF = 0,1,2的离散抖动序列的元素的周期性输出来产生至少一个抖动信号。。。 2（m-n）-1; 以及将所述至少一个抖动信号添加到所述调节器信号。调节器信号包括长度为m位的数字调节器信号，并且调制器输入信号包括长度为n位的数字调制器输入信号，其中m> n。

9. 发明授权

US07091632B2 Stabilization circuit for compensating fluctuations in a voltage at a user 失效
公开(公告)号：US07091632B2
公开(公告)日：2006-08-15
申请号：US10266293
申请日：2002-10-08
申请人： Helmut Lenz
发明人： Helmut Lenz
IPC分类号： H02J3/24
CPC分类号： H02J3/1814 , H02J9/06 , Y02E40/18
摘要： A stabilization circuit wherein voltages of the secondary winding of a transformer are stabilized with respect to mains voltage fluctuations and load fluctuations, an auxiliary voltage is derived either from a secondary winding of the transformer or an auxiliary transformer. Together with the mains voltage portion of this auxiliary voltage acquired by pulse-width modulation forms the primary voltage of the transformer such that the desired stabilization is achieved.

10. 发明授权

US6060285A Process for the production of hetero-bispecific antibodies 失效
标题翻译：异源双特异性抗体的制备方法
公开(公告)号：US6060285A
公开(公告)日：2000-05-09
申请号：US500596
申请日：1990-03-22
申请人： Helmut Lenz , Ulrich Weidle
发明人： Helmut Lenz , Ulrich Weidle
IPC分类号： C07K16/46 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , C12R1/19 , C12R1/91 , C07H15/12 , C12N5/00 , C12N15/00 , C12P21/06
CPC分类号： C07K16/468 , Y10S435/972
摘要： For the production of hetero-bispecific monoclonal antibodies at least the genes for the light chain and for the variable part of the heavy chain are isolated from a hybridoma cell line which secretes an antibody with a desired specificity and they are inserted into a eukaryotic plasmid vector which contains a marker capable of selection together with a strong promoter, this expression vector is transfected into a hybridoma cell line which secretes antibodies with a second desired specificity, the cell line is cultured, the antibodies are obtained and the bispecific antibody is isolated.
摘要翻译：为了生产异双特异性单克隆抗体，至少将轻链基因和重链可变部分从杂交瘤细胞系中分离出来，所述杂交瘤细胞系将具有所需特异性的抗体分泌，并将其插入真核质粒载体其包含能够与强启动子一起选择的标记，将该表达载体转染到以第二所需特异性分泌抗体的杂交瘤细胞系中，培养细胞系，获得抗体并分离双特异性抗体。

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