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1. 发明授权

US08301228B2 Real time radiation treatment planning system 有权
标题翻译：实时辐射治疗计划系统
公开(公告)号：US08301228B2
公开(公告)日：2012-10-30
申请号：US13013051
申请日：2011-01-25
申请人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
发明人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
IPC分类号： A61B6/00
CPC分类号： A61N5/1031 , A61N5/1001 , A61N5/1007 , A61N5/1039 , A61N2005/1012 , A61N2005/1032 , A61N2005/1074 , G06F19/00 , G06F19/3481
摘要： The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm. For pre-planning or virtual simulation purposes, the processing means is arranged to determine in real time the optimal number and position of at least one of the needles, positions of energy emitting sources within the needles, and the dwell times of the energy emitting sources at the positions. For post-planning purposes, the processing means is arranged to determine, based on three-dimensional image information, in real time the real needle positions and the dwell times of the energy emitting sources for the positions.
摘要翻译：本发明涉及一种实时放射治疗计划系统，用于使用空心针对动物体的预先选择的解剖部分进行放射治疗。根据本发明的实施例，系统可以包括处理装置处理装置，其被配置为相对于预先选择的解剖部分内的一个或多个特定器官执行三维成像算法和三维图像分割算法并且相对于针，用于使用至少一个单目标或多目标基于解剖的遗传优化算法将用成像装置获得的图像数据转换成解剖部分的三维图像。对于预先规划或虚拟模拟目的，处理装置被布置成实时确定针中的至少一个针的最佳数量和位置，针内的能量发射源的位置以及能量发射源的停留时间在职位。为了规划后的目的，处理装置被布置成基于三维图像信息实时确定位置的能量发射源的实际针位置和停留时间。

2. 发明授权

US07899517B2 Real time radiation treament planning system 有权
标题翻译：实时辐射处理规划系统
公开(公告)号：US07899517B2
公开(公告)日：2011-03-01
申请号：US10448311
申请日：2003-05-30
申请人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
发明人： Johann Kindlein , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
IPC分类号： A61B5/05
CPC分类号： A61N5/1031 , A61N5/1001 , A61N5/1007 , A61N5/1039 , A61N2005/1012 , A61N2005/1032 , A61N2005/1074 , G06F19/00 , G06F19/3481
摘要： A real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body. A processor is provided with a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm for at least the specific organs within the anatomical portion and the needles. The processor converts the image data into a three-dimensional image of the anatomical portion using at least one single or multi-objective anatomy based genetic optimization algorithm. The processor determines in real time the optimal number and position of the hollow needles, the position of the energy emitting source within each hollow needle and the dwell times of the energy emitting source at each position. For post planning purposes, the processor determines, based on three-dimensional image information in real time, the real needle positions and the dwell times of the energy emitting source for each position.
摘要翻译：一种实时放射治疗计划系统，用于对动物体的预先选择的解剖部分进行放射治疗。为处理器提供三维成像算法和至少在解剖部分和针内的特定器官的三维图像分割算法。处理器使用至少一个基于单目标或多目标解剖学的遗传优化算法将图像数据转换成解剖部分的三维图像。处理器实时确定中空针的最佳数量和位置，能量发射源在每个中空针内的位置以及在每个位置处的能量发射源的驻留时间。对于后期规划目的，处理器基于实时的三维图像信息确定每个位置的能量发射源的实际针位置和停留时间。

3. 发明申请

US20110288361A1 REAL TIME RADIATION TREATMENT PLANNING SYSTEM 有权
标题翻译：实时放射治疗计划系统
公开(公告)号：US20110288361A1
公开(公告)日：2011-11-24
申请号：US13013051
申请日：2011-01-25
申请人： Johann KINDLEIN , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
发明人： Johann KINDLEIN , Dimos Baltas , Georgios Sakas , Frans Kuipers , Hans Martin Schot
IPC分类号： A61M36/12
CPC分类号： A61N5/1031 , A61N5/1001 , A61N5/1007 , A61N5/1039 , A61N2005/1012 , A61N2005/1032 , A61N2005/1074 , G06F19/00 , G06F19/3481
摘要： The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm. For pre-planning or virtual simulation purposes, the processing means is arranged to determine in real time the optimal number and position of at least one of the needles, positions of energy emitting sources within the needles, and the dwell times of the energy emitting sources at the positions. For post-planning purposes, the processing means is arranged to determine, based on three-dimensional image information, in real time the real needle positions and the dwell times of the energy emitting sources for the positions.
摘要翻译：本发明涉及一种实时放射治疗计划系统，用于使用空心针对动物体的预先选择的解剖部分进行放射治疗。根据本发明的实施例，系统可以包括处理装置处理装置，其被配置为相对于预先选择的解剖部分内的一个或多个特定器官执行三维成像算法和三维图像分割算法并且相对于针，用于使用至少一个单目标或多目标基于解剖的遗传优化算法将用成像装置获得的图像数据转换成解剖部分的三维图像。对于预先规划或虚拟模拟目的，处理装置被布置成实时确定针中的至少一个针的最佳数量和位置，针内的能量发射源的位置以及能量发射源的停留时间在职位。为了规划后的目的，处理装置被布置成基于三维图像信息实时确定位置的能量发射源的实际针位置和停留时间。

4. 发明授权

US07749150B2 Device for radiation treatment of proliferative tissue surrounding a cavity in an animal body 失效
标题翻译：用于放射治疗动物体内腔体周围增生组织的装置
公开(公告)号：US07749150B2
公开(公告)日：2010-07-06
申请号：US11165128
申请日：2005-06-24
申请人： Johann Kindlein , Hans Martin Schot
发明人： Johann Kindlein , Hans Martin Schot
IPC分类号： A61N5/00
CPC分类号： A61N5/1015
摘要： The invention relates to a device for radiation treatment of proliferative tissue surrounding a cavity in an animal body comprising a radiation delivering means for placing at least one energy emitting source at a desired position within the cavity for performing radiation treatment. The device includes at least one permanent implant element for placement in the body cavity that is made from a non-deformable material and has an outer surface around which the inner surface of the body cavity will adapt or conform itself. The invention aims to provide a device and method for radiation treatment of proliferative tissue surrounding a cavity in an animal body, wherein the radiation treatment is performed in a far more accurate and reproducible manner and wherein the device causes far less discomfort to the patient.
摘要翻译：本发明涉及一种用于放射治疗包围动物体腔内的增生组织的装置，其包括用于将至少一个能量发射源放置在腔内的期望位置以进行辐射治疗的辐射递送装置。该装置包括至少一个用于放置在体腔中的永久性植入元件，其由不可变形的材料制成并且具有外表面，身体腔的内表面围绕该外表面适应或适应自身。本发明的目的在于提供一种用于放射治疗动物体内空腔周围的增生组织的装置和方法，其中以更准确和更可重复的方式进行放射治疗，并且其中该装置对患者造成的不舒服。

5. 发明授权

US07267643B2 Method and apparatus for temporarily inserting and positioning at least one energy emitting source in an animal body 有权
标题翻译：用于在动物体中临时插入和定位至少一个能量发射源的方法和装置
公开(公告)号：US07267643B2
公开(公告)日：2007-09-11
申请号：US10452123
申请日：2003-06-03
申请人： Albert Dirk Adrianus Koster , Frits Van Krieken , Hans Martin Schot
发明人： Albert Dirk Adrianus Koster , Frits Van Krieken , Hans Martin Schot
IPC分类号： A61N5/00 , A61M36/00
CPC分类号： A61N5/1027 , A61N2005/1011
摘要： The invention relates to a method and apparatus for temporarily inserting and positioning at least one energy emitting source in an animal body, wherein the apparatus comprises at least: a hollow open needle having a proximal needle end and a distal needle end to be inserted into the body, so as to provide a channel in the body; a guide tube having a proximal guide tube end and a distal guide tube end to be inserted into the hollow open needle; the hollow open needle being retractable from the body over the guide tube; a first fixing element for fixating the guide tube with said proximal guide tube end relative to the body; a catheter tube having a closed distal catheter tube end and an open proximal catheter tube end to be inserted with its distal catheter tube end until a predetermined depth into the guide tube and the body via said proximal guide tube end and fixating the catheter tube to the guide tube; at least one energy emitting source for insertion into the catheter tube via said proximal catheter tube end and, which at least one energy emitting source is removed after a predetermined period of time from the catheter tube.According to the invention the hollow open needle and said guide tube are inserted through a part of said body leaving both proximal and distal ends of said guide tube exposed outside either sides of said part of said body, and a second fixing element for fixing the guide tube with said distal guide tube end relative to the body.
摘要翻译：本发明涉及一种用于在动物体内临时插入和定位至少一个能量发射源的方法和装置，其中该装置至少包括：具有近端针端和远端针端的中空开口针，身体，以便在身体中提供通道; 引导管，其具有近端引导管端和待插入中空开放针的远端引导管端; 所述中空开口针可从所述主体伸出所述导管; 第一固定元件，用于将所述引导管与所述近端引导管端相对于所述主体固定; 导管，其具有封闭的远端导管管端和开放的近端导管管端，以将其远端导管管端插入，直到通过所述近端引导管端到达导管和身体的预定深度并且将导管管固定到导管; 至少一个能量发射源，用于经由所述近端导管管端插入所述导管管中，并且在从所述导管管预定的时间段之后，至少一个能量发射源被去除。根据本发明，中空开口针和引导管插入穿过所述主体的一部分，使所述引导管的近端和远端暴露在所述主体的所述部分的任一侧的外侧，以及用于固定引导件的第二固定元件管，其中所述远端引导管端相对于身体。

6. 发明授权

US06251060B1 Apparatus and method for temporarily inserting a radioactive source in an animal body 有权
标题翻译：在动物体内临时插入放射源的装置和方法
公开(公告)号：US06251060B1
公开(公告)日：2001-06-26
申请号：US09375526
申请日：1999-08-17
申请人： Eric Van't Hooft , Hans Martin Schot , Albert Dirk Adrianus Koster , Lu Anne Johnson
发明人： Eric Van't Hooft , Hans Martin Schot , Albert Dirk Adrianus Koster , Lu Anne Johnson
IPC分类号： A61N500
CPC分类号： A61M37/0069 , A61D7/00 , A61N5/1007 , A61N5/1027 , A61N2005/1011
摘要： A method and apparatus for temporarily inserting a radioactive source in a body. A flexible, closed-end sheath is first inserted in the body in a known way. Thereafter a radiation device having a radioactive source therein is inserted into the sheath and detachably connected to a fixing element. After a predetermined period of time, the radiation device is disconnected from the fixing element and removed from the body.
摘要翻译：一种用于将放射源临时插入体内的方法和装置。首先以已知的方式将柔性封闭端护套插入体内。此后，其中具有放射源的辐射装置被插入到护套中并且可拆卸地连接到固定元件。在预定的时间段之后，辐射装置与固定元件断开并从身体移除。

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