专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06977773B2 Scanning microscope and coupling-out element 有权
标题翻译：扫描显微镜和耦合元件
公开(公告)号：US06977773B2
公开(公告)日：2005-12-20
申请号：US10766260
申请日：2004-01-27
申请人： Johann Engelhardt , Werner Knebel , Heinrich Ulrich
发明人： Johann Engelhardt , Werner Knebel , Heinrich Ulrich
IPC分类号： G02B21/00
CPC分类号： G02B21/008 , G02B21/0032
摘要： A scanning microscope has a light source that emits illuminating light for illumination of a specimen, at least one first detector for detection of the detected light proceeding from the specimen, an objective arranged in both an illumination beam path and a detection beam path, and a coupling-out element that is selectably for descan detection and non-descan detection positionable in the illumination and detection beam path. A light-guiding fiber is provided for transporting at least a portion of the detection light from the coupling-out element to the first detector.
摘要翻译：扫描显微镜具有发射用于照射样本的照明光的光源，用于检测从样本进行的检测光的至少一个第一检测器，布置在照明光束路径和检测光束路径中的物镜，以及耦合输出元件，其可选择地用于在照明和检测光束路径中定位的分辨率检测和非降低检测。提供了一种导光纤维，用于将来自耦合输出元件的检测光的至少一部分传输到第一检测器。

2. 发明授权

US5903688A Device for feeding a UV laser into a confocal laser scanning microscope 失效
标题翻译：用于将UV激光馈送到共焦激光扫描显微镜的装置
公开(公告)号：US5903688A
公开(公告)日：1999-05-11
申请号：US793005
申请日：1997-02-06
申请人： Johann Engelhardt , Heinrich Ulrich , Klaus Kierschke
发明人： Johann Engelhardt , Heinrich Ulrich , Klaus Kierschke
IPC分类号： G02B21/00 , G02B21/16 , G02B6/42
CPC分类号： G02B21/0024 , G02B21/0032 , G02B21/0036 , G02B21/16
摘要： A device for feeding a light beam from a UV laser (1) into a laser scanning microscope (2) has a beam-alignment assembly (3) for aligning the laser beam with the beam path of the microscope (2) and an optical-fiber element (4) located between the UV laser (1) and the beam-alignment assembly (3). The aim of the invention is to design the feed device so that it can be used for long periods in order to keep the time and expense necessary to change the feed device as low as possible. To achieve this, the invention provides a beam interrupter (5) located between the UV laser (1) and the optical-fiber element (4). The beam interrupter allows the beam from the UV laser (1) to pass through the optical-fiber element (4) only during scanning, i.e., when pictures are being generated.
摘要翻译： PCT No.PCT / EP95 / 02627 Sec。 371日期1997年2月6日 102（e）日期1997年2月6日PCT提交1995年7月6日PCT公布。出版物WO96 / 06377 日期：1996年2月29日用于将来自UV激光器（1）的光束馈送到激光扫描显微镜（2）的装置具有用于将激光束与显微镜（2）的光束路径对准的光束对准组件（3））和位于UV激光（1）和光束对准组件（3）之间的光纤元件（4）。本发明的目的是设计进给装置，使得其可以长时间使用，以便保持尽可能低地改变进给装置所需的时间和费用。为了实现这一点，本发明提供一种位于UV激光器（1）和光纤元件（4）之间的光束断续器（5）。光束断续器仅允许来自UV激光器（1）的光束仅在扫描期间即当图像被产生时通过光纤元件（4）。

3. 发明授权

US06785302B1 Optical system in the ray path of a confocal fluorescence microscope 有权
标题翻译：光学系统在共焦荧光显微镜的射线路径
公开(公告)号：US06785302B1
公开(公告)日：2004-08-31
申请号：US09554083
申请日：2000-05-12
申请人： Johann Engelhardt , Heinrich Ulrich , William C. Hay
发明人： Johann Engelhardt , Heinrich Ulrich , William C. Hay
IPC分类号： H01S3121
CPC分类号： G01N21/6458 , G02B21/0024 , G02B21/0076 , G02B21/008
摘要： The invention relates to an optical system in the ray path of a confocal fluorescence microscope, comprising at least one laser light source (1, 2), a device positioned in the illuminating/detecting beam (3, 4, 5) for separating the exciting light (8) from the fluorescent light (9), an objective (10) arranged between the device and the object (7), and a detector (11) positioned downstream of the device situated in the detecting beam (5). The aim of the invention is to increase the fluorescence yield of the system while retaining its compact structure. To this end the separating device comprises a mirror (13) which is dimensioned and positioned in the illuminating and/or detecting beam (3, 4, 5) in such a way that for the dark-field illumination of the object (7) it reflects the non-expanded exciting beam arriving from the laser light source (1, 2) into the objective (10) and permits the transit of the fluorescence light (9) arriving from the object (7) in the direction of the detector (11) with full numerical aperture, the fluorescent light beam being reduced by the mirror (13) cross-section active in the detecting beam (5).
摘要翻译：本发明涉及一种共聚焦荧光显微镜的光线路径中的光学系统，包括至少一个激光光源（1,2），位于照明/检测光束（3,4,5）中的装置，用于分离激发光来自荧光灯（9）的光（8），布置在装置和物体（7）之间的物镜（10）和位于位于检测光束（5）中的装置下游的检测器（11）。本发明的目的是提高系统的荧光收率，同时保持其紧凑的结构。为此，分离装置包括反射镜（13），该反射镜的尺寸设置在照明和/或检测光束（3,4,5）中，使得对于物体（7）的暗场照明反射从激光光源（1,2）到达物镜（10）的未扩展的激发光束，并允许从物体（7）到达检测器（11）的方向的荧光（9）的转移）具有全数值孔径，荧光光束被检测光束（5）中的反射镜（13）横截面减小。

4. 发明授权

US06654165B2 Optical arrangement 有权
标题翻译：光学布置
公开(公告)号：US06654165B2
公开(公告)日：2003-11-25
申请号：US10342750
申请日：2003-01-15
申请人： Johann Engelhardt , Joachim Bradl , Heinrich Ulrich
发明人： Johann Engelhardt , Joachim Bradl , Heinrich Ulrich
IPC分类号： G02B2106
CPC分类号： G02B21/0076 , G02B21/0024
摘要： An optical arrangement in the beam path of a light source suitable for fluorescence excitation, preferably in the beam path of a confocal laser scanning microscope, with at least one spectrally selective element (4) to inject the excitation light (3) of at least one light source (2) in the microscope and to extract the excitation light (3) scattered and reflected on the object (10) or the excitation wavelength from the light (13) coming from the object (10) through the detection beam path (12) is characterized for variable configurations with the simplest construction in that excitation light (3, 9) of different wavelengths can be extracted by the spectrally selective element (4). Alternatively, an optical arrangement like this is characterized in that the spectrally selective element (4) can be adjusted to the excitation wavelength to be extracted.
摘要翻译：适合于荧光激发的光源的光路中的光学装置，优选地在共聚焦激光扫描显微镜的光束路径中，具有至少一个光谱选择性元件（4）以将至少一个激发光（3）注入光源（2），并且通过检测光束路径（12）提取从物体（10）的光（13）散射和反射的激发光（3）或来自物体（10）的激发波长）的特征在于具有最简单结构的可变配置，其中不同波长的激发光（3,9）可以由光谱选择元件（4）提取。或者，这样的光学布置的特征在于，可以将光谱选择元件（4）调节到要提取的激发波长。

5. 发明授权

US06510001B1 Optical arrangement with a spectrally selective element 有权
标题翻译：具有光谱选择性元件的光学布置
公开(公告)号：US06510001B1
公开(公告)日：2003-01-21
申请号：US09622489
申请日：2000-08-17
申请人： Johann Engelhardt , Joachim Bradl , Heinrich Ulrich
发明人： Johann Engelhardt , Joachim Bradl , Heinrich Ulrich
IPC分类号： G02B2106
CPC分类号： G02B21/0076 , G02B21/0024
摘要： An optical arrangement in the beam path of a light source suitable for fluorescence excitation, preferably in the beam path of a confocal laser scanning microscope, with at least one spectrally selective element (4) to inject the excitation light (3) of at least one light source (2) in the microscope and to extract the excitation light (3) scattered and reflected on the object or the excitation wavelength from the light (13) coming from the object (10) through the detection beam path(12) is characterized for variable configuration with the simplest construction in that excitation light (3, 9) of different wavelengths can be extracted by the spectrally selective element (4). Alternatively, an optical arrangement like this is characterized in that the spectrally selective element (4) can be adjusted to the excitation wavelength to be extracted.
摘要翻译：适合于荧光激发的光源的光路中的光学装置，优选地在共聚焦激光扫描显微镜的光束路径中，具有至少一个光谱选择性元件（4）以将至少一个激发光（3）注入显微镜中的光源（2）和从物体（10）穿过检测光路（12）散射并反射在物体上或激发波长上的激发光（3）被提取出来对于具有最简单结构的可变配置，其中不同波长的激发光（3,9）可以由光谱选择元件（4）提取。或者，这样的光学布置的特征在于，可以将光谱选择元件（4）调节到要提取的激发波长。

6. 发明授权

US06392794B1 Laser scanning microscope 有权
标题翻译：激光扫描显微镜
公开(公告)号：US06392794B1
公开(公告)日：2002-05-21
申请号：US09660655
申请日：2000-09-13
申请人： Johann Engelhardt , Heinrich Ulrich , William C. Hay
发明人： Johann Engelhardt , Heinrich Ulrich , William C. Hay
IPC分类号： G02B2100
CPC分类号： G02B21/0056 , G02B21/0032 , G02B21/0072 , G02B21/008
摘要： A laser scanning microscope, preferably a confocal laser scanning microscope, and a method for reference correction for a laser scanning microscope, in particular for a confocal laser scanning microscope, having an illumination beam path extending between a laser light source and a specimen, and a detection beam path extending between the specimen and a detection device, is characterized, for error correction with at least one reference beam path used for reference measurement, in that reference light can be coupled out of the illumination beam path into the reference beam path, and that the reference light is qualitatively and/or quantitatively detectable by a detection device.
摘要翻译：激光扫描显微镜，优选共焦激光扫描显微镜，以及用于激光扫描显微镜，特别是用于共聚焦激光扫描显微镜的参考校正方法，其具有在激光光源和样本之间延伸的照明光束路径，以及其特征在于用于用于参考测量的至少一个参考光束路径进行纠错，因为参考光可以从照明光束路径耦合到参考光束路径中，以及参考光是通过检测装置定性和/或定量检测的。

7. 发明授权

US06211988B1 Optical device for scanning a beam in two axes that are substantially perpendicular to each other 有权
标题翻译：用于在基本上彼此垂直的两个轴上扫描光束的光学装置
公开(公告)号：US06211988B1
公开(公告)日：2001-04-03
申请号：US09331457
申请日：1999-08-25
申请人： Johann Engelhardt , Heinrich Ulrich
发明人： Johann Engelhardt , Heinrich Ulrich
IPC分类号： G02B2608
CPC分类号： G02B21/0048 , G02B21/0024 , G02B21/0072 , G02B21/0084
摘要： The invention relates to an optical device for scanning a beam in two axes that are substantially perpendicular to each other, for use in particular in confocal laser scan microscopes, and aims to avoid serious image defects. The invention is characterized in that it has three mirrors (1, 2; 3) of which two mirrors (1, 2) are fixedly positioned at an angle to each other so that they rotate together around the y-axis and in so doing rotate the beam (4) around a pivot point located on the axis of rotation (x-axis) of the third mirror (3) which rotates by itself.
摘要翻译：本发明涉及一种用于扫描基本上彼此垂直的两个轴的光束的光学装置，特别是用于共焦激光扫描显微镜中，并且旨在避免严重的图像缺陷。本发明的特征在于其具有三个反射镜（1,2; 3），其中两个反射镜（1,2）以彼此成一定角度固定地定位，使得它们围绕y轴一起旋转，并且旋转所述梁（4）围绕位于所述第三反射镜（3）的旋转轴线（x轴）上的枢转点自身旋转。

8. 发明授权

US06421475B1 Overload protection system for avoiding damage to optical components 有权
标题翻译：过载保护系统，避免损坏光学部件
公开(公告)号：US06421475B1
公开(公告)日：2002-07-16
申请号：US09402340
申请日：1999-10-05
申请人： Johann Engelhardt , Heinrich Ulrich
发明人： Johann Engelhardt , Heinrich Ulrich
IPC分类号： G02B626
CPC分类号： G02B6/4296 , G02B2006/4297
摘要： An overload protection to avoid damage to optical components (3) by excessive light power from a light source (2), especially to protect a glass fiber system used to transmit laser light (5), has a beam splitter out (4) in the beam path (6) between the light source (2) and the optical component (3) to couple out a small portion of the light, a detector (7) to detect the light intensity of the light coupled out, an electronic evaluation unit (8) to compare the detected light intensity with a presettable maximum value, and a filter or other element (9) to reduce the light power or to cut off the light incident on the optical component (3) in case the maximum value is exceeded.
摘要翻译：过载保护以避免光源（2）的过多光功率损害光学部件（3），特别是保护用于传输激光（5）的玻璃纤维系统，其中的光束分离器（4）位于在光源（2）和光学部件（3）之间的光束路径（6），以耦合出一小部分光;检测器（7），用于检测耦合出的光的光强度;电子评估单元 8）将检测到的光强与预设的最大值进行比较，以及滤波器或其他元件（9），以在超过最大值的情况下降低光功率或切断入射在光学部件（3）上的光。

9. 发明授权

US06738189B1 Microscope for measuring an object from a plurality of angular positions 有权
标题翻译：用于从多个角位置测量物体的显微镜
公开(公告)号：US06738189B1
公开(公告)日：2004-05-18
申请号：US09331189
申请日：1999-11-29
申请人： Heinrich Ulrich , Johann Engelhardt
发明人： Heinrich Ulrich , Johann Engelhardt
IPC分类号： G02B2100
CPC分类号： G02B21/0024 , G02B21/0052 , G02B27/642
摘要： The invention relates to a microscope, in particular a confocal microscope, designed to measure an object from several angular positions while avoiding any rotation of the object to be measured. The microscope has an optical device for rotation of the image to be positioned in the ray path of the microscope.
摘要翻译：本发明涉及一种显微镜，特别是一种共聚焦显微镜，设计用于从几个角度位置测量物体，同时避免待测物体的任何旋转。显微镜具有用于旋转图像以定位在显微镜的射线路径中的光学装置。

10. 发明授权

US06737635B2 Apparatus for combining light and confocal scanning microscope 有权
标题翻译：用于组合光和共焦扫描显微镜的装置
公开(公告)号：US06737635B2
公开(公告)日：2004-05-18
申请号：US09825273
申请日：2001-04-03
申请人： Johann Engelhardt , Juergen Hoffmann , Rafael Storz , Heinrich Ulrich , Joerg Bewersdorf , Holger Birk
发明人： Johann Engelhardt , Juergen Hoffmann , Rafael Storz , Heinrich Ulrich , Joerg Bewersdorf , Holger Birk
IPC分类号： H01J4014
CPC分类号： G02B21/0068 , G02B21/0032 , G02B21/0056 , G02B27/283
摘要： The present invention concerns an apparatus for combining light from at least two laser light sources, preferably in the context of confocal scanning microscopy, and in order to make laser light sources of low output power usable as light sources, in particular for confocal scanning microscopy, is characterized in that the light from the laser light sources has at least approximately the same wavelength; and that at least one beam combining unit that combines the light beams in at least largely lossless fashion is provided.
摘要翻译：本发明涉及一种用于组合来自至少两个激光源的光的装置，优选在共聚焦扫描显微镜的上下文中，并且为了使得可用作光源的低输出功率的激光光源，特别是用于共聚焦扫描显微镜，其特征在于，来自激光光源的光具有至少大致相同的波长; 并且提供以至少大部分无损方式组合光束的至少一个光束组合单元。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式