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1. 发明申请

US20130183307A1 ABERRANT CELL-RESTRICTED IMMUNOGLOBULINS PROVIDED WITH A TOXIC MOIETY 审中-公开
公开(公告)号：US20130183307A1
公开(公告)日：2013-07-18
申请号：US13739974
申请日：2013-01-11
申请人： Johan Renes , Paulus J. G. M. Steverink , Ralph Alexander Willemsen
发明人： Johan Renes , Paulus J. G. M. Steverink , Ralph Alexander Willemsen
IPC分类号： A61K47/48 , C07K16/28
CPC分类号： A61K47/6813 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6883 , A61K2039/505 , A61P35/00 , C07K16/084 , C07K16/085 , C07K16/2833 , C07K16/2884 , C07K16/30 , C07K16/3069 , C07K16/3092 , C07K16/32 , C07K16/40 , C07K2317/32 , C07K2317/34 , C07K2317/569 , C07K2317/76 , C07K2319/33
摘要： Described are immunoglobulins provided with a toxic moiety, comprising at least an immunoglobulin variable region that specifically binds to an MHC-peptide complex preferentially associated with aberrant cells. These immunoglobulins provided with a toxic moiety are preferably used in selectively modulating biological processes. The provided immunoglobulins provided with a toxic moiety are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers and autoimmune diseases.

2. 发明申请

US20110052564A1 ENHANCEMENT OF IMMUNOGENICITY OF ANTIGENS 审中-公开
标题翻译：增强抗原免疫力
公开(公告)号：US20110052564A1
公开(公告)日：2011-03-03
申请号：US12741270
申请日：2008-11-07
申请人： Martijn Frans Ben Gerard Gebbink , Barend Bouma , Paulus Johannes Gerardus Maria Steverink , Johan Renes
发明人： Martijn Frans Ben Gerard Gebbink , Barend Bouma , Paulus Johannes Gerardus Maria Steverink , Johan Renes
IPC分类号： A61K39/395 , A61K39/00 , G01N33/53 , A61P37/02
CPC分类号： A61K39/145 , A61K39/00 , A61K39/0005 , A61K39/12 , A61K39/385 , A61K2039/5252 , A61K2039/55566 , A61K2039/6031 , A61K2039/70 , C07K14/005 , C12N2760/16122 , C12N2760/16134 , C12N2770/24122 , C12N2770/24322 , C12N2770/24334
摘要： The invention provides means and methods for producing and/or selecting immunogenic compositions, comprising providing said composition with at least one crossbeta structure and testing at least one immunogenic property.
摘要翻译：本发明提供用于产生和/或选择免疫原性组合物的方法和方法，包括提供所述组合物至少一种交叉结构并测试至少一种免疫原性。

3. 发明授权

US09821073B2 Polypeptide that binds aberrant cells and induces apoptosis 有权
公开(公告)号：US09821073B2
公开(公告)日：2017-11-21
申请号：US13976974
申请日：2011-12-22
申请人： Maria Johanna J. E. Van Driel , Johan Renes
发明人： Ralph Alexander Willemsen , Maria Johanna J. E. Van Driel , Johan Renes
IPC分类号： C07K16/00 , A61K47/48 , C07K16/28 , C07K16/30 , A61K45/06
CPC分类号： A61K47/64 , A61K45/06 , A61K47/6851 , C07K16/2833 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2319/00
摘要： Described are proteinaceous molecules comprising at least a domain that comprises an amino acid sequence that specifically binds to an MHC-peptide complex on an aberrant cell, functionally connected with a substance that induces apoptosis in aberrant cells, but not in normal cells. These proteinaceous molecules are preferably used in selectively modulating biological processes. The provided proteinaceous molecules are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers.

4. 发明申请

US20050282169A1 Signatory sequences 审中-公开
标题翻译：签名序列
公开(公告)号：US20050282169A1
公开(公告)日：2005-12-22
申请号：US10767911
申请日：2004-01-29
申请人： Allen Turner , Johan Renes
发明人： Allen Turner , Johan Renes
IPC分类号： A01H1/00 , A01K67/00 , C12N15/82 , C12P21/06 , C12Q1/68
CPC分类号： C12Q1/68 , C12Q2563/185
摘要： The invention includes a method of labeling a biological polymer involving including within the polymer a series of monomers that encode a source of origin or other useful information regarding the biological polymer. Preferably, the biological polymer is DNA, and the series of monomers spell the name of the entity creating the biological polymer using the single letter codes of amino acids corresponding to codons encoded by the DNA.
摘要翻译：本发明包括标记生物聚合物的方法，其涉及在聚合物内包含一系列编码原始来源的单体或关于生物聚合物的其它有用信息。优选地，生物聚合物是DNA，并且该系列单体使用对应于由DNA编码的密码子的氨基酸的单字母代码来拼写创建生物聚合物的实体的名称。

5. 发明申请

US20130046564A1 SEPARATION INSURANCE SYSTEM 审中-公开
标题翻译：分离保险制度
公开(公告)号：US20130046564A1
公开(公告)日：2013-02-21
申请号：US13661747
申请日：2012-10-26
申请人： Mark Veldhuizen , Johan Renes , Allen Turner
发明人： Mark Veldhuizen , Johan Renes , Allen Turner
IPC分类号： G06Q40/08
CPC分类号： G06Q40/08 , G06Q40/025
摘要： Described is a computerized system for offering financing to applicants seeking financing for the purchase of real estate. The system comprises gathering information from the applicants regarding the applicants and the real estate; calculating, with computerized software, a separation insurance policy premium for the applicants based upon this and other information; determining the insurance policy price with the mortgage financing; offering the mortgage financing, coupled with the insurance premium, to the applicants; if the applicants accept, entering into a legally binding agreement memorializing the separation insurance policy; periodically and regularly charging the calculated periodic amount to the applicants; and administering the separation insurance in such a manner that, upon divorce or legal separation of the applicants, payments are made on behalf of the applicants for the real estate.
摘要翻译：描述的是一个计算机化系统，为寻求融资购买房地产的申请人提供融资。该系统包括收集申请人和房地产方面的信息; 根据这一信息和其他信息，用计算机软件计算申请人的分居保险费; 用抵押融资确定保险价格; 向申请人提供抵押融资，加上保险费; 如果申请人接受，签订纪律分离保险单的具有法律约束力的协议; 定期和定期向申请人收取计算的定期金额; 并以离婚或合法分居申请人的方式管理分居保险，代表房地产申请人付款。

6. 发明授权

US08301469B1 Mortgage insurance system 失效
标题翻译：分离保险制度
公开(公告)号：US08301469B1
公开(公告)日：2012-10-30
申请号：US12456874
申请日：2009-06-24
申请人： Mark Veldhuizen , Johan Renes , Allen C. Turner
发明人： Mark Veldhuizen , Johan Renes , Allen C. Turner
IPC分类号： G06Q40/00
CPC分类号： G06Q40/08 , G06Q40/025
摘要： Described is a system for offering financing to a couple seeking financing for the purchase of real estate, the improvement comprising gathering information from the couple regarding the couple and the piece of residential real estate; calculating, with computerized software, a divorce insurance policy premium for the couple based upon this and other information; determining the insurance policy premium's price with the mortgage financing; offering the mortgage financing, coupled with the insurance premium, to the couple; if the couple accepts, creating a legally binding document memorializing the mortgage insurance policy, wherein the legally binding document sets forth terms and conditions of the mortgage insurance policy; transmitting the completed, legally binding document to the couple; periodically and regularly charging the calculated periodic amount to the couple; and administering the mortgage insurance policy in such a manner that, upon divorce or legal separation of the couple, paying damages arising from the piece of real estate and associated with the divorce or legal separation.
摘要翻译：描述的是为寻求融资购买房地产的夫妇提供融资的系统，其改进包括收集夫妻关于夫妇和住宅房地产的信息; 根据这一信息和其他信息，用电脑软件计算出夫妻离婚保险费; 用抵押融资确定保险费保费的价格; 向夫妇提供抵押融资，加上保险费; 如果这对夫妇接受，就制定一份纪念抵押保险单的具有法律约束力的文件，其中具有法律约束力的文件规定了抵押保险的条款和条件; 将已完成的具有法律约束力的文件转交给夫妇; 定期和定期地将计算的周期金额收取给夫妇; 并按照夫妻离婚或合法分居的方式管理抵押保险单，支付因不动产造成的损失而与离婚或合法分居有关的损害赔偿。

7. 发明申请

US20120123218A1 Methods and means for clinical investigations 审中-公开
标题翻译：方法和手段进行临床调查
公开(公告)号：US20120123218A1
公开(公告)日：2012-05-17
申请号：US12927521
申请日：2010-11-16
申请人： Johan Renes
发明人： Johan Renes
IPC分类号： A61B5/00
CPC分类号： A61B5/4848 , A61B5/0022 , A61B5/6898 , A61B5/7282 , G06F19/3418
摘要： Described are methods for testing at least one effect of a pharmaceutical substance in a subject, which include administering a pharmaceutical substance to the subject, measuring with at least one sensor contained within a mobile sensor system, at the subject or in close proximity to the subject, at least one parameter value indicative of a the subject's body function, transmitting at least one sensor system signal associated with the at least one parameter value to a receiver contained within a mobile base unit, the receiver being provided with a means for wireless transmission, and wirelessly transmitting a mobile base unit signal associated with the at least one sensor system signal from the receiver to a back-end system, wherein at least the back-end system correlates the at least one parameter value with and/or displays a representation of the at least one effect of the pharmaceutical substance.
摘要翻译：描述了用于测试受试者中药物物质的至少一种效应的方法，其包括向受试者施用药物物质，用包含在移动传感器系统内的至少一个传感器，在受试者处或与受试者紧密相邻地测量至少一个指示受检者身体功能的参数值，将与所述至少一个参数值相关联的至少一个传感器系统信号发送到包含在移动基站单元内的接收器，所述接收器被提供有用于无线传输的装置，以及将与所述至少一个传感器系统信号相关联的移动基本单元信号从所述接收机无线发送到后端系统，其中至少所述后端系统将所述至少一个参数值与所述至少一个参数值相关联和/或显示药物物质的至少一种效应。

8. 发明申请

US20110287047A1 CROSS-BETA STRUCTURES AS CARRIER IN VACCINES 审中-公开
标题翻译：交叉结构作为疫苗携带者
公开(公告)号：US20110287047A1
公开(公告)日：2011-11-24
申请号：US12998691
申请日：2009-11-18
申请人： Barend Bouma , Johan Renes , Paulus J.G.M. Steverink
发明人： Barend Bouma , Johan Renes , Paulus J.G.M. Steverink
IPC分类号： A61K39/385 , A61P37/04 , C07K14/00
CPC分类号： A61K39/385 , A61K2039/6031
摘要： The invention provides means and methods for producing and/or selecting immunogenic compositions, comprising providing said composition with at least one epitope for a B-cell receptor and/or at least one epitope for a T-cell receptor, coupled to a protein that comprises at least one crossbeta structure, and testing at least one immunogenic property.
摘要翻译：本发明提供了用于产生和/或选择免疫原性组合物的方法和方法，包括向所述组合物提供与蛋白质偶联的B细胞受体和/或至少一种T细胞受体表位的至少一个表位，至少一种交叉结构，并测试至少一种免疫原性。

9. 发明申请

US20110008376A1 IMMUNOGENIC COMPOSITIONS CAPABLE OF ACTIVATING T-CELLS 审中-公开
标题翻译：可激活T细胞的免疫组化
公开(公告)号：US20110008376A1
公开(公告)日：2011-01-13
申请号：US12741288
申请日：2008-11-07
申请人： Martijn Frans Ben Gerard Gebbink , Barend Bouma , Paulus Johannes Gerardus Maria Steverink , Johan Renes
发明人： Martijn Frans Ben Gerard Gebbink , Barend Bouma , Paulus Johannes Gerardus Maria Steverink , Johan Renes
IPC分类号： A61K39/00 , G01N33/53 , C12Q1/68 , A61P37/00
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5254 , A61K2039/55516 , A61K2039/55566 , A61K2039/6081 , C07K14/005 , C12N2760/16134 , C12N2770/24322 , C12N2770/24334 , C12N2770/24363
摘要： The invention provides means and methods for producing and/or selecting immunogenic compositions capable of activating a T-cell and/or a T-cell response, comprising providing said composition with at least one crossbeta structure and testing at least one immunogenic property.
摘要翻译：本发明提供了用于产生和/或选择能够激活T细胞和/或T细胞应答的方法和方法，包括提供所述组合物至少一种交叉结构并测试至少一种免疫原性。

10. 发明申请

US20090191228A1 Immunogenic compositions capable of activating T-cells 审中-公开
标题翻译：能够激活T细胞的免疫原性组合物
公开(公告)号：US20090191228A1
公开(公告)日：2009-07-30
申请号：US12291398
申请日：2008-11-07
申请人： Martijn Frans Ben Gerard Gebbink , Barend Bouma , Paulus Johannes Gerardus Maria Steverink , Johan Renes
发明人： Martijn Frans Ben Gerard Gebbink , Barend Bouma , Paulus Johannes Gerardus Maria Steverink , Johan Renes
IPC分类号： A61K39/00 , A61K38/02 , A61K38/14 , A61K38/16 , G01N33/68 , G01N33/92 , A61P37/00
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5254 , A61K2039/55516 , A61K2039/55566 , A61K2039/6081 , C07K14/005 , C12N2760/16134 , C12N2770/24322 , C12N2770/24334 , C12N2770/24363
摘要： Provided is means and methods for producing and/or selecting immunogenic compositions capable of activating a T-cell and/or a T-cell response, comprising providing the composition with at least one cross-beta structure and testing at least one immunogenic property.
摘要翻译：提供了用于产生和/或选择能够激活T细胞和/或T细胞应答的手段和方法，包括提供组合物至少一种交叉β结构并测试至少一种免疫原性。

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