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1. 发明申请

US20050048542A1 Expression profile algorithm and test for cancer prognosis 有权
标题翻译：表达谱算法和癌症预后检测
公开(公告)号：US20050048542A1
公开(公告)日：2005-03-03
申请号：US10883303
申请日：2004-06-30
申请人： Joffre Baker , John Bryant , Soonmyung Paik , Steven Shak
发明人： Joffre Baker , John Bryant , Soonmyung Paik , Steven Shak
IPC分类号： G01N33/48 , G01N33/50 , G01N33/574 , G06F19/20 , G06F19/24 , C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/57415 , G01N33/57484 , G01N33/57492 , G06F19/20 , G06F19/24
摘要： The present invention provides a noninvasive, quantitative test for prognosis determination in cancer patients. The test relies on measurements of the tumor levels of certain messenger RNAs (mRNAs). These mRNA levels are inserted into a polynomial formula (algorithm) that yields a numerical recurrence score, which indicates recurrence risk.
摘要翻译：本发明提供了癌症患者预后测定的无创定量试验。测试依赖于某些信使RNA（mRNA）的肿瘤水平的测量。将这些mRNA水平插入到产生数字复发评分的多项式公式（算法）中，其表示复发风险。

2. 发明申请

US20050079518A1 Prediction of likelihood of cancer recurrence 有权
标题翻译：预测癌症复发的可能性
公开(公告)号：US20050079518A1
公开(公告)日：2005-04-14
申请号：US10872063
申请日：2004-06-17
申请人： Joffre Baker , John Bryant , Soonmyung Paik , Steven Shak
发明人： Joffre Baker , John Bryant , Soonmyung Paik , Steven Shak
IPC分类号： A61B20060101 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.
摘要翻译：本发明提供了基因组，其表达在癌症，特别是乳腺癌的诊断和/或预后中是重要的。

3. 发明申请

US20060286565A1 Prediction of likelihood of cancer recurrence 有权
公开(公告)号：US20060286565A1
公开(公告)日：2006-12-21
申请号：US11345611
申请日：2006-01-31
申请人： Joffre Baker , John Bryant , Soonmyung Paik , Steven Shak
发明人： Joffre Baker , John Bryant , Soonmyung Paik , Steven Shak
IPC分类号： C12Q1/68 , C07H21/04 , C12P19/34 , C12M1/34
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.

4. 发明申请

US20060166231A1 Molecular indicators of breast cancer prognosis and prediction of treatment response 有权
公开(公告)号：US20060166231A1
公开(公告)日：2006-07-27
申请号：US11267807
申请日：2005-11-04
申请人： Joffre Baker , John Bryant , Soonmyung Paik , Steven Shak
发明人： Joffre Baker , John Bryant , Soonmyung Paik , Steven Shak
IPC分类号： C12Q1/68 , G01N33/574 , G06F19/00
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G06F19/18 , G06F19/20
摘要： The present invention relates to quantitative molecular indicators that can guide clinical decisions in breast cancer, such as estrogen receptor (ESR1)-positive, lymph node-negative breast cancer. In particular, the invention concerns certain genes, the varied expression of which indicates the likelihood of recurrence of surgically resected breast cancer in patients who are not treated with a therapeutic agent in the adjuvant setting. In addition, the invention concerns the use of quantitative measurement of the expression of certain genes, including the ESR1 gene, that measure as a continuous variable, to determine (a) the likelihood of a beneficial response to the anti-estrogen therapeutic agent, such as tamoxifen; and (b) the potential magnitude of beneficial response to chemotherapy.

5. 发明申请

US20060166230A1 Predicting response to chemotherapy using gene expression markers 有权
标题翻译：使用基因表达标志物预测化疗反应
公开(公告)号：US20060166230A1
公开(公告)日：2006-07-27
申请号：US11267769
申请日：2005-11-04
申请人： Joffre Baker , John Bryant , Soonmyung Paik , Steven Shak
发明人： Joffre Baker , John Bryant , Soonmyung Paik , Steven Shak
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G06F19/18 , G06F19/20
摘要： The present invention provides gene expression information useful for predicting whether cancer patients are likely to have a beneficial response to treatment response with chemotherapy.
摘要翻译：本发明提供了可用于预测癌症患者是否可能对治疗化疗反应有益的基因表达信息。

6. 发明申请

US20090222326A1 Multidiscipline site development and risk assessment process 审中-公开
标题翻译：多学科现场开发和风险评估过程
公开(公告)号：US20090222326A1
公开(公告)日：2009-09-03
申请号：US12387780
申请日：2009-05-07
申请人： John Bryant
发明人： John Bryant
IPC分类号： G06Q10/00 , G06Q50/00
CPC分类号： G06Q10/06 , G06Q10/0635 , G06Q10/103
摘要： A software application is provided designed to encourage collaboration between professional disciplines related to land development and construction projects. A graphical risk analysis system is provided based on answers to interdisciplinary questions related to risks. Use of the system promotes a complete checklist of interdisciplinary and informational consultation which, when completed, reduces the risk related to land development.
摘要翻译：提供的软件应用旨在鼓励与土地开发和建设项目相关的专业学科之间的协作。根据与风险相关的跨学科问题的答案，提供图形风险分析系统。使用该系统可以提供跨学科和信息咨询的完整清单，完成后可以减少与土地开发相关的风险。

7. 发明申请

US20080041218A1 SYSTEM AND METHOD FOR TEACHING AN INSTRUMENTAL OR VOCAL PORTION OF A SONG 审中-公开
标题翻译：用于教授歌曲的仪器或声部的系统和方法
公开(公告)号：US20080041218A1
公开(公告)日：2008-02-21
申请号：US11754084
申请日：2007-05-25
申请人： Mark Hara , John Bryant , Robert Koelble , Abdias Garcia , Greg Hayworth
发明人： Mark Hara , John Bryant , Robert Koelble , Abdias Garcia , Greg Hayworth
IPC分类号： G09B15/00 , G10H7/00
CPC分类号： G09B15/006 , G10H2240/091
摘要： A recording of a lesson on how to play an instrumental portion of a song that has a plurality of song sections and the one or more of the song sections contains the instrumental portion. The lesson comprises instructions how to play the instrumental portion for each song section, and the instructions are arranged in a chronological sequence as the song sections occur in the song. The recording may also include a recording of a recreation of the song, and in an instruction for each song section there is a recording of the recreated song section that occurs at a beginning of the instruction. The recording may also include a recording of the recreated song section that has the instrumental portion removed and can be played back without interruption so a student may play the instrumental portions as the recording is played.
摘要翻译：关于如何播放具有多个歌曲部分并且一个或多个歌曲部分的歌曲的乐器部分的课程的记录包含乐器部分。该课程包括如何为每个歌曲部分播放乐器部分的指令，并且当歌曲部分出现在歌曲中时按照时间顺序排列指令。记录还可以包括对歌曲的娱乐的记录，并且在每个歌曲部分的指令中，存在在指令开始时发生的重新创建的歌曲部分的记录。记录还可以包括重新创建的歌曲部分的记录，其具有去除了乐器部分并且可以不间断地播放，使得学生可以在播放录音时播放乐器部分。

8. 发明授权

US07003400B2 Apparatus and method for displaying subsurface anomalies and surface features 有权
标题翻译：显示地下异常和表面特征的装置和方法
公开(公告)号：US07003400B2
公开(公告)日：2006-02-21
申请号：US10691253
申请日：2003-10-22
申请人： John Bryant
发明人： John Bryant
IPC分类号： G01V9/00
CPC分类号： G01V1/34
摘要： The present invention provides a method of combining various types of data and software in order to arrive at a composite graphical representation of a construction site, including surface and subsurface features. A 2-D or 3-D graph of subsurface contoured surfaces is created. A 3-D wire-frame model of surface and subsurface features is created. Aerial photographs of the site can be incorporated and the aerial photographs contoured surfaces and wire-frame model are to produce a complete Visual Reduction Modeling Language (VRML) model of both surface and subsurface features. The VRML model allows the user to identify and visualize a relationship between sub-surface features and above ground features.
摘要翻译：本发明提供了一种组合各种数据和软件的方法，以便得到包括表面和地下特征在内的施工现场的复合图形表示。创建地下轮廓表面的二维或三维图形。创建了表面和地下特征的3-D线框模型。该场地的航空照片可以并入，航空照片轮廓和线框模型将产生一个完整的视觉减少建模语言（VRML）的表面和地下特征模型。 VRML模型允许用户识别和可视化表面特征与地面特征之间的关系。

9. 发明申请

US20050090988A1 Apparatus and method for displaying subsurface anomalies and surface features 有权
标题翻译：显示地下异常和表面特征的装置和方法
公开(公告)号：US20050090988A1
公开(公告)日：2005-04-28
申请号：US10691253
申请日：2003-10-22
申请人： John Bryant
发明人： John Bryant
IPC分类号： G01V1/28 , G01V1/34
CPC分类号： G01V1/34
摘要： The present invention provides a method of combining various types of data and software in order to arrive at a composite graphical representation of a construction site, including surface and subsurface features. A 2-D or 3-D graph of subsurface contoured surfaces is created. A 3-D wire-frame model of surface and subsurface features is created. Aerial photographs of the site can be incorporated and the aerial photographs contoured surfaces and wire-frame model are to produce a complete Visual Reduction Modeling Language (VRML) model of both surface and subsurface features. The VRML model allows the user to identify and visualize a relationship between sub-surface features and above ground features.
摘要翻译：本发明提供了一种组合各种数据和软件的方法，以便得到包括表面和地下特征在内的施工现场的复合图形表示。创建地下轮廓曲面的二维或三维图形。创建了表面和地下特征的3-D线框模型。该场地的航空照片可以并入，航空照片轮廓和线框模型将产生一个完整的视觉减少建模语言（VRML）的表面和地下特征模型。 VRML模型允许用户识别和可视化表面特征与地面特征之间的关系。

10. 发明申请

US20050086096A1 Multidiscipline site development and risk assessment process 有权
标题翻译：多学科现场开发和风险评估过程
公开(公告)号：US20050086096A1
公开(公告)日：2005-04-21
申请号：US10689290
申请日：2003-10-20
申请人： John Bryant
发明人： John Bryant
IPC分类号： G06Q10/00 , G06Q40/00 , G06F17/60
CPC分类号： G06Q10/10 , G06Q10/0635 , G06Q40/08 , G06Q50/16 , G06Q50/165
摘要： A software application is provided designed to encourage collaboration between professional disciplines related to land development and construction projects. A graphical risk analysis system is provided based on answers to interdisciplinary questions related to risks. Use of the system promotes a complete checklist of interdisciplinary and informational consultation which, when completed, reduces the risk related to land development.
摘要翻译：提供的软件应用旨在鼓励与土地开发和建设项目相关的专业学科之间的协作。根据与风险相关的跨学科问题的答案，提供图形风险分析系统。使用该系统可以提供跨学科和信息咨询的完整清单，完成后可以减少与土地开发有关的风险。

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