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1. 发明申请

US20130252951A1 7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 7-羟基 - 吡唑并[1,5-A]吡嗪化合物及其作为CCR2受体拮抗剂的用途
公开(公告)号：US20130252951A1
公开(公告)日：2013-09-26
申请号：US13876220
申请日：2011-09-26
申请人： Joe William Boyd , Paul Meo , Michael Higginbottom , Iain Simpson , David Mountford , Edward Daniel Savory
发明人： Joe William Boyd , Paul Meo , Michael Higginbottom , Iain Simpson , David Mountford , Edward Daniel Savory
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The compounds of formula (I) are antagonists of the CCR2 receptor Wherein R1-7 and A are as defined in the claims.
摘要翻译：式（I）化合物是CCR2受体的拮抗剂，其中R1-7和A如权利要求中所定义。

2. 发明申请

US20130324556A1 Protease Activated Receptor 2 (PAR2) Antagonists 审中-公开
标题翻译：蛋白酶活化受体2（PAR2）拮抗剂
公开(公告)号：US20130324556A1
公开(公告)日：2013-12-05
申请号：US13981960
申请日：2012-01-27
申请人： Joe William Boyd , Paul Meo , Michael Higginbottom , Iain Simpson , David Mark Mountford , Edward Daniel Savory
发明人： Joe William Boyd , Paul Meo , Michael Higginbottom , Iain Simpson , David Mark Mountford , Edward Daniel Savory
IPC分类号： C07D211/16 , C07D211/18 , C07D401/06 , C07D211/46 , C07D471/04 , C07D211/54 , C07D211/62 , C07D295/215 , C07D207/06 , C07D413/04 , C07D211/22 , C07D211/58
CPC分类号： C07D211/16 , C07D207/06 , C07D211/18 , C07D211/20 , C07D211/22 , C07D211/46 , C07D211/54 , C07D211/58 , C07D211/62 , C07D295/185 , C07D295/192 , C07D295/215 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/04 , C07D471/04
摘要： A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrate thereof Wherein Y, Z, R3, U, R4, m and n are as defined in the claims.
摘要翻译：式（I）化合物或其药学上可接受的盐，溶剂化物或水合物。其中Y，Z，R3，U，R4，m和n如权利要求中所定义。

3. 发明授权

US09353086B2 CXCR4 receptor antagonists 有权
标题翻译： CXCR4受体拮抗剂
公开(公告)号：US09353086B2
公开(公告)日：2016-05-31
申请号：US13878968
申请日：2011-10-13
申请人： Edward Daniel Savory , Alison Stewart , Allison Carley , Giles Brown , Iain Simpson , Kathryn Oliver , Lee Patient , Michael Higginbottom , Andrew Graham Cole
发明人： Edward Daniel Savory , Alison Stewart , Allison Carley , Giles Brown , Iain Simpson , Kathryn Oliver , Lee Patient , Michael Higginbottom , Andrew Graham Cole
IPC分类号： A61K31/55 , A61K31/551 , A61K31/439 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/08 , C07D471/12 , A61K45/06 , C07D401/12
CPC分类号： C07D471/08 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds that are antagonists of the CXCR4 receptor.
摘要翻译：公开了作为CXCR4受体的拮抗剂的化合物。

4. 发明申请

US20130289020A1 CXCR4 Receptor Antagonists 有权
标题翻译： CXCR4受体拮抗剂
公开(公告)号：US20130289020A1
公开(公告)日：2013-10-31
申请号：US13878968
申请日：2011-10-13
申请人： Edward Daniel Savory , Allson Stewart , Allison Cartey , Giles Brown , Iain Simpson , Kathryn Oliver , Lee Patient , Michael Higginbottom , Andrew Graham Cole
发明人： Edward Daniel Savory , Allson Stewart , Allison Cartey , Giles Brown , Iain Simpson , Kathryn Oliver , Lee Patient , Michael Higginbottom , Andrew Graham Cole
IPC分类号： C07D401/14 , C07D401/12 , C07D471/08 , C07D413/14 , C07D471/04 , C07D405/14 , C07D417/14
CPC分类号： C07D471/08 , A61K45/06 , C07B59/002 , C07B2200/05 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds that are antagonists of the CXCR4 receptor.
摘要翻译：公开了作为CXCR4受体的拮抗剂的化合物。

5. 发明申请

US20110207746A1 NEW COMPOUNDS I 有权
标题翻译：新化合物
公开(公告)号：US20110207746A1
公开(公告)日：2011-08-25
申请号：US13062318
申请日：2009-09-16
申请人： Edward Daniel Savory , Michael Higginbottom , Kathryn Oliver , VietAnh Anne Horgan
发明人： Edward Daniel Savory , Michael Higginbottom , Kathryn Oliver , VietAnh Anne Horgan
IPC分类号： A61K31/497 , C07D471/04 , A61K31/437 , A61P29/00 , A61P37/06 , A61P19/02 , A61P25/28 , A61P1/00 , A61P9/10 , A61P11/06 , A61P11/00 , A61P9/00 , A61P17/00 , A61P17/06 , A61P1/16 , A61P3/10 , A61P9/04
CPC分类号： C07D471/04 , A61K31/437
摘要： The present invention relates to compounds of formula (I), and their pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers or N-oxides, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases and immune disorders.
摘要翻译：本发明涉及作为SSAO活性抑制剂的式（I）化合物及其药学上可接受的盐，溶剂合物，水合物，几何异构体，互变异构体，旋光异构体或N-氧化物。本发明进一步涉及包含这些化合物的药物组合物以及这些化合物用于治疗其中SSAO活性抑制是有益的医学病症如炎性疾病和免疫疾病的用途。

6. 发明授权

US08263616B2 4,5,6,7-tetrahydroimidazo[4,5-c]pyridine compounds 有权
标题翻译： 4,5,6,7-四氢咪唑并[4,5-c]吡啶化合物
公开(公告)号：US08263616B2
公开(公告)日：2012-09-11
申请号：US13062318
申请日：2009-09-16
申请人： Edward Daniel Savory , Michael Higginbottom , Kathryn Oliver , Viet-Anh Anne Horgan
发明人： Edward Daniel Savory , Michael Higginbottom , Kathryn Oliver , Viet-Anh Anne Horgan
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437
摘要： The present invention relates to compounds of formula (I), and their pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers or N-oxides, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases and immune disorders.
摘要翻译：本发明涉及作为SSAO活性抑制剂的式（I）化合物及其药学上可接受的盐，溶剂合物，水合物，几何异构体，互变异构体，旋光异构体或N-氧化物。本发明进一步涉及包含这些化合物的药物组合物以及这些化合物用于治疗其中SSAO活性抑制是有益的医学病症如炎性疾病和免疫疾病的用途。

7. 发明申请

US20120302583A1 New Compounds I 有权
标题翻译：新化合物
公开(公告)号：US20120302583A1
公开(公告)日：2012-11-29
申请号：US13567146
申请日：2012-08-06
申请人： Edward Daniel Savory , Michael Higginbottom , Kathryn Oliver , Viet-Anh Anne Horgan
发明人： Edward Daniel Savory , Michael Higginbottom , Kathryn Oliver , Viet-Anh Anne Horgan
IPC分类号： A61K31/437 , A61K31/497 , A61P29/00 , A61P37/00 , A61P19/02 , A61P1/00 , A61P9/10 , A61P25/00 , A61P25/28 , A61P11/00 , A61P17/00 , A61P3/10 , A61P1/16 , A61P9/04 , A61P1/04 , A61P11/06 , A61P9/00 , A61P17/06 , A61K31/444
CPC分类号： C07D471/04 , A61K31/437
摘要： The present invention relates to a method for the treatment or prevention of inflammation, an inflammatory disease, an immune or an autoimmune disorder, which comprises administering to a mammal in need of such treatment an effective amount of a compound compound of formula (I), and their pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers or N-oxides, which are inhibitors of SSAO activity.
摘要翻译：本发明涉及治疗或预防炎症，炎性疾病，免疫或自身免疫性疾病的方法，其包括向需要这种治疗的哺乳动物施用有效量的式（I）化合物和其药学上可接受的盐，溶剂化物，水合物，几何异构体，互变异构体，光学异构体或N-氧化物，其是SSAO活性的抑制剂。

8. 发明申请

US20080262214A1 Synthesis of 2-Substituted Adenosines 审中-公开
标题翻译： 2-取代腺苷的合成
公开(公告)号：US20080262214A1
公开(公告)日：2008-10-23
申请号：US10581544
申请日：2004-12-03
申请人： Edward Daniel Savory
发明人： Edward Daniel Savory
IPC分类号： C07H19/167
CPC分类号： C07H19/167 , Y02P20/55
摘要： A method of synthesis of a 2-substituted adenosine of formula I which comprises converting a compound of formula II to a compound of formula (I), wherein: R is C 1-6 alkoxy (straight or branched), a phenoxy group (unsubstituted, or mono-, or di-substituted by halo, amino, CF3-, cyano, nitro, C 1-6 alkyl, or C 1-6 alkoxy), a benzoyl group (unsubstituted, or mono-, or di-substituted by halo, amino, CF3-, cyano, nitro, C1_6 alkyl, or C1_6 alkoxy), or a benzoyl group (unsubstituted, or mono-, or di-substituted by halo, amino, CF3-, cyano, nitro, C 1-6 alkyl, or C 1-6 alkoxy); R′═H, or a protecting group.
摘要翻译：一种合成式I的2-取代腺苷的方法，其包括将式II化合物转化为式（I）化合物，其中：R是C 1-6烷氧基（直链或支链），苯氧基（未取代的，或被卤素，氨基，CF 3 - ，氰基，硝基，C 1-6烷基或C 1-6烷氧基单取代，或被二取代的苯甲酰基，卤素，氨基，CF 3 - ，氰基，硝基，C 1-6烷基或C 1-6烷氧基）或苯甲酰基（未取代的，或被卤素，氨基，CF 3 - ，氰基，硝基，C 1-6 烷基或C 1-6烷氧基）; R'-H，或保护基。

9. 发明申请

US20120010188A1 Imidazopyridine Compounds 审中-公开
标题翻译：咪唑并吡啶化合物
公开(公告)号：US20120010188A1
公开(公告)日：2012-01-12
申请号：US13132143
申请日：2009-12-04
申请人： Marianne Nilsson , Martin Haraldsson , Sofia Henriksson , Rikard Emond , Edward Daniel Savory , Iain David Simpson
发明人： Marianne Nilsson , Martin Haraldsson , Sofia Henriksson , Rikard Emond , Edward Daniel Savory , Iain David Simpson
IPC分类号： A61K31/437 , C07D413/14 , A61K31/5377 , A61P29/00 , A61P37/00 , A61P19/02 , A61P7/00 , A61P1/00 , A61P1/04 , A61P9/10 , A61P25/00 , A61P25/28 , A61P11/06 , A61P11/00 , A61P17/00 , A61P17/06 , A61P1/16 , A61P3/10 , A61P9/04 , C07D471/04
CPC分类号： C07D498/04 , A61K31/4188 , A61K31/437 , A61K31/4985 , A61K31/5025 , A61K31/519 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The invention relates to compounds of formula (I): and their pharmaceutically acceptable salts and solvates, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment or prevention of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases and immune disorders.
摘要翻译：本发明涉及式（I）化合物及其药学上可接受的盐和溶剂化物，其是SSAO活性的抑制剂。本发明还涉及包含这些化合物的药物组合物以及这些化合物用于治疗或预防其中SSAO活性抑制是有益的医学病症的用途，例如炎性疾病和免疫疾病。

10. 发明授权

US08633318B2 Compounds for treatment or prevention of inflammation, an inflammatory disease, or an immune or an autoimmune disorder 失效
标题翻译：用于治疗或预防炎症，炎性疾病或免疫或自身免疫疾病的化合物
公开(公告)号：US08633318B2
公开(公告)日：2014-01-21
申请号：US13062366
申请日：2009-09-16
申请人： Edward Daniel Savory , Iain David Simpson
发明人： Edward Daniel Savory , Iain David Simpson
IPC分类号： A61K31/4162 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I), and their pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomers or N-oxides, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment of medical conditions wherein inhibition of SSAO activity is beneficial, such as such as inflammatory diseases and immune disorders.
摘要翻译：本发明涉及作为SSAO活性抑制剂的式（I）化合物及其药学上可接受的盐，溶剂合物，水合物，几何异构体，互变异构体，旋光异构体或N-氧化物。本发明还涉及包含这些化合物的药物组合物和这些化合物用于治疗其中SSAO活性的抑制是有益的医学病症的用途，例如炎性疾病和免疫疾病。

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