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1. 发明申请

US20050064450A1 Methods of making repetitive sequences removed probes and uses thereof 审中-公开
标题翻译：重复序列的方法去除探针及其用途
公开(公告)号：US20050064450A1
公开(公告)日：2005-03-24
申请号：US10798949
申请日：2004-03-12
申请人： Joe Lucas , Zhong Chen
发明人： Joe Lucas , Zhong Chen
IPC分类号： C07H21/04 , C12N20060101 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/68 , C12Q1/6816 , C12Q1/6832 , C12Q2600/156 , C12Q2565/119 , C12Q2539/101 , C12Q2525/151
摘要： The invention discloses novel methods and compositions for the detection of a target nucleic acid molecule in a sample. In particular, the invention provides a method of producing a probe having removed repetitive sequences comprising: (a) providing a source nucleic acid molecule containing repetitive sequences; (b) providing a driver nucleic acid molecule attached to a label and containing repetitive sequences that hybridize with the repetitive sequences of the source nucleic acid molecule; (c) hybridizing the source nucleic acid molecule and the driver nucleic acid molecule in the presence of a molecule that binds the label of step (b) wherein the repetitive sequences of source nucleic acid molecule hybridize with the repetitive sequences of the driver nucleic acid molecule to form a product; (d) subtracting the hybridized repetitive sequences of the product of step (c) by extraction with a protein dissolving solution to remove the hybridized repetitive sequences from the product; and (e) recovering the probe having repetitive sequences removed therefrom.
摘要翻译：本发明公开了用于检测样品中靶核酸分子的新方法和组合物。特别地，本发明提供了生产具有去除的重复序列的探针的方法，包括：（a）提供含有重复序列的源核酸分子; （b）提供连接到标记并包含与源核酸分子的重复序列杂交的重复序列的驱动核酸分子; （c）在结合步骤（b）的标记的分子存在下使源核酸分子和驱动核酸分子杂交，其中源核酸分子的重复序列与驱动核酸分子的重复序列杂交形成产品; （d）通过用蛋白质溶解溶液萃取来减去步骤（c）的产物的杂交重复序列，以从产物中除去杂交的重复序列; 和（e）回收具有从其中除去的重复序列的探针。

2. 发明申请

US20060143862A1 Adjustable caster and leveling assembly 有权
标题翻译：可调脚轮和调平总成
公开(公告)号：US20060143862A1
公开(公告)日：2006-07-06
申请号：US11320365
申请日：2005-12-28
申请人： Dennis Dominic , Joe Lucas
发明人： Dennis Dominic , Joe Lucas
IPC分类号： E05D11/10
CPC分类号： B60B33/0002 , B62B2301/05 , Y10T16/182 , Y10T16/191 , Y10T16/193 , Y10T16/5401
摘要： An adjustable caster comprising a reversible mounting bracket offering added flexibility in adjusting the height of the caster and configured to removably attach to a structure to be supported by the adjustable caster; an internally threaded sleeve mounted to and extending from the mounting bracket, the sleeve having proximal and distal ends and a sleeve axis extending there between; an externally threaded stem configured to be removably threaded into the sleeve at either the distal or proximal end; a caster wheel assembly attached to the stem; and an adjustment assembly operatively associated with the stem and fully accessible to a user of the caster when the caster is assembled and the mounting bracket is attached to the caster-supported structure, the vertical adjustment assembly configured to adjust the vertical displacement of the stem along the sleeve axis.
摘要翻译：可调节脚轮包括可逆安装支架，其在调节脚轮的高度方面提供了增加的灵活性，并且构造成可移除地附接到由可调节脚轮支撑的结构; 安装到安装支架上并从安装支架延伸的内螺纹套筒，套筒具有近端和远端以及在其间延伸的套筒轴线; 外螺纹杆，构造成在远端或近端可拆卸地拧入套筒; 连接到杆上的脚轮组件; 以及调节组件，其可操作地与所述杆杆相关联，并且当所述脚轮组装并且所述安装支架附接到所述脚轮支撑结构时，所述脚轮的使用者可完全接近所述脚轮，所述竖直调整组件被构造成调节所述杆沿竖直位移套筒轴。

3. 发明申请

US20060097064A1 Elastomeric railway tie pad 有权
标题翻译：弹性铁路扎带
公开(公告)号：US20060097064A1
公开(公告)日：2006-05-11
申请号：US10984588
申请日：2004-11-08
申请人： Tom English , Joe Lucas , Dean Putnam
发明人： Tom English , Joe Lucas , Dean Putnam
IPC分类号： E01B1/00
CPC分类号： E01B19/003 , E01B2/003 , E01B2204/01
摘要： An elastomeric member is disclosed that adjusts the modulus of track over a rigid structure such as a bridge or a tunnel. Methods that employ such an elastomeric member to reduce the modulus of the track over the structure to a magnitude approximating the modulus of track over the terrain surrounding the structure are also disclosed.
摘要翻译：公开了一种弹性体构件，其调节在刚性结构（例如桥或隧道）上的轨道的模量。还公开了使用这种弹性体构件以将结构上的轨道的模量减小到接近围绕结构的地形上的轨道的模量的幅度的方法。

4. 发明申请

US20060075600A1 Vertically adjustable caster 审中-公开
标题翻译：可垂直调节脚轮
公开(公告)号：US20060075600A1
公开(公告)日：2006-04-13
申请号：US10962945
申请日：2004-10-12
申请人： Dennis Dominic , Joe Lucas
发明人： Dennis Dominic , Joe Lucas
IPC分类号： B60B33/06
CPC分类号： B60B33/0018 , B60B33/0002 , B60B33/0039 , B60B33/0049 , B60B33/0057 , B60B33/0068 , B60B33/0073 , Y10T16/193
摘要： A vertically adjustable caster comprising a reversible mounting bracket offering added flexibility in adjusting the height of the caster and configured to removably attach to a structure to be supported by the vertically adjustable caster; an internally threaded sleeve mounted to and extending from the mounting bracket, the sleeve having proximal and distal ends and a sleeve axis extending there between; an externally threaded stem configured to be removably threaded into the sleeve at either the distal or proximal end; a caster wheel assembly attached to the stem; and a vertical adjustment assembly operatively associated with the stem and fully accessible to a user of the caster when the caster is assembled and the mounting bracket is attached to the caster-supported structure, the vertical adjustment assembly configured to adjust the vertical displacement of the stem along the sleeve axis.
摘要翻译：一种可垂直调节的脚轮，其包括可逆安装支架，其在调节脚轮的高度方面增加了灵活性，并被构造成可移除地附接到由垂直可调的脚轮支撑的结构; 安装到安装支架上并从安装支架延伸的内螺纹套筒，套筒具有近端和远端以及在其间延伸的套筒轴线; 外螺纹杆，构造成在远端或近端可拆卸地拧入套筒; 连接到杆上的脚轮组件; 以及垂直调节组件，其可操作地与所述杆相关联，并且当所述脚轮组装并且所述安装支架附接到所述脚轮支撑结构时，所述脚轮的使用者可完全接近所述脚轮的使用者，所述垂直调节组件被配置为调节所述杆的垂直位移沿着袖轴。

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