专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4977190A Preparation of riboflavin, produced by a microbial method, in the form of spray-dried granules or microgranules 失效
标题翻译：通过微生物法制备以喷雾干燥颗粒或微粒形式的核黄素的制备
公开(公告)号：US4977190A
公开(公告)日：1990-12-11
申请号：US363853
申请日：1989-06-09
申请人： Joachim Meyer , Wolfgang Buehler , Johannes Grimmer , Gunter Eipper , Hans Kiefer , Christoph Martin
发明人： Joachim Meyer , Wolfgang Buehler , Johannes Grimmer , Gunter Eipper , Hans Kiefer , Christoph Martin
IPC分类号： A23K20/174 , A23K40/10 , A61K9/14 , A61K31/519 , A61K31/525 , C07D475/14 , C12P17/18
CPC分类号： A23K20/174 , A23K40/10 , Y10S514/951
摘要： Riboflavin produced by a microbial method is prepared in the form of free-flowing, non-dusting, spray-dried granules or microgranules as a feed additive by removing water from the mixture discharged from microbial fermentation for the preparation of riboflavin, wherein the mixture is subjected to(a) a fluidized-bed spray-drying process(b) a one-material spray-drying process or(c) a disk spray-drying process without significant amounts of binders being added to the discharged fermentation mixture.
摘要翻译：通过微生物法生产的核黄素以自由流动，无粉尘，喷雾干燥的颗粒或微粒形式作为饲料添加剂的形式，通过从用于制备核黄素的微生物发酵排出的混合物中除去水，其中混合物为进行（a）流化床喷雾干燥方法（b）单材料喷雾干燥方法或（c）圆盘喷雾干燥方法，没有将显着量的粘合剂加入到排出的发酵混合物中。

2. 发明授权

US5210023A Method of purifying ferment-produced riboflavin 失效
标题翻译：净化发酵的RIBOFLAVIN的方法
公开(公告)号：US5210023A
公开(公告)日：1993-05-11
申请号：US724056
申请日：1991-07-01
申请人： Johannes Grimmer , Hans Kiefer , Christoph Martin
发明人： Johannes Grimmer , Hans Kiefer , Christoph Martin
IPC分类号： C07D475/14 , C12P17/18
CPC分类号： C07D475/14
摘要： A method of purifying ferment-produced riboflavin, wherein the impure riboflavin is suspended in water or dilute aqueous acid, and the suspension is heated at a temperature of from 75.degree. to 130.degree. C. for from 0.3 to 3 hours with stirring, during which time crystal transformation takes place, after which the mixture is cooled and the purified product is isolated in known manner.
摘要翻译：一种纯化发酵生产的核黄素的方法，其中不纯的核黄素悬浮在水中或稀释酸水溶液，悬浮液在75-130℃的温度下搅拌加热0.3-3小时，在此期间发生时间晶体转变，然后将混合物冷却，以已知方式分离纯化产物。

3. 发明授权

US5300303A Spray granules or microgranules of pure riboflavin which contain no binder are non-dusting and free-flowing, and the preparation thereof 失效
标题翻译：不含粘合剂的纯核黄素的喷雾颗粒或微粒是无粉尘和自由流动的，其制备方法
公开(公告)号：US5300303A
公开(公告)日：1994-04-05
申请号：US920539
申请日：1992-07-28
申请人： Johannes Grimmer , Hans Kiefer , Christoph Martin
发明人： Johannes Grimmer , Hans Kiefer , Christoph Martin
IPC分类号： A61K9/16 , A61K31/525 , B01J2/04 , C07D475/14 , A61K9/14
CPC分类号： C07D475/14 , A61K31/525 , A61K9/1688
摘要： A process for preparing spray granules or microgranules, which contain no binder, are non-dusting and free-flowing, from finely divided pure riboflavin, comprises subjecting an aqueous or water-containing suspension of the pure finely divided riboflavin toa) a fluidized bed spray dryingb) a single-nozzle spray drying orc) a disk-type spray dryingin particular a fluidized bed spray drying, without adding binders to the suspension, and the spray granules or microgranules of riboflavin obtainable by this process.
摘要翻译：制备不含粘合剂的喷雾颗粒或微粒的方法是从细碎的纯核黄素中无粉尘和自由流动的方法，包括使纯细碎核黄素的含水或含水悬浮液经a）流化床喷雾干燥b）单喷嘴喷雾干燥或c）盘式喷雾干燥，特别是流化床喷雾干燥，不向悬浮液中添加粘合剂，以及可通过该方法获得的核黄素的喷雾颗粒或微粒。

4. 发明授权

US5169759A Removal of riboflavin from fermentation suspensions 失效
标题翻译：从发酵悬浮液中除去RIBOFLAVIN
公开(公告)号：US5169759A
公开(公告)日：1992-12-08
申请号：US644609
申请日：1991-01-23
申请人： Tillmann Faust , Joachim Meyer , Georg Wellinghoff , Walter Gosele , Christoph Martin , Johannes Grimmer
发明人： Tillmann Faust , Joachim Meyer , Georg Wellinghoff , Walter Gosele , Christoph Martin , Johannes Grimmer
IPC分类号： C07D475/14 , C12P17/18 , C12P25/00
CPC分类号： C12P25/00
摘要： Riboflavin is removed from fermentation suspensions by them being heated at from 50.degree. to 90.degree. C. for from 1 to 3 hours, than cooled to from 0.degree. to 30.degree. C. over a period of from 1 to 5 hours, and subsequently being centrifuged to give a sediment fraction and liquid fraction in such a way that the sediment fraction contains predominantly riboflavin crystals as solid, and the liquid fraction contains virtually no crystalline riboflavin, and, where appropriate, resuspending the sediment fraction in from 0.5 to 2 parts by volume of water per part by volume of sediment fraction and repeating procedure c.
摘要翻译：将核黄素从发酵悬浮液中除去，在50〜90℃下加热1〜3小时，冷却至0〜30℃，时间为1〜5小时，随后为离心分离以得到沉淀物部分和液体部分，使得沉淀物部分主要含有核黄素晶体作为固体，并且液体部分几乎不含结晶核黄素，并且在适当情况下将沉降物组分重悬于0.5至2份中每部分体积的沉淀物含量的水量和重复程序c。

5. 发明授权

US5017700A Preparation of riboflavin-5'-phosphate (5'-FMN) and its sodium salt, and of riboflavin-4',5'-cyclophosphoric acid ester chloride as an intermediate 失效
标题翻译：制备核黄素-5'-磷酸（5'-FMN）及其钠盐，以及核黄素-4'，5'-环磷酸酯氯化物作为中间体
公开(公告)号：US5017700A
公开(公告)日：1991-05-21
申请号：US413590
申请日：1989-09-28
申请人： Johannes Grimmer , Hans Kiefer
发明人： Johannes Grimmer , Hans Kiefer
IPC分类号： A61K31/675 , A61P3/02 , C07F9/6561 , C07F9/6574
CPC分类号： C07F9/65742
摘要： Riboflavin-4',5'-cyclophosphoric acid chloride of the formula I ##STR1## its preparation by reacting an alkali metal salt of riboflavin, in an aprotic solvent, with phosphorus oxychloride, its use for the preparation of riboflavin-5'-phosphate and of the sodium salt of riboflavin-5'-phosphate, and a process for the preparation of riboflavin-5'-phosphate or its sodium salt via the novel phosphoric acid ester chloride.
摘要翻译：核黄素-4'，5'-环磷酰氯通式Ⅰ（Ⅰ）其核苷酸碱金属盐在非质子传递溶剂中与磷酰氯反应，其用于制备核黄素-5 β-磷酸盐和核黄素-5'-磷酸钠钠盐，以及通过新型磷酸酯氯化物制备核黄素-5'-磷酸或其钠盐的方法。

6. 发明授权

US5095115A Preparation of riboflavin 5'-phosphate (FMN) and its sodium salt in a lactone 失效
标题翻译：五磷酸五磷酸（FMN）及其盐中的盐酸盐的制备
公开(公告)号：US5095115A
公开(公告)日：1992-03-10
申请号：US571230
申请日：1990-08-23
申请人： Johannes Grimmer , Hans Kiefer
发明人： Johannes Grimmer , Hans Kiefer
IPC分类号： A61K31/675 , A61P3/02 , C07F9/6524 , C07F9/6561 , C07F9/6574
CPC分类号： C07F9/65618 , C07F9/65742
摘要： An improved process for preparing riboflavin 5'-phosphate (FMN) or its monosodium salt by reacting riboflavin with excess phosphorus oxychloride in a solvent, hydrolyzing of the resulting reaction mixture and, if desired, partially neutralizing with aqueous sodium hydroxide solution, comprises reacting the riboflavin with from 1.2 to 3 moles of phosphorus oxychloride per mole of riboflavin in a suitable lactone, especially .gamma.-butyrolactone, as solvent. The process is particularly advantageous when the reaction mixture is hydrolyzed at from 80.degree. to 90.degree. C. continuously or batchwise.
摘要翻译：通过使核黄素与过量的三氯氧化磷在溶剂中反应制备核黄素5'-磷酸（FMN）或其单钠盐的改进方法，水解所得反应混合物，如果需要，用氢氧化钠水溶液部分中和，在适当的内酯，特别是γ-丁内酯中，每摩尔核黄素使用1.2至3摩尔磷酰氯的核黄素作为溶剂。当反应混合物连续或间歇地在80℃至90℃下水解时，该方法特别有利。

7. 发明授权

US5616737A Stereoselective preparation of (-) 3a,6,6,9a-tetramethyl-perhydronaphtho[2,1-b]furan 失效
标题翻译：（ - ）3a，6,6,9a-四甲基 - 过氢萘并[2,1-b]呋喃的立体选择性制备
公开(公告)号：US5616737A
公开(公告)日：1997-04-01
申请号：US674914
申请日：1996-07-03
申请人： Johannes Grimmer , Christoph Martin
发明人： Johannes Grimmer , Christoph Martin
IPC分类号： B01J21/04 , C07B53/00 , C07B61/00 , C07D307/92 , C11B9/00
CPC分类号： C07D307/92
摘要： A process for the stereoselective preparation of (-)3a,6,6,9a-tetramethylperhydronaphtho[2,1-b]furan of the formula Ia ##STR1## by dehydration and cyclization of decahydro-2-hydroxy- 2,5,5,8-tetramethyl-1-naphthaleneethanol using solid acidic catalysts, wherein the decahydro-2-hydroxy- 2,5,5,8-tetramethyl-1-naphthaleneethanol is heated in the molten state at from 80.degree. to 200.degree. C. in the presence of from 10 to 100% by weight, based on the diol, of an active acidic aluminum oxide commercially supplied for (preparative) column chromatography.
摘要翻译：通过脱水和环化十氢-2-羟基-2的立体选择性制备式（Ia）的（ - ）3a，6,6,9a-四氢呋喃并[2,1-b]呋喃的方法， 5,5,8-四甲基-1-萘乙醇使用固体酸性催化剂，其中十氢-2-羟基-2,5,5,8-四甲基-1-萘乙醇在80〜200℃的熔融状态下加热在10至100重量％的存在下，基于二醇，市售的（制备型）柱色谱法的活性酸性氧化铝。

8. 发明授权

US4421931A Preparation of anthranilic acid amides 失效
标题翻译：邻氨基苯甲酰胺的制备
公开(公告)号：US4421931A
公开(公告)日：1983-12-20
申请号：US338243
申请日：1982-01-11
申请人： Peter Tonne , Winfried Ludwig , Gerhard Kilpper , Johannes Grimmer
发明人： Peter Tonne , Winfried Ludwig , Gerhard Kilpper , Johannes Grimmer
IPC分类号： C07C231/00 , C07C233/00 , C07C102/04 , C07C103/28 , C07C103/76
CPC分类号： C07C231/00 , C07C233/00
摘要： Anthranilic acid amides are prepared by mixing phthalamic acid with a caustic alkali solution, a catalyst and a hypohalite, allowing the mixture to stand for from 1 to 1,000 seconds, then introducing the amine and thereafter addig acid until the pH of the mixture is from 6 to 8.The anthranilic acid amides obtainable by the process of the invention are valuable starting materials for the preparation of dyes, scents and pesticides.
摘要翻译：邻氨基苯甲酸酰胺通过将邻苯二甲酰氨基磺酸与苛性碱溶液，催化剂和次卤酸盐混合，使混合物静置1至1,000秒，然后引入胺然后加入酸直至混合物的pH为6 通过本发明的方法获得的邻氨基苯甲酰胺是用于制备染料，香料和农药的有价值的原料。

9. 发明申请

US20070219383A1 Method for Reducing Alkyne Compuonds 审中-公开
标题翻译：减少炔烃的方法
公开(公告)号：US20070219383A1
公开(公告)日：2007-09-20
申请号：US11662440
申请日：2005-09-08
申请人： Johannes Grimmer , Thomas Muller
发明人： Johannes Grimmer , Thomas Muller
IPC分类号： C07D317/64 , C01C1/00 , C07C403/08 , C07C45/00
CPC分类号： C07C403/24 , C07C403/08 , C07C2601/16
摘要： The present invention relates to a method for preparing cyclohexene derivatives of the general formulae I or II by reducing alkyne compounds of the general formulae III or IV with a mixture of zinc and at least one ammonium salt of the formula V as reducing agent, in which the substituents R1 to R8 have independently of one another the meaning specified in the description, wherein the reducing agent comprises from 0.3 to 0.49 mol of at least one ammonium salt of the formula V per mol of zinc.
摘要翻译：本发明涉及通过用通式Ⅴ的锌和至少一种铵盐作为还原剂的混合物还原通式III或Ⅳ的炔化合物来制备通式I或II的环己烯衍生物的方法，其中取代基R 1至R 8彼此独立地具有说明书中指定的含义，其中还原剂包含0.3至0.49mol的至少一种铵盐式V每摩尔锌。

10. 发明授权

US4806643A Preparation of riboflavin 失效
标题翻译：核黄素的制备
公开(公告)号：US4806643A
公开(公告)日：1989-02-21
申请号：US932312
申请日：1986-11-19
申请人： Johannes Grimmer
发明人： Johannes Grimmer
IPC分类号： C07D475/14
CPC分类号： C07D475/14
摘要： Riboflavin of the formula I ##STR1## is prepared by an improved process by condensing a 4,5-dimethyl-N-(D)-ribityl-2-phenylazoaniline of the formula II ##STR2## where R is H, --CL, --NO.sub.2, --CH.sub.3 or --OCH.sub.3 in the o- or p-position, with barbituric acid of the formula III ##STR3## in the presence of an acid as a condensing agent, by a process in which the acidic condensing agent used is an aliphatic secondary carboxylic acid of the general formula IV ##STR4## where R.sup.1 is methyl or ethyl and R.sup.2 is alkyl of 3 or 4 carbon atoms.
摘要翻译：式I（I）的核黄素通过将下式（II）的4,5-二甲基-N-（D） - 二基-2-苯基偶氮苯胺缩合得到改进的方法来制备，其中R是 H，-CL，-NO 2，-CH 3或-OCH 3与通式III的巴比妥酸（III）在作为缩合剂的酸存在下，通过在其中使用的酸性缩合剂是通式IV（IV）的脂族二羧酸，其中R 1是甲基或乙基，R 2是3或4个碳原子的烷基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式