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1. 发明申请

US20140001352A1 METHOD FOR THE DIELECTRIC BARRIER ELECTROSPRAY IONIZATION OF LIQUID SAMPLES AND FOR THE SUBSEQUENT MASS SPECTROMETRIC ANALYSIS OF THE GENERATED SAMPLE IONS 审中-公开
标题翻译：用于液体样品的电介质电子沉积离子化方法和用于生成样品离子的后续质谱分析
公开(公告)号：US20140001352A1
公开(公告)日：2014-01-02
申请号：US14006408
申请日：2012-03-26
申请人： Joachim Franzke , Ann-Kathrin Stark , Michael Schilling , Dirk Janasek , Guenter Jestel , Ruediger Wilberg , Cordula Meyer
发明人： Joachim Franzke , Ann-Kathrin Stark , Michael Schilling , Dirk Janasek , Guenter Jestel , Ruediger Wilberg , Cordula Meyer
IPC分类号： H01J49/10 , H01J49/00
CPC分类号： H01J49/10 , H01J49/0031 , H01J49/165
摘要： The invention relates to a method for the dielectric barrier electrospray ionization of liquid samples and for the subsequent mass spectrometric analysis of the generated sample ions, in which the respective liquid sample is conducted in a capillary-shaped feed channel, the surrounding wall of which comprises on the outer side, spaced from the free end, an electrode which is separated from the wall by a separating layer made of a dielectric material, wherein at a distance from the free end of the feed channel an inlet of a mass spectrometer forming a counter electrode is arranged, creating an ion formation clearance, the formed ions reaching an openable and closable trap of the mass spectrometer through the inlet, wherein a square-wave voltage is applied between the electrode and the inlet for generating the sample ions and the trap of the mass spectrometer is alternately opened and closed, and wherein the sample ions reaching the trap of the mass spectrometer are analyzed in the mass spectrometer. The aim of the invention is to only have positive or negative sample ions reach the mass spectrometer while preserving the advantages of applying a square-wave voltage. The aim is achieved by applying an asymmetrical square-wave voltage between the electrode and the inlet, in which voltage the frequency ratio of the positive and negative polarities is different.
摘要翻译：本发明涉及一种用于液体样品的电介质阻挡电喷雾离子化的方法，并且用于随后对生成的样品离子的质谱分析，其中相应的液体样品在毛细管状进料通道中传导，其周围壁包括在外侧与自由端隔开的电极通过由电介质材料制成的隔离层与壁隔开，其中与进料通道的自由端距离形成计数器的质谱仪的入口电极被布置成产生离子形成间隙，所形成的离子通过入口到达质谱仪的可开启和闭合的陷阱，其中在电极和入口之间施加方波电压以产生样品离子和陷阱质谱仪交替打开和关闭，并且其中以质量分析到达质谱仪的阱的样品离子光谱仪本发明的目的是仅使正或负的样品离子到达质谱仪，同时保持施加方波电压的优点。目的是通过在电极和入口之间施加不对称的方波电压来实现，其中正极和负极的频率比的电压不同。

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