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    • 3. 发明申请
    • DENTAL COMPOSITION
    • 牙科成分
    • US20120238662A1
    • 2012-09-20
    • US13512769
    • 2010-12-07
    • Joachim E. KleeHelmut RitterSven PohleOliver ElsnerMareike Bardts
    • Joachim E. KleeHelmut RitterSven PohleOliver ElsnerMareike Bardts
    • C08G63/91A61K6/00
    • A61K6/0835A61K6/0038A61K6/083C08F218/06C08F265/02C08F267/04C08L33/00
    • Dental cement composition comprising a polymerizable polyacidic polymer having repeating units in the polymer backbone, which are represented by the following formula (I)1 (II), and/or (III): wherein X represents O, S, or NR′, whereby R′ represents a hydrogen atom or a straight or branched C1-C6 alkyl group, C3-C6 cycloalkyl group, or C4-C8 cycloalkylalkyl group, Y a group of the following formula (IV), wherein each of L1, L2, L3 and L4, which are independent from each other represents a single bond, a straight or branched C1-C6 alkylene group, a straight or branched C1-C6 alkenylene, or a straight or branched C1-C20 alkylene group which includes 1 to 8 atoms selected from oxygen and sulfur atoms, X′ represents O, S, or NR″, whereby R″ represents a hydrogen atom or a straight or branched C1-C6 alkyl group, C3-C6 cycloalkyl group, or C4-C8 cycloalkylalkyl group, m is 0 to 3, and n is 1 to 3.
    • 含有聚合物主链中具有重复单元的聚合性聚酸聚合物的牙科水泥组合物,其由下式(I)1(II)和/或(III)表示:其中X表示O,S或NR',由此 R'表示氢原子或直链或支链C1-C6烷基,C3-C6环烷基或C4-C8环烷基烷基,Y为下式(Ⅳ)的基团,其中L1,L2,L3和 L4彼此独立地表示单键,直链或支链C1-C6亚烷基,直链或支链C1-C6亚烯基或包含1至8个选自以下的1至8个原子的直链或支链C 1 -C 20亚烷基 氧原子和硫原子,X'表示O,S或NR“,其中R”表示氢原子或直链或支链C 1 -C 6烷基,C 3 -C 6环烷基或C 4 -C 8环烷基烷基,m为0 至3,n为1至3。
    • 8. 发明申请
    • POLYMER FOR A GLASS IONOMER CEMENT
    • 玻璃离子水泥聚合物
    • US20130289216A1
    • 2013-10-31
    • US13988049
    • 2011-12-20
    • Joachim E. KleeHelmut RitterMaximilliam MaierJulia GanselAndreas FacherOliver EelsnerSven Pohle
    • Joachim E. KleeHelmut RitterMaximilliam MaierJulia GanselAndreas FacherOliver EelsnerSven Pohle
    • A61K6/083
    • A61K6/0835C08F8/00C08F8/12C08F8/46C08F220/06C08F220/18C08F220/12C08L33/08C08L33/10C08L33/26
    • A process for producing a water-soluble, hydrolysis-stable, polymerizable polymer, comprising a) a step of copolymerizing a mixture comprising (i) a first copolymerizable monomer comprising at least one optionally protected carboxylic acid group and a first polymerizable organic moiety, and (ii) a second copolymerizable monomer comprising one or more optionally protected primary and/or secondary amino groups and a second polymerizable organic moiety, for obtaining an amino group containing copolymer; b) a step of coupling to the amino group containing copolymer a compound having a polymerizable moiety and a functional group reactive with an amino group of repeating units derived from the second copolymerizable monomer in the amino group containing copolymer obtained in the first step wherein the optionally protected amino group is deprotected, so that polymerizable pendant groups are linked to the backbone by hydrolysis-stable linking groups, and, optionally, a step of deprotecting the protected carboxylic acid group after step (a) or step (b), for obtaining a polymerizable polymer.
    • 一种制备水溶性,水解稳定的可聚合聚合物的方法,包括:a)使包含(i)包含至少一个任选保护的羧酸基团的第一可共聚单体和第一可聚合有机部分的混合物共聚的步骤,以及 (ii)包含一个或多个任选保护的伯和/或仲氨基和第二可聚合有机部分的第二可共聚单体,用于获得含氨基的共聚物; b)在第一步骤中获得的含氨基的共聚物中偶联到具有可聚合部分的化合物和与衍生自第二可共聚单体的重复单元的氨基反应的官能团的步骤,其中任选地 保护的氨基被脱保护,使得可聚合侧基通过水解稳定的连接基团连接到骨架上,并且任选地在步骤(a)或步骤(b)之后将保护的羧酸基脱保护的步骤,以获得 可聚合聚合物。
    • 9. 发明授权
    • Dental adhesive composition
    • 牙科粘合剂组成
    • US08546463B2
    • 2013-10-01
    • US12386022
    • 2009-04-13
    • Joachim E. KleeUwe Lehmann
    • Joachim E. KleeUwe Lehmann
    • A61K6/083A61C5/00
    • C07F9/12A61K6/0023C07F9/091C07F9/093C08F216/125C08F220/58C08F222/385C08F230/02C08L43/02C08L33/00
    • Dental composition comprising an aqueous mixture containing (i) a polymerizable acidic phosphoric acid ester monomer of the following formula (A): wherein a is an integer of from 1 to 10; R1 represents a hydrogen atom or a moiety of the following formula (Y) wherein X independently represent an oxygen atom, a sulfur atom, or a group NR, wherein R may be a hydrogen atom, a C1-6 alkyl group or an acyl group; L represents an (a+b)-valent organic residue containing 1 to 20 carbon atoms and optionally including ether, thioether or amino groups or further acidic groups, whereby the carbon atoms comprise at least a+b carbon atoms selected from primary and secondary aliphatic carbon atoms, secondary alicyclic carbon atoms, and aromatic carbon atoms, each of said a+b carbon atoms linking a phosphate or 2-(oxaallyl) derivative group; b is an integer of from 1 to 10; R2 which may be the same or different, independently may be hydrogen, an allyl group or a moiety R1 wherein b is 1; provided that at least one of R1 and R2 is not hydrogen; (ii) one or more polymerizable N-substituted alkyl acrylic or acrylic acid amide monomers; (iii) an organic water-miscible solvent and/or water; (iv) a polymerization initiator; (v) an inhibitor and/or a stabilizer; (vi) optionally an organic or inorganic acid; and (vii) optionally a filler and/or a fluoride releasing compound.
    • 1.一种牙科用组合物,其含有含有(i)下述通式(A)的可聚合酸性磷酸酯单体的水性混合物:其中a为1〜10的整数, R1表示氢原子或下式(Y)的部分,其中X独立地表示氧原子,硫原子或基团NR,其中R可以是氢原子,C1-6烷基或酰基 ; L表示含有1至20个碳原子的(a + b)价有机残基,并且任选地包括醚,硫醚或氨基或其它酸性基团,其中碳原子包含至少一个选自伯和仲脂族 碳原子,仲脂环碳原子和芳族碳原子,所述a + b个碳原子各自连接磷酸酯或2-(氧杂烯丙基)衍生物基团; b为1〜10的整数, R 2可以相同或不同,独立地可以是氢,烯丙基或部分R1,其中b是1; 条件是R 1和R 2中的至少一个不是氢; (ii)一种或多种可聚合的N-取代的烷基丙烯酸或丙烯酸酰胺单体; (iii)有机水混溶性溶剂和/或水; (iv)聚合引发剂; (v)抑制剂和/或稳定剂; (vi)任选的有机或无机酸; 和(vii)任选的填料和/或氟化物释放化合物。