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1. 发明授权

US4863735A Biodegradable polymeric drug delivery system with adjuvant activity 失效
标题翻译：具有佐剂活性的可生物降解聚合物药物递送系统
公开(公告)号：US4863735A
公开(公告)日：1989-09-05
申请号：US914380
申请日：1986-10-02
申请人： Joachim B. Kohn , Robert S. Langer , Steven M. Niemi , James G. Fox
发明人： Joachim B. Kohn , Robert S. Langer , Steven M. Niemi , James G. Fox
IPC分类号： A61K9/22 , A61K39/39 , A61K47/48 , C08G69/10
CPC分类号： C08G69/10 , A61K39/39 , A61K47/48192 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , Y10S514/885 , Y10S514/953 , Y10S514/963 , Y10S514/964 , Y10S514/965
摘要： An antigen delivery system utilizing a biodegradable polymer with good mechanical properties in combination with a material stimulating the immune system. The material having adjuvant activity may be polymer degradation products or an adjuvant which is contained within or bound to the polymer. In one embodiment, the polymer is formed from tyrosine dipeptides. Poly(CTTH-iminocarbonate) is a preferred tyrosine dipeptide polymer for constructing implantable delivery systems for antigenic material. The polymer is not an adjuvant in itself but degrades into products which stimulate the immune system. The tyrosine dipeptide can also be used as a conventional adjuvant. The advantages of the system are that a polymer can be used to form a biodegradable integral structure which is useful as both an implantable source of an antigen or other biologically active compound and as a control means for the rate of release of the biologically active compound, wherein the result is sustained, relatively constant delivery of antigen with simultaneous stimulation of the immune response.
摘要翻译：使用具有良好机械性能的生物可降解聚合物与刺激免疫系统的材料组合的抗原递送系统。具有佐剂活性的材料可以是聚合物降解产物或包含在聚合物内或与聚合物结合的佐剂。在一个实施方案中，聚合物由酪氨酸二肽形成。聚（CTTH-亚氨基碳酸酯）是用于构建用于抗原材料的可植入递送系统的优选的酪氨酸二肽聚合物。聚合物本身不是佐剂，但会降解成刺激免疫系统的产物。酪氨酸二肽也可以用作常规佐剂。该系统的优点是可以使用聚合物形成可生物降解的整体结构，其可用作抗原的可植入源或其它生物活性化合物，并且作为生物活性化合物的释放速率的对照手段，其中所述结果是持续的，相对恒定的抗原递送，同时刺激免疫应答。

2. 发明授权

US08685367B2 Inherently radiopaque polymeric products for embolotherapy 有权
标题翻译：固有的不透射线聚合物产品用于电击治疗
公开(公告)号：US08685367B2
公开(公告)日：2014-04-01
申请号：US10952274
申请日：2004-09-27
申请人： Donald K. Brandom , Eric Schmid , Joan Zeltinger , Durgadas Bolikal , Joachim B. Kohn
发明人： Donald K. Brandom , Eric Schmid , Joan Zeltinger , Durgadas Bolikal , Joachim B. Kohn
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K31/785 , A61K49/0442
摘要： Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.
摘要翻译：优选的实施方案涉及固有的不透射线的，生物相容的，生物可再吸收的聚合物颗粒的组合物和使用它们来栓塞体腔的方法。

3. 发明授权

US08415449B2 Bioresorbable polymers synthesized from monomer analogs of natural metabolites 有权
标题翻译：由天然代谢物的单体类似物合成的生物可吸收聚合物
公开(公告)号：US08415449B2
公开(公告)日：2013-04-09
申请号：US13387798
申请日：2010-07-31
申请人： Joachim B. Kohn , Durgadas Bolikal , Ramiro Rojas
发明人： Joachim B. Kohn , Durgadas Bolikal , Ramiro Rojas
IPC分类号： C08G64/00 , C08G63/02
CPC分类号： C08G79/02 , A61K47/59 , A61K47/60 , C08G79/025
摘要： This invention discloses biocompatible polymers prepared from monomers (IV), and (IVa), or derivatives thereof, for which the variables are described in the claims and specification. These polymers may be bioresorbable and thus useful for manufacture of medical devices. Therefore, methods for preparing these polymers and medical devices prepared therefrom are also encompassed by this disclosure.
摘要翻译：本发明公开了由权利要求和说明书中描述的变体描述的由单体（IV）和（IVa）或其衍生物制备的生物相容性聚合物。这些聚合物可以是生物可再吸收的，因此可用于制造医疗器械。因此，制备这些聚合物的方法和由其制备的医疗装置也包括在本公开中。

4. 发明申请

US20120135523A1 PREPARATION AND USES OF POLYARYLATES 有权
标题翻译：聚氨酯的制备和用途
公开(公告)号：US20120135523A1
公开(公告)日：2012-05-31
申请号：US13361268
申请日：2012-01-30
申请人： Ken James , Brochini Stephen , Varawut Tangpasuthadol , Joachim B. Kohn
发明人： Ken James , Brochini Stephen , Varawut Tangpasuthadol , Joachim B. Kohn
IPC分类号： C12N5/071 , C08G63/685 , C07C237/20
CPC分类号： C08G63/78 , A61L17/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , B01J2219/00722 , C08G63/19 , C08G63/6856 , C08G63/6858 , C08G64/045 , C08G64/12 , C40B40/14 , C08L69/00
摘要： The present invention is directed to polyarylates comprising repeating units having the structure: as well as their preparation and use as cell growth substrates.
摘要翻译：本发明涉及包含具有以下结构的重复单元的聚芳酯：以及它们作为细胞生长底物的制备和用途。

5. 发明申请

US20090285895A1 Pharmaceutical Formulation for Regulating the Timed Release of Biologically Active Compounds Based on a Polymer Matrix 审中-公开
标题翻译：用于调节基于聚合物基质的生物活性化合物的定时释放的药物制剂
公开(公告)号：US20090285895A1
公开(公告)日：2009-11-19
申请号：US12426902
申请日：2009-04-20
申请人： Joachim B. Kohn , Deborah M. Schachter
发明人： Joachim B. Kohn , Deborah M. Schachter
IPC分类号： A61K38/02 , A61K9/14
CPC分类号： A61K47/14 , A61K38/12
摘要： A formulation containing a biologically active compound having a structure with hydrogen bonding sites is blended with a polymer having a structure with complementary hydrogen bonding sites, the polymer forming hydrolytic degradation products that promote the release of the biologically active compound from the polymer.
摘要翻译：含有具有氢键合位点结构的生物活性化合物的制剂与具有互补氢键位置结构的聚合物共混，所述聚合物形成促进生物活性化合物从聚合物释放的水解降解产物。

6. 发明授权

US07585929B2 Preparation and uses for polyarylates 有权
标题翻译：聚芳酯的制备和用途
公开(公告)号：US07585929B2
公开(公告)日：2009-09-08
申请号：US10889914
申请日：2004-07-13
申请人： Ken James , Stephen Brocchini , Varawut Tangpasuthadol , Joachim B. Kohn
发明人： Ken James , Stephen Brocchini , Varawut Tangpasuthadol , Joachim B. Kohn
IPC分类号： C08G63/06
CPC分类号： C08G63/78 , A61L17/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , B01J2219/00722 , C08G63/19 , C08G63/6856 , C08G63/6858 , C08G64/045 , C08G64/12 , C40B40/14 , C08L69/00
摘要： The present invention is directed to polyarylates comprising repeating units having the structure: as well as their preparation and use as cell growth substrates.
摘要翻译：本发明涉及包含具有以下结构的重复单元的聚芳酯：以及它们作为细胞生长底物的制备和用途。

7. 发明申请

US20080187567A1 N-SUBSTITUTED MONOMERS AND POLYMERS 有权
标题翻译： N-取代的单体和聚合物
公开(公告)号：US20080187567A1
公开(公告)日：2008-08-07
申请号：US11873979
申请日：2007-10-17
申请人： Joachim B. Kohn , Durgadas Bolikal , Jaap Schut , Ernest G. Baluca
发明人： Joachim B. Kohn , Durgadas Bolikal , Jaap Schut , Ernest G. Baluca
IPC分类号： A61F2/00 , C08G63/06 , C07C233/01
CPC分类号： A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/00 , B33Y70/00 , B33Y80/00 , C08G63/6856 , C08G64/045 , C08G64/12 , C08G64/183 , C08G64/186 , C08G79/04 , C08L85/02 , C08L69/00
摘要： Biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an amide group, wherein said amide groups are N-substituted and the N-substituent and degree of N-substitution are effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without N-substitution.
摘要翻译：包含多个含有酰胺基团的单体重复单元的生物相容性生物可吸收聚合物，其中所述酰胺基团是N-取代的，N-取代基和N-取代度对降低熔体粘度，溶液粘度或两者均有效，与没有N-取代的相同聚合物相比。

8. 发明授权

US06359102B1 Biphasic polymerization process 失效
标题翻译：双相聚合工艺
公开(公告)号：US06359102B1
公开(公告)日：2002-03-19
申请号：US09107753
申请日：1998-06-29
申请人： John E. Kemnitzer , George L. Brode , Joachim B. Kohn
发明人： John E. Kemnitzer , George L. Brode , Joachim B. Kohn
IPC分类号： C08G6424
CPC分类号： C08G64/24 , C08G63/6856 , C08G63/79 , C08G63/87 , C08G64/12
摘要： Improvements are disclosed for biphasic polymerization processes in which an aqueous solution of a first monomer that is hydrolytically unstable below a pH of about six or above a pH of about eight is admixed with a water-immiscible organic solvent and there is added to the admixture a catalyst selected from tertiary amine, quaternary amine and phosphonium catalysts, an acid-forming co-monomer for the first monomer, an acid scavenger, after which the resulting polymer is recovered, wherein the improvement includes providing the aqueous solution at a pH between about si and about eight, and adding to the admixture the acid-forming co-monomer and the acid scavenger at relative rates effective to maintain the pH of the admixture between about six and about eight. The catalyst may be added in a molar ratio to the first monomer effective to provide a predetermined weight-average or number-average molecular weight for the resulting polymer. Biphasic polymerization processes for monomers that are not pH sensitive are also disclosed.
摘要翻译：对于双相聚合方法公开了改进，其中将水解稳定性低于约6或大于约pH 8的水解不稳定的第一单体的水溶液与水不混溶的有机溶剂混合并加入到混合物a 选自叔胺，季胺和鏻催化剂的催化剂，用于第一单体的酸形成共聚单体，酸清除剂，之后回收所得聚合物，其中改进包括将水溶液提供在约si 和约8，并且以相对速率加入酸形成共聚单体和酸清除剂，以有效地将混合物的pH保持在约6至约8之间。催化剂可以与第一单体的摩尔比加入，有效地为所得聚合物提供预定的重均分子量或数均分子量。还公开了对不敏感的单体的双相聚合方法。

9. 发明授权

US06319492B1 Copolymers of tyrosine-based polyarylates and poly(alkylene oxides) 有权
公开(公告)号：US06319492B1
公开(公告)日：2001-11-20
申请号：US09520665
申请日：2000-03-07
申请人： Joachim B. Kohn , Chun Yu
发明人： Joachim B. Kohn , Chun Yu
IPC分类号： A61K3174
CPC分类号： C08G69/44 , A61K9/204 , A61K38/00 , A61L17/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , A61L31/148 , C07K14/001 , C08G63/672 , C08G63/6856 , C08G63/6858 , C08G64/045 , C08G64/12 , C08G64/1641 , C08G64/183 , C08G69/10 , C08L69/00
摘要： Implantable medical devices and drug delivery implants containing polyarylate random block copolymers are disclosed, along with methods for drug delivery and for preventing the formation of adhesions between injured tissues employing the polyarylate random block copolymers.

10. 发明授权

US6048521A Copolymers of tyrosine-based polyarlates and poly(alkylene oxides) 失效
标题翻译：基于酪氨酸的聚芳酯和聚（环氧烷）的共聚物
公开(公告)号：US6048521A
公开(公告)日：2000-04-11
申请号：US85571
申请日：1998-05-27
申请人： Joachim B. Kohn , Chun Yu
发明人： Joachim B. Kohn , Chun Yu
IPC分类号： A61K9/20 , A61L17/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , A61L31/14 , C08G63/672 , C08G63/685 , C08G63/78 , C08G64/04 , C08G64/12 , C08G64/18 , C40B40/14 , C08L69/00 , A61L24/04 , C08L77/00
CPC分类号： C08G64/183 , A61L17/10 , A61L27/18 , A61L27/34 , A61L31/06 , A61L31/10 , A61L31/148 , C08G63/672 , C08G63/6856 , C08G63/6858 , C08G63/78 , C08G64/045 , C08G64/12 , A61K9/204 , B01J2219/00722 , C40B40/14
摘要： Implantable medical devices and drug delivery implants containing polyarylate random block copolymers are disclosed, along with methods for drug delivery and for preventing the formation of adhesions between injured tissues employing the polyarylate random block copolymers.
摘要翻译：公开了含有多芳基化物无规嵌段共聚物的植入式医疗装置和药物递送植入物，以及用于药物递送和用于使用多芳基化物无规嵌段共聚物的损伤组织之间形成粘连的方法。

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