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1. 发明授权

US6001825A Use of novel organoselenium compounds as pro-oxidizing agents their methods of preparation and pharmaceutical compositions and application thereof 失效
标题翻译：使用新型有机硒化合物作为前体氧化剂，其制备方法和药物组合物及其应用
公开(公告)号：US6001825A
公开(公告)日：1999-12-14
申请号：US771442
申请日：1996-12-20
申请人： Jinzhu Xu , Georges Appere , Jean Chaudiere , Jean-Claude Yadan
发明人： Jinzhu Xu , Georges Appere , Jean Chaudiere , Jean-Claude Yadan
IPC分类号： C07D293/10 , C07D293/12 , C07J51/00 , A61K33/04
CPC分类号： C07D293/12 , C07D293/10 , C07J51/00
摘要： Compounds represented by the following formula I: ##STR1## in which: R.sup.1 to R.sup.5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR.sup.6 R.sup.7).sub.n in which n=0 or 1, and CO are disclosed. These compounds are useful as anti-tumor drugs, especially with pro-oxidizing activity.
摘要翻译：由下式I表示的化合物：其中：R 1至R 5可以具有其中烷基，取代或未取代的芳基，m等于0或1的各种含义，X选自（CR 6 R 7）n，其中n = 0或1，并公开CO。这些化合物可用作抗肿瘤药物，特别是具有促氧化活性。

2. 发明授权

US6057310A Organoselenium compounds with pro-oxidant activity and pharmaceutical use thereof 失效
标题翻译：具有促氧化活性的有机硒化合物及其药物用途
公开(公告)号：US6057310A
公开(公告)日：2000-05-02
申请号：US120436
申请日：1998-07-22
申请人： Jinzhu Xu , Georges Appere , Jean Chaudiere , Jean-Claude Yadan
发明人： Jinzhu Xu , Georges Appere , Jean Chaudiere , Jean-Claude Yadan
IPC分类号： C07D293/10 , C07D293/12 , C07J51/00 , A61K31/41 , C07D421/12
CPC分类号： C07D293/12 , C07D293/10 , C07J51/00
摘要： Compounds represented by the following formula I: ##STR1## in which: R.sup.1 to R.sup.5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR.sup.6 R.sup.7).sub.n in which n=0 or 1, and CO are disclosed. These compounds are useful as anti-tumor drugs, especially with pro-oxidizing activity.
摘要翻译：由下式I表示的化合物：其中：R 1至R 5可以具有其中烷基，取代或未取代的芳基，m等于0或1的各种含义，X选自（CR 6 R 7）n，其中n = 0或1，并公开CO。这些化合物可用作抗肿瘤药物，特别是具有促氧化活性。

3. 发明授权

US6130212A Use of novel organoselenium compounds as pro-oxidizing agents, their methods of preparation and pharmaceutical compositions and application thereof 失效
标题翻译：使用新型有机硒化合物作为前体氧化剂，其制备方法和药物组合物及其应用
公开(公告)号：US6130212A
公开(公告)日：2000-10-10
申请号：US329755
申请日：1999-06-10
申请人： Jinzhu Xu , Georges Appere , Jean Chaudiere , Jean-Claude Yadan
发明人： Jinzhu Xu , Georges Appere , Jean Chaudiere , Jean-Claude Yadan
IPC分类号： A61K33/04 , C07D293/10 , C07D293/12 , C07J51/00 , A61K31/58 , A61K31/395 , A61K31/41
CPC分类号： C07D293/12 , C07D293/10 , C07J51/00
摘要： Compounds represented by the following formula I: ##STR1## in which: R.sup.1 to R.sup.5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR.sup.6 R.sup.7).sub.n in which n=0 or 1, and CO are disclosed. These compounds are useful as anti-tumor drugs, especially with pro-oxidizing activity.
摘要翻译：由下式I表示的化合物：其中：R 1至R 5可以具有其中烷基，取代或未取代的芳基，m等于0或1的各种含义，X选自（CR 6 R 7）n，其中n = 0或1，并公开CO。这些化合物可用作抗肿瘤药物，特别是具有促氧化活性。

4. 发明授权

US06407083B1 Uses of novel organoselenium compounds with pro-oxidant activity 失效
标题翻译：使用具有促氧化活性的新型有机硒化合物
公开(公告)号：US06407083B1
公开(公告)日：2002-06-18
申请号：US09648784
申请日：2000-08-28
申请人： Jinzhu Xu , Georges Appere , Jean Chaudiere , Jean-Claude Yadan
发明人： Jinzhu Xu , Georges Appere , Jean Chaudiere , Jean-Claude Yadan
IPC分类号： C07D29312
CPC分类号： C07D293/12 , C07D293/10 , C07J51/00
摘要： Compounds represented by the following formula I: in which: R1 to R5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR6R7)n in which n=0 or 1, and CO are disclosed. These compounds are useful as anti-tumor drugs, especially with pro-oxidizing activity.
摘要翻译：由下式I表示的化合物：其中：R 1至R 5可以具有其中烷基，取代或未取代的芳基，m等于0或1的各种含义，X选自（CR 6 R 7）n，其中n = 0或1，并公开CO。这些化合物可用作抗肿瘤药物，特别是具有促氧化活性。

5. 发明授权

US6093532A Method for storing a biological organ transplant graft using a benzisoselen-azoline or -azine compound 失效
标题翻译：使用苯并异硒咯啉或哒嗪化合物储存生物器官移植移植物的方法
公开(公告)号：US6093532A
公开(公告)日：2000-07-25
申请号：US303421
申请日：1999-05-03
申请人： Irene Erdelmeier , Jean Chaudiere , Marc Moutet , Jean-Claude Yadan
发明人： Irene Erdelmeier , Jean Chaudiere , Marc Moutet , Jean-Claude Yadan
IPC分类号： A61K31/395 , A61K31/41 , A61K31/495 , A61P9/00 , A61P9/10 , A61P11/16 , A61P27/02 , A61P29/00 , A61P37/04 , A61P43/00 , C07D293/10 , C07D293/12 , C07D421/12 , C12N5/02 , C12N5/00 , G01N31/00
CPC分类号： C07D293/10 , C07D293/12 , Y10T436/108331
摘要： The invention concerns novel benzisoselen-azoline and -azine derivatives. These novel derivatives have the following general formula (II): ##STR1## where: R.sup.1 to R.sup.8 and R.sup.10 have various meanings, in particular H, alkyl, etc . . . ; ##STR2## Y.sup.- represents the anion of a pharmaceutically acceptable anion; n=0, 1; m=0, 1, 2; p=1, 2, 3; q=2, 3, 4; r=0, 1; and their pharmaceutically acceptable salts of acids or bases; there being no more than one substituent R.sup.9 in each molecule with general formula II. These novel derivatives can be used in medication.
摘要翻译：本发明涉及新型苯并异硒咯啉和吖嗪衍生物。这些新型衍生物具有以下通式（II）：其中：R1至R8和R10具有各种含义，特别是H，烷基等。。。 ; Y-表示药学上可接受的阴离子的阴离子; n = 0,1; m = 0,1,2; p = 1,2,3。 q = 2,3,4; r = 0，1; 及其药学上可接受的酸或碱的盐; 在每个具有通式II的分子中，不超过一个取代基R9。这些新型衍生物可用于药物治疗。

6. 发明授权

US5973009A Aromatic diselenides and selenosulfides, their preparation and their uses, more particularly their therapeutical use 失效
标题翻译：芳族二硒化物和硒硫化物，其制备及其用途，更具体地说是其治疗用途
公开(公告)号：US5973009A
公开(公告)日：1999-10-26
申请号：US997669
申请日：1997-12-23
申请人： Catherine Tailhan-Lomont , Irene Erdelmeier , Marc Moutet , Jean Chaudiere , Jean-Claude Yadan
发明人： Catherine Tailhan-Lomont , Irene Erdelmeier , Marc Moutet , Jean Chaudiere , Jean-Claude Yadan
IPC分类号： A61K31/095 , A61K31/38 , A61K31/381 , A61K31/415 , A61K31/425 , A61K31/426 , A61K31/495 , A61K31/555 , A61K38/00 , A61P1/00 , A61P9/00 , A61P11/00 , A61P27/02 , A61P31/12 , A61P37/04 , A61P43/00 , C07C391/02 , C07D233/66 , C07D277/20 , C07D277/32 , C07D333/26 , C07D333/30 , C07D517/04 , C07K5/08
CPC分类号： C07D517/04 , C07C391/02 , C07D233/66 , C07D333/30
摘要： The objects of the present invention are:novel organoselenium compounds: aromatic diselenides and selenosulphides;the use of said novel compounds as antioxidant agents;pharmaceutical compositions containing them;a method of preparation of said novel compounds. pa Said novel cyclic organoselenium compounds have the general formula (I): ##STR1##
摘要翻译：本发明的目的是：新型有机硒化合物：芳族二硒化物和硒代硫化物; 使用所述新型化合物作为抗氧化剂; 含有它们的药物组合物; 一种制备所述新化合物的方法。所述新型环状有机硒化合物具有通式（I）：

7. 发明授权

US5968920A Compounds having a benzisoselen-azoline and -azine structure, method for preparing same and therapeutic uses thereof 失效
标题翻译：具有苯并异硒咯啉和嗪结构的化合物，其制备方法及其治疗用途
公开(公告)号：US5968920A
公开(公告)日：1999-10-19
申请号：US549809
申请日：1996-01-30
申请人： Irene Erdelmeier , Jean Chaudiere , Marc Moutet , Jean-Claude Yadan
发明人： Irene Erdelmeier , Jean Chaudiere , Marc Moutet , Jean-Claude Yadan
IPC分类号： A61K31/395 , A61K31/41 , A61K31/495 , A61P9/00 , A61P9/10 , A61P11/16 , A61P27/02 , A61P29/00 , A61P37/04 , A61P43/00 , C07D293/10 , C07D293/12 , C07D421/12 , C12N5/02
CPC分类号： C07D293/10 , C07D293/12 , Y10T436/108331
摘要： The invention concerns novel benzisoselen-azoline and -azine derivatives. These novel derivatives have the following general formula (II): ##STR1## where: R.sup.1 to R.sup.8 and R.sup.10 have various meanings, in particular H, alkyl, etc . . . ; ##STR2## Y.sup.- represents the anion of a pharmaceutically acceptable anion; n=0, 1; m=0, 1, 2; p=1, 2, 3; q=2, 3, 4; r=0, 1; and their pharmaceutically acceptable salts of acids or bases; there being no more than one substituent R.sup.9 in each molecule with general formula II. These novel derivatives can be used in medication.
摘要翻译： PCT No.PCT / FR95 / 00447 Sec。 371日期1996年1月30日 102（e）日期1996年1月30日PCT提交1995年4月7日PCT公布。 WO95 / 27706 PCT公开号日期1995年10月19日本发明涉及新型苯并异硒咯啉和吖嗪衍生物。这些新型衍生物具有以下通式（II）：其中：R1至R8和R10具有各种含义，特别是H，烷基等。。。 ; Y-表示药学上可接受的阴离子的阴离子; n = 0,1; m = 0,1,2; p = 1,2,3。 q = 2,3,4; r = 0，1; 及其药学上可接受的酸或碱的盐; 在每个具有通式II的分子中，不超过一个取代基R9。这些新型衍生物可用于药物治疗。

8. 发明授权

US5726063A Method of colorimetric analysis of malonic dialdehyde and 4-hydroxy-2-enaldehydes as indexes of lipid peroxidation, kits for carrying out said method, substituted indoles for use in said method and their preparation 失效
标题翻译：丙二醛和4-羟基-2-醛的比色分析方法作为脂质过氧化指标，用于实施所述方法的试剂盒，用于所述方法的取代的吲哚及其制备方法
公开(公告)号：US5726063A
公开(公告)日：1998-03-10
申请号：US702197
申请日：1996-08-23
申请人： Dominique Gerard-Monnier , Irene Erdelmeier , Jean Chaudiere , Jean-Claude Yadan
发明人： Dominique Gerard-Monnier , Irene Erdelmeier , Jean Chaudiere , Jean-Claude Yadan
IPC分类号： C07D209/04 , C07D409/04 , C07D421/04 , G01N33/52
CPC分类号： C07D409/04 , C07D209/04 , C07D421/04 , Y10T436/20 , Y10T436/200833
摘要： A colorimetric assay of enaldehydes or of malonic dialdehyde as lipid peroxidation indices in an aqueous medium including a) addition to the medium of a reagent of a compound of general formula I and their optional addition salts with organic or inorganic bases or with organic or inorganic acids. ##STR1## in which formula: A and C, which may be identical or different, each represent H, ##STR2## wherein A and C cannot simultaneously represent H, with: R.sup.1 =H; alkyl; aralkyl; aryl substituted on the aryl ring; alkyl sulfonate Y.sup.+ ; alkyl phosphonate, Y.sup.+ ; or alkyl carboxylate, Y.sup.+ ; R.sup.2 =H; --OR.sup.4 ; F; Cl; Br; I; --NO.sub.2 ; SO.sub.3.sup.31 Y.sup.+ ; --CN; --COOR.sup.4 ; or --CONR.sup.5 R.sup.6 ; R.sup.3 =H; --OR.sup.4 ; --NR.sup.5 R.sup.6 ; --SR.sup.4 ; F; Cl; Br; I; --NO.sub.2 ; --SO.sub.3 --Y.sup.+ ; --CN; --COR.sup.5 ; --COOR.sup.4 ; or --CONR.sup.5 R.sup.6 ; R.sup.4 =H; alkyl; aralkyl; or aryl substituted on the aryl ring; R.sup.5 =H; alkyl; aralkyl; or aryl substituted on the aryl ring; R.sup.6 =H; aryl, aralkyl; or aryl substituted on the aryl ring; Y.sup.+ =cation of an organic or inorganic base; ##STR3## wherein alkyl represents a linear or branched group comprising 1 to 6 carbon; aryl is substituted on the aryl ring with one or more groups which may be identical or different selected from C.sub.1-6 alkyl, alkoxy, hydroxy, amino and carboxyl; b) acidification of the medium; and c) incubation of the acidified medium. Requisites or kits for the implementation of the process are also disclosed.
摘要翻译：在水性介质中，醛或丙二醛作为脂质过氧化指数的比色测定法，其包括a）加入通式I化合物的试剂和它们与有机或无机碱或与有机或无机酸的任选加成盐的介质。各自表示H，其中A和C不能同时表示H，其中：R1 = H; 烷基; 芳烷基在芳环上取代的芳基; 烷基磺酸盐Y +; 烷基膦酸酯，Y +; 或羧酸烷基酯，Y +; R2 = H; -OR4; F; Cl; Br; 一世; -NO2; SO331 Y +; -CN; -COOR4; 或-CONR5R6; R3 = H; -OR4; -NR5R6; -SR4; F; Cl; Br; 一世; -NO2; -SO 3 -Y +; -CN; -COR5; -COOR4; 或-CONR5R6; R4 = H; 烷基; 芳烷基或在芳基环上取代的芳基; R5 = H; 烷基; 芳烷基或在芳基环上取代的芳基; R6 = H; 芳基，芳烷基; 或在芳基环上取代的芳基; Y + =有机或无机碱的阳离子; B = 含1〜6碳的长条组; 芳基在芳基环上被一个或多个可以相同或不同的选自C 1-6烷基，烷氧基，羟基，氨基和羧基的基团取代; b）培养基的酸化; 和c）培养酸化培养基。还披露了用于实施该过程的必要条件或工具包。

9. 发明授权

US06525040B1 Cyclic organoselenium compounds, their preparation and their uses 失效
标题翻译：循环有机硒化合物，其制备及其用途
公开(公告)号：US06525040B1
公开(公告)日：2003-02-25
申请号：US09331736
申请日：2000-05-16
申请人： Irene Erdelmeier , Catherine Tailhan-Lomont , Marc Moutet , Jean Chaudiere , Jean-Claude Yadan
发明人： Irene Erdelmeier , Catherine Tailhan-Lomont , Marc Moutet , Jean Chaudiere , Jean-Claude Yadan
IPC分类号： C07D29312
CPC分类号： C07D517/04 , C07D293/10 , C07D293/12 , C07D329/00 , C07D343/00
摘要： The invention is directed to novel cyclic organoselenium compounds useful as antioxidants, pharmaceutical compositions containing them, and methods for their preparation.
摘要翻译：本发明涉及可用作抗氧化剂的新型环状有机硒化合物，含有它们的药物组合物及其制备方法。

10. 发明授权

US6040328A Aromatic diselenides and selenosulfides, their preparation and their uses, more particularly their therapeutical use 失效
标题翻译：芳族二硒化物和硒硫化物，其制备及其用途，更具体地说是其治疗用途
公开(公告)号：US6040328A
公开(公告)日：2000-03-21
申请号：US387593
申请日：1999-08-31
申请人： Catherine Tailhan-Lomont , Irene Erdelmeier , Marc Moutet , Jean Chaudiere , Jean-Claude Yadan
发明人： Catherine Tailhan-Lomont , Irene Erdelmeier , Marc Moutet , Jean Chaudiere , Jean-Claude Yadan
IPC分类号： A61K31/095 , A61K31/38 , A61K31/381 , A61K31/415 , A61K31/425 , A61K31/426 , A61K31/495 , A61K31/555 , A61K38/00 , A61P1/00 , A61P9/00 , A61P11/00 , A61P27/02 , A61P31/12 , A61P37/04 , A61P43/00 , C07C391/02 , C07D233/66 , C07D277/20 , C07D277/32 , C07D333/26 , C07D333/30 , C07D517/04 , C07K5/08 , A61K31/335 , C07D277/04 , C07D333/32
CPC分类号： C07D517/04 , C07C391/02 , C07D233/66 , C07D333/30
摘要： The objects of the present invention are:novel organoselenium compounds: aromatic diselenides and selenosulphides;the use of said novel compounds as antioxidant agents;pharmaceutical compositions containing them;a method of preparation of said novel compounds.Said novel cyclic organoselenium compounds have the general formula (I): ##STR1##
摘要翻译：本发明的目的是：新型有机硒化合物：芳族二硒化物和硒代硫化物; 使用所述新型化合物作为抗氧化剂; 含有它们的药物组合物; 一种制备所述新化合物的方法。所述新型环状有机硒化合物具有通式（I）：

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