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1. 发明申请

US20130287733A1 INTERFERON ALPHA MUTANT AND ITS POLYETHYLENE GLYCOL DERIVATIVE 有权
标题翻译：干ON HA ANT ANT TIVE TIVE TIVE TIVE TIVE TIVE TIVE TIVE TIVE TIVE TIVE
公开(公告)号：US20130287733A1
公开(公告)日：2013-10-31
申请号：US13431226
申请日：2012-03-27
申请人： Jinyi LIU , Xiaoxia NIU , Minyi ZHOU , Yi YANG , Jianbo SUN , Yongqing CHENG
发明人： Jinyi LIU , Xiaoxia NIU , Minyi ZHOU , Yi YANG , Jianbo SUN , Yongqing CHENG
IPC分类号： C07K14/56
CPC分类号： C07K14/56 , A61K38/00 , A61K47/60
摘要： IFN-alpha mutants are obtained by substituting Cys for Tyr at position 85 or 86 in existing IFN-alpha. Their polyethylene glycol derivatives with high in vitro antiviral activity and prolonged in vivo half-life are also provided, wherein a polyethylene glycol moiety is covalently bound to the free Cys residue of an IFN-alpha mutant. The preparation methods of PEG derivatives of IFN-alpha mutants and medical compositions comprising the derivatives are also provided. The test results showed that the IFN-alpha mutants of the present invention are ready to prepare and have high activity; their polyethylene glycol derivatives have extended lifetime in the body and low clearance rate.
摘要翻译：通过将Cys替换为现有IFN-α中85或86位的Tyr获得IFN-α突变体。还提供了其具有高体外抗病毒活性和延长的体内半衰期的聚乙二醇衍生物，其中聚乙二醇部分与IFN-α突变体的游离Cys残基共价结合。还提供了IFN-α突变体的PEG衍生物和包含衍生物的医药组合物的制备方法。试验结果表明，本发明的IFN-α突变体准备准备并具有高活性; 它们的聚乙二醇衍生物在体内具有延长的使用寿命和较低的清除率。

2. 发明申请

US20140001968A1 CIRCUIT AND METHOD FOR CONTROLLING LIGHT EMITTING DIODE 审中-公开
标题翻译：用于控制发光二极管的电路和方法
公开(公告)号：US20140001968A1
公开(公告)日：2014-01-02
申请号：US13596332
申请日：2012-08-28
申请人： Jianbo SUN
发明人： Jianbo SUN
IPC分类号： H05B37/02
CPC分类号： H05B33/0845
摘要： A method for controlling a current flowing through one or more light emitting diodes (LEDs) comprising receiving a Pulse Width Modulation (PWM) control signal, which includes rising and falling edges; receiving a first voltage signal; generating a second voltage signal based on the PWM control signal and the first voltage signal, wherein the second voltage increases gradually in response to one of the rising and falling edges of the PWM signal and decreases gradually in response to the other of the rising and falling edges of the PWM signal; and providing a current to the one or more LEDs, wherein the current varies gradually according to the second voltage.
摘要翻译：一种用于控制流过一个或多个发光二极管（LED）的电流的方法，包括接收包括上升沿和下降沿的脉宽调制（PWM）控制信号; 接收第一电压信号; 基于PWM控制信号和第一电压信号产生第二电压信号，其中第二电压响应于PWM信号的上升沿和下降沿之一逐渐增加，并且响应于另一个上升和下降而逐渐减小 PWM信号的边沿; 以及向所述一个或多个LED提供电流，其中所述电流根据所述第二电压逐渐变化。

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