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    • 4. 发明授权
    • Medical information system
    • 医疗信息系统
    • US06656115B1
    • 2003-12-02
    • US09653814
    • 2000-09-01
    • Jinsei MiyazakiKenji Iwano
    • Jinsei MiyazakiKenji Iwano
    • A61B500
    • G06Q50/22G06F19/00G06F19/3418G06Q10/10G16H10/60G16H40/40G16H40/63Y10S128/904
    • A medical information system has a patient terminal device, a server, and an administrator terminal device. The patient terminal device, the server, and the administrator terminal device are connected together on a network. The patient terminal device includes sensors for measuring information used as indices of the condition of a patient's health; a part for transferring measured data obtained by the sensors to the patient terminal device; a part for transferring the measured data from the sensors to the server via the network; a part for accepting control information from the server, and a part for taking action based on the control information. The server includes a part for transmitting the control information to the patient terminal device; and a part for storing and sorting out the measured data transferred from the patient terminal device. The administrator terminal includes a part for reviewing the measured data stored and sorted out in the server.
    • 医疗信息系统具有患者终端设备,服务器和管理员终端设备。 患者终端设备,服务器和管理员终端设备在网络上连接在一起。 患者终端设备包括用于测量用作患者健康状况指标的信息的传感器; 用于将由所述传感器获得的测量数据传送到所述患者终端设备的部件; 通过网络将测量数据从传感器传送到服务器的部分; 用于接收来自服务器的控制信息的部分和基于控制信息采取行动的部分。 服务器包括用于将控制信息发送到患者终端设备的部件; 以及用于存储和分类从患者终端设备传送的测量数据的部分。 管理员终端包括用于查看在服务器中存储和整理的测量数据的部分。
    • 9. 发明授权
    • Cocaine derivative, protein conjugate thereof, monoclonal antibody producing cell line, method for preparing the cell line and monoclonal antibody
    • 可卡因衍生物,其蛋白质缀合物,产生单克隆抗体的细胞系,制备细胞系的方法和单克隆抗体
    • US06174723B1
    • 2001-01-16
    • US08982963
    • 1997-12-02
    • Keiko YugawaNobuyuki SigetohJinsei MiyazakiTadayasu Mitsumata
    • Keiko YugawaNobuyuki SigetohJinsei MiyazakiTadayasu Mitsumata
    • C12N506
    • G01N33/946A61K47/60A61K47/643C07D451/12C07K16/16
    • A method for preparing a cocaine-protein conjugate easily by using a cocaine derivative having a methoxy carbonyl group and benzoyl group. This conjugate is useful for the detection of cocaine or cocaine derivatives. A monoclonal antibody, a monoclonal antibody producing cell line, and a method for producing the monoclonal antibody producing cell line by using the above cocaine-protein conjugate as an immunogen is also described. The method of the invention comprises preparing a cocaine-protein conjugate with a pyridyl dithiococaine derivative of Formula (I): where R is either H or R′; and where R′ is: wherein n=1 to 4 and Ph is a benzene ring, and wherein said monoclonal antibody detects 10−9 M cocaine; and which derivative binds to a protein by a disulfide bond; immunizing A/J mouse with the conjugate; fusing its spleen cell and a myeloma cell line; cloning the fusion to produce a monoclonal antibody producing cell line; culturing the cell line, and purifying a supernatant of the culture to form a monoclonal antibody to specifically bind to cocaine or cocaine derivatives.
    • 通过使用具有甲氧基羰基和苯甲酰基的可卡因衍生物容易地制备可卡因 - 蛋白质结合物的方法。 该缀合物可用于检测可卡因或可卡因衍生物。 还描述了单克隆抗体,产生单克隆抗体的细胞系,以及通过使用上述可卡因蛋白质缀合物作为免疫原来制备产生单克隆抗体的细胞系的方法。 本发明的方法包括用式(I)的吡啶基二硫代可卡因衍生物制备可卡因蛋白质结合物:其中R是H或R'; 其中R'为:其中n = 1-4,Ph为苯环,其中所述单克隆抗体检测10-9M可卡因; 哪个衍生物通过二硫键与蛋白质结合; 用缀合物免疫A / J小鼠; 融合其脾细胞和骨髓瘤细胞系; 克隆融合物以产生产生单克隆抗体的细胞系; 培养细胞系,并纯化培养物的上清液以形成特异性结合可卡因或可卡因衍生物的单克隆抗体。