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1. 发明授权

US08101634B2 Bicyclic compounds and use as antidiabetics 失效
标题翻译：双环化合物并用作抗糖尿病药
公开(公告)号：US08101634B2
公开(公告)日：2012-01-24
申请号：US12517620
申请日：2007-12-05
申请人： Jing Fang , Jun Tang , Andrew J Carpenter , Gregory Peckham , Christopher R Conlee , Kien S Du , Subba Reddy Katamreddy
发明人： Jing Fang , Jun Tang , Andrew J Carpenter , Gregory Peckham , Christopher R Conlee , Kien S Du , Subba Reddy Katamreddy
IPC分类号： A61K31/424 , A61K31/445 , C07D401/14 , C07D413/14
CPC分类号： C08F2/00 , C07D211/22 , C07D211/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C08F2400/02
摘要： The present invention relates to novel compounds that are useful in the treatment of metabolic disorders, particularly type II diabetes mellitus and related disorders, and also to the methods for the making and use of such compounds.
摘要翻译：本发明涉及可用于治疗代谢紊乱，特别是II型糖尿病和相关病症的新型化合物，以及制备和使用这些化合物的方法。

2. 发明申请

US20120077812A1 BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS 审中-公开
标题翻译：双酚化合物和用作抗生素
公开(公告)号：US20120077812A1
公开(公告)日：2012-03-29
申请号：US13307266
申请日：2011-11-30
申请人： JING FANG , Jun Tang , Andrew J. Carpenter , Gregory Peckham , Christopher R. Conlee , Kien S. Du , Subba Reddy Katamreddy
发明人： JING FANG , Jun Tang , Andrew J. Carpenter , Gregory Peckham , Christopher R. Conlee , Kien S. Du , Subba Reddy Katamreddy
IPC分类号： A61K31/5377 , A61K31/445 , C07D401/04 , A61K31/506 , A61K31/501 , C07D401/12 , A61K31/454 , C07D413/04 , C07D413/12 , A61K31/4545 , A61K31/497 , A61P3/00 , A61P3/10 , A61P3/04 , A61P3/06 , A61P9/10 , C07D211/32
CPC分类号： C08F2/00 , C07D211/22 , C07D211/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C08F2400/02
摘要： The present invention relates to novel compounds that are useful in the treatment of metabolic disorders, particularly type II diabetes mellitus and related disorders, and also to the methods for the making and use of such compounds.
摘要翻译：本发明涉及可用于治疗代谢紊乱，特别是II型糖尿病和相关病症的新型化合物，以及制备和使用这些化合物的方法。

3. 发明申请

US20100029650A1 BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS 失效
标题翻译：双酚化合物和用作抗生素
公开(公告)号：US20100029650A1
公开(公告)日：2010-02-04
申请号：US12517620
申请日：2007-12-05
申请人： Jing Fang , Jun Tang , Andrew J. Carpenter , Gregory Peckham , Christopher R. Conlee , Kien S. Du , Subba Reddy Katamreddy
发明人： Jing Fang , Jun Tang , Andrew J. Carpenter , Gregory Peckham , Christopher R. Conlee , Kien S. Du , Subba Reddy Katamreddy
IPC分类号： A61K31/5377 , C07D401/14 , A61K31/4965 , C07D401/12 , A61K31/4545 , C07D413/14
CPC分类号： C08F2/00 , C07D211/22 , C07D211/24 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C08F2400/02
摘要： The present invention relates to novel compounds that are useful in the treatment of metabolic disorders, particularly type II diabetes mellitus and related disorders, and also to the methods for the making and use of such compounds.
摘要翻译：本发明涉及可用于治疗代谢紊乱，特别是II型糖尿病和相关病症的新型化合物，以及制备和使用这些化合物的方法。

4. 发明申请

US20130332522A1 FAST CHANNEL FOR SYSTEM MANAGEMENT 审中-公开
标题翻译：用于系统管理的快速通道
公开(公告)号：US20130332522A1
公开(公告)日：2013-12-12
申请号：US13491792
申请日：2012-06-08
申请人： Jun Tang , Huajun Luo , Xichun Xu , Jerry Liu , Zhuocheng Xiao , Chunhui Shi , Sean A. Cannella , David C. James
发明人： Jun Tang , Huajun Luo , Xichun Xu , Jerry Liu , Zhuocheng Xiao , Chunhui Shi , Sean A. Cannella , David C. James
IPC分类号： G06F15/16
CPC分类号： G06F8/65 , G06F9/542
摘要： A push-based communication channel can be established and dedicated to time-sensitive tasks in the system management space for client management. Managed clients can establish and maintain communication with a server including system management software over the channel. Subsequently, the server can send messages regarding time-sensitive/urgent tasks over the channel. In response to a message, a client can execute an action as a function of the message. In accordance with one embodiment, the client contacts the server over a pull-based communication channel to acquire a task for execution.
摘要翻译：可以建立基于推送的通信通道，专门用于系统管理空间中的时间敏感任务，以进行客户端管理。受管理的客户端可以建立和维护与包括通道上的系统管理软件的服务器的通信。随后，服务器可以通过该通道发送有关时间敏感/紧急任务的消息。响应于消息，客户机可以根据消息执行动作。根据一个实施例，客户端通过基于牵引的通信信道与服务器联系以获得执行的任务。

5. 发明授权

US08598156B2 Chemical compounds 有权
标题翻译：化合物
公开(公告)号：US08598156B2
公开(公告)日：2013-12-03
申请号：US13637127
申请日：2011-03-23
申请人： Jeffrey Michael Axten , Seth Wilson Grant , Dirk A. Heerding , Jesus Rual Medina , Stuart Paul Romeril , Jun Tang
发明人： Jeffrey Michael Axten , Seth Wilson Grant , Dirk A. Heerding , Jesus Rual Medina , Stuart Paul Romeril , Jun Tang
IPC分类号： A01N43/62 , A61K31/55
CPC分类号： C07D487/04 , A61K31/405 , A61K45/06 , C07D403/04 , C07D491/04 , C07D495/04 , A61K2300/00
摘要： The invention is directed to substituted indoline derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, and R3 are defined herein. The compounds of the invention are inhibitors of PERK and can be useful in the treatment of cancer, ocular diseases, and diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease, stroke, Type 1 diabetes Parkinson disease, Huntington's disease, amyotrophic lateral sclerosis, myocardial infarction, cardiovascular disease, atherosclerosis, and arrhythmias, and more specifically cancers of the breast, colon, pancreatic, and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译：本发明涉及取代的二氢吲哚衍生物。具体地，本发明涉及式I化合物：其中R1，R2和R3如本文所定义。本发明的化合物是PERK的抑制剂，可用于治疗癌症，眼部疾病和与活化的未折叠蛋白反应途径相关的疾病，例如阿尔茨海默氏病，中风，1型糖尿病帕金森病，亨廷顿舞蹈病，肌萎缩性侧索硬化症，心肌梗死，心血管疾病，动脉粥样硬化和心律失常，更具体地说是乳腺癌，结肠癌，胰腺癌和肺癌。因此，本发明进一步涉及包含本发明化合物的药物组合物。本发明还涉及使用本发明化合物或包含本发明化合物的药物组合物抑制PERK活性和与之相关疾病的治疗方法。

6. 发明授权

US08102791B2 Interleaver address generation in turbo decoders for mobile multimedia multicast system communication systems 有权
标题翻译：用于移动多媒体多播系统通信系统的Turbo解码器中的交织器地址生成
公开(公告)号：US08102791B2
公开(公告)日：2012-01-24
申请号：US12179599
申请日：2008-07-25
申请人： Jun Tang
发明人： Jun Tang
IPC分类号： H04J11/00
CPC分类号： H03M13/2771 , H03M13/276 , H03M13/2764 , H03M13/3972 , H04L1/005
摘要： Address generation for interleaving in a wireless communication system includes at least one input generation module to generate at least one input signal. A first address generator module and a second address generator module generate a first output address for interleaving and a second output address for interleaving. A selector module selects an address for interleaving from the first and the second output address based on predetermined criteria. At least one input translation module is receives an input signal and translate the received input signal to generate a nominal input signal based on a value of the received input signal. An address generation module generates an address for interleaving based on the nominal input signal.
摘要翻译：在无线通信系统中用于交织的地址生成包括至少一个输入生成模块以产生至少一个输入信号。第一地址发生器模块和第二地址发生器模块产生用于交织的第一输出地址和用于交织的第二输出地址。选择器模块基于预定标准从第一和第二输出地址选择用于交织的地址。至少一个输入转换模块接收输入信号并且转换所接收的输入信号以基于所接收的输入信号的值产生标称输入信号。地址生成模块基于标称输入信号生成用于交织的地址。

7. 发明申请

US20100020736A1 INTERLEAVER ADDRESS GENERATION IN TURBO DECODERS FOR MEDIAFLO COMMUNICATION SYSTEMS 有权
标题翻译：用于媒体通信系统的涡轮解码器中的交互地址生成
公开(公告)号：US20100020736A1
公开(公告)日：2010-01-28
申请号：US12179599
申请日：2008-07-25
申请人： Jun Tang
发明人： Jun Tang
IPC分类号： H04H20/71
CPC分类号： H03M13/2771 , H03M13/276 , H03M13/2764 , H03M13/3972 , H04L1/005
摘要： Address generation for interleaving in a wireless communication system includes at least one input generation module to generate at least one input signal. A first address generator module and a second address generator module generate a first output address for interleaving and a second output address for interleaving. A selector module selects an address for interleaving from the first and the second output address based on predetermined criteria. At least one input translation module is receives an input signal and translate the received input signal to generate a nominal input signal based on a value of the received input signal. An address generation module generates an address for interleaving based on the nominal input signal.
摘要翻译：在无线通信系统中用于交织的地址生成包括至少一个输入生成模块以产生至少一个输入信号。第一地址发生器模块和第二地址发生器模块产生用于交织的第一输出地址和用于交织的第二输出地址。选择器模块基于预定标准从第一和第二输出地址选择用于交织的地址。至少一个输入转换模块接收输入信号并且转换所接收的输入信号以基于所接收的输入信号的值产生标称输入信号。地址生成模块基于标称输入信号生成用于交织的地址。

8. 发明授权

US07532465B2 Computer enclosure with drive bracket 失效
标题翻译：带驱动器支架的电脑外壳
公开(公告)号：US07532465B2
公开(公告)日：2009-05-12
申请号：US11306538
申请日：2005-12-31
申请人： Yun-Lung Chen , Jun Tang
发明人： Yun-Lung Chen , Jun Tang
IPC分类号： H05K1/16
CPC分类号： G06F1/187
摘要： A computer enclosure includes a chassis (10), a drive bracket (20) pivotably attached to the chassis, a holder (40) mounted in the chassis, and a positioning member (30) attached to the drive bracket. The holder includes a first clamp (45) with a first groove (451) defined therein. The positioning member includes a first positioning piece (33) corresponding to the first clamp. When the drive bracket is pivoted on the chassis, the first positioning piece is interferentially intruded in the first groove of the first clamp to adjustably position the drive bracket.
摘要翻译：计算机外壳包括底架（10），可枢转地连接到底盘的驱动器支架（20），安装在底盘中的保持器（40）和附接到驱动支架的定位构件（30）。保持器包括第一夹具（45），其中限定有第一凹槽（451）。定位构件包括对应于第一夹具的第一定位件（33）。当驱动支架在底盘上枢转时，第一定位件被周向地插入第一夹具的第一槽中，以可调整地定位驱动支架。

9. 发明授权

US07495102B2 Azaindole inhibitors of aurora kinases 有权
标题翻译：极光激酶的阿片苷抑制剂
公开(公告)号：US07495102B2
公开(公告)日：2009-02-24
申请号：US11855183
申请日：2007-09-14
申请人： Martha A. Sarpong , Nicholas D. Adams , Jeffrey Michael Axten , Amita M. Chaudhari , Dashyant Dhanak , Toshihiro Hamajima , Kenneth Allen Newlander , Cynthia A. Parrish , Jerry Leroy Adams , Domingos J. Silva , Jun Tang
发明人： Martha A. Sarpong , Nicholas D. Adams , Jeffrey Michael Axten , Amita M. Chaudhari , Dashyant Dhanak , Toshihiro Hamajima , Kenneth Allen Newlander , Cynthia A. Parrish , Jerry Leroy Adams , Domingos J. Silva , Jun Tang
IPC分类号： C07D453/02
CPC分类号： C07D471/04
摘要： The present invention relates to a compound represented by Formula (I): and pharmaceutically acceptable salts. Compounds of the present invention inhibit Aurora kinase, making them especially suitable for the treatment of a number of diseases, including solid tumor cancers and hematological cancers.
摘要翻译：本发明涉及由式（I）表示的化合物及其药学上可接受的盐。本发明的化合物抑制Aurora激酶，使其特别适用于治疗许多疾病，包括实体瘤癌症和血液癌症。

10. 发明授权

US07427623B2 4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof 失效
标题翻译： 4-氨基-2,3-二取代噻吩并[2,3-d]嘧啶及其药物组合物
公开(公告)号：US07427623B2
公开(公告)日：2008-09-23
申请号：US10489052
申请日：2002-09-10
申请人： Jerry Leroy Adams , Deborah Lynne Bryan , Yanhong Feng , Shinichiro Matsunaga , Yutaka Maeda , Yasushi Miyazaki , Masato Nakano , Jean-Philippe Rocher , Hideyuki Sato , Marcus Semones , Domingos J. Silva , Jun Tang
发明人： Jerry Leroy Adams , Deborah Lynne Bryan , Yanhong Feng , Shinichiro Matsunaga , Yutaka Maeda , Yasushi Miyazaki , Masato Nakano , Jean-Philippe Rocher , Hideyuki Sato , Marcus Semones , Domingos J. Silva , Jun Tang
IPC分类号： A61K31/519 , C07D495/04 , A61P35/00 , A61P9/00
CPC分类号： C07D491/04 , C07D495/04
摘要： Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译：本文描述了可用作TIE-2和/或VEGFR-2抑制剂的呋喃和噻吩并嘧啶衍生物。所述的发明还包括制备这些呋喃并噻吩并嘧啶衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。

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