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1. 发明授权

US06790937B2 Recombinant scFV antibodies specific to Eimeria spp. responsible for coccidiosis 失效
标题翻译：对艾美球虫属特异性的重组scFV抗体负责球虫病
公开(公告)号：US06790937B2
公开(公告)日：2004-09-14
申请号：US10083424
申请日：2002-02-26
申请人： Jin-Kyoo Kim , Jae-Yong Han , Ki-Duck Song , Sung-Won Kim , Won-Gi Min , Eun-Jung Son , Hyun Soon Lillehoj , Erik Peter Lillehoj
发明人： Jin-Kyoo Kim , Jae-Yong Han , Ki-Duck Song , Sung-Won Kim , Won-Gi Min , Eun-Jung Son , Hyun Soon Lillehoj , Erik Peter Lillehoj
IPC分类号： C12P2108
CPC分类号： C07K16/20 , C07K2317/622 , Y10S530/822
摘要： The present invention relates to (a) variable regions of heavy and light chains of an antibody specific to a surface antigen in sporozoite of Eimeria spp.; (b) a recombinant scFV (single chain variable fragment) antibody prepared using the variable regions; (c) a method for preparing a recombinant scFv antibody; and (d) an expression vector for expressing a recombinant scFv antibody.
摘要翻译：本发明涉及（a）艾美球虫子孢子中表面抗原特异性抗体的重链和轻链的可变区; （b）使用可变区制备的重组scFV（单链可变片段）抗体; （c）制备重组scFv抗体的方法; 和（d）用于表达重组scFv抗体的表达载体。

2. 发明申请

US20120245082A1 Novel Antimicrobial Activity of Chicken NK-2 Peptide Against Apicomplexan Protozoa 有权
标题翻译：鸡NK-2肽对Apicomplexan原生动物的新型抗菌活性
公开(公告)号：US20120245082A1
公开(公告)日：2012-09-27
申请号：US13071112
申请日：2011-03-24
申请人： Hyun Soon Lillehoj , Sung Hyen Lee , Yeong ho Hong
发明人： Hyun Soon Lillehoj , Sung Hyen Lee , Yeong ho Hong
IPC分类号： A61K38/17 , A61P33/02 , C07K14/465
CPC分类号： C07K14/465 , A61K38/17 , C07K14/52
摘要： NK-2 synthetic peptide derived from cationic core region of porcine NK-lysin has an antimicrobial and antitumor polypeptide that is considered to play a pivotal role in innate defense immunity. To evaluate the antimicrobial properties of synthetic chicken NK-lysin peptides, we investigated cytolytic activity against apicomplexan parasites like Eimeria sporozoites, Neospora tachyzoites and Cryptosporidum sporozoites. The chicken NK-2 (cNK-2) lytic peptide which corresponds to amino acid residues of porcine NK-2 peptide significantly disrupted Eimeria and Cryptosporidum sporozoites and Neospora tachyzoites. In contrast, no bactericidal activity was observed on E. coli BMH71-18. The cNK-2 lytic peptide is novel antimicrobial agent which can be used to intervene and treat economically costly infections in the animal industry.
摘要翻译：来源于猪NK-lysin的阳离子核心区域的NK-2合成肽具有抗原和抗肿瘤多肽，被认为在先天免疫中具有关键作用。为了评估合成鸡NK-赖氨酸肽的抗菌性能，我们研究了针对致密虫寄生虫如艾美球虫子孢子，新孢子虫速殖子和隐孢子虫子孢子的溶细胞活性。对应于NK-2肽氨基酸残基的鸡NK-2（cNK-2）裂解肽显着破坏艾美球虫和隐孢子虫子孢子和新孢子虫速殖子。相反，在大肠杆菌BMH71-18上没有观察到杀菌活性。 cNK-2裂解肽是新型抗菌剂，可用于干预和治疗动物行业经济上昂贵的感染。

3. 发明授权

US08691943B2 Antimicrobial activity of chicken NK-2 peptide against apicomplexan protozoa 有权
标题翻译：鸡NK-2肽对apicomplexan原生动物的抗菌活性
公开(公告)号：US08691943B2
公开(公告)日：2014-04-08
申请号：US13071112
申请日：2011-03-24
申请人： Hyun Soon Lillehoj , Sung Hyen Lee , Yeong ho Hong
发明人： Hyun Soon Lillehoj , Sung Hyen Lee , Yeong ho Hong
IPC分类号： A61K38/00 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K38/04 , C07K1/00 , A01N37/18 , A61P33/02 , A61K51/00
CPC分类号： C07K14/465 , A61K38/17 , C07K14/52
摘要： NK-2 synthetic peptide derived from cationic core region of porcine NK-lysin has an antimicrobial and antitumor polypeptide that is considered to play a pivotal role in innate defense immunity. To evaluate the antimicrobial properties of synthetic chicken NK-lysin peptides, we investigated cytolytic activity against apicomplexan parasites like Eimeria sporozoites, Neospora tachyzoites and Cryptosporidum sporozoites. The chicken NK-2 (cNK-2) lytic peptide which corresponds to amino acid residues of porcine NK-2 peptide significantly disrupted Eimeria and Cryptosporidum sporozoites and Neospora tachyzoites. In contrast, no bactericidal activity was observed on E. coli BMH71-18. The cNK-2 lytic peptide is novel antimicrobial agent which can be used to intervene and treat economically costly infections in the animal industry.
摘要翻译：来源于猪NK-lysin的阳离子核心区域的NK-2合成肽具有抗原和抗肿瘤多肽，被认为在先天免疫中具有关键作用。为了评估合成鸡NK-赖氨酸肽的抗菌性能，我们研究了针对致密虫寄生虫如艾美球虫子孢子，新孢子虫速殖子和隐孢子虫子孢子的溶细胞活性。对应于NK-2肽氨基酸残基的鸡NK-2（cNK-2）裂解肽显着破坏艾美球虫和隐孢子虫子孢子和新孢子虫速殖子。相反，在大肠杆菌BMH71-18上没有观察到杀菌活性。 cNK-2裂解肽是新型抗菌剂，可用于干预和治疗动物行业经济上昂贵的感染。

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