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1. 发明授权

US09689009B2 Microorganism producing o-phosphoserine and method of producing L-cysteine or derivatives thereof from O-phosphoserine using the same 有权
公开(公告)号：US09689009B2
公开(公告)日：2017-06-27
申请号：US13278106
申请日：2011-10-20
申请人： Jin Sook Chang , Jae Hyun Jo , Hyun Ae Bae , Byeong Cheol Song , Sol Kim , Hye Won Kim , Hye Won Um , Sung Hoo Jhon , Yong Uk Shin , Eun Bin Yang , Kyoung Min Lee , Soo An Shin
发明人： Jin Sook Chang , Jae Hyun Jo , Hyun Ae Bae , Byeong Cheol Song , Sol Kim , Hye Won Kim , Hye Won Um , Sung Hoo Jhon , Yong Uk Shin , Eun Bin Yang , Kyoung Min Lee , Soo An Shin
IPC分类号： C12P13/12 , C12P13/06 , C12N9/10 , C12N9/16 , C12N15/70 , C12N15/77
CPC分类号： C12P13/12 , C12N9/1085 , C12N9/16 , C12N15/70 , C12N15/77 , C12P13/06 , C12Y205/01065 , C12Y301/03003
摘要： The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and the activity of PhnC, PhnD, and PhnE is reduced, and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having these reduced and enhanced properties noted above are also provided herein.

2. 发明授权

US08557549B2 Microorganism producing O-phosphoserine and method of producing L-cysteine or derivatives thereof from O-phosphoserine using the same 有权
标题翻译：生产O-磷酸丝氨酸的微生物及使用其制备O-磷酸丝氨酸的L-半胱氨酸或其衍生物的方法
公开(公告)号：US08557549B2
公开(公告)日：2013-10-15
申请号：US13278105
申请日：2011-10-20
申请人： Jin Sook Chang , Jae Hyun Jo , Hyun Ae Bae , Byeong Cheol Song , Sol Kim , Hye Won Kim
发明人： Jin Sook Chang , Jae Hyun Jo , Hyun Ae Bae , Byeong Cheol Song , Sol Kim , Hye Won Kim
IPC分类号： C12P13/12
CPC分类号： C12P13/12 , C12N9/1085 , C12N9/16 , C12N15/70 , C12N15/77 , C12P13/06 , C12Y205/01065 , C12Y301/03003
摘要： The present invention provides methods for the production of cysteine or derivates thereof by culturing a microorganism having reduced activity of endogenous phosphoserine phosphatase and enhanced activity of phosphoglycerate dehydrogenase and/or phosphoserine aminotransferase. The O-phosphoserine produced by such an organism can then be reacted with a sulfide in the presence of a sulfydrylase or a microorganism expressing a sulfhydrylase to produce cysteine or a derivative thereof. Microorganisms having the properties noted above are also provided herein.
摘要翻译：本发明提供了通过培养具有降低的内源性磷酸丝氨酸磷酸酶活性和提高磷酸甘油酸脱氢酶和/或磷酸丝氨酸氨基转移酶活性的微生物来生产半胱氨酸或其衍生物的方法。由这样的生物体产生的O-磷酸丝氨酸然后可以在硫酸酯或表达巯基化酶的微生物的存在下与硫化物反应，以产生半胱氨酸或其衍生物。具有上述性质的微生物也在本文中提供。

3. 发明授权

US08530200B2 Corynebacteria strain for enhancement of 5′-guanosine monophosphate productivity and a method of producing 5′-guanosine monophosphate using the same 有权
标题翻译：用于增强5'-鸟苷一磷酸生产力的棒状杆菌菌株和使用其制备5'-鸟苷酸单磷酸的方法
公开(公告)号：US08530200B2
公开(公告)日：2013-09-10
申请号：US13140302
申请日：2009-12-17
申请人： Jinman Cho , Hye Won Kim , Yoon Seok Oh , Jang Hee Park
发明人： Jinman Cho , Hye Won Kim , Yoon Seok Oh , Jang Hee Park
IPC分类号： C12P19/32 , C12P19/30
CPC分类号： C12P19/32 , C12N9/0006 , Y02P20/582
摘要： Disclosed is a method of producing 5′-guanosine monophosphate using a novel microorganism which has a malate dehydrogenase activity higher than that of a wild-type, thereby showing improved ATP productivity. Also, a novel microorganism is disclosed. The method comprises: culturing the corynebacteria strain which is enhanced in malate dehydrogenase activity over the endogenous activity, thus producing ATP in high yield; producing XMP in the culture; adding to the culture an enzyme or microorganism having XMP amination activity; and obtaining GMP from the culture.
摘要翻译：公开了一种使用具有比野生型高的苹果酸脱氢酶活性的新型微生物生产5'-鸟苷酸单磷酸酯的方法，从而显示出提高的ATP生产率。另外，公开了一种新型微生物。该方法包括：培养在内源性活性中苹果酸脱氢酶活性增强的棒状杆菌菌株，从而以高产率产生ATP; 在文化中生产XMP; 向培养基中加入具有XMP胺化活性的酶或微生物; 并从文化中获得GMP。

4. 发明公开

US20230176133A1 ALL-SOLID-STATE BATTERY ANALYSIS SYSTEM AND METHOD OF USING THE SAME 审中-公开
公开(公告)号：US20230176133A1
公开(公告)日：2023-06-08
申请号：US17985868
申请日：2022-11-13
申请人： Ju Yeong Seong , Im Sul Seo , Jeong Hyun Seo , Je Sik Park , Sung Woo Noh , Sang Heon Lee , Chung Bum Lim , Hye Won Kim , Jae Young Hong , So Young Joo , Yu Jeong Min , Ji Ung Jeong , Heon Cheol Shin
发明人： Ju Yeong Seong , Im Sul Seo , Jeong Hyun Seo , Je Sik Park , Sung Woo Noh , Sang Heon Lee , Chung Bum Lim , Hye Won Kim , Jae Young Hong , So Young Joo , Yu Jeong Min , Ji Ung Jeong , Heon Cheol Shin
IPC分类号： G01R31/382 , H01M10/42 , H01M10/44
CPC分类号： G01R31/382 , H01M10/44 , H01M10/4285 , H01M10/0562
摘要： The present disclosure relates to an all-solid-state battery analysis system capable of reliably obtaining an electrochemical signal according to the degree of charge of an electrode, and an all-solid-state battery analysis method using the same. The system may include a body member, of cylindrical shape, having a first cavity extending therethrough in a vertical direction and a second cavity extending therethrough in a horizontal direction and communicating with the first cavity. The system may include a first conductive member including a first base having a plate shape and a first protrusion protruding from the first base having a shape corresponding to a shape of the first cavity; and a second conductive member including a second base having a plate shape and a second protrusion protruding from the second base and having a shape corresponding to the shape of the first cavity.

5. 发明授权

US08465962B2 Microorganism having enhanced L-valine productivity and method for producing L-valine using the same 有权
标题翻译：具有增强的L-缬氨酸生产力的微生物和使用其生产L-缬氨酸的方法
公开(公告)号：US08465962B2
公开(公告)日：2013-06-18
申请号：US13310536
申请日：2011-12-02
申请人： Hye Won Kim , Ji-Hye Lee , Soo Youn Hwang , Jong Hyun Kim
发明人： Hye Won Kim , Ji-Hye Lee , Soo Youn Hwang , Jong Hyun Kim
IPC分类号： C12N1/20 , C12N15/00 , C12P13/08
CPC分类号： C12R1/15 , C12P13/08
摘要： The present invention relates to a microorganism having an enhanced L-valine productivity and a method for producing L-valine using the same. More particularly, the present invention relates to a Corynebacterium glutamicum mutant strain that has resistance to L-valine and derivatives thereof so as to have an enhanced L-valine productivity, and a method for producing L-valine using the same.
摘要翻译：本发明涉及具有增强的L-缬氨酸生产力的微生物和使用其的L-缬氨酸生产方法。更具体地，本发明涉及对L-缬氨酸及其衍生物具有抗性的L-缬氨酸生产力提高的谷氨酸棒杆菌突变菌株和使用其的L-缬氨酸生产方法。

6. 发明申请

US20100041109A1 CORYNEBACTERIUM GLUTAMICUM VARIETY PRODUCING L-ARGININE AND METHOD FOR FABRICATING THE SAME 有权
标题翻译：生产L-阿魏酸的罗丹明葡萄球菌及其制备方法
公开(公告)号：US20100041109A1
公开(公告)日：2010-02-18
申请号：US12522280
申请日：2008-01-11
申请人： Hye Won Kim , Hyejin Choi , Ji-Hye Lee , Soo Youn Hwang
发明人： Hye Won Kim , Hyejin Choi , Ji-Hye Lee , Soo Youn Hwang
IPC分类号： C12P13/10 , C12N1/21
CPC分类号： C12P13/10
摘要： The present invention relates to an L-arginine producing mutant strain, and a method for fabricating the same. In particular, the present invention relates to a polynucleotide comprising an argD2 gene (Ncgl2355) that is a putative gene of acetylornithine aminotransferase involved in arginine biosynthesis of Corynebacterium glutamicum, a polypeptide encoded by the polynucleotide, a recombinant vector comprising the polynucleotide, a transformant capable of producing L-arginine in a high yield, which is prepared by introducing the recombinant vector into an L-arginine producing host microorganism to overexpress the argD2 gene, and a method for producing L-arginine by culturing the transformant. The transformant of the present invention overexpresses the argD2 gene to produce L-arginine in a high yield, thereby being used in medicinal and pharmaceutical industries.
摘要翻译：本发明涉及L-精氨酸生产突变菌株及其制造方法。特别地，本发明涉及包含argD2基因（Ncgl2355）的多核苷酸，其是参与谷氨酸棒杆菌的精氨酸生物合成的乙酰鸟氨酸氨基转移酶的推定基因，由该多核苷酸编码的多肽，包含多核苷酸的重组载体，能够转化的转化体通过将重组载体导入产生L-精氨酸的宿主微生物以过表达argD2基因而制备L-精氨酸，以及通过培养转化体来生产L-精氨酸的方法。本发明的转化体以高产率过表达argD2基因产生L-精氨酸，从而用于医药和制药工业。

7. 发明授权

US08815545B2 Corynebacteria strain having enhanced 5′-xanthosine monophosphate productivity and a method of producing 5′-xanthosine monophosphate using the same 有权
标题翻译：具有增强的5'-黄嘌呤一磷酸生产力的棒状杆菌菌株和使用其制备5'-黄苷单磷酸的方法
公开(公告)号：US08815545B2
公开(公告)日：2014-08-26
申请号：US13140321
申请日：2009-12-17
申请人： Jinman Cho , Hye Won Kim , Jinman Lee , Ji-Hye Lee , Yoon Seok Oh , Jang Hee Park
发明人： Jinman Cho , Hye Won Kim , Jinman Lee , Ji-Hye Lee , Yoon Seok Oh , Jang Hee Park
IPC分类号： C12P19/30 , C12N1/12 , C12N9/04 , C12P19/32
CPC分类号： C12N9/0006 , C12P19/32
摘要： Disclosed is a novel microorganism which has a malate dehydrogenase activity higher than that of a wild-type. Also, a recombinant vector which has the structure shown in the cleavage map of FIG. 1, a Corynebacteria strain transformed therewith, and a method of producing 5′-xanthosine monophosphate by culturing the transformed strain are disclosed.
摘要翻译：公开了具有比野生型高的苹果酸脱氢酶活性的新型微生物。此外，具有图1的切割图所示结构的重组载体。 1，通过转化的棒状杆菌菌株和通过培养转化菌株来生产5'-芒硝单磷酸的方法。

8. 发明申请

US20130045511A1 MICROORGANISM HAVING ENHANCED L-VALINE PRODUCTIVITY AND METHOD FOR PRODUCING L-VALINE USING THE SAME 有权
标题翻译：具有增强的L-精氨酸生产力的微生物和使用其生产L-缬氨酸的方法
公开(公告)号：US20130045511A1
公开(公告)日：2013-02-21
申请号：US13310536
申请日：2011-12-02
申请人： Hye Won Kim , Ji-Hye Lee , Soo Youn Hwang , Jong Hyun Kim
发明人： Hye Won Kim , Ji-Hye Lee , Soo Youn Hwang , Jong Hyun Kim
IPC分类号： C12P13/08 , C12N1/21
CPC分类号： C12R1/15 , C12P13/08
摘要： The present invention relates to a microorganism having an enhanced L-valine productivity and a method for producing L-valine using the same. More particularly, the present invention relates to a Corynebacterium glutamicum mutant strain that has resistance to L-valine and derivatives thereof so as to have an enhanced L-valine productivity, and a method for producing L-valine using the same.
摘要翻译：本发明涉及具有增强的L-缬氨酸生产力的微生物和使用其的L-缬氨酸生产方法。更具体地，本发明涉及对L-缬氨酸及其衍生物具有抗性的L-缬氨酸生产力提高的谷氨酸棒杆菌突变菌株和使用其的L-缬氨酸生产方法。

9. 发明申请

US20110117220A1 PREPARATION METHOD OF PLANT EXTRACT USING HIGH PRESSURE-ENZYMATIC DECOMPOSITION TECHNIQUE AND THE COSMETIC COMPOSITION CONTAINING THE EXTRACT 审中-公开
标题翻译：使用高压 - 分解技术的植物提取物的制备方法和包含提取物的化妆品组合物
公开(公告)号：US20110117220A1
公开(公告)日：2011-05-19
申请号：US12944775
申请日：2010-11-12
申请人： Hyun Seo Kang , Hye Won Kim , Chan Koo Kang , Sung A. Cho , Jun Cheol Cho , Sang Hoon Han
发明人： Hyun Seo Kang , Hye Won Kim , Chan Koo Kang , Sung A. Cho , Jun Cheol Cho , Sang Hoon Han
IPC分类号： A61K36/82 , A61K36/00 , A61K36/899
CPC分类号： A61K36/82 , A61K36/899 , A61K36/8994
摘要： The present invention relates to a method of preparing a plant extract using a high-pressure enzymatic decomposition technique (HPED technique) and to a cosmetic composition containing the prepared plant extract as an active ingredient. The plant extract prepared using the high-pressure enzymatic decomposition technique developed according to the present invention contains various kinds and large amounts of effective components compared to extracts prepared using other extraction techniques, such that the effects of the effective components can be maximized.
摘要翻译：本发明涉及使用高压酶分解技术（HPED技术）制备植物提取物的方法和含有所制备的植物提取物作为活性成分的化妆品组合物。使用根据本发明开发的高压酶分解技术制备的植物提取物与使用其它提取技术制备的提取物相比含有多种和大量的有效成分，使得有效成分的效果可以最大化。

10. 发明申请

US20110300582A1 Corynebacteria Strain Having Enhanced 5'-Xanthosine Monophosphate Productivity and a Method of Producing 5'-Xanthosine Monophosphate Using the Same 有权
标题翻译：具有增强的5'-芒硝单磷酸生产力的棒状杆菌菌株及其使用同样方法产生5'-Xanthosine Monophosphate
公开(公告)号：US20110300582A1
公开(公告)日：2011-12-08
申请号：US13140321
申请日：2009-12-17
申请人： Jinman Cho , Hye Won Kim , Jinman Lee , Ji-Hye Lee , Yoon Seok Oh , Jang Hee Park
发明人： Jinman Cho , Hye Won Kim , Jinman Lee , Ji-Hye Lee , Yoon Seok Oh , Jang Hee Park
IPC分类号： C12P19/30 , C12N1/21 , C12N15/77 , C12N1/20
CPC分类号： C12N9/0006 , C12P19/32
摘要： Disclosed is a novel microorganism which has a malate dehydrogenase activity higher than that of a wild-type. Also, a recombinant vector which has the structure shown in the cleavage map of FIG. 1, a Corynebacteria strain transformed therewith, and a method of producing 5′-xanthosine monophosphate by culturing the transformed strain are disclosed.
摘要翻译：公开了具有比野生型高的苹果酸脱氢酶活性的新型微生物。此外，具有图1的切割图所示结构的重组载体。 1，通过转化的棒状杆菌菌株和通过培养转化菌株来生产5'-芒硝单磷酸的方法。

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