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1. 发明授权

US09603933B2 Composition for enteric hard capsules, and enteric hard capsule prepared using the composition 有权
公开(公告)号：US09603933B2
公开(公告)日：2017-03-28
申请号：US13879845
申请日：2011-02-21
申请人： Jin Ryul Son , Hyon Ho Baek , Eun Hee Park , Sung Wan Lee , Min Gyu Song , Ja Hyun Cha , Jae Uk Cha , Won Hwa Ko
发明人： Jin Ryul Son , Hyon Ho Baek , Eun Hee Park , Sung Wan Lee , Min Gyu Song , Ja Hyun Cha , Jae Uk Cha , Won Hwa Ko
IPC分类号： A61K47/38 , A61K9/48
CPC分类号： A61K47/38 , A61K9/4816
摘要： A composition for enteric hard capsules, and an enteric hard capsule prepared using the composition. The composition for enteric hard capsules may include polyol having at least three hydroxyl groups. During the storage of the enteric hard capsule prepared using the composition, the separation of salt from the capsule is delayed.

2. 发明申请

US20130203868A1 COMPOSITION FOR ENTERIC HARD CAPSULES, AND ENTERIC HARD CAPSULE PREPARED USING THE COMPOSITION 有权
标题翻译：用于肠粘膜的组合物和使用组合物制备的肠梗阻
公开(公告)号：US20130203868A1
公开(公告)日：2013-08-08
申请号：US13879845
申请日：2011-02-21
申请人： Jin Ryul Son , Hyon Ho Baek , Eun Hee Park , Sung Wan Lee , Min Gyu Song , Ja Hyun Cha , Jae Uk Cha , Won Hwa Ko
发明人： Jin Ryul Son , Hyon Ho Baek , Eun Hee Park , Sung Wan Lee , Min Gyu Song , Ja Hyun Cha , Jae Uk Cha , Won Hwa Ko
IPC分类号： A61K47/38
CPC分类号： A61K47/38 , A61K9/4816
摘要： A composition for enteric hard capsules, and an enteric hard capsule prepared using the composition. The composition for enteric hard capsules may include polyol having at least three hydroxyl groups. During the storage of the enteric hard capsule prepared using the composition, the separation of salt from the capsule is delayed.
摘要翻译：肠溶硬胶囊的组合物和使用该组合物制备的肠溶硬胶囊。肠溶硬胶囊的组合物可以包括具有至少三个羟基的多元醇。在使用该组合物制备的肠溶性硬胶囊的储存期间，盐与胶囊的分离被延迟。

3. 发明申请

US20130072579A1 METHOD OF PREPARAING ENTERIC HARD CAPSULE AND ENTERIC HARD CAPSULE PREPARED THEREBY 有权
标题翻译：制备肠溶硬胶囊和肠内硬化胶囊的方法
公开(公告)号：US20130072579A1
公开(公告)日：2013-03-21
申请号：US13634590
申请日：2011-02-21
申请人： Jin Ryul Son , Hyon Ho Baek , Eun Hee Park , Sung Wan Lee , Min Gyu Song , Ja Hyun Cha , Jae Uk Cha , Won Hwa Ko
发明人： Jin Ryul Son , Hyon Ho Baek , Eun Hee Park , Sung Wan Lee , Min Gyu Song , Ja Hyun Cha , Jae Uk Cha , Won Hwa Ko
IPC分类号： A61K47/38
CPC分类号： A61K47/38 , A61J3/077 , A61K9/4816
摘要： A method of preparing enteric hard capsules, and an enteric hard capsule prepared by the method. The method may include: dissolving an enteric base material, a capsule forming aid, and a neutralizing agent in water at room temperature to prepare an aqueous composition; heating the aqueous composition to a first temperature that is higher than a gelation start temperature of the aqueous composition; cooling the heated aqueous composition to a second temperature that is lower than the gelation start temperature; immersing a mold pin heated to a third temperature that is higher than the gelation start temperature into the aqueous composition; removing the mold pin from the aqueous composition to obtain a film coated on the mold pin; maintaining the film on the mold pin at a fourth temperature that is higher than the gelation start temperature for a first time period to fix the film onto the mold pin; and drying the fixed film at a fifth temperature for a second time period to obtain a capsule shell.
摘要翻译：制备肠溶硬胶囊的方法和通过该方法制备的肠溶硬胶囊。该方法可以包括：在室温下将肠溶基质材料，胶囊形成助剂和中和剂溶于水中以制备含水组合物; 将所述水性组合物加热到高于所述水性组合物的凝胶化开始温度的第一温度; 将加热的水性组合物冷却至低于凝胶化开始温度的第二温度; 将加热到高于凝胶化开始温度的第三温度的模具针浸入水性组合物中; 从水性组合物中取出模具销以获得涂在模具销上的薄膜; 在第一温度高于第一时间的凝胶化开始温度的第四温度下将薄膜保持在模具销上，以将薄膜固定在模具销上; 并在第五温度下将固定膜干燥第二时间以获得胶囊壳。

4. 发明授权

US08710105B2 Method of preparing enteric hard capsule and enteric hard capsule prepared thereby 有权
标题翻译：制备肠溶硬胶囊和肠溶硬胶囊的方法
公开(公告)号：US08710105B2
公开(公告)日：2014-04-29
申请号：US13634590
申请日：2011-02-21
申请人： Jin Ryul Son , Hyon Ho Baek , Eun Hee Park , Sung Wan Lee , Min Gyu Song , Ja Hyun Cha , Jae Uk Cha , Won Hwa Ko
发明人： Jin Ryul Son , Hyon Ho Baek , Eun Hee Park , Sung Wan Lee , Min Gyu Song , Ja Hyun Cha , Jae Uk Cha , Won Hwa Ko
IPC分类号： A61K47/38
CPC分类号： A61K47/38 , A61J3/077 , A61K9/4816
摘要： A method of preparing enteric hard capsules, and an enteric hard capsule prepared by the method. The method may include: dissolving an enteric base material, a capsule forming aid, and a neutralizing agent in water at room temperature to prepare an aqueous composition; heating the aqueous composition to a first temperature that is higher than a gelation start temperature of the aqueous composition; cooling the heated aqueous composition to a second temperature that is lower than the gelation start temperature; immersing a mold pin heated to a third temperature that is higher than the gelation start temperature into the aqueous composition; removing the mold pin from the aqueous composition to obtain a film coated on the mold pin; maintaining the film on the mold pin at a fourth temperature that is higher than the gelation start temperature for a first time period to fix the film onto the mold pin; and drying the fixed film at a fifth temperature for a second time period to obtain a capsule shell.
摘要翻译：制备肠溶硬胶囊的方法和通过该方法制备的肠溶硬胶囊。该方法可以包括：在室温下将肠溶基质材料，胶囊形成助剂和中和剂溶于水中以制备含水组合物; 将所述水性组合物加热到高于所述水性组合物的凝胶化开始温度的第一温度; 将加热的水性组合物冷却至低于凝胶化开始温度的第二温度; 将加热到高于凝胶化开始温度的第三温度的模具针浸入水性组合物中; 从水性组合物中取出模具销以获得涂在模具销上的薄膜; 在第一温度高于第一时间的凝胶化开始温度的第四温度下将薄膜保持在模具销上，以将薄膜固定在模具销上; 并在第五温度下将固定膜干燥第二时间以获得胶囊壳。

5. 发明授权

US09044406B2 Aqueous composition for enteric hard capsule, method of preparing enteric hard capsule, and enteric hard capsule prepared using the method 有权
标题翻译：用于肠溶硬胶囊的水性组合物，制备肠溶性硬胶囊的方法和使用该方法制备的肠溶性硬胶囊
公开(公告)号：US09044406B2
公开(公告)日：2015-06-02
申请号：US13378249
申请日：2009-10-13
申请人： Jin Ryul Son , Hyon Ho Baek , Sung Wan Lee , Min Gyu Song , Jae Uk Cha , Eun Hee Park
发明人： Jin Ryul Son , Hyon Ho Baek , Sung Wan Lee , Min Gyu Song , Jae Uk Cha , Eun Hee Park
IPC分类号： B28B1/38 , A61K9/48 , A61K47/38
CPC分类号： A61K9/4816 , A61K47/38
摘要： An aqueous composition for an enteric hard capsule, a method of preparing an enteric hard capsule, and an enteric hard capsule prepared using the method. The aqueous composition for an enteric hard capsule includes an enteric base material, a capsule forming aid, and a neutralizing agent. The method of preparing an enteric hard capsule includes: preparing an aqueous composition by dissolving an enteric base material, a capsule forming aid, and a neutralizing agent in water; preheating the aqueous composition to a temperature that is less than the gelation temperature for the aqueous composition; immersing a mold pin heated to a temperature that is greater than the gelation temperature for the aqueous composition into the aqueous composition; taking the mold pin out of the aqueous composition to obtain a film formed on the mold pin; and maintaining the film at a temperature that is equal to or greater than the gelation temperature for the aqueous composition for a predetermined period of time to fix the film on the mold pin and drying the film.
摘要翻译：肠溶硬胶囊的水性组合物，制备肠溶性硬胶囊的方法以及使用该方法制备的肠溶性硬胶囊。用于肠溶硬胶囊的水性组合物包括肠溶基质材料，胶囊形成助剂和中和剂。制备肠溶性硬胶囊的方法包括：通过将肠溶基质材料，胶囊形成助剂和中和剂溶解在水中来制备水性组合物; 将含水组合物预热至低于水性组合物的凝胶化温度的温度; 将模具针浸入加热到水性组合物的水凝胶化温度以上的温度下，将模具针从水性组合物中取出以获得在模具销上形成的膜; 并将膜维持在等于或大于水性组合物凝胶化温度一段预定时间的温度以将膜固定在模具销上并干燥该膜。

6. 发明申请

US20120161364A1 AQUEOUS COMPOSITION FOR ENTERIC HARD CAPSULE, METHOD OF PREPARING ENTERIC HARD CAPSULE, AND ENTERIC HARD CAPSULE PREPARED USING THE METHOD 有权
标题翻译：肠型硬胶囊的水性组合物，制备肠型硬胶囊的方法和使用该方法制备的肠梗阻
公开(公告)号：US20120161364A1
公开(公告)日：2012-06-28
申请号：US13378249
申请日：2009-10-13
申请人： Jin Ryul Son , Hyon Ho Baek , Sung Wan Lee , Min Gyu Song , Jae Uk Cha , Eun Hee Park
发明人： Jin Ryul Son , Hyon Ho Baek , Sung Wan Lee , Min Gyu Song , Jae Uk Cha , Eun Hee Park
IPC分类号： C08L1/10 , B28B1/38 , C08L1/14
CPC分类号： A61K9/4816 , A61K47/38
摘要： An aqueous composition for an enteric hard capsule, a method of preparing an enteric hard capsule, and an enteric hard capsule prepared using the method. The aqueous composition for an enteric hard capsule includes an enteric base material, a capsule forming aid, and a neutralizing agent. The method of preparing an enteric hard capsule includes: preparing an aqueous composition by dissolving an enteric base material, a capsule forming aid, and a neutralizing agent in water; preheating the aqueous composition to a temperature that is less than the gelation temperature for the aqueous composition; immersing a mold pin heated to a temperature that is greater than the gelation temperature for the aqueous composition into the aqueous composition; taking the mold pin out of the aqueous composition to obtain a film formed on the mold pin; and maintaining the film at a temperature that is equal to or greater than the gelation temperature for the aqueous composition for a predetermined period of time to fix the film on the mold pin and drying the film.
摘要翻译：肠溶硬胶囊的水性组合物，制备肠溶性硬胶囊的方法以及使用该方法制备的肠溶性硬胶囊。用于肠溶硬胶囊的水性组合物包括肠溶基质材料，胶囊形成助剂和中和剂。制备肠溶性硬胶囊的方法包括：通过将肠溶基质材料，胶囊形成助剂和中和剂溶解在水中来制备水性组合物; 将含水组合物预热至低于水性组合物的凝胶化温度的温度; 将模具针浸入加热到水性组合物的水凝胶化温度以上的温度下，将模具针从水性组合物中取出以获得在模具销上形成的膜; 并将膜维持在等于或大于水性组合物凝胶化温度一段预定时间的温度以将膜固定在模具销上并干燥该膜。

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