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1. 发明授权

US06329515B1 Bio-inorganic compound capable of stable, solid-state storage of genes and preparation thereof 有权
标题翻译：能够稳定，固态储存基因的生物无机化合物及其制备方法
公开(公告)号：US06329515B1
公开(公告)日：2001-12-11
申请号：US09393981
申请日：1999-09-10
申请人： Jin Ho Choy , Seo Young Kwak , Jong Sang Park
发明人： Jin Ho Choy , Seo Young Kwak , Jong Sang Park
IPC分类号： C07H2100
CPC分类号： C12N15/1003
摘要： Disclosed is a bio-inorganic hybrid composite for retaining and carrying bio-materials with stability and reversible dissociativity, represented by the following chemical Formula I and a method for preparing the same. The bio-inorganic hybrid composite is prepared by (a) coprecipitating with an alkaline material an aqueous solution comprising a bivalent metal (M(II)) and a trivalent metal (N(III)) at a molar ratio satisfying the condition of ⅕≦b/(a+b)≦½ wherein a and b represent a mole number of M and N, respectively, to form a stable layered double hydroxide in which anions are intercalated and (b) subjecting the intercalated anions to ion exchange reaction with a bio-material to compensate for layer charges of the layered double hydroxide. This composite is harmless to the body and artificially controls the appropriate expression of the bio-material retained therein. [M2+1−xN3+x(Oh)2][ABIOn−]x/n.yH2O [I] wherein, M is a bivalent metal cation; N is a trivalent metal cation; ABIO is an anionic bio-material with n charges; x is a rational number between 0 to 1; and y is a positive number.
摘要翻译：公开了一种用于保持和携带具有稳定性和可逆解离性的生物材料的生物 - 无机杂化复合材料，其由以下化学式I表示，及其制备方法。生物 - 无机杂化复合物通过以下步骤制备：（a）以满足条件⅕的摩尔比与碱性物质共沉淀包含二价金属（M（II））和三价金属（N（III））的水溶液， = b /（a + b）<=½其中a和b分别表示M和N的摩尔数，以形成其中插入阴离子的稳定的层状双氢氧化物，（b）使插入的阴离子进行离子交换反应用生物材料来补偿层状双氢氧化物的层电荷。这种复合物对人体无害，人为地控制其中保留的生物材料的合适表达。其中M是二价金属阳离子; N是三价金属阳离子; ABIO是具有n个电荷的阴离子生物材料; x是 0到1之间的有理数; 安迪是一个正数。

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