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1. 发明授权

US5527683A Photo-induced DNA-cleaving agents 失效
标题翻译：光诱导的DNA切割剂
公开(公告)号：US5527683A
公开(公告)日：1996-06-18
申请号：US407582
申请日：1995-03-20
申请人： Jih R. Hwu , Shwu-Chen Tsay , Buh-Luen Chen , Himatkumar V. Patel , Wan-Lin Chen , Chun C. Lin , Ching-Tai Chou
发明人： Jih R. Hwu , Shwu-Chen Tsay , Buh-Luen Chen , Himatkumar V. Patel , Wan-Lin Chen , Chun C. Lin , Ching-Tai Chou
IPC分类号： C07H21/00 , C12N15/10 , C12Q1/68 , C07H19/04 , C12P19/34 , C12Q1/70
CPC分类号： C07H21/00 , C12N15/10 , C12Q1/68
摘要： The present invention discloses a photo-induced DNA-cleaving agent composition comprises N-aryl-N-(alkyl or arylalkyl)hydroxylamine having the following formula: ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl, phenyl, C.sub.1 -C.sub.6 alkoxy, phenoxy, C.sub.1 -C.sub.6 alkoxycarbonyl, halogen or halo(C.sub.1 -C.sub.6 alkyl)wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkoxycarbonyl, halogen or halo(C.sub.1 -C.sub.6 alkyl); R.sub.2 is hydrogen; R.sub.3 is hydrogen or phenyl; R.sub.4 is hydrogen, phenyl, hydroxylphenyl, methoxyphenyl, dimethoxyphenyl, dimethylaminophenyl or naphthyl. The present N-aryl-N-(alkyl or arylalkyl)hydroxylamine is stable in dark, but it can react with O.sub.2 to form HO. radicals under irradiation of UV light for a period of 2-3 hours. The HO. radicals then react with DNA to accomplish cleavage of DNA.
摘要翻译：本发明公开了一种光致DNA切割剂组合物，其包含具有下式的N-芳基-N-（烷基或芳烷基）羟胺：其中R是C1-C6烷基，苯基，C1-C6 烷氧基，苯氧基，C1-C6烷氧基羰基，卤素或卤素（C1-C6烷基），其中R1是氢，C1-C6烷基，苯基，C1-C6烷氧基，C1-C6烷氧基羰基，卤素或卤素（C1-C6烷基） R2是氢; R3是氢或苯基; R4是氢，苯基，羟基苯基，甲氧基苯基，二甲氧基苯基，二甲基氨基苯基或萘基。本发明N-芳基-N-（烷基或芳基烷基）羟胺在黑暗中稳定，但可与O 2反应形成HO。紫外线照射下的自由基2-3小时。 HO。然后自由基与DNA反应以完成DNA的切割。

2. 发明授权

US5734032A Photo-induced DNA-cleaving agents 失效
标题翻译：光诱导的DNA切割剂
公开(公告)号：US5734032A
公开(公告)日：1998-03-31
申请号：US581314
申请日：1995-12-29
申请人： Jih Ru Hwu , Shwu-Chen Tsay , Buh-Luen Chen , Himatkumar V. Patel , Wan-Lin Chen , Chun Chieh Lin , Ching-Tai Chou
发明人： Jih Ru Hwu , Shwu-Chen Tsay , Buh-Luen Chen , Himatkumar V. Patel , Wan-Lin Chen , Chun Chieh Lin , Ching-Tai Chou
IPC分类号： C07H21/00 , C12N15/10 , C12Q1/68 , C01B21/14
CPC分类号： C07H21/00 , C12N15/10 , C12Q1/68
摘要： The present invention discloses a photo-induced DNA-cleaving agent composition comprises N-aryl-N-(alkyl or arylalkyl)hydroxylamine having the following formula: ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl, phenyl, C.sub.1 -C.sub.6 alkoxy, phenoxy, C.sub.1 -C.sub.6 alkoxycarbonyl, halogen or halo(C.sub.1 -C.sub.6 alkyl)wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkoxycarbonyl, halogen or halo(C.sub.1 -C.sub.6 alkyl); R.sub.2 is hydrogen; R.sub.3 is hydrogen or phenyl; R.sub.4 is hydrogen, phenyl, hydroxylphenyl, methoxyphenyl, dimethoxyphenyl, dimethylaminophenyl or naphthyl. The present N-aryl-N-(alkyl or arylalkyl)hydroxylamine is stable in dark, but it can react with O.sub.2 to form HO.multidot. radicals under irradiation of UV light for a period of 2-3 hours. The HO.multidot. radicals then react with DNA to accomplish cleavage of DNA.
摘要翻译：本发明公开了一种光致DNA切割剂组合物，其包含具有下式的N-芳基-N-（烷基或芳烷基）羟胺：其中R是C1-C6烷基，苯基，C1-C6 烷氧基，苯氧基，C1-C6烷氧基羰基，卤素或卤素（C1-C6烷基），其中R1是氢，C1-C6烷基，苯基，C1-C6烷氧基，C1-C6烷氧基羰基，卤素或卤素（C1-C6烷基） R2是氢; R3是氢或苯基; R4是氢，苯基，羟基苯基，甲氧基苯基，二甲氧基苯基，二甲基氨基苯基或萘基。本发明的N-芳基-N-（烷基或芳基烷基）羟胺在黑暗中稳定，但在紫外线照射下可与O 2反应形成HOx自由基2-3小时。然后，HOx自由基与DNA反应以完成DNA的切割。

3. 发明授权

US07585826B2 Compositions counteracting pesticides and malodorants 有权
标题翻译：防止农药和恶臭的组合物
公开(公告)号：US07585826B2
公开(公告)日：2009-09-08
申请号：US11726703
申请日：2007-03-22
申请人： Jih-Ru Hwu , Shwu-Chen Tsay
发明人： Jih-Ru Hwu , Shwu-Chen Tsay
IPC分类号： A61K31/28
CPC分类号： A62D3/38 , A61L9/01 , A62D2101/04 , Y10S71/903
摘要： This invention relates to compositions that counteract chemicals such as pesticides and malodorants. Also disclosed are a method for preparing such compositions and a method for applying such compositions to counteract pesticides or malordorants.
摘要翻译：本发明涉及抵抗诸如杀虫剂和恶臭剂的化学物质的组合物。还公开了制备这种组合物的方法以及用于施用这样的组合物以抵抗农药或恶臭剂的方法。

4. 发明授权

US06348454B1 Syntheses of new isodethiaazacephems and isodethiaazacephams, and use as potent antibacterial agents 有权
标题翻译：新异二硫杂吖嗪和异二氮杂嗪的合成，并用作有效的抗菌剂
公开(公告)号：US06348454B1
公开(公告)日：2002-02-19
申请号：US09310270
申请日：1999-05-12
申请人： Jih Ru Hwu , Shwu-Chen Tsay , Shahram Hakimelahi
发明人： Jih Ru Hwu , Shwu-Chen Tsay , Shahram Hakimelahi
IPC分类号： C07D48704
CPC分类号： C07D487/04
摘要： An isodethiaazacephem derivative having the following formula (I): wherein RI is hydrogen or —SO2RIII; RII is —CO2RIV or —SO2RIII in which RIII is a hydrogen, C1-C6 alkyl, aralkyl having a total carbon number of 7-12, aryl, or a halogenated C1-C6 alkyl; and RIV is a hydrogen, C1-C6 alkyl, aralkyl having a total carbon number of 7-12 or aryl; and RV is a substituted acetamido radical.
摘要翻译：具有下式（I）的异二硫杂ace嗪衍生物：其中R 1是氢或-SO 2 R 3; RII是-CO 2 RIV或-SO 2 RIII，其中R III是氢，C 1 -C 6烷基，总碳数为7-12的芳烷基，芳基或卤代C 1 -C 6烷基; 且RIV为氢，C1-C6烷基，总碳数为7-12的芳烷基或芳基; RV是取代的乙酰氨基。

5. 发明授权

US06288265B1 Phloroglucidic acid and derivatives as antibacterial agents 有权
标题翻译：角质苷酸及其衍生物作为抗菌剂
公开(公告)号：US06288265B1
公开(公告)日：2001-09-11
申请号：US09399879
申请日：1999-09-20
申请人： Jih Ru Hwu , Shwu-Chen Tsay , Gholam H. Hakimelahi , Chun Chieh Lin , Wen Nan Tseng , Ali A. Moshfegh , Abdolmajid Azaripour , Hasan Mottaghian
发明人： Jih Ru Hwu , Shwu-Chen Tsay , Gholam H. Hakimelahi , Chun Chieh Lin , Wen Nan Tseng , Ali A. Moshfegh , Abdolmajid Azaripour , Hasan Mottaghian
IPC分类号： C07C6976
CPC分类号： C07D501/00
摘要： A series of phloroglucide derivatives are synthesized, which possess potent antibacterial activities. They include unsymmetrical phloroglucide analogs, phloroglucides attached to cephalosporins at the C-3′ position, and 7-(phloroglucidamido)cephalosporins.
摘要翻译：合成了一系列具有强力抗菌活性的花生四烯衍生物。它们包括不对称的间苯三酚类似物，在C-3'位置连接到头孢菌素的间苯三酚和7-（间苯三酰胺）头孢菌素。

6. 发明申请

US20070152569A1 Novel benzo[b]furan derivatives and their use 审中-公开
标题翻译：新型苯并[b]呋喃衍生物及其用途
公开(公告)号：US20070152569A1
公开(公告)日：2007-07-05
申请号：US11324480
申请日：2006-01-04
申请人： Jih-Ru Hwu , Shwu-Chen Tsay , Kao-Shuh Chuang
发明人： Jih-Ru Hwu , Shwu-Chen Tsay , Kao-Shuh Chuang
IPC分类号： H01L51/00 , C07D405/02
CPC分类号： H01L51/0073 , C07D307/86
摘要： The present invention relates to novel benzo[b]furan derivatives, particular to novel benzo[b]furan derivatives having substituents at the 4-position. The present invention also relates to a use of the benzo[b]furan derivatives as electroluminescent material in OLED.
摘要翻译：本发明涉及新的苯并[b]呋喃衍生物，特别涉及在4-位具有取代基的新的苯并[b]呋喃衍生物。本发明还涉及苯并[b]呋喃衍生物作为OLED中的电致发光材料的用途。

7. 发明授权

US06812247B2 Organometallic complex 失效
标题翻译：有机金属络合物
公开(公告)号：US06812247B2
公开(公告)日：2004-11-02
申请号：US10261130
申请日：2002-09-30
申请人： Kuang-Lieh Lu , Jih-Ru Hwu , Shwu-Chen Tsay , Sheng-Fa Yu , Jui-Te Hung , Jiann-Jyh Huang
发明人： Kuang-Lieh Lu , Jih-Ru Hwu , Shwu-Chen Tsay , Sheng-Fa Yu , Jui-Te Hung , Jiann-Jyh Huang
IPC分类号： A61K3324
CPC分类号： A61K31/282 , A61K31/555
摘要： A metal complex and its use for binding or cleaving a nucleic acid. The metal complex has the formula: M is Pt, Pd, Ni, Co, or Cu; X is aryl, heteroaryl, cyclyl, or heterocyclyl; Y is halogen, tosylate, mesylate, triflate, pyrophosphate, or carboxylate; each of A1 and A2, independently, is N or C; each of A3 and A4, independently, is N, S, or O, wherein A1, A2, A3, and A4 taken together have one positive charge; and each of R1 and R2, independently, is alkyl, aryl, heteroaryl, alkoxyl, aryloxyl, heteroaryloxyl, alkoxylcarbonyl, aryloxylcarbonyl, or heteroaryloxylcarbonyl.
摘要翻译：金属络合物及其用于结合或切割核酸的用途。金属络合物具有下式：M是Pt，Pd，Ni，Co或Cu; X是芳基，杂芳基，环基或杂环基; Y是卤素，甲苯磺酸酯，甲磺酸酯，三氟甲磺酸酯，焦磷酸酯或羧酸酯; A1和A2各自独立地为N或C; A3和A4各自独立地为N，S或O，其中A1，A2，A3和A4一起具有一个正电荷; R 1和R 2各自独立地是烷基，芳基，杂芳基，烷氧基，芳氧基，杂芳氧基，烷氧基羰基，芳氧基羰基或杂芳氧基羰基。

8. 发明授权

US06458833B1 Organometallic complex 失效
标题翻译：有机金属络合物
公开(公告)号：US06458833B1
公开(公告)日：2002-10-01
申请号：US09989768
申请日：2001-11-20
申请人： Kuang-Lieh Lu , Jih-Ru Hwu , Shwu-Chen Tsay , Sheng-Fa Yu , Jui-Te Hung , Jiann-Jyh Huang
发明人： Kuang-Lieh Lu , Jih-Ru Hwu , Shwu-Chen Tsay , Sheng-Fa Yu , Jui-Te Hung , Jiann-Jyh Huang
IPC分类号： A61K3324
CPC分类号： A61K31/282 , A61K31/555
摘要： A metal complex and its use for binding or cleaving a nucleic acid. The metal complex has the formula: M is Pt, Pd, Ni, Co, or Cu; X is aryl, heteroaryl, cyclyl, or heterocyclyl; Y is halogen, tosylate, mesylate, triflate, pyrophosphate, or carboxylate; each of A1 and A2, independently, is N or C; each of A3 and A4, independently, is N, S, or 0, wherein A1, A2, A3, and A4 taken together have one positive charge; and each of R1 and R2, independently, is alkyl, aryl, heteroaryl, alkoxyl, aryloxyl, heteroaryloxyl, alkoxylcarbonyl, aryloxylcarbonyl, or heteroaryloxylcarbonyl.
摘要翻译：金属络合物及其用于结合或切割核酸的用途。金属络合物具有下式：M是Pt，Pd，Ni，Co或Cu; X是芳基，杂芳基，环基或杂环基; Y是卤素，甲苯磺酸酯，甲磺酸酯，三氟甲磺酸酯，焦磷酸酯或羧酸酯; A1和A2各自独立地为N或C; A3和A4各自独立地为N，S或0，其中A1，A2，A3和A4一起具有一个正电荷; R 1和R 2各自独立地是烷基，芳基，杂芳基，烷氧基，芳氧基，杂芳氧基，烷氧基羰基，芳氧基羰基或杂芳氧基羰基。

9. 发明授权

US5733890A Adenylate analogs as potent anti-herpes virus agents 失效
标题翻译：腺苷酸类似物作为有效的抗疱疹病毒剂
公开(公告)号：US5733890A
公开(公告)日：1998-03-31
申请号：US727292
申请日：1996-10-09
申请人： Jih Ru Hwu , Gholam H. Hakimelahi , Shwu-Chen Tsay , Ali A. Moosavi-Movahedi , Majid M. Sadeghi
发明人： Jih Ru Hwu , Gholam H. Hakimelahi , Shwu-Chen Tsay , Ali A. Moosavi-Movahedi , Majid M. Sadeghi
IPC分类号： C07H19/16 , A61K31/70 , C07H19/19 , C07H19/20
CPC分类号： C07H19/16
摘要： Novel adenylate analogs having the following formula are synthesized in the present invention, which are found active against herpes simplex viruses: ##STR1## wherein R.sup.1 is hydroxyl, C.sub.1 -C.sub.4 alkoxy, an amino ester radical of --NHR.sup.3 COOR.sup.4, wherein R.sup.3 is a bivalent C.sub.1 -C.sub.4 saturated hydrocarbon and R.sup.4 is C.sub.1 -C.sub.4 alkyl; and R.sup.2 is hydroxyl, --O.sup.+ NH.sub.4 or ##STR2##
摘要翻译：在本发明中合成具有下列结构式的新型腺苷酸类似物，其被发现针对单纯疱疹病毒具有活性：-NHR3COOR4的氨基酯基，其中R3是二价C1-C4饱和烃，R4是C1-C4烷基; 并且R 2是羟基，-O + NH 4或

10. 发明申请

US20090098098A1 ANTI-BACTERIAL, ANTI-VIRUS, AND ANTI-FUNGUS COMPOSITION, ITS PREPARATION AND USE 有权
标题翻译：抗菌，抗病毒和抗真菌组合物，其制备和使用
公开(公告)号：US20090098098A1
公开(公告)日：2009-04-16
申请号：US12240755
申请日：2008-09-29
申请人： Jih-Ru Hwu , Shwu-Chen Tsay
发明人： Jih-Ru Hwu , Shwu-Chen Tsay
IPC分类号： A01N59/20 , A01N59/16 , A01N55/02 , A01N43/14 , A01P1/00 , A01P3/00
CPC分类号： A61L2/22 , A61K31/28 , A61K33/24 , A61K45/06 , A61L2/186 , A61K2300/00
摘要： The present invention relates to an anti-bacterial, anti-virus, and anti-fungus composition, its preparation and use. The composition of the present invention mainly includes the following three ingredients in an adequate ratio: (A) a metal compound having a catalytic function; (B) a mixture of a coenzyme having reducing ability and quinones, and (C) an additive. The anti-bacterial, anti-virus, and anti-fungus composition of the present invention is capable of destroying viruses as well as killing bacterial and fungi. Therefore, the composition can be formulated as an aerosol and a film for applying to protection devices such as respirators, masks, gloves, filters, condoms, etc. The present composition can also be used in household, vehicle, hospital, school, restaurant, hotel, internet coffee shop for applying to filter of air-conditioner, tap, stool, interior of elevator and its keyboard. Additionally, the present composition can be applied to human being such as applying to hand, foot, genital organs, oral cavity, and the like in a lower dose to attain the effect of destroying of bacteria, viruses, and fungi.
摘要翻译：本发明涉及抗菌，抗病毒和抗真菌组合物，其制备和应用。本发明的组合物主要包括足够比例的以下三种成分：（A）具有催化功能的金属化合物; （B）具有还原能力的辅酶和醌类的混合物，和（C）添加剂。本发明的抗细菌，抗病毒和抗真菌组合物能够破坏病毒以及杀死细菌和真菌。因此，该组合物可以配制成用于应用于诸如呼吸器，面罩，手套，过滤器，避孕套等保护装置的气雾剂和膜。本发明组合物还可以用于家庭，车辆，医院，学校，餐厅，酒店，互联网咖啡店，适用于空调，水龙头，凳子，电梯内部及其键盘。此外，本发明的组合物可以以较低剂量施用于人，例如施用于手，脚，生殖器，口腔等，以达到破坏细菌，病毒和真菌的效果。

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