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1. 发明授权

US08785459B2 Quinazoline compounds as kinase inhibitors 有权
标题翻译：喹唑啉化合物作为激酶抑制剂
公开(公告)号：US08785459B2
公开(公告)日：2014-07-22
申请号：US13337863
申请日：2011-12-27
申请人： Jiann-Jyh Huang , Chu-Bin Liao , Pao-Nien Chen
发明人： Jiann-Jyh Huang , Chu-Bin Liao , Pao-Nien Chen
IPC分类号： A01N43/54 , A61K31/517 , C07D239/02 , C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C12N9/99 , C07D239/94 , C12Y207/00
摘要： A compound for treating protein kinase-related disease or disorder having a structure of formula (A): wherein X is N or CH; Y is NH, O, or CH2; Z is an aryl or a heteroaryl; and R1, R2, R3, and R4 are independently H, halo, nitro, cyano, aryl, heteroaryl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, —ORa, —C(O)Ra, —C(O)NRaRb, —NRaC(O)Rb, —NRaRb, —S(O)2Ra, —S(O)2NRaRb, —NRaS(O)2Rb, —N═CRaRb, or —NRaC(O)NHRb, wherein each of Ra and Rb, independently, is H, alkyl, alkenyl, alkynyl, aryl, aryloxy, alkoxy, hydroxy, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl, or Ra and Rb, together with the nitrogen atom to which they are bonded, form heteroaryl, heterocycloalkyl, or heterocycloalkenyl; or R3 and R4 are as defined above, and R1 and R2 together with the carbons, to which they are attached, form a heterocycloalkenyl or heteroaryl.
摘要翻译：一种用于治疗具有式（A）结构的蛋白激酶相关疾病或病症的化合物：其中X是N或CH; Y是NH，O或CH 2; Z是芳基或杂芳基; 并且R 1，R 2，R 3和R 4独立地是H，卤素，硝基，氰基，芳基，杂芳基，烷基，烯基，炔基，环烷基，杂环烷基，环烯基，杂环烯基，-OR a，-C（O） O）NR a R b，-NR a C（O）R b，-NR a R b，-S（O）2 R a，-S（O）2 NR a R b，-NR a（O）2 R b，-N = CR a R b或-NR a C（O）NHR b，的R a和R b独立地是H，烷基，烯基，炔基，芳基，芳氧基，烷氧基，羟基，杂芳基，环烷基，杂环烷基，环烯基或杂环烯基，或者R a和R b与它们所键合的氮原子一起，形成杂芳基，杂环烷基或杂环烯基; 或R 3和R 4如上所定义，并且R 1和R 2与它们所连接的碳一起形成杂环烯基或杂芳基。

2. 发明申请

US20130165458A1 QUINAZOLINE COMPOUNDS AS KINASE INHIBITORS 有权
标题翻译：喹唑啉化合物作为激酶抑制剂
公开(公告)号：US20130165458A1
公开(公告)日：2013-06-27
申请号：US13337863
申请日：2011-12-27
申请人： Jiann-Jyh Huang , Chu-Bin Liao , Pao-Nien Chen
发明人： Jiann-Jyh Huang , Chu-Bin Liao , Pao-Nien Chen
IPC分类号： A61K31/517 , C07D401/12 , C07D215/44 , A61K31/4706 , A61K31/4709 , C12N9/99 , A61P3/10 , A61P13/12 , A61P19/02 , A61P37/00 , A61P35/02 , C07D239/94 , A61P35/00
CPC分类号： C12N9/99 , C07D239/94 , C12Y207/00
摘要： A compound for treating protein kinase-related disease or disorder having a structure of formula (A): wherein X is N or CH; Y is NH, O, or CH2; Z is an aryl or a heteroaryl; and R1, R2, R3, and R4 are independently H, halo, nitro, cyano, aryl, heteroaryl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, heterocycloalkenyl, —ORa, —C(O)Ra, —C(O)NRaRb, —NRaC(O)Rb, —NRaRb, —S(O)2Ra, —S(O)2NRa Rb, —NRaS(O)2Rb, —N═CRaRb, or —NRaC(O)NHRb, wherein each of Ra and Rb, independently, is H, alkyl, alkenyl, alkynyl, aryl, aryloxy, alkoxy, hydroxy, heteroaryl, cycloalkyl, heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl, or Ra and Rb, together with the nitrogen atom to which they are bonded, form heteroaryl, heterocycloalkyl, or heterocycloalkenyl; or R3 and R4 are as defined above, and R1 and R2 together with the carbons, to which they are attached, form a heterocycloalkenyl or heteroaryl.
摘要翻译：一种用于治疗具有式（A）结构的蛋白激酶相关疾病或病症的化合物：其中X是N或CH; Y是NH，O或CH 2; Z是芳基或杂芳基; 并且R 1，R 2，R 3和R 4独立地是H，卤素，硝基，氰基，芳基，杂芳基，烷基，烯基，炔基，环烷基，杂环烷基，环烯基，杂环烯基，-OR a，-C（O） O）NR a R b，-NR a C（O）R b，-NR a R b，-S（O）2 R a，-S（O）2 NR a R b，-NR a（O）2 R b，-N = CR a R b或-NR a C（O） R a和R b各自独立地是H，烷基，烯基，炔基，芳基，芳氧基，烷氧基，羟基，杂芳基，环烷基，杂环烷基，环烯基或杂环烯基，或者R a和R b与它们所在的氮原子一起杂芳基，杂环烷基或杂环烯基; 或R 3和R 4如上所定义，并且R 1和R 2与它们所连接的碳一起形成杂环烯基或杂芳基。

3. 发明授权

US08058236B2 Aqueous inhalation pharmaceutical composition 有权
标题翻译：水性吸入药物组合物
公开(公告)号：US08058236B2
公开(公告)日：2011-11-15
申请号：US11440775
申请日：2006-05-25
申请人： Pao-Nien Chen , Shyh-Fong Chen , Shu-Chien Liu , Fan-Jung Liu
发明人： Pao-Nien Chen , Shyh-Fong Chen , Shu-Chien Liu , Fan-Jung Liu
IPC分类号： A61K38/28 , C07K14/62
CPC分类号： A61K9/0078 , A61K38/28
摘要： An aqueous inhalation pharmaceutical composition comprising a polypeptide or protein is provided. The composition of the present invention can improve the bioavailability of the polypeptide and protein, and avoid inducing toxicity in the lung.
摘要翻译：提供包含多肽或蛋白质的含水吸入药物组合物。本发明的组合物可以改善多肽和蛋白质的生物利用度，并避免在肺中诱导毒性。

4. 发明授权

US06183777B2 Controlled release tacrine dosage form 失效
标题翻译：对照释放他克林剂型
公开(公告)号：US06183777B2
公开(公告)日：2001-02-06
申请号：US09006856
申请日：1998-01-14
申请人： Pao-Nien Chen , Chuan-Ming Lai , Shu-Jian Liu , Fan-Jung Liu , Shu-Bin Lu
发明人： Pao-Nien Chen , Chuan-Ming Lai , Shu-Jian Liu , Fan-Jung Liu , Shu-Bin Lu
IPC分类号： A61K924
CPC分类号： A61K31/00 , A61K9/209
摘要： Disclosed is a controlled release tacrine dosage form, which comprises: (a) a core; (b) an inner active layer comprising tacrine and a binder; (c) a release-controlling layer comprising one or more release-controlling-film-forming polymer; and (d) an active overcoat comprising tacrine and a binder. Also disclosed is a process for preparing the controlled release dosage form.
摘要翻译：公开了一种控释他克林剂型，其包括：（a）核心;（b）包含他克林和粘合剂的内部活性层;（c）包含一个或多个释放控制膜形成的释放控制层聚合物; 和（d）包含他克林和粘合剂的活性外涂层。还公开了制备控释剂型的方法。

5. 发明申请

US20070140976A1 Aqueous inhalation pharmaceutical composition 有权
标题翻译：水性吸入药物组合物
公开(公告)号：US20070140976A1
公开(公告)日：2007-06-21
申请号：US11440775
申请日：2006-05-25
申请人： Pao-Nien Chen , Shyh-Fong Chen , Shu-Chien Liu , Fan-Jung Liu
发明人： Pao-Nien Chen , Shyh-Fong Chen , Shu-Chien Liu , Fan-Jung Liu
IPC分类号： A61K38/22 , A61K38/23 , A61K38/24 , A61K38/25 , A61K38/26 , A61K38/27 , A61K38/36 , A61K38/28 , A61K9/12
CPC分类号： A61K9/0078 , A61K38/28
摘要： An aqueous inhalation pharmaceutical composition comprising a polypeptide or protein is provided. The composition of the present invention can improve the bioavailability of the polypeptide and protein, and avoid inducing toxicity in the lung.
摘要翻译：提供包含多肽或蛋白质的含水吸入药物组合物。本发明的组合物可以改善多肽和蛋白质的生物利用度，并避免在肺中诱导毒性。

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