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1. 发明申请

US20050233376A1 Biochip scanner device 审中-公开
标题翻译：生物芯片扫描仪装置
公开(公告)号：US20050233376A1
公开(公告)日：2005-10-20
申请号：US11166238
申请日：2005-06-27
申请人： Jiann-Hua Wang , Hui-Ju Chen , Tzu-Chiang Wu , Chien-Ho Chuang , Tsung-Kai Chuang
发明人： Jiann-Hua Wang , Hui-Ju Chen , Tzu-Chiang Wu , Chien-Ho Chuang , Tsung-Kai Chuang
IPC分类号： C12M1/34 , C12Q1/68 , G01N21/64
CPC分类号： G01N21/6428 , G01N21/6452 , G01N21/6456
摘要： A biochip scanner device includes a light source for emitting a light beam; a light processing unit for focusing the light beam onto the biochip to excite fluorescence from a sample spot on the biochip; a filter for filtering off the light beam from the light source and the scattered light from the surface on the biochip; a photomultiplier tube (PMT) for detecting and converting the fluorescence into a current signal; and an output device for outputting/displaying the current signal detected by the PMT. The output device controls the platform to match the pattern of the biochip. No conversion of the output signal of the output device into image data is needed. A real-time analysis proceeds while samples are being scanned on the biochip. The biochip scanner device of the present invention reads the current signal from PMT directly without processing it into image data and setting lens before the PMT is no longer needed. As a result, the structure of the device is simplified and the cost for production is reduced.
摘要翻译：生物芯片扫描器装置包括用于发射光束的光源; 光处理单元，用于将光束聚焦到生物芯片上以从生物芯片上的样品点激发荧光; 用于滤除来自光源的光束的滤光器和来自生物芯片上的表面的散射光; 用于检测并将荧光转换成电流信号的光电倍增管（PMT）; 以及用于输出/显示由PMT检测的电流信号的输出装置。输出设备控制平台以匹配生物芯片的图案。不需要将输出设备的输出信号转换为图像数据。在生物芯片上扫描样品时，进行实时分析。本发明的生物芯片扫描器装置在PMT不再需要之前直接从PMT读取当前信号而不将其处理成图像数据和设置透镜。结果，简化了装置的结构，降低了生产成本。

2. 发明授权

US07042565B2 Fluorescent microarray analyzer 失效
标题翻译：荧光微阵列分析仪
公开(公告)号：US07042565B2
公开(公告)日：2006-05-09
申请号：US10777720
申请日：2004-02-13
申请人： Jiann-Hua Wang , Hui Ju Chen , Tzu-Chiang Wu , Chien-Ho Chuang , Tsung-Kai Chuang
发明人： Jiann-Hua Wang , Hui Ju Chen , Tzu-Chiang Wu , Chien-Ho Chuang , Tsung-Kai Chuang
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N2021/6417
摘要： A fluorescent microarray analyzer includes a light source for emitting a light beam, a light processing unit for focusing the light beam on the biochip and exciting fluorescent targets on the biochip to produce fluorescence, a focusing lens for focusing the fluorescence on a spectrophotometer, a spectrophotometer for detecting signal of the fluorescence, and an output device for selectively outputting/displaying the signal detected by the spectrophotometer. The resulting signal of the output device does not need to be converted into image data for analysis. For acquiring a more accurate result of detection of signal of fluorescence from the fluorescent targets, the photomultiplier tube of the conventional biochip scanner device is replaced with the spectrophotometer of fluorescent microarray analyzer of the present invention and the filter is removed. Without converting the signal into an image, no errors arise as what happened in process of converting an electrical signal into image data in the conventional biochip. Also, a real-time analysis of the signal proceeds while scanning samples on the biochip.
摘要翻译：荧光微阵列分析仪包括用于发射光束的光源，用于将光束聚焦在生物芯片上并激发生物芯片上的荧光靶产生荧光的光处理单元，用于将荧光聚焦在分光光度计上的聚焦透镜，分光光度计用于检测荧光信号;以及输出装置，用于选择性地输出/显示由分光光度计检测的信号。输出装置的结果信号不需要转换为图像数据进行分析。为了从荧光靶获得更准确的荧光信号结果，用本发明的荧光微阵列分析仪的分光光度计代替常规生物芯片扫描器装置的光电倍增管，并除去滤光片。在不将信号转换为图像的情况下，在传统生物芯片中将电信号转换为图像数据的过程中没有发生错误。此外，在生物芯片上扫描样品时，信号的实时分析进行。

3. 发明申请

US20080085213A1 Cartridge-type reagent chip analyzer 审中-公开
标题翻译：盒式试剂芯片分析仪
公开(公告)号：US20080085213A1
公开(公告)日：2008-04-10
申请号：US11542179
申请日：2006-10-04
申请人： Tzu-Chiang Wu , Mao-Ji Lin , Chien-Ho Chuang , Tsung-Kai Chuang , Jiann-Hua Wang
发明人： Tzu-Chiang Wu , Mao-Ji Lin , Chien-Ho Chuang , Tsung-Kai Chuang , Jiann-Hua Wang
IPC分类号： G01N33/48
CPC分类号： G01N33/48714
摘要： A cartridge-type reagent chip analyzer is provided to analyze various specifications of reagent chips. A primary feature of the present invention is to provide a gear mounted on a base and two gear racks symmetrically meshing with the gear. The gear racks are connected to two guiding components and connected to the base by two springs respectively. When a reagent chip is inserted, the guiding components are pushed apart and guide the reagent chip to enter the analyzer. When the reagent chip is ejected out of the analyzer, the springs force the guiding components back to their original positions.
摘要翻译：提供了一种盒型试剂芯片分析仪，用于分析试剂芯片的各种规格。本发明的主要特征在于提供安装在基座上的齿轮和与齿轮对称地啮合的两个齿轮架。齿轮架连接到两个引导部件，并分别由两个弹簧连接到基座。当插入试剂芯片时，引导部件被推开并引导试剂芯片进入分析器。当试剂芯片从分析仪中排出时，弹簧迫使导向部件回到原来的位置。

4. 发明申请

US20050157300A1 Biochip scanner device 审中-公开
标题翻译：生物芯片扫描仪装置
公开(公告)号：US20050157300A1
公开(公告)日：2005-07-21
申请号：US10760465
申请日：2004-01-21
申请人： Jiann-Hua Wang , Hui Chen , Tzu-Chiang Wu , Chien-Ho Chuang , Tsung-Kai Chuang
发明人： Jiann-Hua Wang , Hui Chen , Tzu-Chiang Wu , Chien-Ho Chuang , Tsung-Kai Chuang
IPC分类号： C12M1/34 , C12Q1/68 , G01N21/64
CPC分类号： G01N21/6456 , G01N21/6428 , G01N21/6452
摘要： A biochip scanner device includes a light source for emitting a light beam; a light processing unit for focusing the light beam onto the biochip to excite fluorescence from a fluorescent target on the biochip; a filter for filtering off the light beam from the light source; a photomultiplier tube (PMT) for detecting and converting the fluorescence into an electrical signal; and an output device for outputting/displaying the electrical signal detected by the PMT. No conversion of the output signal of the output device into image data is needed. A real-time analysis proceeds while samples are being scanned on the biochip. The biochip scanner device of the present invention reads the electrical signal from PMT directly without processing it into image data and setting lens before the PMT is no longer needed. As a result, the structure of the device is simplified and the cost for production is reduced.
摘要翻译：生物芯片扫描器装置包括用于发射光束的光源; 光处理单元，用于将光束聚焦到生物芯片上以从生物芯片上的荧光目标激发荧光; 用于滤除来自光源的光束的滤光器; 用于检测和转换荧光成电信号的光电倍增管（PMT）; 以及用于输出/显示由PMT检测的电信号的输出装置。不需要将输出设备的输出信号转换为图像数据。在生物芯片上扫描样品时，进行实时分析。本发明的生物芯片扫描器装置在PMT不再需要之前，直接从PMT读取电信号而不将其处理成图像数据和设置透镜。结果，简化了装置的结构，降低了生产成本。

5. 发明授权

US08195408B2 Method for setting up system of reagent chip analyzer 有权
标题翻译：方法设置试剂芯片分析仪系统
公开(公告)号：US08195408B2
公开(公告)日：2012-06-05
申请号：US11964152
申请日：2007-12-26
申请人： Tzu-Chiang Wu , Chien-Ho Chuang , Tsung-Kai Chuang , Jiann-Hua Wang
发明人： Tzu-Chiang Wu , Chien-Ho Chuang , Tsung-Kai Chuang , Jiann-Hua Wang
IPC分类号： G01N31/00
CPC分类号： G01N35/00732 , G01N2035/00851
摘要： A method for setting up a system of a reagent chip analyzer is provided. The method is adapted to modify parameters and testing conditions according to data of an authorization tag, so as to improve the adaptability range of the reagent chip analyzer for reagent chips of multiple specifications. The method includes: reading an identification code, authorization times, and specifications and analysis parameters of the reagent chip from an RFID tag; determining whether to load the specifications and the analysis parameters of the reagent chip according to the identification code and the authorization times; and if it is determined to load the specifications and the analysis parameters of the reagent chip, decreasing the authorization times by one, and analyzing the reagent chip according to the specifications and the analysis parameters of the reagent chip.
摘要翻译：提供了一种用于设置试剂芯片分析仪的系统的方法。该方法适用于根据授权标签的数据修改参数和测试条件，以提高多种规格的试剂芯片的试剂芯片分析仪的适应范围。该方法包括：从RFID标签读取试剂芯片的识别码，授权时间，规格和分析参数; 根据识别码和授权时间确定是否加载试剂芯片的规格和分析参数; 如果确定加载试剂芯片的规格和分析参数，则将授权时间减少一次，并根据试剂芯片的规格和分析参数对试剂芯片进行分析。

6. 发明申请

US20050179900A1 CCD-based biochip reader 失效
标题翻译：基于CCD的生物芯片阅读器
公开(公告)号：US20050179900A1
公开(公告)日：2005-08-18
申请号：US10777651
申请日：2004-02-13
申请人： Jiann-Hua Wang , Tsung-Kai Chuang , Tzu-Chiang Wu , Chien-Ho Chuang
发明人： Jiann-Hua Wang , Tsung-Kai Chuang , Tzu-Chiang Wu , Chien-Ho Chuang
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/6428 , G01N21/6456
摘要： A CCD-based biochip reader includes a light source for emitting light beams, a collimating lens for converting the light beams into wide parallel rays of light, passing said wide parallel rays of light through a biochip and exciting fluorescence from fluorescent targets on the biochip, a focusing lens for focusing the fluorescence, a filter for filtering out said parallel rays of light, and a charge-coupled device camera for generating images from said fluorescence. For recording intensity of the fluorescence from the fluorescent targets, images of the charge-coupled device camera is converted into digital data through an image converting device. Wide parallel laser beams are produced by the laser and through the collimating lens, and excite all samples on the biochip with high efficiency at the same time. In addition, time for analysis is saved when fluorescent images of a large area on biochips are collected and analyzed through the charge-coupled device camera.
摘要翻译：基于CCD的生物芯片读取器包括用于发射光束的光源，用于将光束转换成宽平行光线的准直透镜，使所述宽平行光线通过生物芯片并从生物芯片上的荧光目标激发荧光，用于聚焦荧光的聚焦透镜，用于滤出所述平行光线的滤光器和用于从所述荧光产生图像的电荷耦合器件相机。为了记录来自荧光目标的荧光的强度，电荷耦合器件相机的图像通过图像转换装置转换成数字数据。通过激光和准直透镜产生宽平行激光束，同时以高效率激发生物芯片上的所有样品。此外，通过电荷耦合器件相机收集和分析生物芯片上大面积的荧光图像时，可节省分析时间。

7. 发明授权

US07173701B2 CCD-based biochip reader 失效
标题翻译：基于CCD的生物芯片阅读器
公开(公告)号：US07173701B2
公开(公告)日：2007-02-06
申请号：US10777651
申请日：2004-02-13
申请人： Jiann-Hua Wang , Tsung-Kai Chuang , Tzu-Chiang Wu , Chien-Ho Chuang
发明人： Jiann-Hua Wang , Tsung-Kai Chuang , Tzu-Chiang Wu , Chien-Ho Chuang
IPC分类号： G01J21/64
CPC分类号： G01N21/6452 , G01N21/6428 , G01N21/6456
摘要： A CCD-based biochip reader includes a light source for emitting light beams, a collimating lens for converting the light beams into wide parallel rays of light, passing said wide parallel rays of light through a biochip and exciting fluorescence from fluorescent targets on the biochip, a focusing lens for focusing the fluorescence, a filter for filtering out said parallel rays of light, and a charge-coupled device camera for generating images from said fluorescence. For recording intensity of the fluorescence from the fluorescent targets, images of the charge-coupled device camera is converted into digital data through an image converting device. Wide parallel laser beams are produced by the laser and through the collimating lens, and excite all samples on the biochip with high efficiency at the same time. In addition, time for analysis is saved when fluorescent images of a large area on biochips are collected and analyzed through the charge-coupled device camera.
摘要翻译：基于CCD的生物芯片读取器包括用于发射光束的光源，用于将光束转换成宽平行光线的准直透镜，使所述宽平行光线通过生物芯片并从生物芯片上的荧光目标激发荧光，用于聚焦荧光的聚焦透镜，用于滤出所述平行光线的滤光器和用于从所述荧光产生图像的电荷耦合器件相机。为了记录来自荧光目标的荧光的强度，电荷耦合器件相机的图像通过图像转换装置转换成数字数据。通过激光和准直透镜产生宽平行激光束，同时以高效率激发生物芯片上的所有样品。此外，通过电荷耦合器件相机收集和分析生物芯片上大面积的荧光图像时，可节省分析时间。

8. 发明申请

US20060133959A1 Luminometer for simultaneously detecting multiple samples 审中-公开
标题翻译：用于同时检测多个样品的发光计
公开(公告)号：US20060133959A1
公开(公告)日：2006-06-22
申请号：US11155584
申请日：2005-06-20
申请人： Jiann-Hua Wang , Tsung-Kai Chuang , Tzu-Chiang Wu , Chien-Ho Chuang
发明人： Jiann-Hua Wang , Tsung-Kai Chuang , Tzu-Chiang Wu , Chien-Ho Chuang
IPC分类号： G01N21/64
CPC分类号： G01N21/253 , G01N21/76
摘要： A luminometer includes a movable carrier carrying a number of luminescence collectors arranged in an array for simultaneously detecting the same number of samples received in multiple wells defined in a microplate. An optic fiber optically couples each luminescence detector to an associated charge-coupled device whereby a luminescence signal emitted from each sample is transmitted to the charge-coupled device and converted thereby into a corresponding electric signal. The charge-coupled devices are isolated from each other by partitions, which eliminate undesired interference among the luminescence signals transmitted to the charge-coupled device. A driving unit is provided to move the carrier between rows of the wells defined in the microplate.
摘要翻译：发光计包括携带多个以阵列排列的发光收集器的可移动载体，用于同时检测在微板中限定的多个孔中接收的相同数量的样品。光纤将每个发光检测器光耦合到相关联的电荷耦合器件，由此从每个样本发射的发光信号传输到电荷耦合器件，从而转换成相应的电信号。电荷耦合器件通过分隔彼此隔离，这消除了传输到电荷耦合器件的发光信号之间的不期望的干扰。提供了一个驱动单元，用于在微孔板中限定的孔的行之间移动载体。

9. 发明申请

US20090275806A1 Protable biomedical detective device 审中-公开
标题翻译：保护性生物医学侦探装置
公开(公告)号：US20090275806A1
公开(公告)日：2009-11-05
申请号：US12114204
申请日：2008-05-02
申请人： Tzu-Chiang Wu , Mao-Ji Lin , Chien-Ho Chuang , Tsung-Kai Chuang , Jiann-Hua Wang
发明人： Tzu-Chiang Wu , Mao-Ji Lin , Chien-Ho Chuang , Tsung-Kai Chuang , Jiann-Hua Wang
IPC分类号： A61B5/00
CPC分类号： A61B10/0096 , A61B10/0045
摘要： The present invention relates to a portable biomedical detective device comprising a carrier, a detective unit disposed in the carrier, an operating unit for converting biomedical signals of the detection into digitalized results, a display unit shown the digitalized results, and a power supply to drive the detective unit, the operating unit and the display unit. Therefore, biomedical signals on a biomedical cassette can be detected and converted into digital results by the portable biomedical detective device, which is light for carrying easily.
摘要翻译：本发明涉及便携式生物医学检测装置，其包括载体，设置在载体中的检测单元，用于将检测的生物医学信号转换为数字化结果的操作单元，显示数字化结果的显示单元和驱动的电源检测单元，操作单元和显示单元。因此，可以通过便携式生物医学检测装置检测生物医学盒上的生物医学信号并将其转换成数字结果，该装置轻便携带。

10. 发明申请

US20070253867A1 Cylindrical reagent chip analyzer 审中-公开
标题翻译：圆柱试剂芯片分析仪
公开(公告)号：US20070253867A1
公开(公告)日：2007-11-01
申请号：US11542259
申请日：2006-10-04
申请人： Tzu-Chiang Wu , Mao-Ji Lin , Chien-Ho Chuang , Tsung-Kai Chuang , Jiann-Hua Wang
发明人： Tzu-Chiang Wu , Mao-Ji Lin , Chien-Ho Chuang , Tsung-Kai Chuang , Jiann-Hua Wang
IPC分类号： G01N21/00
CPC分类号： G01N21/255 , G01N21/272 , G01N21/8483
摘要： A cylindrical reagent chip analyzer, comprises a rotating seat with a sample collection device mounted thereon, a motor, an image receiver connected to a computer. The motor drives the rotating seat to rotate. A lens of the image receiver is focused on reagent chips on the sample collection device. The image receiver then takes the images of the reagent chips and inputs the image data into the computer. The testing results are obtained after a color code comparison program analyzes the taken images.
摘要翻译：一种圆柱形试剂芯片分析仪，包括安装有样品收集装置的旋转座，马达，连接到计算机的图像接收器。电机驱动旋转座椅旋转。图像接收器的透镜聚焦在样品收集装置上的试剂芯片上。然后，图像接收器接收试剂芯片的图像，并将图像数据输入计算机。在颜色代码比较程序分析所拍摄的图像之后获得测试结果。

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